Beaver Run Resort Floorplan

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This meeting took place in 2016



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Cancer Pathophysiology: Integrating the Host and Tumor Environments (C3)


Organizer(s) Sheila A. Stewart, Sandra S. McAllister and Lisa M. Coussens
March 28—April 1, 2016
Beaver Run Resort • Breckenridge, Colorado USA
Discounted Abstract Deadline: Dec 1, 2015
Abstract Deadline: Jan 4, 2016
Scholarship Deadline: Dec 1, 2015
Discounted Registration Deadline: Jan 28, 2016

Sponsored by Incyte Corporation, Infinity Pharmaceuticals, Inc., Journal of Molecular Cell Biology (JMCB), Roche and TESARO, Inc.

Summary of Meeting:
The local and systemic tumor microenvironments (TME) play a pivotal role in all stages of cancer development, including initiation, malignant conversion and metastasis, as well as regulating how neoplastic cells respond to cytotoxic, targeted and immune-based therapies. Research over the last decade has revealed the incredible diversity and plasticity that constitute the TME. Thus, the focus of this meeting will be to bring together a wide breadth of experts who focus on the various aspects of the TME with the intent of creating a more complete picture of the potential therapeutic landscape. The unique feature of this meeting is its breadth of experts focused on both the systemic and local TME, who also recognize varied paracrine interactions with heterogeneous neoplastic cells. Presentations will focus on emerging studies to enable attendees access to senior investigators, as well as new investigators spanning the diversity of disciplines called “cancer biology.” In addition to invited speakers, time will be allotted for short oral presentations selected from submitted abstracts and three integrated poster sessions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Monday, March 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, April 1 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Saturday, April 2 in order to fully experience the meeting.

MONDAY, MARCH 28

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

TUESDAY, MARCH 29

07:00—08:00
Breakfast

Summit Gallery
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Douglas Hanahan, ISREC, Switzerland
Microenvironments, Metastasis and Therapeutic Targeting

09:00—11:30
The Tumor Systemic Environment I: Circulating Cells, Microvesicles and Cytokines
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Lisa M. Coussens, Oregon Health & Science University, USA

Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA
Systemic Regulation of Breast Cancer Progression

Julio Aguirre-Ghiso, Julio Aguirre-Ghiso, USA
Regulation of Tumor Dormancy

Christine Chaffer, Whitehead Institute for Biomedical Research, Canada
Role of the Primary Tumor in Determining Metastatic Success

Serkan Kir, Dana-Farber Cancer Institute, USA
Short Talk: PTH-related Protein and Adipose Tissue Browning in Cancer Cachexia

Michael Bradley Burns, University of Minnesota, USA
Poster Teaser: Genomic Landscape of Colorectal Tumors Shapes the Microbiome of the Tumor Microenvironment

Anna Brichkina, Institute of Molecular and Cell Biology, Singapore
Poster Teaser: p38MAPK-Dependent Reprogramming of Tumour Microenvironment as a Target for Lung Cancer Treatment

Courtney B. Betts, Oregon Health and Science University, USA
Poster Teaser: Reproductive State Dependent Alterations in Mammary Dendritic Cells and a Potential Role for Collagen

Carmen Bergom, Medical College of Wisconsin, USA
Poster Teaser: Novel Tools for Mapping Determinants of Radiation Sensitivity in the Tumor Microenvironment

Amy E. Baek, University of Illinois at Urbana-Champaign, USA
Poster Teaser: Effects of the Cholesterol Metabolite 27- Hydroxychoesterol on Immune Cells and Metastasis

Liz C. Halvorsen, BC Cancer Agency, Canada
Poster Teaser: CCR5 Antagonists as Immune-Modulating Agents for the Treatment of Breast Cancer Metastasis

09:40—10:00
Coffee Break

Foyer
11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
The Tumor Systemic Environment II: Processes that Promote Cancer Progression
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA

Pepper Jo Schedin, Oregon Health & Science University, USA
Weaning-Induced Tissue Remodeling, Metastasis and Young Women’s Breast Cancer

Derek Radisky, Mayo Clinic, USA
Epithelial and Stromal Alterations that Drive Breast Cancer Progression from Benign Breast Disease

Giorgio Trinchieri, NCI, National Institutes of Health, USA
Cancer as a Disease of the Symbiont/Metaorganism

Mauricio da Silva Caetano, University of Texas MD Anderson Cancer Center, USA
Short Talk: Gender –Specific Role of Epithelial STAT3 in K-Ras Mutant Lung Tumorigenesis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 1

Peaks 1-3

WEDNESDAY, MARCH 30

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Immune Cells I: Adaptive and Innate Immune Cells in the TME
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Judith A. Varner, University of California, San Diego, USA

David G. DeNardo, Washington University Medical School, USA
Reprogramming the Tumor Microenvironment to Facilitate Responses to Immunotherapy.

Mikala Egeblad, Cold Spring Harbor Laboratory, USA
Cancer Cell Expression of a Chemokine Receptor Promotes Immune Evasion

Andy Minn, University of Pennsylvania, USA
Viral Mimicry in the Tumor Microenvironment Regulates Therapy Resistance

Daniela F. Quail, Memorial Sloan Kettering Cancer Center, USA
Deciphering Mechanisms of Resistance to Microenvironment-Targeted Therapies

Lauren I. R. Ehrlich, University of Texas at Austin, USA
Short Talk: Endogenous Dendritic Cells from the Tumor Microenvironment Directly Support T-ALL Growth through IGF1R Activation

Sharon A. Glynn, National University of Ireland Galway, Ireland
Poster Teaser: Para-endocrine Interactions Between Prostate Cancer and Bone Marrow Mesenchymal Stem Cells Enhance Tumour Cell Invasive Capacity and Proliferation

Ryan S. Lane, Oregon Health & Science University, USA
Poster Teaser: Inducible PD-L1 expression on Lymphatic Endothelial Cells in the Tumor Microenvironment

Kevin C. Flanagan, Washington University in St. Louis, USA
Poster Teaser: c-Myb and C/EBPbeta Control Stromal-Derived Pro-Tumorigenic OPN Expression

Nako Maishi, Hokkaido University, Japan
Poster Teaser: Tumor Endothelial Cells Promote Metastasis via Biglycan

Ariel Munitz, Tel Aviv University, Israel
Poster Teaser: Eosinophils are an Integral Part of the Tumor Microenvironment Exerting Potent Anti-Tumorigenic Functions

Bhavna Murali, Washington University in St. Louis, USA
Poster Teaser: Inhibition of the Stromal p38MAPK Pathway Abrogates Breast Cancer Metastases

09:20—09:40
Coffee Break

Foyer
11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Immune Cells II: Immune Regulation of Cancer Progression
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* David G. DeNardo, Washington University Medical School, USA

Judith A. Varner, University of California, San Diego, USA
PI3Kgamma Signaling in Immune Cells and Cancer

Shannon J. Turley, Genentech, Inc., USA
Immunological Hallmarks of the Stromal Niche

Roberta Faccio, Washington University, USA
Dickkopf-Related Protein 1 (Dkk1) Exerts Immune Suppressive Effects in Cancer by Regulating Expansion and Function of Myeloid Derived Suppressor Cells

Yu Zhu, Washington University, USA
Short Talk: Pancreatic Tumor-Associated Macrophages Have Different Origin and Functions

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 2

Peaks 1-3

THURSDAY, MARCH 31

07:00—08:00
Breakfast

Summit Gallery
08:00—11:15
Paracrine Signaling I: Primary Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Ittai Ben-Porath, Hebrew University of Jerusalem, Israel

Sheila A. Stewart, Washington University School of Medicine, USA
Age-Related Changes in the Tumor Microenvironment Drive Increased Tumorigenesis

Amanda Lund, Oregon Health & Science University, USA
Lymphatic Vessels and Immune Regulation in the Tumor Microenvironment

Arne Ostman, Karolinska Institutet, Sweden
PDGFR-Positive Fibroblasts and Pericytes: Impact on Tumor Progression and Treatment Response

Zachary T. Schafer, University of Notre Dame, USA
The Regulation of Cancer Cell Death by Extracellular Matrix Attachment

Katharine White, University of California, San Francisco, USA
Short Talk: Arginine to Histidine Mutations can Confer Adaptive pH Sensing and Are Enriched in a Subset of Cancers

Jessica Olive, Harvard University, USA
Poster Teaser: Examining the Effects of the Systemic Environment on Intratumoral Heterogeneity, Breast Cancer Progression and Therapeutic Resistance

Camilla Salvagno, Netherlands Cancer Institute, Netherlands
Poster Teaser: Therapeutic Synergy Between Macrophage Blockade and Chemotherapy in Breast Cancer Elicits Neutrophil-Dependent Therapy Resistance

Honami Naora, University of Texas MD Anderson Cancer Center, USA
Poster Teaser: Transcriptional Dysregulation of Megakaryopoiesis and Erythropoiesis: Implications for the Tumor Microenvironment

Edward J. Richards, Massachusetts Institute of Technology, USA
Poster Teaser: TAM Family RTKs Promote the Metastatic Niche at the Tumor-Immune Interface through Suppressing Cytokine Production in Residing Immune Cell Populations

09:20—09:40
Coffee Break

Foyer
11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Paracrine Signaling II: Microenvironment at Metastatic Sites
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Sheila A. Stewart, Washington University School of Medicine, USA

Mara H. Sherman, The Salk Institute, USA
Stromal Regulation and Therapeutic Targeting of the Pancreatic Cancer Epigenome

Yuval Shaked, Technion - Israel Institute of Technology, Israel
Macrophage-Induced Lymphangiogenesis following Paclitaxel Chemotherapy Is Regulated by VEGFR3

Ittai Ben-Porath, Hebrew University of Jerusalem, Israel
Regulation of Transitions in Differentiation State in Basal-Like Breast Cancer

Mark A. Eckert, University of Chicago, USA
Short Talk: Compartment-Resolved Proteomics Reveals a Stromal Signature of Ovarian Cancer Metastasis

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
19:30—22:00
Poster Session 3

Peaks 1-3

FRIDAY, APRIL 1

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Therapeutic Considerations I: Targeting the TME
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Shahin Rafii, Weill Cornell Medical College, USA

Gabriele A.I. Bergers, University of California, San Francisco, USA
Intertwined Functional Regulation of Angiogenesis, Invasion and Immune Modulation in Cancer

Robert S. Kerbel, Sunnybrook Research Institute, Canada
Impact of the Organ Microenvironment on the Response of Primary Tumors Versus Metastases to Antiangiogenic Therapy

Jennifer Wargo, University of Texas MD Anderson Cancer Center, USA
Understanding the Heterogeneity and Dynamics of the Anti-Tumor Immune Response

Xinming Su, Washington University, USA
Short Talk: Integrin Beta3 Antagonism Increases Immune Suppression in Cancer

Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer: Immune Cells as Targets for Anti-Cancer Therapy

09:20—09:40
Coffee Break

Foyer
11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Therapeutic Considerations II: Targeting the Systemic Environment
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Robert S. Kerbel, Sunnybrook Research Institute, Canada

Shahin Rafii, Weill Cornell Medical College, USA
Maladapted Vascular Niche Initiates Tumor Invasion and Metastasis

Seth B. Coffelt, Netherlands Cancer Institute, Netherlands

Kyoko Hida, Hokkaido University, Japan
Heterogeneity of Tumor Endothelial Cells

Jessica Cedervall, Uppsala University, Sweden
Short Talk: Tumor-induced Neutrophil Extracellular Traps (NETs) - Drivers of Systemic Inflammation and Organ Failure

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Peaks 4-5
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Peaks 1-3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Peaks 1-3

SATURDAY, APRIL 2

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Incyte Corporation Infinity Pharmaceuticals, Inc.
Journal of Molecular Cell Biology (JMCB) Roche
TESARO, Inc.
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:


Educational grant from Celgene Corporation

Don Whitley Scientific Limited
HypOxygen
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA200185-01

Funding for this conference was made possible (in part) by 1R13CA200185-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676