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This meeting took place in 2015



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Neural Control of Metabolic Physiology and Diseases (D4)


Organizer(s) Dongsheng Cai and Martin G. Myers, Jr.
April 12—17, 2015
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Dec 4, 2014
Abstract Deadline: Jan 13, 2015
Scholarship Deadline: Dec 4, 2014
Discounted Registration Deadline: Feb 12, 2015

Sponsored by Arena Pharmaceuticals, Inc. and Merck & Co., Inc.

Summary of Meeting:
The central nervous system, including the hypothalamus in particular, is important for the control of energy balance and metabolic homeostasis. Current research continues to generate important new understanding of the molecular, cellular, and neural mechanisms underlying this control. From a disease perspective, dysregulation of these processes appears to be crucial for the development and progression of the metabolic syndrome- including obesity, glucose intolerance/diabetes and hypertension- as well as the pathogenesis associated with aging. Recent research has begun to define and characterize the neural pathways involved in these processes. This symposium will bring together breaking research advances from both the basic science and translational realms, including new knowledge of neural circuits, plasticity and signaling, as well as insights into roles for hypothalamic/brain pathways in disease development. Also importantly, several new areas will be addressed, including state-of-art technologies for neuroscience research, adult neural stem cells, neural degeneration, microglia, aging, and related alterations of metabolic resilience.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, APRIL 12

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, APRIL 13

07:00—08:00
Breakfast

Superior/Superior Lobby/Wasatch
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Martin G. Myers, Jr., University of Michigan, USA

Jeffrey M. Friedman, Rockefeller University, USA
Transcriptional Control of Hypothalamic Neurons

09:00—11:15
Hypothalamic Circuits
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Joel K. Elmquist, University of Texas Southwestern Medical Center, USA

* William F. Colmers, University of Alberta, Canada

Martin G. Myers, Jr., University of Michigan, USA
The Transcriptome of LepRb Neurons and its Regulation

Scott M. Sternson, HHMI/Janelia Research Campus, USA
Neural Circuits and Motivational Mechanisms for Hunger

Michael Krashes, NIDDK, National Institutes of Health, USA
A Neural Basis for Melanocortin-4 Receptor-Regulated Appetite

Zhiping P. Pang, Rutgers University, USA
Short Talk: Regulation of Synaptic Transmission by Leptin

09:40—10:00
Coffee Break

Ballroom Lobby
11:15—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 1: The CNS as a Therapeutic Target for Pharmacologic Intervention

Ballroom 2-3
* Lora K. Heisler, University of Aberdeen, UK

* James Trevaskis, MedImmune, USA

Arian F. Baquero, Novo Nordisk Inc., USA
Functional Actions of FGF19 in Arcuate Nucleus Neurons

Daniela Herrera Moro Chao, Paris-Diderot 7, France
Hypothalamus-Brainstem Circuits Are Needed for the Therapeutic Effects of Iminosugars on Metabolic Syndrome

Lenka Maletinská, Institute of Organic Chemistry and Biochemistry, Czech Republic
Anti-Obesity Effects of Lipidized PrRP Analogs after Peripheral Administration

Brian Finan, Novo Nordisk, USA
Using GLP-1 to Carry Dexamethasome to Treat Hypothalamic Inflammation and Metabolic Diseases

Nicole Bellefontaine, University of Michigan, USA
nNOS-NO Signaling Is Involved in Diet-Induced Obesity

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Nutrient Sensing and Hypothalamus
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Gary J. Schwartz, Albert Einstein College of Medicine, USA

Alan G. Watts, University of Southern California, USA
Catecholaminergic Neurons and the Regulation of Glycemia: The Importance of Hindbrain-Hypothalamic Interactions

Darleen A. Sandoval, University of Michigan, USA
Using Genetics and Pharmacology to Understand GLP-1 Physiology

Tony K.T. Lam, Toronto General Research Institute, Canada
Nutrient and Hormonal Signaling in the Small Intestine

Alain J. De Solis, Max Planck Institute for Metabolism, Germany
Short Talk: Impact of Postnatal Undernutrition on Developing AgRP/NPY Neurons

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 1

Primrose

TUESDAY, APRIL 14

07:00—08:00
Breakfast

Superior/Superior Lobby/Wasatch
08:00—11:15
Hypothalamic Circuits and Signaling
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Andrew Butler, St. Louis University, USA

* Al S. Garfield, Pfizer Inc., USA

Harvey J. Grill, University of Pennsylvania, USA
Role of CNS GLP-1R Signaling in Mediating the Feeding Inhibitory Effects of Systemically Delivered and Endogenous GLP-1R Ligands

Shane T. Hentges, Colorado State University, USA
Amino Acid Transmitters in Hypothalamic Circuits Regulating Energy Balance

Maribel Rios, Tufts University School of Medicine, USA
The Role of Brain-Derived Neurotrophic Factor in Hypothalamic Feeding Circuits

David Olson, University of Michigan, USA
Functional Analysis of PVH Neurons in Energy Balance

Baoji Xu, The Scripps Research Institute Florida, USA
Short Talk: Control of Body Weight via BDNF-Expressing Neurons in the Paraventricular Hypothalamus

Clemence Girardet, St. Louis University, USA
Short Talk: Melanocortin-3 Receptors and the Appetitive Response to Weight Loss

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Hypothalamic Injuries and Immunity in Obesity

Ballroom 2-3
* Joshua Thaler, University of Washington, USA

* George Stratigopoulos, Columbia University, USA

Yuanqing Gao, Helmholtz Zentrum München, Germany
Advanced Glycation End Products (AGEs) and Hypothalamic Innate Immune Response

Kazuhito Sai, North Carolina State University, USA
TAK1 Links Hypothalamic Inflammation and ER Stress in Causing Obesity

Suneil K. Koliwad, University of California, San Francisco, USA
Microglia Mediate the Impact of Saturated Fat on Hypothalamic Inflammation and Metabolic Control

Lea Decarie-Spain, University of Montreal Hospital Research Centre, Canada
Saturated Fat Induces Neural Inflammation in Nucleaus Accumbens

Mauricio D. Dorfman, University of Washington, USA
Cx3cr1 Signaling Modulates Microglial Activation and Protects Against Diet-Induced Obesity

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Therapies for Targeting the CNS Mechanisms of Obesity and Diabetes
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Qingchun Tong, University of Texas Medical School at Houston, USA

* Simon M. Luckman, University of Manchester, UK

Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
GLP1 Manipulation for Control of Obesity and Diabetes

Roger D. Cone, University of Michigan, USA
Novel Sites and Modalities of Melanocortin-4 Receptor Signaling

Randy J. Seeley, University of Michigan, USA
Key Systems Mediating the Response to Bariatric Surgery

Luke K. Burke, University of Cambridge, UK
Short Talk: Lorcaserin Promotes Anorectic and Glycemic effects via Divergent Neurocircuits

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 2

Primrose

WEDNESDAY, APRIL 15

07:00—08:00
Breakfast

Superior/Superior Lobby/Wasatch
08:00—11:15
Hypothalamic or Brain Dysfunction in Metabolic Control
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Dongsheng Cai, Albert Einstein College of Medicine, USA

* Sebastien G. Bouret, University of Southern California, USA

Jens C. Brüning, Max Planck Institute for Metabolism Research, Germany
Novel Regulators of AgRP-Neuron Activity

Giles S.H. Yeo, University of Cambridge, UK
Hypothalamic FTO and Leptin Resistance

Tamas L. Horvath, Yale School of Medicine, USA
Hypothalamic Control of Integrative Physiology and Health

Kevin L. Grove, Novo Nordisk and Oregon National Primate Research Center, USA
Development of Functional Inputs into NPY/AgRP/GABA (NAG) and POMC Neurons in the Hypothalamus

Chun-Xia Yi, Helmholtz Zentrum München, Germany
Short Talk: Microglial TNFalpha Induces Mitochondrial Stress to Cause Obesity and Diabetes

Eglantine Balland, Monash University, Australia
Short Talk: Many Causes of Leptin Resistance in Obesity

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—11:40
NIDDK Workshop on NIH Common Fund Initiatives
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Philip F. Smith, NIDDK, National Institutes of Health, USA
Resources and Funding Opportunities

11:40—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Brain Mechanisms of Diabetes: Neuroinflammation and Others
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Vincent Prevot, INSERM, University of Lille, France

Dongsheng Cai, Albert Einstein College of Medicine, USA
Hypothalamic Microinflammation in Diabetes

Michael W. Schwartz, University of Washington, USA
Cooperation between Brain and Islet in Glucose Homeostasis and Diabetes

Suzanne DeLaMonte, Brown University, USA
Type 3 Diabetes: Metabolic Basis of Alzheimer’s Diseases

Kevin W. Williams, University of Texas Southwestern Medical Center, USA
Short Talk: IRE1alpha/XBP1s Connects ER Stress with Dysregulation of Energy Balance and Glucose Homeostasis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 3

Primrose

THURSDAY, APRIL 16

07:00—08:00
Breakfast

Superior/Superior Lobby/Wasatch
08:00—11:15
Cellular Signaling in the CNS
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Christoph Buettner, Mount Sinai School of Medicine, USA

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
SF-1 in the Hypothalamus: A Molecular Link between Energy Balance Regulation and Exercise

Heike Münzberg, Pennington Biomedical Research Center, USA
Central Circuits of Thermoregulatory Leptin Action

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Hypothalamic AMPK and Mediators

Carol F. Elias, University of Michigan, USA
Hypothalamic Signals and Circuits Linking Metabolism and Reproduction

Qingchun Tong, University of Texas Medical School at Houston, USA
Short Talk: GABAergic Projections from Lateral Hypothalamus to Paraventricular Hypothalamic Nucleus Promote Feeding

Yong Xu, Baylor College of Medicine, USA
Short Talk: SRC-2 in POMC Neurons Mediates Energy Reserving Effects of FOXO1

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 3: New Directions in Understanding the Central Regulation of Metabolism

Ballroom 2-3
* Christa M. Patterson, University of Michigan, USA

* Herbert Herzog, Garvan Institute, Australia

Angela M. Ramos-Lobo, University of São Paulo, Brazil
Long-Term Consequences of the Absence of Leptin Action in Early Life

Ceren Ozek, University of Pennsylvania, USA
On “Trk”: The Role of Intact Hypothalamus and Hindbrain TrkB Signaling in Central Regulation of Energy Balance

Liliia Butiaeva, McGill University, Canada
Time-Lapse Imaging of Hypothalamic Leptin Receptor Neurons in Living Mice

John N. Campbell, Beth Israel Deaconess Medical Center, USA
Single Cell RNA-Seq of AgRP Neurons Reveals Novel Subpopulations with Unique Gene Signatures

Haijiang Cai, California Institute of Technology, USA
Central Amygdala Circuits Mediate the Influence of Multiple Anorexigenic Signals

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Rewarding and Ingestive Behaviors
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
* Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA

* Ralph DiLeone, Yale University School of Medicine, USA

Gary J. Schwartz, Albert Einstein College of Medicine, USA
Gut-Brain Nutrient Sensing and Reward

Jeffrey M. Zigman, University of Texas Southwestern Medical Center, USA
Ghrelin Control of Food Reward and Related Behaviors

Luis de Lecea, Stanford University, USA
Leptin Modulates Corticosterone Release through an Inhibitory Circuit in the Lateral Hypothalamus

Gwenaël Labouébe, University of Lausanne, Switzerland
Short Talk: A Novel Thalamo-Accumbal Circuit that Controls Motivated Sucrose-Seeking Behavior

19:00—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Ballroom 3
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1-2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 1-2

FRIDAY, APRIL 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Arena Pharmaceuticals, Inc. Merck & Co., Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK104612-01

Funding for this conference was made possible (in part) by 1 R13 DK104612-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Chroma Technology Corporation Research Diets, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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