This meeting took place in 2015



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The Biological Code of Cell Signaling: A Tribute to Tony Pawson (F1)


Organizer(s) Tony Hunter and Rune Linding
January 11—16, 2015
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Discounted Abstract Deadline: Sep 23, 2014
Abstract Deadline: Oct 15, 2014
Scholarship Deadline: Sep 23, 2014
Discounted Registration Deadline: Nov 12, 2014

Sponsored by the Journal of Molecular Cell Biology (JMCB), Regeneron Pharmaceuticals, Inc., Roche and Thermo Fisher Scientific Inc.

Summary of Meeting:
Prompted by the recent loss of one of the brightest stars in the life sciences, this Keystone Symposia meeting has been designed to honor the memory of Tony Pawson. The aim of the meeting is to provide a forward-looking symposium rooted in his prodigious scientific legacy. It constitutes a natural evolution of previous symposia he organized (such as the “Omics Meets Cell Biology” series and “The Evolution of Protein Phosphorylation”). As such, the scientific focus of the symposium is on the role of post-translational modifications (PTMs), modular protein domains and signaling networks as driving forces of human evolution and disease. The cellular world that Tony, with others, unlocked consists of dynamic protein networks created through the interactions of different protein modules, which together drive almost every intra- and inter-cellular decision process we know today. His most important contribution in this field is undoubtedly his discovery of the first protein interaction module, the SH2 domain, but numerous other interaction domains followed, leading to current investigations of how the dysregulation of these networks leads to new signaling states in disease that are critical for processes in, for instance, cancer, such as tumor progression, or drug resistance. The symposium thus spans the entire spectrum of fields that have been touched by Tony Pawson's prolific and inspiring research, while maintaining a strong forward-looking perspective.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SUNDAY, JANUARY 11

16:00—20:00
Arrival and Registration

18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.


MONDAY, JANUARY 12

07:00—08:00
Breakfast

08:00—11:00
Tony Pawson: More than 35 Years of Research Discovery
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Opening session providing a global overview of Tony’s scientific legacy by scientists who can deliver personal, exciting and emotional retrospectives, mixed with an overview of their own research.

* Rune Linding, University of Copenhagen, Denmark

Tony Hunter, The Salk Institute, USA
A Tale of Two Tonys: Forty Years of Scientific Crosstalk

Alan Bernstein, Canadian Institute for Advanced Research, Canada
Tony Pawson: Wonderful Scientist, Colleague and True Friend

John D. Scott, University of Washington, USA
Guiding Signals through Anchored Enzyme Complexes

Nina Jones, University of Guelph, Canada
Short Talk: Phosphotyrosine Signaling at the Kidney Slit Diaphragm

Marius Sudol, National University of Singapore, Singapore
Poster Talk: Signaling by WW and SH2 Domain-Containing Proteins

Arthur Weiss, University of California, San Francisco, USA
Intercellular Signaling by Transmembrane Proteins

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Modular Protein Domains - Past, Present and Future
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
From SH2 to all other building blocks of signaling networks.

Peer Bork, European Molecular Biology Laboratory, Germany
Predicting Biological Function at Different Spatial Scales

Sachdev S. Sidhu, University of Toronto, Canada
Modulation of Cell Signaling with Synthetic Proteins

Toby Gibson, European Molecular Biology Laboratory, Germany
Regulation by Molecular Switching

* Bruce J. Mayer, University of Connecticut Health Center, USA
SH2 Domains Three Ways: The Dynamics of Receptor Tyrosine Kinase Signaling

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 13

07:00—08:00
Breakfast

08:00—11:00
Protein Modules and Drugs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
How to perturb domains and target them for medical intervention.

* Giulio Superti-Furga, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Integration of Individual Signaling Domains into Increasingly Complex Layers of Regulation: From the ABL Tyrosine Kinase to the Mechanism of Action of Anticancer Drugs

Shohei Koide, University of Chicago, USA
Poster Talk: Controlling Signaling Networks with Monobody Inhibitors against Modular Interaction Domains

Rudolf H. Aebersold, Institute of Molecular Systems Biology, ETH Zürich, Switzerland
Genetic Variability and the Quantitative Proteome

Frank Sicheri, Lunenfeld-Tanenbaum Research Institute, Canada
Structural Basis for Poly-Ubiquitin Chain Cleavage: Lessons Learned from OTUB1 and OTULIN/Gumby

Xiaolei Su, University of California, San Francisco, USA
Poster Talk: Reconstituting TCR Signaling Pathways Reveals a Role for T Cell Microclusters

Vishva M. Dixit, Genentech, Inc., USA
Ubiquitin Modification in Cancer Pathogenesis

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Kinome Biology
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Kinase signaling networks - phosphorylation-based signaling.

* Benjamin E. Turk, Yale University, USA
Large-Scale Analysis of Protein Kinase Specificity

Stefan Knapp, University of Oxford, UK
Short Talk: Selective Targeting of Kinase Signaling Networks

Rune Linding, University of Copenhagen, Denmark
Biological Forecasting in the Cancer Kinome

Edward Y. Skolnik, New York University Medical Center, USA
Poster Talk: Regulation of Pancreatic b Cells by Protein Histidine Phosphorylation

Susan S. Taylor, University of California, San Diego, USA
PKA: Evolution of a Dynamic Macromolecular Switch

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 2


WEDNESDAY, JANUARY 14

07:00—08:00
Breakfast

08:00—11:00
From Modules and Networks to Cellular Phenotypes
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
How changes in protein modules and signaling networks translate into cellular switches.

Norbert Perrimon, Harvard Medical School, USA
Spatio-Temporal Regulation of Signaling in Drosophila

* John Kuriyan, University of California, Berkeley, USA
Control of Catalytic Activity in the EGF Receptor

Ivan Dikic, Goethe University Medical School, Germany
Linear Ubiquitination in Regulation of Inflammation

Michael Tyers, University of Montreal, Canada
From Large Networks to Small Molecules

Lee Bardwell, University of California, Irvine, USA
Poster Talk: Synergy, Interdependency and Redundancy in Multi-Site Phosphorylation

James E. Ferrell Jr., Stanford University, USA
Trigger Waves in Mitosis and Apoptosis

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Evolution of Phosphorylation, PTMs and Modular Protein Domains
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
How cells evolved to function the way they do

* Gerard Manning, Genentech, Inc., USA
Evolutionary Comparisons to Explore the Function and Diversity of Signaling Biology

Chris Tan, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Short Talk: Co-Evolution of Protein Phosphorylation and Protein-Protein Interaction Networks

Liam J. Holt, University of California, Berkeley, USA
Poster Talk: Ancestral Resurrection Reveals Evolutionary Mechanisms of Kinase Plasticity

Benjamin G. Neel, Ontario Cancer Institute, Canada
PTP1B Promotes Survival of HER2+ Breast Cancer in Hypoxia by Regulating Moyamoya Disease-Associated E3 Ligase, RNF213 and Cellular Dioxygenase Activity

Robert Rottapel, Princess Margaret Hospital, Toronto Medical Discovery Tower, Canada
Short Talk: Abl Mediates a TAZ:RUNZ2 Self-Reinforcing Feedback Loop Required for Osteoblastogenesis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

19:30—22:00
Poster Session 3


THURSDAY, JANUARY 15

07:00—08:00
Breakfast

08:00—11:00
Network Medicine - Targeting Signaling Networks
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Relating knowledge of signaling networks to advances in patients’ outcomes.

* Michael B. Yaffe, Massachusetts Institute of Technology, USA
Using Systems Biology to Target Cancer

Douglas A. Lauffenburger, Massachusetts Institute of Technology, USA
Crosstalk and Feedback in Receptor Tyrosine Kinase Signaling Networks

Ruth H. Palmer, Umea University, Sweden
Poster Talk: Investigation of Anaplastic Lymphoma Kinase Signaling

Johannes L. Bos, University Medical Center Utrecht, Netherlands
Targeting Spatial and Temporal Control of Endothelial Barrier Function

Oliver Hantschel, Swiss Federal Institute of Technology Lausanne, Switzerland
Poster Talk: The SH2 Domain of ABL Kinases Regulates Kinase Autophosphorylation by Controlling Activation Loop Accessibility

Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Phase Separation of Multi-Valent Signaling Proteins

09:20—09:40
Coffee Break

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

17:00—19:00
Signaling Networks Driving Disease Progression and Resistance to Drugs
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting
Current limitations in our understanding of disease progression and potential solutions.

* Joan S. Brugge, Harvard Medical School, USA
Signaling Pathways that Regulate Adaptive Resistance to Cancer Therapies

Richard M. Marais, Cancer Research UK Manchester Institute, UK
NRAS and BRAF Signaling in Melanoma: From Basic Biology to Clinical Efficacy

Clark D. Wells, Indiana University School of Medicine, USA
Differential Roles of Angiomotin Proteins in the Development of Breast Cancer

19:00—19:30
Closing Remarks: Tony Pawson’s Legacy
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

* Tony Hunter, The Salk Institute, USA

* Rune Linding, University of Copenhagen, Denmark

19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.


FRIDAY, JANUARY 16

 
Departure


*Session Chair †Invited, not yet responded.

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Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

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Sheraton Steamboat Resort Floorplan




Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Journal of Molecular Cell Biology (JMCB) Regeneron Pharmaceuticals, Inc.
Roche Thermo Fisher Scientific Inc.

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

PLOS

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676