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This meeting took place in 2016



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Cytokine JAK-STAT Signaling in Immunity and Disease (A2)


Organizer(s) Curt M. Horvath, John J. O'Shea and Stephanie S. Watowich
January 10—14, 2016
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Discounted Abstract Deadline: Sep 21, 2015
Abstract Deadline: Oct 20, 2015
Scholarship Deadline: Sep 21, 2015
Discounted Registration Deadline: Nov 10, 2015

Sponsored by Incyte Corporation, Pfizer Inc. and Theravance Biopharma

Summary of Meeting:
Cytokines are important extracellular factors that direct a variety of biological responses in normal physiology and disease. Cytokine signaling is mediated in large part through four Janus kinase (JAK) proteins and seven Signal Transducer and Activator of Transcription (STAT) proteins, and these molecules intersect with a wide array of additional intracellular signals to drive significant global alterations in gene expression. Cytokine JAK-STAT pathways are intimately associated with innate and adaptive immunity, inflammation, stem cell and developmental biology, and diverse aspects of cancer biology. As JAK-STAT pathways produce both common and unique phenotypes critical for a vast range of biological phenomena, the basic understanding of how these signal transduction cascades are regulated, function and integrate with additional cellular responses has been continuously refined by discoveries of general and pathway-specific mechanisms. Furthermore, drug discovery efforts have produced small molecules targeting JAKs and STATs that are promising agents in clinical treatment of inflammation, arthritis and a variety of cancers. This meeting, coinciding with the 25th year of the discovery of JAK-STAT signaling, will couple invited speakers who have made significant contributions to allied disciplines with cytokine JAK-STAT veterans, with ample opportunities for short talks selected from submitted abstracts.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 15 in order to fully experience the meeting.

SUNDAY, JANUARY 10

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, JANUARY 11

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Curt M. Horvath, Northwestern University, USA

John J. O'Shea, NIAMS, National Institutes of Health, USA
Jaks and Stats in Immunity and Disease

09:00—11:30
Receptor Activation and STAT Signaling
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Stephanie S. Watowich, University of Texas MD Anderson Cancer Center, USA

* Sandra Pellegrini, Institut Pasteur, France

K. Christopher Garcia, Stanford University School of Medicine, USA
Tuning Cytokine Receptor Signaling

Andrew Brooks, University of Queensland Diamantina Institute, Australia
Mechanism of JAK2 Activation by the Growth Hormone Receptor

Jeff Babon, Walter and Eliza Hall Institute of Medical Research, Australia
Inhibition of JAK/STAT Signaling by the SOCS Family of Proteins

Ryan D. Ferrao, Genentech, USA
Short Talk: Structural and Biophysical Characterization of a JAK1 Binding Motif Shared by Class II Cytokine Receptors: Breaking the “Box1” Code

Tim R. Hercus, University of South Australia and SA Pathology, Australia
Short Talk: Function of the Beta Common Family of Cytokines

09:40—10:00
Coffee Break

Foyer
11:30—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
11:30—14:30
On Own for Lunch

14:30—16:30
Workshop 1: All Things Interferon

Storm Peak/Mt. Werner
* David E. Levy, New York University School of Medicine, USA

* Thomas A.F. Decker, Vienna Biocenter, University of Vienna, Austria

Nancy Au-Yeung, Northwestern University, USA
Chromatin Regulation of Type I Interferon-Stimulated Genes

Teresa D. Collins, University of Florida, USA
A Suppressor of Cytokine Signaling-1 Mimetic Peptide Ameliorates Lupus Pathology through Interferon-gamma Signaling Inhibition

Christine Delgado, University of Colorado Anschutz Medical Campus, USA
JAK1 and CK2 Mediate Immune Suppressive Effects of Type I Interferons and May be a Target for Host-Directed Therapy of Bacterial Infection

Nathalie M. Grandvaux, Université de Montréal, Canada
A Novel STAT2/IRF9-Dependent Pathway Mediates the Synergistic Action of IFNbeta+TNFalpha to Regulate Delayed Antiviral and Immunoregulatory Genes

Srinivasan Rengachari, EMBL-Grenoble, France
Structural Insights into ISGF3 Assembly

Kelly Shepardson, Montana State University, USA
Type I Interferons Regulate Host Susceptibility to Post-Influenza Bacterial Superinfection via STAT6

Prerak Trivedi, St. Vincent’s Institute, Australia
Preclinical Characterization of JAK1/JAK2 Inhibitors for Treatment of Type 1 Diabetes

Joshua D. Milner, NIAID, National Institutes of Health, USA
Germline STAT Mutations Cause Abnormal Cross-Regulation in Disease Pathogenesis

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Chromatin and Gene Regulation
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* George R. Stark, Cleveland Clinic, USA

Sandra Pellegrini, Institut Pasteur, France
Fine Tuning of Type I Interferon Response in Humans and Mice

Uwe Vinkemeier, University of Nottingham Medical School, UK
STAT Protein Polymerization and its Role in Cytokine-Dependent Gene Transcription

Jennifer Grandis, University of California, San Francisco, USA
Targeting STAT3 Signaling in Head and Neck Cancer

Yue Xiong, University of North Carolina at Chapel Hill, USA
Short Talk: The Function and Mechanism of TET DNA Dioxygenases in JAK-STAT Signaling and Antiviral Infection

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer/Rainbow/Twilight
19:30—22:00
Poster Session 1

Sunshine

TUESDAY, JANUARY 12

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:15
Immune Regulation
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* John J. O'Shea, NIAMS, National Institutes of Health, USA

* Lionel B. Ivashkiv, Hospital for Special Surgery, New York, USA

Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Regulation of Lymphocyte Activation and Effector Functions

Susan M. Kaech, Yale University School of Medicine, USA
Fattening Up T Cell Memory

Mark H. Kaplan, Indiana University School of Medicine, USA
Transcriptional Regulation of T Helper Cell Development

Joseph E. Craft, HHMI, Yale University, USA
STAT Regulation of Follicular T Helper Cell Development and Differentiation

Tiphanie Vogel, Washington University in St. Louis, USA
Short Talk: Altered Phosphorylation Kinetics, Cellular Location and Transcriptional Activity of a STAT3 GOF Mutation in the DNA Binding Domain

Massimo G. Gadina, NIAMS, National Institutes of Health, USA
Short Talk: Tofacitinib Ameliorates Murine Lupus and its Associated Vascular Damage

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Sunshine
13:00—22:00
Poster Viewing

Sunshine
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Inflammation
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Mark H. Kaplan, Indiana University School of Medicine, USA

* Joseph E. Craft, HHMI, Yale University, USA

Stephanie S. Watowich, University of Texas MD Anderson Cancer Center, USA
Innate Immune Regulation by STAT3

Lionel B. Ivashkiv, Hospital for Special Surgery, New York, USA
Regulation of Macrophage Activation by STAT Signaling and Epigenetic Mechanisms

Simon A. Jones, Cardiff University School of Medicine, UK
Interleukin-6 Responses in Inflammation and Immunity

Chien-Kuo Lee, National Taiwan University, Taiwan
Short Talk: STAT1 Regulates Marginal Zone B Cell Differentiation in Response to Inflammation and Infection with Blood-Borne Streptococcus Pneumoniae

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer/Rainbow/Twilight
19:30—22:00
Poster Session 2

Sunshine

WEDNESDAY, JANUARY 13

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:15
Stem Cells and Development
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Serge Y. Fuchs, University of Pennsylvania, USA

Alessandra Sacco, Sanford-Burnham-Prebys Medical Discovery Institute, USA
STAT3 Signaling Regulates Muscle Stem Cell Function

Christine J. Watson, University of Cambridge, UK
The Role of Stat3 in Cell Fate Switching in Mammary Gland

Sandra E. Nicholson, Walter and Eliza Hall Institute of Medical Research, Australia
SOCS Protein Regulation of NK Cell-Mediated Tumor Immunity

* Erika A. Bach, New York University School of Medicine, USA
JAK-STAT Signaling in Drosophila Tumor Models

Anthony R. Green, University of Cambridge, UK
Short Talk: Cytokine-Mediated Differentiation Reflects Genome-Wide Loss of a uSTAT Transcriptional Program

Zachary C. Murphy, University of Rochester, USA
Short Talk: JAK-STAT Signaling Regulates the Survival and Terminal Maturation of Embryonic Erythroid Cells Downstream of EpoR

09:20—09:40
Coffee Break

Foyer
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Infection and Disease
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Alessandra Sacco, Sanford-Burnham-Prebys Medical Discovery Institute, USA

* Christine J. Watson, University of Cambridge, UK

Thomas A.F. Decker, Vienna Biocenter, University of Vienna, Austria
JAK STAT Cooperation with the NFkB Pathway in the Regulation of Host Responses and Innate Immunity to Bacteria

Curt M. Horvath, Northwestern University, USA
Activation and Inhibition Mechanisms in IFN-JAK-STAT Signaling and Innate Antiviral Immunity

David E. Levy, New York University School of Medicine, USA
Mitochondrial STAT3 Supports Malignant Transformation through Metabolic Reprogramming

Serge Y. Fuchs, University of Pennsylvania, USA
Short Talk: Type 1 Interferons as Effectors of Genotoxic and Proteotoxic Stress: Role in Accelerated Aging and Diabetes

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer/Rainbow/Twilight

THURSDAY, JANUARY 14

07:00—08:00
Breakfast

Foyer/Rainbow/Twilight
08:00—11:15
Metabolic Disease and Cancer
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Uwe Vinkemeier, University of Nottingham Medical School, UK

* Andrew Brooks, University of Queensland Diamantina Institute, Australia

Ajay Chawla, University of California, San Francisco, USA
Innate Mechanisms of Thermogenesis

Ross L. Levine, Memorial Sloan-Kettering Cancer Center, USA
Role of JAK-STAT Pathway Activation in MPN Pathogenesis and Therapeutic Response

Andrew Larner, Virginia Commonwealth University, USA
STAT3 Rapidly Exits and Re-Enters the Mitochondria in Cells Exposed to Oxidative Stress or Cytokines

Tony Tiganis, Monash University, Australia
PTPs and STATs in Obesity and Cancer

Jesse Balic, Hudson Institute of Medical Research, Australia
Short Talk: Requirement for STAT3 Serine 727 Phosphorylation in Gastric Tumourigenesis

Marcin T. Kortylewski, Beckman Research Institute, City of Hope, USA
Short Talk: Cell-Selective Oligonucleotide STAT3 Inhibitors for Cancer Immunotherapy

09:20—09:40
Coffee Break

Foyer
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Therapeutic Targeting of JAK-STAT Pathways

Storm Peak/Mt. Werner
* Veronika Sexl, University of Veterinary Medicine, Austria

* Ross L. Levine, Memorial Sloan-Kettering Cancer Center, USA

Etty (Tika) Benveniste, University of Alabama at Birmingham, USA
Role of the JAK/STAT Pathway in Parkinson's Disease

Dirk Fahrenkamp, RWTH Aachen, Germany
Intramolecular Hydrophobic Interactions are Critical Mediators of STAT5 Dimerization

John S. McMurray, M.D. Anderson Cancer Center, USA
Targeting the SH2 Domain of STAT6: Potent Therapeutics for Asthma

Claudia Mertens, Rockefeller University, USA
Mutations in the Linker Domain Affect Phospho STAT3 Function and Suggest Targets for Interrupting STAT3

Jan Pencik, LBI-CR & Medical University of Vienna, Austria
Loss of IL-6/Stat3 Signaling Drives Metastatic Prostate Cancer in Mice and Men

Tiiu Saarne, AstraZeneca R&D Gothenburg, Sweden
Topical Administration of JAK1-Selective Inhibitor Reduces Airway Inflammation

Haiyan S. Li, University of Texas MD Anderson Cancer Center, USA
Dendritic Cell-Mediated Anti-Tumor Immunity is Restrained by STAT3 Suppression of Id2

Rich Woessner, AstraZeneca Pharmaceuticals, USA
Response to Checkpoint Inhibitor Antibodies is Enhanced by the Addition of STAT3 Antisense Treatment in Preclinical Tumor Models

16:30—17:00
Coffee Available

Foyer
17:00—18:45
Cancer Microenvironment and Therapeutics
Meeting has ended...abstracts no longer viewable online.

Storm Peak/Mt. Werner
* Andrew Larner, Virginia Commonwealth University, USA

* Sandra E. Nicholson, Walter and Eliza Hall Institute of Medical Research, Australia

Veronika Sexl, University of Veterinary Medicine, Austria
JAK-STAT in NK Cells: For the Better or Worse in Tumour Surveillance?

George R. Stark, Cleveland Clinic, USA
Novel Paradigms for STAT-Mediated Gene Regulation

Giorgio G. Inghirami, Weill Cornell Medical College, USA
The Pathogenetic Role of JAK/STAT Signaling Pathway in T-Cell Lymphoma

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions

Storm Peak/Mt. Werner
* James E. Darnell, Rockefeller University, USA

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Foyer/Sunshine
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sunshine

FRIDAY, JANUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Incyte Corporation Pfizer Inc.
Theravance Biopharma
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI120498-01

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