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This meeting took place in 2015



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Viruses and Human Cancer (D2)


Organizer(s) Charles R.M. Bangham, Thomas F. Schulz and Paul M. Lieberman
March 29—April 3, 2015
Big Sky Resort • Big Sky, Montana USA
Discounted Abstract Deadline: Dec 2, 2014
Abstract Deadline: Jan 6, 2015
Scholarship Deadline: Dec 2, 2014
Discounted Registration Deadline: Jan 27, 2015

Sponsored by Merck & Co., Inc., Regeneron Pharmaceuticals, Inc. and Roche

Summary of Meeting:
In 1970, an authoritative book entitled “Viruses and Cancer” was published by Sir Christopher Andrews, one of the discoverers of influenza virus. On page 135 he wrote “Despite these findings, there is no doubt that as regards the generality of cancers in man, and indeed in other mammals, there is no direct evidence that viruses are concerned”. It is now estimated that about 20% of human cancers are caused by infectious agents, among them at least 7 viruses. The increasing appreciation of the role of viruses in cancer pathogenesis has not only already led to the development of two successful vaccines (against HBV and HPV) that prevent cancer, it has also directly contributed to many fundamental discoveries in cancer biology. In the last decade the understanding of virus-induced cancers has been accelerated by the extraordinary developments in genomics, epigenetics and RNA biology. To review this rapidly burgeoning field, this multidisciplinary symposium brings together experts in virology, oncology, immunology, genomics and genetics. The objective of the symposium is to explore how advances in cancer biology can inform the understanding of virus-induced cancers, and how viruses continue to reveal fundamental principles in cancer. Particular emphasis will be laid on the interaction between virus and host in persistent infections by oncogenic viruses. The meeting will cover examples of cancers where a viral cause is still under debate and the rapid development of technology for the detection of unknown viruses.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, MARCH 29

16:00—20:00
Arrival and Registration

Lower Atrium
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Jefferson

MONDAY, MARCH 30

07:00—08:00
Breakfast

Gallatin
08:00—08:15
Welcome Remarks
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
Charles R.M. Bangham, Imperial College Department of Medicine, UK

08:00—11:30
Mimicry of Host Pathways
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Thomas F. Schulz, Hannover Medical School, Germany

Carolina Arias, University of California San Francisco, USA
Cell Lineage Dramatically Impacts Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression

Blossom A. Damania, University of North Carolina at Chapel Hill, USA
Subversion of Host Cell Signaling by KSHV

Ulrike Protzer, Technische Universität München, Germany
Cytolytic and Non-Cytolytic Control of Hepatitis B Virus Persistence

Eleonora Forte, Northwestern University, USA
Short Talk: A Partial Tumor Virus Mimic of miR-142-3p Disrupts Adherens Junctions

Lori D. Frappier, University of Toronto, Canada
Short Talk: Mechanism and Consequences of CK2 Kinase Hijacking by Epstein-Barr Virus Nuclear Antigen 1 (EBNA1)

09:20—09:40
Coffee Break

Lower Atrium
11:30—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin
11:30—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Viral Mimicry

Jefferson/Madison
* Paul M. Lieberman, Wistar Institute, USA

Silvia Gramolelli, Hannover Medical School, Germany
Kaposi Sarcoma Herpesvirus (KSHV) K15 Protein Contributes to the Increased Invasiveness and Angiogenic Properties of Infected Endothelial Cells

Alexander S. Hahn, University of Erlangen-Nuremberg, Germany
Rhadinovirus Receptor Tropism for Endothelial Cell Surface Molecules

Christine Happel, NCI, National Institutes of Health, USA
KSHV Regulation of the MicroRNA Biogenesis Pathway

Robert F. Kalejta, University of Wisconsin-Madison, USA
Retinoblastoma Protein Cleft and LxCxE Docking Motif Required for Human Cytomegalovirus vCdk UL97-Mediated Activation of E2F-Responsive Transcription

Frank Neipel, Universitaet Erlangen, Germany
The Ephrin A2 Receptor Tyrosin Kinase (EphA2) Is Required for KSHV Endocytosis and Membrane Fusion in Endothelial Cells

Vijay Kumar, International Centre for Genetic Engineering and Biotechnology, India
HBx Oncoprotein Hijacks the Nucleolar Functions to Promote Cellular Transformation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:15
Latency and Persistence I
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Maria G. Masucci, Karolinska Institute, Sweden

Alison A. McBride, NIAID, National Institutes of Health, USA
Papillomaviruses exploit Multiple Cellular Processes to Replicate their Genomes at Different Phases of the Virus Life Cycle

David Thorley-Lawson, Tufts University School of Medicine, USA
How EBV Persists in vivo and its Relevance to Human Cancer

Paul M. Lieberman, Wistar Institute, USA
Epigenetic Regulation of Gammaherpesvirus Latency

Giuseppe Balistreri, University of Helsinki, Finland
Short Talk: Stress Response and G2 Cell-Cycle Arrest during KSHV Lytic Phase Ensure Efficient Viral Lytic Gene Expression and Make Reactivated Cells Addicted to Anti-Apoptotic Pathways

Jennifer Corcoran, Dalhousie University, Canada
Short Talk: Viral Activation of MK2-hsp27-p115RhoGEF-RhoA Signaling Axis Causes Cytoskeletal Rearrangements, P-Body Disruption and ARE-mRNA Stabilization

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
19:30—22:00
Poster Session 1

Gallatin

TUESDAY, MARCH 31

07:00—08:00
Breakfast

Gallatin
08:00—11:00
Inflammation and Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Ulrike Protzer, Technische Universität München, Germany

Stacy M. Horner, Duke University Medical Center, USA
Activation and Evasion of Innate Immune and Inflammatory Signaling by HCV

Paivi M. Ojala, Institute of Biotechnology, University of Helsinki, Finland
Lymphatic Reprogramming in KSHV Pathogenesis and Cancer

Benjamin E. Gewurz, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: The NF-kappaB Landscape in EBV-Transformed Lymphoblastoid B-Cells

Mei-Ru Chen, National Taiwan University, Taiwan
Modification of Nuclear Envelope Induced by EBV Replication

Sang Hyuk Chung, University of Houston, USA
Short Talk: Mechanisms by which Estrogen Receptor alpha Cooperates with HPV Oncogenes for Cervical Carcinogenesis

Masaru Shimada, Yokohama City University, Japan
Short Talk: The Role of Apoptosis Inducing Factor 1 (AIFM1) in HPV-Inducing Cancer

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:30
Latency and Persistence II
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Paul M. Lieberman, Wistar Institute, USA

Masao Matsuoka, Kyoto University, Japan
Role of HTLV-1 bZIP Factor Gene in Viral Pathogenesis

Charles R.M. Bangham, Imperial College Department of Medicine, UK
Regulation of HTLV-1 Clonality: When Does Leukemia Result?

Maria G. Masucci, Karolinska Institute, Sweden
Disruption of Cellular Processes in Epstein-Barr Virus Replication and Oncogenesis

Thomas F. Schulz, Hannover Medical School, Germany
BET Chromatin Proteins Regulate Gammaherpesviral Latency and Retroviral Integration

Vaibhav Jain, University of Florida, USA
Short Talk: Role of LANA N-Terminus Histone Binding Domain in Transcriptional Control and Episome Maintenance

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
19:30—22:00
Poster Session 2

Gallatin

WEDNESDAY, APRIL 1

07:00—08:00
Breakfast

Gallatin
08:00—11:15
Genetics and Epigenetics I
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Martin J. Allday, Imperial College London, UK

Yorifumi Satou, Kumamoto University, Japan
HTLV-1 Inserts an Ectopic CTCF-Binding Site into the Human Genome

Lucas L. Willems, Université de Liège, FNRS, Belgium
Mechanisms of BLV Persistence and Leukemogenesis

Paul F. Lambert, University of Wisconsin, USA
What Drives Development of HPV-Associated Cancers?

Christine E. Birdwell, Louisiana State University Health Sciences Center-Shreveport, USA
Short Talk: Epigenetic Consequences of Epstein-Barr Infection in Epithelial Cells

Sarah Jill de Jong, Rockefeller University, USA
Short Talk: EV3 Deficiency - A New Genetic Etiology Predisposing to Severe beta-HPV Infection and Squamous Cell Carcinoma

Massimo Tommasino, Infections and Cancer Biology Group-IARC, France
Role of Viral Infections in Human Cancers

09:20—09:40
Coffee Break

Lower Atrium
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Innate Defense

Jefferson/Madison
* Lucas L. Willems, Université de Liège, FNRS, Belgium

Amy Y. Hafez, Duke University, USA
EBV-Mediated B-Cell Transformation Is Suppressed by Oncogene-Induced Senescence through the DNA Damage Response

Alexander M. Price, Duke University, USA
Characterizing Survival in the Absence of LMP1-Mediated NF-kappaB Signaling Early after B-Cell Infection

Erica L. Sanchez, University of Washington, USA
Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival

Guigen Zhang, Hannover Medical School, Germany
Recruitment of an Innate Immune DNA Sensor by the Cytoplasmic Isoforms of KSHV LANA

Joseph M. Ziegelbauer, NCI, National Institutes of Health, USA
KSHV MicroRNAs Target Growth Arrest and DNA Damage-Inducible Gene (GADD45B) and Protect Cells from DNA Damage Consequences

Martin K. Thomsen, Aarhus University, Denmark
The Innate DNA Sensing Pathway Is Not Operative in Hepatocytes: Impact on HBV Infection

14:30—16:30
Workshop 3: Virus Discovery and Therapy

Amphitheater
* W. Ian Lipkin, Columbia University, USA

Alan K. Chiang, University of Hong Kong, China
Targeting EBV in EBV-Associated Malignancies

Johanna Classon, Karolinska Institutet, Sweden
Human Cytomegalovirus and the Androgen Receptor in Prostate Cancer

David Stein, Oregon State University, USA
Inhibition of Primary Effusion Lymphoma in SCID Mice by Blocking the Expression of vIL-6 in an Oncogenic Virus

Ruth F. Jarrett, University of Glasgow, UK
Viruses and Hodgkin Lymphoma

Jaap M. Middeldorp, VU University Medical Center, Netherlands
Cytolytic Virus Activation Therapy for Epstein-Barr Virus Driven Tumors

J.J. Miranda, Gladstone Institutes and University of California, San Francisco, USA
Viral Specificity of Small Molecule Latency Disruptors

16:30—17:00
Coffee Available

Lower Atrium
17:00—18:40
Genetics and Epigenetics II
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Paul F. Lambert, University of Wisconsin, USA

Martin J. Allday, Imperial College London, UK
EBNA3 Proteins and the Modulation of Nuclear Processes during the Transformation of B Cells by EBV

Matthew D. Weitzman, Children's Hospital of Philadelphia, USA
Viral Manipulation of DNA Replication and Damage Responses

Micah A. Luftig, Duke University Medical Center, USA
Short Talk: A New Temporal Model for Epstein-Barr Virus Immortalization of Human B Cells

Kayla Martin, Temple University, USA
Short Talk: Epstein-Barr Virus Protein LMP1 Mediates Epigenetic-Driven Changes in Host and Viral Gene Expression through PARP1

18:40—19:15
Immunity, Intracellular Defense and Vaccines
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
John T. Schiller, National Cancer Institute, National Institutes of Health, USA
Prophylactic HPV Vaccines: Why They Work So Well

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin

THURSDAY, APRIL 2

07:00—08:00
Breakfast

Gallatin
08:00—11:15
Host Defense
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Charles R.M. Bangham, Imperial College Department of Medicine, UK

Barbara Rehermann, NIDDK, National Institutes of Health, USA
Host Responses to HCV: Inflammation and Innate Immune Cell Responses

Adam J. Gehring, St. Louis University School of Medicine, USA
Immunotherapy for Chronic HBV Infection and HBV-Related Liver Cancer: New Strategies to Exploit the Viral Life Cycle for Personalize Therapy

Genoveffa Franchini, NCI, National Institutes of Health, USA
Polymorphisms in the Orf-I Gene in HTLV-I Replication in Monocytes and Immune Evasion

Cliona M. Rooney, Baylor College of Medicine, USA
Use of Viruses to Enhance the Efficacy of CAR-T-Cells

Cécile Bauche, Theravectys, France
Short Talk: Development of an Anti-HTLV-1 Vaccine for the Treatment of Adult T-Cell Leukemia/Lymphoma

Katja Spiess, University of Copenhagen, Denmark
Short Talk: A Rationally Designed Chemokine-Based Toxin Targeting Human Cytomegalovirus Provides Efficient and Selective Killing of HCMV Infected Cells

09:20—09:40
Coffee Break

Lower Atrium
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Genomics and Virus Discovery
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Ruth F. Jarrett, University of Glasgow, UK

Patrick S. Moore, University of Pittsburgh Cancer Institute, USA
How to Find a New Human Virus: Lessons from Merkel Cell Polyomavirus and Kaposi's Sarcoma Herpesvirus

Anne Palser, Wellcome Trust Sanger Institute, UK
EBV Sequencing Data

W. Ian Lipkin, Columbia University, USA
Microbe Hunting

Aaron J. Arvey, Gilead, USA
Short Talk: Host and Viral Transcriptome Landscape of AIDS-Related Lymphomas

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Gallatin
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Gallatin

FRIDAY, APRIL 3

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Merck & Co., Inc. Regeneron Pharmaceuticals, Inc.
Roche
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA192463-01

Funding for this conference was made possible (in part) by 1R13CA192463-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Novartis Institutes for BioMedical Research


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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