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This meeting took place in 2015



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Neuroepigenetics (B5)


Organizer(s) Hongjun Song and Li-Huei Tsai
February 22—26, 2015
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Oct 21, 2014
Abstract Deadline: Nov 19, 2014
Scholarship Deadline: Oct 21, 2014
Discounted Registration Deadline: Dec 18, 2014

Supported by the Directors' Fund

Summary of Meeting:
Following the completion of the Human Genome Project, much of biology’s focus has shifted from the raw sequence of genes to their regulation over time and in response to environmental stimuli, in which epigenetics represents a core mechanism. To date, an increasing body of evidence has surfaced indicating that multiple neurological disorders are, in part, caused by aberrant epigenetic modifications. While tremendous progress has been made in understanding epigenetic regulation of gene expression in the nervous system, researchers have yet to learn how the neural epigenome responds to positive (such as learning experiences, enriched environment) and negative (such as epilepsy, injury, stroke) signals as a whole and at the individual gene level, and how the epigenome is regulated at the molecular level. This knowledge is important to better understand normal brain development, plasticity and function and how the epigenome becomes malfunctioned in diseases. Different from proliferating cells commonly studied in epigegenetics, one major subject of the emerging new field of neuroepigenetics deals with various post-mitotic neurons. This Keystone Symposia meeting aims to bring together experts and pioneers in studying neuroepigenetics to provide an up-to-date and comprehensive picture of epigenetic mechanisms in neural development, plasticity, neuronal function and dysfunction. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, FEBRUARY 22

16:00—20:00
Arrival and Registration

Eldorado Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Zia Ballroom

MONDAY, FEBRUARY 23

07:00—08:00
Breakfast

Zia Ballroom
07:30—08:00
Poster Setup

Zia Ballroom
08:00—17:00
Poster Viewing

Zia Ballroom
08:00—09:40
Keynote Session
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Hongjun Song, University of Pennsylvania, USA

Fred (Rusty) H. Gage, The Salk Institute for Biological Studies, USA
Somatic Mosaicism in the Human Brain

* Li-Huei Tsai, Massachusetts Institute of Technology, USA

Michael E. Greenberg, Harvard Medical School, USA
Signaling Networks that Regulate Synapse Development and Cognitive Function

09:40—10:00
Coffee Break

Zia Concourse
10:00—11:45
Epigenetic Mechanisms in Embryonic Development of the Nervous System
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Lisa M. Monteggia, University of Texas Southwestern Medical Center, USA

Antonella Riccio, University College London, UK
Epigenetic Mechanisms of Neuronal Development

Peng Jin, Emory University School of Medicine, USA
Tet-Mediated Active DNA Demethylation in Neurogenesis

Jürgen A. Knoblich, IMBA, Institute of Molecular Biotechnology, Austria
Proliferation Control and Tumorigenesis in Neural Stem Cell Lineages

11:45—12:45
Lunch

Zia Ballroom
12:15—14:30
Poster Session 1

Zia Ballroom
14:30—15:30
Workshop 1: NIH Grants

Anasazi Ballroom
* Hongjun Song, University of Pennsylvania, USA

Robert D. Riddle, NINDS, National Institutes of Health, USA

Andrea C. Beckel-Mitchener, NIMH, National Institutes of Health, USA

15:30—16:30
Workshop 2: High-Throughput Sequencing for Neuroepigenetics

Anasazi Ballroom
* Kinichi Nakashima, Kyushu University, Japan

Menno P. Creyghton, Hubrecht Institute, Netherlands
Charting Enhancer Networks in the Human and Non-Human Primate Brain

Matthew A. Lalli, University of California, Santa Barbara, USA
Transcriptome Profiling of Williams Syndrome iPSC Neurodevelopment Reveals a Critical Defect in Cell-Cycle Exit of Neural Stem Cells

Tie-Yuan Zhang, Douglas Mental Health University Institute, McGill University, Canada
Next-Generation Sequencing Analysis Indicates Maternal Care Differentially Influences Epigenomic Regulation in the Hippocampal Dentate Gyrus of Rats

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Epigenetic Mechanisms in Adult Neurogenesis
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Isabelle M. Mansuy, University and ETH Zürich, Switzerland

Jeffrey S. Nye, Johnson & Johnson, USA
Translation of Neuroepigenetics Discoveries to Neurotherapeutics: An Industry Perspective

Xiang-Dong Fu, University of California, San Diego, USA
Critical Barriers for Neuronal Induction and Maturation in Human Cells

Vidya Ramesh, Helmholtz Center Munich, Germany
Short Talk: Uhrf1/Np95 Acts a Key Regulator of Neural Stem Cell Differentiation in vivo

Anne Schaefer, Mount Sinai School of Medicine, USA
Short Talk: Epigenetic Control of Neuronal Specification and Function by PRC2

Sika Zheng, University of California, Riverside, USA
Short Talk: Alternative Splicing Reprogramming during Neuronal Maturation

19:00
On Own for Dinner


TUESDAY, FEBRUARY 24

07:00—08:00
Breakfast

Zia Ballroom
08:00—11:00
Epigenetic Mechanisms Regulating Synapse Formation, Plasticity and Behavior
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Michael E. Greenberg, Harvard Medical School, USA

Li-Huei Tsai, Massachusetts Institute of Technology, USA
A Novel Mechanism Regulating the Expression of Early Response Genes in Neurons

J. David Sweatt, University of Alabama at Birmingham, USA
Epigenetic Mechanisms in Associative Conditioning

Lisa M. Monteggia, University of Texas Southwestern Medical Center, USA
Analysis of the Unique Roles of Individual HDACs in Behavior and Synaptic Plasticity

Hongjun Song, University of Pennsylvania, USA
Activity-Induced Epigenetic Mechanisms in Synaptic and Behavior Plasticity

Timothy Bredy, University of California, Irvine, USA
Short Talk: Epitranscriptomic Mechanisms of Memory Stability

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Zia Ballroom
13:00—22:00
Poster Viewing

Zia Ballroom
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Molecular Mechanisms
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
Isabelle M. Mansuy, University and ETH Zürich, Switzerland
Non-Genetic Inheritance of the Impact of Traumatic Stress across Generations in Mice

Michael G. Rosenfeld, HHMI/University of California, San Diego, USA
Enhancer, lncRNA and Architectural Codes of Regulated Transcriptional Programs Involved in Learning and Memory

Paolo Sassone-Corsi, University of California, Irvine, USA
The Epigenetic Language of the Circadian Clock

Alexi Nott, Massachusetts Institute of Technology, USA
Short Talk: HDAC3 Mediates Epigenomic Regulation of Transcription Relevant to Autism-Associated Behaviors

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Zia Ballroom
19:30—22:00
Poster Session 2

Zia Ballroom

WEDNESDAY, FEBRUARY 25

07:00—08:00
Breakfast

Zia Ballroom
08:00—11:00
The Role of Epigenetic Mechanisms in Brain Disorders and Repair
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Antonella Riccio, University College London, UK

Philip L. De Jager, Brigham & Women's Hospital, USA
An Integrative Approach to Deconstructing the Role of the Brain's Epigenome in Cognitive Aging

Guo-li Ming, University of Pennsylvania, USA
Epigenetic Regulation in Regeneration and Repair after Injury

Jenny Hsieh, University of Texas Southwestern Medical Center, USA
Transcriptional/Epigenetic Circuitry to Control Adult Hippocampal Neurogenesis

Brooke H. Miller, University of Florida College of Medicine, USA
Short Talk: In vivo Analysis of the Effects of miR-132 on Epigenetic Factors Associated with Major Psychiatric Disorders

Michael J. Ziller, Max Planck Institute of Psychiatry, Germany
Short Talk: Dissecting Neural Differentiation Regulatory Networks through Epigenetic Footprinting

09:20—09:40
Coffee Break

Zia Concourse
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Zia Concourse
17:00—18:45
Epigenomes
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
* Li-Huei Tsai, Massachusetts Institute of Technology, USA

* Hongjun Song, University of Pennsylvania, USA

Manolis Kellis, Massachusetts Institute of Technology / Broad Institute, USA
Conserved Epigenomic Signals in Mice and Humans Reveal Immune Basis of Alzheimer’s Disease

Chuan He, University of Chicago, USA
Gene Expression Regulation through Reversible RNA and DNA Methylation

Joseph R. Ecker, The Salk Institute for Biological Studies, USA
Epigenomic Signatures of Neuronal Cell Diversity in the Mammalian Brain

18:45—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Anasazi Ballroom
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Zia Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Zia Ballroom

THURSDAY, FEBRUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13NS090818-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Abcam plc

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


neurogenetics (published by Springer)

NeuroscientistNews

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676