Beaver Run Resort Floorplan

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This meeting took place in 2015



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Viral Immunity (A2)


Organizer(s) Jonathan W. Yewdell, Donna L. Farber, Nicole Baumgarth and Jack R. Bennink
January 11—16, 2015
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Sep 22, 2014
Abstract Deadline: Oct 14, 2014
Scholarship Deadline: Sep 22, 2014
Discounted Registration Deadline: Nov 11, 2014

Supported by the Directors' Fund

Summary of Meeting:
The most exciting recent advances in viral immunity include the increased understanding of the role of innate immune mechanisms, interaction between innate and adaptive immunity, pathogen manipulation of host responses, activation of immune responses and immune effector functions. Despite these advances, basic mechanisms of anti-viral immunity are poorly characterized for many acute infections and less well understood for chronic infections. Efforts are required to exploit recent research advances to improve vaccine design and therapeutic intervention. This meeting will cover both innate and adaptive immunity and juxtapose animal models with human studies as it attempts to foster collaborative efforts among attending viral immunologists working in disparate systems and models. The overall meeting objective is to accelerate progress in understanding and manipulating anti-viral immunity to improve human health.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 11

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, JANUARY 12

07:00—08:00
Breakfast

Summit Gallery
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
Welcoming Remarks

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
Trans-Kingdom Metagenomic Interactions Regulate Viral Immunity

09:00—11:30
Innate Anti-Viral Immunity
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Carolina B. López, University of Pennsylvania, USA

* Kenneth L. Rock, University of Massachusetts Medical School, USA

Nicole Baumgarth, University of California, Davis, USA
Responder and Non-Responder B-1 Cells and their Functions in Influenza Infection

Leo James, MRC Laboratory of Molecular Biology, UK
Sensing Infection without PAMPs or DAMPs

John R. Teijaro, The Scripps Research Institute, USA
Short Talk: In Vivo Reverse Pharmacolgy of S1P1R Probes Reveal Plasmacytoid Dendritic Cells Are Essential for Cytokine Amplification

Steven Bradfute, University of New Mexico, USA
Short Talk: Mechanisms of Immunity in Post-Exposure Vaccination against Ebola Virus Infection

Christine A. Biron, Brown University, USA
Conditioning of Innate Anti-Viral Immunity

09:40—10:00
Coffee Break

Foyer
11:30—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Localized Anti-Viral Immunity
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Cornelia C. Bergmann, Cleveland Clinic Foundation, USA

* Kevin L. Legge, University of Iowa Carver College of Medicine, USA

Heather D. Hickman, NIAID, National Institutes of Health, USA
Effector CD8+ T Cell Function and Behavior in Virus-Infected Tissue

Dorian B. McGavern, National Institutes of Health, USA
Pathogen Distribution and Innate Cytokines Program Immune Dynamics following CNS Infection

Matteo Iannacone, Vita-Salute San Raffaele University, Italy
Short Talk: Determinants of Hepatic CD8+ T Cell Trafficking, Antigen Recognition and Effector Function

E. John Wherry, University of Pennsylvania, USA
Anti-Viral Immune Cooperativity

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

TUESDAY, JANUARY 13

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Anti-Viral Lymphocyte Triggering/Differentiation
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* David G. Brooks, Princess Margaret Cancer Center, Canada

* Jennifer M. Lund, Fred Hutchinson Cancer Research Center, USA

Donna L. Farber, Columbia University Medical Center, USA
Memory T Cell Compartmentalization in Mice and Men

Troy D. Randall, University of Alabama at Birmingham, USA
Epitope-Specific Regulation of CD8 T Cell Responses to Influenza Virus

George Kassiotis, Francis Crick Institute, UK
Short Talk: Clonotypic Selection of the CD4+ T Cell Response by B Cells

Carola G. Vinuesa, Australian National University, Australia
Post-Transcriptional Regulation of T Cell Help for B Cells

Johan K. Sandberg, Karolinska Institute, Sweden
Short Talk: Broad and Persistent MAIT Cell Dysfunction in Chronic HIV-1 Infection

Gabriel D. Victora, Rockefeller University, USA
Clonal Dynamics of Germinal Center Selection

09:20—09:40
Coffee Break

Foyer
11:15—12:45
NIAID Workshop: How to Succeed in Science

Colorado Ballroom
Jonathan W. Yewdell, NIAID, National Institutes of Health, USA

11:15—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 1: Mechanisms of Protection

Colorado Ballroom
* David C. Tscharke, Australian National University, Australia

* Ma Isabel Salazar, National School for Biological Sciences, Mexico

Asiel A. Benitez, Regeneron Pharmaceuticals, Inc, USA
An in vivo siRNA Screen with Influenza A Virus Identifies Ifih1 as a Potent Repressor of Viral Replication

Marcella Flores, amfAR, The Foundation for AIDS Research, USA
FcgammaRIIB Prevents Inflammatory Type I Interferon Production from Murine pDCs during a Viral Memory Response

Helen M. Lazear, University of North Carolina, USA
Interferon Lambda Restricts West Nile Virus Neuroinvasion by Enhancing Integrity of the Blood-Brain Barrier

Timothy J. Nice, Oregon Health and Science University, USA
Interferon Lambda Durably Clears Persistent Enteric Norovirus Infection Independent of Adaptive Immunity

Rakieb Andargachew, Emory University, USA
Functional and Tetramer Avidities Are Inaccurate Measures of Polyclonal CD4+ TCR Affinity in Acute and Chronic Viral Infection

Rebecca T. Veenhuis, Johns Hopkins University School of Medicine, USA
Virus-Specific Antibodies Inhibit Inflammasome Activation in Chronic HCV and HIV Infection

Anna Gram, Leiden University Medical Center, Netherlands
A Novel Viral Immune Evasion Molecule Interferes with Antigen Presentation during the Late Phase of Epstein-Barr Virus Infection

Eleonora Melzi, University of Glasgow, UK
Bluetongue Virus Infection of Lymphoid Stromal Cells Is Associated with Delayed Immune Response and Systemic Infection of the Mammalian Host

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Immune Effector Functions
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Xavier Saelens, Ghent University, Belgium

* Rustom Antia, Emory University, USA

Olivier Schwartz, Institut Pasteur, France
HIV Cell-Cell Transmission and Immune Antiviral Responses

Annette Oxenius, Institute for Microbiology, ETH Zürich, Switzerland
T Cell Control of Cytomegalovirus Infection in Glandular Tissues

Christopher Chiu, Imperial College London, UK
Short Talk: Protective Resident Memory CD8+ T Cells in Experimental Human Infection with Respiratory Syncytial Virus

Ted C. Pierson, NIAID, National Institutes of Health, USA
Deconstructing the Human Neutralizing Antibody Response to Dengue Virus

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

WEDNESDAY, JANUARY 14

07:00—08:00
Breakfast

Summit Gallery
08:00—11:30
Anti-Viral Lymphocyte Receptor/Peptide Repertoire
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Alessandro Sette, La Jolla Institute for Allergy & Immunology, USA

* Fernando Esquivel-Guadarrama, Universidad Autonoma del Estado de Morelos, Mexico

Victor Appay, INSERM and Kumamoto University, France
CD8+ T Cell Efficacy Against HIV: Recruiting the Right Cells

Andrea J. Sant, University of Rochester, USA
The Role and Specificity of CD4 T Cells in Response to Influenza Infection and Vaccination

David C. Tscharke, Australian National University, Australia
Short Talk: Virus Antigen Presentation on MHC I Is Complex and Poorly Reflected in the CD8+ T Cell Response

Katherine Kedzierska, University of Melbourne, Australia
TCR Repertoire and Universal Immunity to Human Influenza Viruses

Dietmar Zehn, Technical University of Munich, Germany
Short Talk: Linking Functional Diversity and TCR Affinity in Chronic Infections

Ian A. York, Centers for Disease Control and Prevention, USA
Short Talk: Anti-Hemagglutinin Antibody Repertoire and Function in Mice

James E. Crowe, Jr., Vanderbilt University Medical Center, USA
Genetic and Structural Basis for Antibody Mediated Neutralization of Viruses

09:20—09:40
Coffee Break

Foyer
11:30—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom
11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Barrier Functions of the Immune System
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* David L. Woodland, Keystone Symposia on Molecular and Cellular Biology, USA

* Allan J. Zajac, University of Alabama, Birmingham, USA

David Masopust, University of Minnesota, USA
Mucosal Anti-Viral CD8 T Cell Immunity

Kevan L. Hartshorn, Boston University School of Medicine, USA
Antimicrobial Peptides and Influenza Virus

Scott E. Evans, University of Texas MD Anderson Cancer Center, USA
Short Talk: Lung Epithelial Cells Are Principal Effector Cells of Inducible Antiviral Resistance

Veronika von Messling, Paul-Ehrlich-Institut, Germany
Virus-Host Innate Immunity Interface: How Morbilliviruses Take Over their Hosts

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

THURSDAY, JANUARY 15

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Virus versus Host
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Barry T. Rouse, University of Tennessee, USA

* Sam Basta, Queen's University, Canada

Nancy J. Sullivan, Vaccine Research Center, National Institutes of Health, USA
Ebola Vaccine Immunity

Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Genetic Innovations in Evolutionary Arms Races between Primate and Viral Genomes

Marcia A. Blackman, Trudeau Institute, USA
T Cell Immune Control of a Persistent Gamma-herpesvirus

Louis J. Picker, Oregon Health & Science University, USA
Breaking the Rules of CD8+ T Cell Recognition to Enhance Immunity

Jonathan W. Yewdell, NIAID, National Institutes of Health, USA
Influenza versus Immune System

09:20—09:40
Coffee Break

Foyer
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: T Cell Immunity

Colorado Ballroom
* Jack R. Bennink, NIAID, National Institutes of Health, USA

* Patricia V. Aguilar, University of Texas Medical Branch, USA

Andrew G. Soerens, University of Washington, USA
Regulatory T Cells Facilitate Entry of Antigen-Bearing Dendritic Cells into the Draining Lymph Node following Intravaginal HSV-2 Infection

Derek L. Clouthier, University of Toronto, Canada
GITR Intrinsically Sustains Early Type 1 and Late Follicular Helper CD4 T Cell Accumulation to Control a Chronic Viral Infection

Daniela Weiskopf, La Jolla Institute for Allergy & Immunology, USA
Prominent Expansion of a Cytotoxic CD4+T Cell Subset is Associated with a Protective Role in Dengue Virus Infection

Blandine Monel, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, USA
CD8+ T Cell from Elite Controllers Establish Functional Immunological Synapses with HIV Abortively Infected CD4+ T Cells

Tracy J. Ruckwardt, NIAID, National Institutes of Health, USA
Induction of RSV-Specific CD8+ T Cell Responses by Lung-Migratory Dendritic Cells Occurs in an APC, Epitope and Time-Dependent Manner

Sam X. Li, University of Colorado Denver, USA
Tetherin/BST-2 Promotes T Cell Responses to Retrovirus Infection in vivo

Michael Quinn, Thomas Jefferson University, USA
Memory T Cells Specific for Murine CMV Reemerge after Challenge and Recapitulate Immunity in Various Adoptive Transfer Scenarios

Ben A. Youngblood, St. Jude Children's Research Hospital, USA
Effector CD8 T Cells Dedifferentiate into Central-Memory T Cells

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Getting Real: Translational Anti-Viral Immunity
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
* Jonathan W. Yewdell, NIAID, National Institutes of Health, USA

* Donna L. Farber, Columbia University Medical Center, USA

Sabra L. Klein, Johns Hopkins University, USA
SeXX Affects Immunity to Influenza

Scott E. Hensley, Wistar Institute, USA
Short Talk: Antigenic Explanation for Atypical H1N1 Infections among Middle-Aged Adults

Dirk Hans Busch, Technical University Munich, Germany
T Cell Differentiation on the Single Cell Level and its Implications for Adoptive Immunotherapy

Robert L. Coffman, Dynavax Technologies, USA
Systems Biology Analysis of the Human Response to Hepatitis B Vaccines using Alum or CpG Oligonucleotide Adjuvants

19:00—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Colorado Ballroom
Donna L. Farber, Columbia University Medical Center, USA

Nicole Baumgarth, University of California, Davis, USA

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Breckenridge Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Breckenridge Ballroom

FRIDAY, JANUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI114151-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Dynavax Technologies Corporation


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