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This meeting took place in 2015


Here are the related meetings in 2018:
Bioenergetics and Metabolic Disease (J4)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Beige and Brown Fat: Basic Biology and Novel Therapeutics (D5)


Organizer(s) Bruce M. Spiegelman and Sven Enerbäck
April 17—22, 2015
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Dec 16, 2014
Abstract Deadline: Jan 15, 2015
Scholarship Deadline: Dec 16, 2014
Discounted Registration Deadline: Feb 18, 2015

Sponsored by AstraZeneca

Summary of Meeting:
The epidemic of obesity and diabetes has become a world-wide health risk. These metabolic disorders are a direct threat to the health and economic well-being of many nations. Unfortunately, education about diet and exercise are not sufficient to meet this emergency and new therapies are badly needed. Brown fat has emerged as one of the few genuinely new approaches to these problems. Brown fat exists in most or all adult humans and can dissipate caloric energy and improve both obesity and diabetes in experimental animals. This meeting will focus on new pathways controlling brown fat development and thermogenesis. We will delve into the types of brown fat cells, beige, classical brown and others. We will also put a special emphasis on emerging approaches, both biological and chemical, that can manipulate these cells for therapeutic purposes. It is our hope and belief that this meeting can nucleate expanded efforts in both academia and pharma to explore this promising research area. There has not been a Keystone Symposia conference dedicated to brown fat. While there has been a session here and there at the Obesity meeting, the science and the biomedical needs warrant this new and focused conference. Of course, this will also bridge the Obesity and Diabetes communities, and lead to pharma/academic collaborations.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, APRIL 17

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

SATURDAY, APRIL 18

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—08:15
Welcome Remarks

Ballroom 2-3
Bruce M. Spiegelman, Harvard Medical School, USA

Sven Enerbäck, University of Gothenburg, Sweden

08:15—09:15
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Bruce M. Spiegelman, Harvard Medical School, USA

Vamsi K. Mootha, Massachusetts General Hospital, USA
A Systems Approach to Mitochondrial Bioenergetics

09:15—11:30
Brown and Beige: Lineage and Development I
Meeting has ended...abstracts no longer viewable online.
Lineage and development of brown fat cells.

Ballroom 2-3
Patrick Seale, University of Pennsylvania, USA
Transcriptional Control of Brown and Beige Fat Cell Fate

James G. Granneman, Wayne State University School of Medicine, USA
Mechanisms of Brown Adipocyte Recruitment by Adrenergic Receptor Activation in Vivo

* Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
De Novo Birth of Beige Fat Cells

Jacob M. McGlashon, University of Iowa, USA
Short Talk: Pet-1+ Serotonin Neurons Induce White Adipose Browning, Activate Brown Adipose and Are Required for Metabolic Homeostasis

09:40—10:00
Coffee Break

Ballroom Lobby
11:30—13:00
Poster Setup

Ballroom 1
13:00—22:00
Poster Viewing

Ballroom 1
11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Brown and Beige: Lineage and Development II
Meeting has ended...abstracts no longer viewable online.
Lineage and development of brown fat cells.

Ballroom 2-3
* Barbara Cannon, Stockholm University, Sweden
White, Beige/Brite and Brown Adipocytes

Stephan Herzig, Helmholtz Zentrum München, Germany
Transcriptional Co-Factor Loops in BAT Activation and Systemic Energy Balance

Saverio Cinti, University of Ancona, Italy
White, Brown and Pink Adipocytes: The Extraordinary Plasticity of the Adipose Organ

Jeremie Boucher, AstraZeneca, Sweden
Short Talk: Identification of Compounds Inducing UCP1 in Differentiating Human White Preadipocytes

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1
19:30—22:00
Poster Session 1

Ballroom 1

SUNDAY, APRIL 19

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Transcriptional Control of Brown Fat I
Meeting has ended...abstracts no longer viewable online.
Transcriptional control of brown fat and the thermogenic gene program.

Ballroom 2-3
Shingo Kajimura, University of California, San Francisco, USA
Pharmacological Approaches to Promote Beige Adipocyte Development

Bruce M. Spiegelman, Harvard Medical School, USA
Regulation of Heat Production by Various Shades of Fat: A Novel Thermogenic Pathway in Beige Fat

* Stephen R. Farmer, Boston University School of Medicine, USA
Novel Signaling/Transcriptional Pathways Regulating Conversion of Progenitors to Beige/Brite Adipocytes

Domenico Accili, Columbia University, USA
Sirtuins and Brown Fat Development

Ann Marie Hammarstedt, Lundberg Laboratory for Diabetes Research, Sweden
Short Talk: BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

Carol Renfrew Haft, NIDDK, National Institutes of Health, USA
Short Talk: Funding Opportunities

09:20—09:40
Coffee Break

Ballroom Lobby
11:00—13:00
Poster Setup

Ballroom 1
13:00—22:00
Poster Viewing

Ballroom 1
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Transcriptional Control of Brown Fat II
Meeting has ended...abstracts no longer viewable online.
Transcriptional control of brown fat and the thermogenic gene program.

Ballroom 2-3
* Ajay Chawla, University of California, San Francisco, USA
Innate Control of Thermogenesis

Alan R. Saltiel, UC, San Diego, USA
Inflammation and Energy Homeostasis

Laurie J. Goodyear, Joslin Diabetes Center, Harvard Medical School, USA
Exercise Regulation of Beige and Brown Fat

Matthew T. Andrews, University of Minnesota, USA
Short Talk: Integrating Molecular and Functional Analysis of Brown Adipose Tissue across the Physiological Extremes of Natural Hibernation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1
19:30—22:00
Poster Session 2

Ballroom 1

MONDAY, APRIL 20

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Human BAT and Therapeutic Modulation I
Meeting has ended...abstracts no longer viewable online.
The types of human BAT and how their functions and amounts can be modulated.

Ballroom 2-3
* Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA

Sven Enerbäck, University of Gothenburg, Sweden
Human Brown Adipose Tissue

Aaron M. Cypess, NIDDK, National Institutes of Health, USA
The Responses of Human Brown, Beige and White Fat to Pharmacological Stimulation

Steven A. Kliewer, University of Texas Southwestern Medical Center, USA
FGF21: Regulating the Fuel and the Fire of Metabolism

Wouter D. van Marken Lichtenbelt, Maastricht University, Netherlands
Recruitment of Human Brown and Beige Fat

Kirsi A. Virtanen, Turku University Hospital and University of Turku, Finland
Short Talk: Fatty Acids Taken Up by Activated Human Brown Adipose Tissue Are Mainly Oxidized

09:20—09:40
Coffee Break

Ballroom Lobby
11:00—13:00
Poster Setup

Ballroom 1
13:00—22:00
Poster Viewing

Ballroom 1
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Human BAT and Therapeutic Modulation II
Meeting has ended...abstracts no longer viewable online.
The types of human BAT and how their functions and amounts can be modulated.

Ballroom 2-3
* Sven Enerbäck, University of Gothenburg, Sweden

Masayuki Saito, Tenshi College, Japan
Brown Adipose Tissue as a Therapeutic Target for Human Obesity

Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Deciphering Human Brown Adipogenesis by Functional and Clonal Analyses

Francesc Villarroya, Universidad de Barcelona, Spain
BAT as Endocrine Organ: Identification of New Brown Adipokines

Denis P. Blondin, University of Sherbrooke, Canada
Short Talk: Postprandial Energy Metabolism of Brown Adipose Tissue in Cold-Acclimated Humans

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1
19:30—22:00
Poster Session 3

Ballroom 1

TUESDAY, APRIL 21

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Novel Pathways of Energy Expenditure
Meeting has ended...abstracts no longer viewable online.
New findings related to control of BAT amounts and function that work through the nervous system, immune cells and blood vessels.

Ballroom 2-3
Sheila Collins, Sanford Burnham Prebys Medical Discovery Institute, USA
Signaling Mechanisms Activating Brown Adipocytes and Thermogenesis by cAMP and cGMP from Mice to Humans

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
Nuclear Receptors in Vagal Sensory Neurons Regulate Adipose Tissue and Energy Expenditure

* Antonio J. Vidal-Puig, University of Cambridge, UK
BMP 8b and Brown Fat Thermogenesis

Alexander Pfeifer, University of Bonn, Germany
CyclicGMP Signaling Enhances Brown Fat Function - Pharmacological Studies

Aaron P. Frank, Cedars-Sinai Medical Center, USA
Short Talk: Roux-en-Y Gastric Bypass Induces Browning of Gonadal Adipose Tissues

09:20—09:40
Coffee Break

Ballroom Lobby
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Biochemistry and Bioenergetics of BAT
Meeting has ended...abstracts no longer viewable online.
Bioenergetic findings related to BAT function.

Ballroom 3
Yuriy Kirichok, University of California, San Francisco, USA
Mitochondrial Uncoupling and Thermogenesis in Brown Fat

Leslie P. Kozak, Polish Academy of Sciences, Poland
The Genetics of Brown Adipocyte Induction in White Fat Depots

* Mary-Ellen Harper, University of Ottawa, Canada
Redox, ROS and the Control of UCP1

Egor Akimov, Center of Sports Innovation Technologies and Teams Management, Russia
Short Talk: Participation of Brown Adipose Tissue in Lactate Utilization during Muscular Work

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Ballroom 3
* Sven Enerbäck, University of Gothenburg, Sweden

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1-2
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 1-2

WEDNESDAY, APRIL 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

AstraZeneca

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK104499-01

Funding for this conference was made possible (in part) by 1 R13 DK104499-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Adipogen International Avanti Polar Lipids, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Ember Therapeutics


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676