Snowbird Resort Floorplan

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This meeting took place in 2015


Here are the related meetings in 2018:
T Cell Dysfunction, Cancer and Infection (A3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

T Cells: Regulation and Effector Function (D3)


Organizer(s) Alexander Y. Rudensky, Dan R. Littman and Kristin A. Hogquist
March 29—April 3, 2015
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Dec 2, 2014
Abstract Deadline: Jan 7, 2015
Scholarship Deadline: Dec 2, 2014
Discounted Registration Deadline: Jan 28, 2015

Sponsored by Arena Pharmaceuticals, Inc., BioLegend, Inc., Pfizer Inc., Regeneron Pharmaceuticals, Inc., Roche and Takeda Pharmaceutical Company Limited. Supported by an educational donation provided by Amgen.

Summary of Meeting:
T lymphocytes play a pivotal role in the immune system of vertebrate animals as a key regulatory and effector cell type. Recently, a remarkable progress has been made in the understanding of molecular and cellular mechanisms of differentiation and activation of T lymphocytes and in the elucidation of diverse functional T cell subsets and their biological roles in a variety of physiological and pathological settings. This meeting will bring together leading investigators from the academia and industry studying diverse aspects of T cell biology. The overarching goal of this broadly themed meeting is to facilitate development of a synthetic view of increasingly complex mechanisms of T cell differentiation and function and of interactions between diverse types of T lymphocytes and other cells of the immune system in health and disease. By attracting a diverse array of scientists and students this integrative meeting will cover a wide array of topics and stimulate discussions and interactions, and foster collaborations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 29

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, MARCH 30

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Wendell A. Lim, University of California, San Francisco, USA
The Molecular Logic of Cellular Signaling Systems

09:00—12:00
T Cell Development
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Thomas Boehm, Max Planck Institute of Immunobiology and Epigenetics, Germany
Evolutionary Origins of T Lymphocyte Lineages

* Kristin A. Hogquist, University of Minnesota, USA
T Cell Adolescence

Avinash S. Bhandoola, HHS/National Institutes of Health, USA
Transcription Factor T Cell Factor 1 in Adaptive and Innate Lymphoid Cell Development

Ichiro Taniuchi, RIKEN Research Center for Allergy and Immunology, Japan
Transcriptional Regulation of T Cell Development in the Thymus

Virginia S. Shapiro, Mayo Graduate School College of Medicine, USA
Short Talk: Immature Recent Thymic Emigrants Are Eliminated by Complement

09:40—10:00
Coffee Break

Ballroom Lobby
12:00—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 1

Ballroom 2-3
* Susan R. Schwab, New York University School of Medicine, USA

* Grégoire Altan-Bonnet, National Cancer Institute, National Institutes of Health, USA

Brenda Y. Han, University of California, San Francisco, USA
Zinc Finger Protein Zfp335 Is Required for the Formation of the Naïve T Cell Compartment

Hiroyuki Takaba, University of Tokyo, Japan
Identification of a Novel Autoimmune Regulator of Immune Tolerance

Michal Polonsky, Weizmann Institute of Science, Israel
Characterizing the Dynamics of T-Helper Cell Differentiation Using Live Cell Imaging Analysis of Small Cell Numbers

Julia M. Marchingo, Walter and Eliza Hall Institute of Medical Research, Australia
Predicting T Cell Expansion from Quantitative Principles

Enfu Hui, University of California, San Francisco, USA
Dissecting the Molecular Mechanism of PD-1 Signaling Using Reconstitution Approaches

Adriana M. Mujal, University of California, San Francisco, USA
Selective Requirement of the Septin Cytoskeleton Differentiates Cytokine- and Antigen-Driven CD8+ T Cell Proliferation

Katherine Bao, Duke University, USA
Basic Leucine Zipper Transcription Factor, ATF-Like (BATF) Is Essential for the Development of Protective Immunity Against Parasitic Helminth Infection

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:15
Innate T Cells
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Wendy L. Havran, The Scripps Research Institute, USA
gamma delta T Cells and the Regulation of Immune Responses at Epithelial Surfaces

Albert S. Bendelac, University of Chicago, USA
Innate and Innate-Like Lymphocytes

Laurent Gapin, University of Colorado and National Jewish Medical and Research Center, USA
Specificity and Development of iNKT Cells

Marc-Werner Dobenecker, Rockefeller University, USA
Short Talk: Coupling of T Cell Receptor Specificity to Natural Killer T Cell Development by Bivalent Histone H3 Methylation

Daniel G. Pellicci, University of Melbourne, Australia
Short Talk: T Cell Recognition of CD1a Presenting Self-Lipid Antigens

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Wasatch

TUESDAY, MARCH 31

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
T Cell Recognition and Activation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Pamela L. Schwartzberg, NHGRI, National Institutes of Health, USA
Itk-Mediated Integration of T Helper Cell Differentiation

Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
Toward an Integrative Biology of T Cells and Dendritic Cells

Mark M. Davis, Stanford University, USA
T Cell Recognition and Human Immunology

Morgan Huse, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Lipid-Based Control of T Cell Polarity and Function

Cheng Zhu, Georgia Institute of Technology, USA
Short Talk: Cooperative TCR–pMHC–CD8 Bond Lifetime Distinguishes Thymocyte Fate

11:00—12:00
Understanding NIH Peer Review
The objective of this workshop is for grant writers to learn to think like reviewers in order to understand how to write for their target audience. Workshop is presented by David Winter, Scientific Review Officer, NIH

Ballroom 2-3
09:20—09:40
Coffee Break

Ballroom Lobby
11:15—13:15
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:15
T Cells at Mucosal Surfaces
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Dan R. Littman, HHMI/New York University School of Medicine, USA
Programming of T Cell Effector Functions by the Intestinal Microbiota

Daniel J. Cua, Merck Research Laboratories, USA
Inflammatory T Cells

Mitchell Kronenberg, La Jolla Institute for Allergy and Immunology, USA
Genetic Control of NKT Cell Differentiation

Marion Pepper, University of Washington, USA
Short Talk: The Differentiation and Function of Allergen-Specific Th2 Memory Cells

Darina S. Spasova, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Systemic Viral Infection Fails to Produce Memory T Cells in the Absence of Commensal Microbiota

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Wasatch

WEDNESDAY, APRIL 1

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
T Cell Response to Pathogens
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* E. John Wherry, University of Pennsylvania, USA
Regulating T Cell Responses during Chronic Infection

Marc K. Jenkins, University of Minnesota Medical School, USA
Mechanisms of Immune Memory by CD4+ T Cells

Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
The Human T Cell Response to Microbes

Christopher A. Hunter, University of Pennsylvania, USA
Imaging Treg and Plasma Cell Responses to Infection

Tianxia Guan, Yale University, USA
Short Talk: The Transcription Factors Zeb1 and Zeb2 Reciprocally Regulate Memory and Effector CD8+ T Cell Fates during Viral Infection

Klaas P.J.M. Van Gisbergen, Sanquin Research, Netherlands
Short Talk: The Transcriptional Regulator Hobit and its Homologue Blimp-1 Cooperatively Establish Tissue-Residency of Lymphocytes

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 2

Ballroom 2-3
Andreia Da Costa, University of Washington, USA
Migratory Treg Balance Is Critical to the Maintenance of CD8+ T Cell Homeostasis and Memory Development in West Nile Virus Infected Mice

Brian J. Laidlaw, University of California, San Francisco, USA
Regulatory CD4+ T Cell Derived IL-10 Critical in Promoting Memory CD8+ T Cell Maturation

Jyh Liang Hor, Peter Doherty Institute, University of Melbourne, Australia
Temporal Regulation of T Cell Priming and Cellular Dynamics during Peripheral Viral Infection

Laura K. Mackay, University of Melbourne, Australia
Transcriptional Regulation of Tissue-Resident Memory T Cell Development

* Dale I. Godfrey, University of Melbourne, Australia
Identification of Phenotypically and Functionally Heterogeneous Mouse Mucosal Associated Invariant T Cells Using MR1 Tetramers

* Olivier Lantz, Institut Curie, France
Distal TCR Valpha Segment Usage Determines the Abundance of MAIT Cells in Mice: A Functional Characterization of Naturally Occurring MAIT Cells

Frederic Van Gool, University of California, San Francisco, USA
Potential Role of Group-2 Innate Lymphoid Cells in Autoimmunity

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:15
T Cell Differentiation, Metabolism and Effector Function
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Erika L. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Regulation of T Cell Function and Fate

Grégoire Altan-Bonnet, National Cancer Institute, National Institutes of Health, USA
Collective Synchronization and Tuning of Self/Non-Self Discrimination in T Cell Activation

Stephen C. Jameson, University of Minnesota Medical School, USA
The Transcription Factor KLF2 Regulates CD4+ T Cell Differentiation

Shannon M. Kahan, University of Alabama at Birmingham, USA
Short Talk: IL-2 Production by Activated Naïve and Effector CD8 T Cells Predicts Memory Formation

Laura A. Solt, The Scripps Research Institute, USA
Short Talk: RORa and RORgt Coordinately Regulate Metabolic Processes Essential for TH17 Cell Development and Function

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Wasatch

THURSDAY, APRIL 2

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
T Cell Trafficking and Cellular Interactions
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immunity: Creating a Spatiotemporal Understanding of Host Defense

Michael L. Dustin, University of Oxford, UK
Role of Antigen Stop Signal in T Cell Tolerance and Priming

* Ulrich H. Von Andrian, Harvard Medical School, USA
CX3CR1 Identifies Three Distinct Subsets of Antigen-Experienced CD8+ T Cells

Susan R. Schwab, New York University School of Medicine, USA
Chemokine Receptor Signaling and T Cell Survival

Brian C. Schaefer, Uniformed Services University, USA
Short Talk: Regulation of T Cell Receptor Signaling to NF-kappaB by Microtubule Transport of Signalosomes to Aggresomes

Wolfgang Kastenmüller, University of Bonn, Germany
Short Talk: Multiple Spatially and Temporally Distinct T Cell-Dendritic Cell Interactions Support Effective Anti-Viral Immunity

09:20—09:40
Coffee Break

Ballroom Lobby
11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 3

Ballroom 2-3
* Akihiko Yoshimura, Keio University, Japan
Treg Induction Mechanism by Gram-Positive Bacterium Clostridium butyricum in the Intestine

Abby L. Geis, Arkansas College of Osteopathic Medicine, USA
A Pro-Inflammatory Response of Mucosal Tregs to Enterotoxigenic Bacteroides fragilis Promotes IL-17-Dependent Colon Neoplasia

Reshma Singh, Novartis Institutes for BioMedical Research, USA
Trafficking and Function of EGFR Variant III Chimeric Antigen Receptor (CAR) T Cells for Glioblastoma

* Markus Mohrs, Trudeau Institute, USA
Virtual Memory CD8 T Cells Expand during Helminth Infection and Confer Protection Against Bacterial Challenge

Edward Y. Kim, Massachusetts General Hospital, Harvard Medical School, USA
Dynamic Treg Interactions with Intratumoral APCs Promote Local CTL Dysfunction

Sarah Q. Crome, University Health Network, Canada
Regulatory Innate Lymphocytes Suppress Anti-Tumor T Cells

Lokesh A. Kalekar, University of Minnesota - Twin Cities, USA
Anergy Induction in Polyclonal CD4 T Cells Prevents Autoimmunity and Generates Inducible Regulatory T Cell (iTreg) Intermediates

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
T Cell Regulation and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Diane Mathis, Harvard Medical School, USA
IL:33 a Muscle Alarm for Harm

Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Differentiation and Function of Regulatory T Cells

Shimon Sakaguchi, Osaka University, Japan
Control of Immune Responses by Regulatory T Cells

Richard M. Siegel, NIAMS, National Institutes of Health, USA
Short Talk: Fas/CD95 Promotes T Cell Differentiation and Prevents Autoimmunity Independently of its Ability to Induce Cell Death

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1-2
20:15—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 1-2

FRIDAY, APRIL 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Educational donation provided by Amgen Arena Pharmaceuticals, Inc.
BioLegend, Inc. Pfizer Inc.
Regeneron Pharmaceuticals, Inc. Roche
Takeda Pharmaceutical Company Limited
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI115994-01

Funding for this conference was made possible [in part] by 1 R13 AI 115994 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

eBioscience, an Affymetrix company Essential Pharmaceuticals

Mucosal Immunology Studies Team (MIST)

 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676