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Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online before the meeting...these abstracts will be available in the Abstract Book at the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

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Sheraton Steamboat Resort Floorplan

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NOTES:
This meeting occurs in 2015.
This meeting will be conducted in English.

All programs are subject to change. Check this site for updates.


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Twitter hashtag for this meeting: #KSPawson

The Biological Code of Cell Signaling: A Tribute to Tony Pawson (F1)

Scientific Organizers: Tony Hunter and Rune Linding


January 11—16, 2015

Sheraton Steamboat Resort, Steamboat Springs, Colorado, USA


Sponsored by the Journal of Molecular Cell Biology (JMCB), Regeneron Pharmaceuticals, Inc., Roche and Thermo Fisher Scientific Inc.


Abstract submission is closed. Registered attendees can bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested. DEADLINES:
Scholarship Deadline: Sep 23, 2014 [details]
Discounted Abstract Deadline: Sep 23, 2014 [details]
Abstract Deadline: Oct 15, 2014 [details]
Discounted Registration Deadline: Nov 12, 2014 [details]

Register Yourself Deadlines and Fees
Deadlines and Fees for 2015-F1 ''The Biological Code of Cell Signaling: A Tribute to Tony Pawson''
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Rates and Deadlines listed below are for the 2015-F1 "The Biological Code of Cell Signaling: A Tribute to Tony Pawson" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On September 23, 2014 100.00 USD*
- 50.00 USD discount
Abstract Deadline
More details
After September 23, 2014 until November 12, 2014 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
September 23, 2014 n/a
Discounted NON-STUDENT Registration
More details
Before and On November 12, 2014 775.00 USD
(includes 150.00 discount)
Regular NON-STUDENT Registration
More details
After November 12, 2014 925.00 USD
Discounted STUDENT Registration
More details
Before and On November 12, 2014 550.00 USD
(includes 150.00 discount)
Regular STUDENT Registration
More details
After November 12, 2014 700.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will    accept no liability for money loss through bank charges, transfers or currency fluctuations.

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About Discounted Abstract Deadline
About Global Health Travel Award Deadline
About Scholarship Deadline
About Abstract Deadline
About Discounted Registration Deadline
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 11

16:00—20:00
Arrival and Registration

18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.


MONDAY, JANUARY 12

07:00—08:00
Breakfast

08:00—11:00
Tony Pawson: More than 35 Years of Research Discovery
Registered attendees can view abstracts starting on 12/11/2014
Opening session providing a global overview of Tony’s scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.

* Rune Linding, University of Copenhagen, Denmark

Tony Hunter, The Salk Institute, USA
A Tale of Two Tonys: Forty Years of Scientific Crosstalk

Alan Bernstein, Canadian Institute for Advanced Research, Canada
Tony Pawson: Wonderful Scientist, Colleague and True Friend

John D. Scott, University of Washington, USA
Guiding Signals through Anchored Enzyme Complexes

Nina Jones, University of Guelph, Canada
Short Talk: Phosphotyrosine Signaling at the Kidney Slit Diaphragm

Marius Sudol, National University of Singapore, Singapore
Poster Talk: Signaling by WW and SH2 Domain-Containing Proteins

Arthur Weiss, University of California, San Francisco, USA
Intercellular Signaling by Transmembrane Proteins

09:40—10:00
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Modular Protein Domains - Past, Present and Future
Registered attendees can view abstracts starting on 12/11/2014
From SH2 to all other building blocks of signaling networks.

Peer Bork, European Molecular Biology Laboratory, Germany
Predicting Biological Function at Different Spatial Scales

Sachdev S. Sidhu, University of Toronto, Canada
Modulation of Cell Signaling with Synthetic Proteins

Toby Gibson, European Molecular Biology Laboratory, Germany
Regulation by Molecular Switching

* Bruce J. Mayer, University of Connecticut Health Center, USA
SH2 Domains Three Ways: The Dynamics of Receptor Tyrosine Kinase Signaling

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 13

07:00—08:00
Breakfast

08:00—11:00
Protein Modules and Drugs
Registered attendees can view abstracts starting on 12/11/2014
How to perturb domains and target them for medical intervention.

* Giulio Superti-Furga, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Integration of Individual Signaling Domains into Increasingly Complex Layers of Regulation: From the ABL Tyrosine Kinase to the Mechanism of Action of Anticancer Drugs

Shohei Koide, University of Chicago, USA
Poster Talk: Controlling Signaling Networks with Monobody Inhibitors against Modular Interaction Domains

Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Genetic Variability and the Quantitative Proteome

Frank Sicheri, Lunenfeld-Tanenbaum Research Institute, Canada
Structural Basis for Poly-Ubiquitin Chain Cleavage: Lessons Learned from OTUB1 and OTULIN/Gumby

Xiaolei Su, University of California, San Francisco, USA
Poster Talk: Reconstituting TCR Signaling Pathways Reveals a Role for T Cell Microclusters

Vishva M. Dixit, Genentech, Inc., USA
Ubiquitin Modification in Cancer Pathogenesis

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Kinome Biology
Registered attendees can view abstracts starting on 12/11/2014
Kinase signaling networks - phosphorylation-based signaling.

* Benjamin E. Turk, Yale University, USA
Large-Scale Analysis of Protein Kinase Specificity

Stefan Knapp, University of Oxford, UK
Short Talk: Selective Targeting of Kinase Signaling Networks

Rune Linding, University of Copenhagen, Denmark
Biological Forecasting in the Cancer Kinome

Liam J. Holt, University of California, Berkeley, USA
Poster Talk: Ancestral Resurrection Reveals Evolutionary Mechanisms of Kinase Plasticity

Susan S. Taylor, University of California, San Diego, USA
PKA: Evolution of a Dynamic Macromolecular Switch

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 2


WEDNESDAY, JANUARY 14

07:00—08:00
Breakfast

08:00—11:00
From Modules and Networks to Cellular Phenotypes
Registered attendees can view abstracts starting on 12/11/2014
How changes in protein modules and signaling networks translate into cellular switches.

Norbert Perrimon, Harvard Medical School, USA
Spatio-Temporal Regulation of Signaling in Drosophila

* John Kuriyan, University of California, Berkeley, USA
Control of Catalytic Activity in the EGF Receptor

Ivan Dikic, Goethe University Medical School, Germany
Linear Ubiquitination in Regulation of Inflammation

Michael Tyers, University of Montreal, Canada
From Large Networks to Small Molecules

Lee Bardwell, University of California, Irvine, USA
Poster Talk: Synergy, Interdependency and Redundancy in Multi-Site Phosphorylation

James E. Ferrell Jr., Stanford University, USA
Trigger Waves in Mitosis and Apoptosis

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Evolution of Phosphorylation, PTMs and Modular Protein Domains
Registered attendees can view abstracts starting on 12/11/2014
How cells evolved to function the way they do

* Gerard Manning, Genentech, Inc., USA
Evolutionary Comparisons to Explore the Function and Diversity of Signaling Biology

Chris Tan, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Short Talk: Co-Evolution of Protein Phosphorylation and Protein-Protein Interaction Networks

Edward Y. Skolnik, New York University Medical Center, USA
Poster Talk: Activation of TRPC4 by Protein Histidine Phosphatase 1 is Critical for Normal Trafficking of KATP Channels to the Plasma Membrane in Pancreatic Beta Cells in Response to Low Glucose and Leptin

Benjamin G. Neel, Ontario Cancer Institute, Canada
PTP1B Promotes Survival of HER2+ Breast Cancer in Hypoxia by Regulating Moyamoya Disease-Associated E3 Ligase, RNF213 and Cellular Dioxygenase Activity

Robert Rottapel, Princess Margaret Hospital, Toronto Medical Discovery Tower, Canada
Short Talk: Abl Mediates a TAZ:RUNZ2 Self-Reinforcing Feedback Loop Required for Osteoblastogenesis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 3


THURSDAY, JANUARY 15

07:00—08:00
Breakfast

08:00—11:00
Network Medicine - Targeting Signaling Networks
Registered attendees can view abstracts starting on 12/11/2014
Relating knowledge of signaling networks to advances in patients’ outcomes.

* Michael B. Yaffe, Massachusetts Institute of Technology, USA
Using Systems Biology to Target Cancer

Douglas A. Lauffenburger, Massachusetts Institute of Technology, USA
Crosstalk and Feedback in Receptor Tyrosine Kinase Signaling Networks

Ruth H. Palmer, Gothenburg University, Sweden
Poster Talk: Investigation of Anaplastic Lymphoma Kinase Signaling

Johannes L. Bos, University Medical Center Utrecht, Netherlands
Targeting Spatial and Temporal Control of Endothelial Barrier Function

Oliver Hantschel, Swiss Federal Institute of Technology Lausanne, Switzerland
Poster Talk: The SH2 Domain of ABL Kinases Regulates Kinase Autophosphorylation by Controlling Activation Loop Accessibility

Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Phase Separation of Multi-Valent Signaling Proteins

09:20—09:40
Coffee Break

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:30
Signaling Networks Driving Disease Progression and Resistance to Drugs
Registered attendees can view abstracts starting on 12/11/2014
Current limitations in our understanding of disease progression and potential solutions.

* Joan S. Brugge, Harvard Medical School, USA
Signaling Pathways that Regulate Adaptive Resistance to Cancer Therapies

Richard M. Marais, Cancer Research UK Manchester Institute, UK
NRAS and BRAF Signaling in Melanoma: From Basic Biology to Clinical Efficacy

Peter Littlefield, University of California, San Francisco, USA
Poster Talk: Crystal Structure of an EGFR/HER3 Heterodimer Reveals the Molecular Basis for Activating HER3 Mutations

Joseph Schlessinger, Yale University School of Medicine, USA
Cell Signaling by Receptor Tyrosine Kinases: From Basic Principles to Cancer Therapy

Clark D. Wells, Indiana University School of Medicine, USA
Differential Roles of Angiomotin Proteins in the Development of Breast Cancer

19:30—20:00
Closing Remarks: Tony Pawson’s Legacy
Registered attendees can view abstracts starting on 12/11/2014

* Tony Hunter, The Salk Institute, USA

* Rune Linding, University of Copenhagen, Denmark

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is generously provided by other supporters of Keystone Symposia.


FRIDAY, JANUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Journal of Molecular Cell Biology (JMCB) Regeneron Pharmaceuticals, Inc.
Roche Thermo Fisher Scientific Inc.

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

PLOS

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Amanda Deem, Assistant Director of Development, Email: AmandaD@keystonesymposia.org,
Phone:+1 970-262-2668

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676