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This meeting took place in 2016



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Heart Failure: Genetics, Genomics and Epigenetics (Z1)


Organizer(s) Stuart A. Cook, Christine E. Seidman and Yigal M. Pinto
April 3—7, 2016
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Dec 3, 2015
Abstract Deadline: Jan 7, 2016
Scholarship Deadline: Dec 3, 2015
Discounted Registration Deadline: Feb 4, 2016

Sponsored by Bayer HealthCare Pharmaceuticals, Pfizer Inc. and Takeda Pharmaceutical Company Limited


Summary of Meeting:
Heart failure (HF) is a worldwide epidemic with treatments costing tens of billions of dollars every year. Despite this investment, HF therapies have limited efficacy in reducing disease progression. Recent insights in fundamental myocyte biology, HF etiologies and pathogenic mechanisms are propelling new strategies to treat and prevent HF. This meeting will explore biologic and technical advances that inform the genetic architecture, molecular pathogenesis and innovative approaches to treat HF. This comes at a time when very large human HF datasets are available and can be interrogated using advanced computational and bioinformatic approaches. Specific aims are to: 1) Consider genes, molecules, signaling pathways and biomarkers involved in systolic and diastolic HF in humans; 2) Explore disease mechanisms underlying HF in model systems; 3) Understand the role of epigenetics, miRNAs and lncRNAs in HF pathogenesis; and 4) Review translational programs in genomic, pharmacologic and cell-based therapeutics to treat HF. The outcomes of this meeting should be far-reaching for basic, translational and clinical communities. The meeting should also provide an excellent training program for junior scientists and serve as a catalyst for collaboration among research, clinical and industrial participants. This meeting is being held in conjunction with the “Cardiac Development, Regeneration and Repair” meeting that provides an outstanding opportunity for joint sessions in genetics, iPSC disease modeling, stem cell therapeutics and epigenetics.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 3 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 7 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 8 in order to fully experience the meeting.

SUNDAY, APRIL 3

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, APRIL 4

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
James A. Spudich, Stanford University, USA
Mutations to Mechanisms to Therapies

08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Peter W. Reddien, Whitehead Institute, USA
The Role of Muscle Cells in Directing Regeneration in Planarians

09:00—11:30
Heart Failure 2016: Syndromes, Mechanisms and Treatments
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Christine E. Seidman, Harvard Medical School, USA

* Hugh Watkins, University of Oxford, UK

Frank R. Heinzel, , Germany
What We Don't Know?

Denise Hilfiker-Kleiner, Medizinische Hochschule Hannover, Germany
Molecular Mechanisms Underlying Peripartum Cardiomyopathy

Robert N. Willette, GlaxoSmithKline, USA
Challenges and Opportunities in Heart Failure Drug Discovery: An Industry Perspective

Leanne Elizabeth Felkin, Imperial College London, UK
Short Talk: Recovery of Cardiac Function in Cardiomyopathy due to Titin Truncation

Pu Qin, GlaxoSmithKline, USA
Short Talk: Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress and Improves Survival

09:00—11:30
Cardiac Lineage Commitment and Specification
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Christine L. Mummery, Leiden University Medical Center, Netherlands

Vincent M. Christoffels, Academic Medical Center, Netherlands
T-Box Transcription Factors in Conduction System Lineage Determination

Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, USA
Transcriptional Regulation of Heart Development and Chromatin Structure

Katherine E. Yutzey, Cincinnati Children's Hospital Medical Center, USA
Epicardial-Derived Lineages in Heart Development and Disease

Alexandre R. Colas, Sanford-Burnham Medical Research Institute, USA
Short Talk: Id1 Is an Evolutionarily Conserved Master Regulator of Cardiogenic Mesoderm Formation

Daniel M. DeLaughter, Harvard Medical School, USA
Short Talk: Single Cell Transcriptional Atlas of Cardiac Development

09:40—10:00
Coffee Break

Ballroom Lobby
11:30—14:30
On Own for Lunch

11:30—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
14:30—16:30
Workshop and Panel 1: Molecular Etiology of Heart Failure

Ballroom 1-3
* Norbert Hubner, Max Delbrück Center for Molecular Medicine, Germany

* Denise Hilfiker-Kleiner, Medizinische Hochschule Hannover, Germany

Daniel I. Swerdlow, University College London, UK
Heart FailuRe Molecular Epidemiology for Therapeutic TargetS (HERMES) Consortium: Design of a Collaborative Genetic Meta-Analysis Investigating Causal Pathways in Heart Failure

J. Gustav Smith, Lund University, Sweden
Discovery and Initial Characterization of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure

Lek Wen Tan, Genome Institute of Singapore, Singapore
Circular RNA Landscape in Human and Mouse Heart

Anthony Cammarato, Johns Hopkins University, USA
Influence of Actin Pseudo-Acetylation on in vivo and in vitro Cardiac Performance

Yasmine Aguib, Aswan Heart Centre, MYF, Egypt
Defining the Genetic Architecture of Cardiomyopathy within the Egyptian Population

Saptarsi M. Haldar, Gladstone Institutes and University of California, San Francisco, USA
Therapeutic Targeting of Chromatin-Dependent Signaling in Heart Failure

Selvi Celik, Lund University, Sweden
Atrial Natriuretic Peptide Expression is Negatively Regulated by a Long Noncoding Antisense RNA Transcript (NPPA-AS1) in Human Cardiomyocytes

Rudolf J. Wiesner, Institute of Vegetative Physiology, Germany
Mosaic Mitochondrial Respiratory Chain Deficiency Causes Cardiac Arrhythmia during Aging

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Cardiovascular Tissue and Organs on Chips (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Karl Tryggvason, Karolinska Institutet, Sweden

Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
Dissecting Gene Variant Effects with Tissue Models

Christopher S. Chen, Boston University, USA
Mechanoregulation of Form and Function: A Story of Cell Adhesion and the Cytoskeleton

Eric N. Olson, University of Texas Southwestern Medical Center, USA
Myoediting: Correction of DMD by CRISPR/Cas9 Gene Editing

Kevin Beussman, University of Washington, USA
Short Talk: Intracellular Assessment of the Maturation of Excitation-Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 1

Primrose

TUESDAY, APRIL 5

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Sarcomere Genetics: So What’s New?
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Norbert Hubner, Max Delbrück Center for Molecular Medicine, Germany

* Carolyn Ho, Brigham and Women's Hospital, USA

Stuart A. Cook, Duke-NUS Graduate Medical School Singapore, Singapore
Disease Mechanisms in Titin Cardiomyopathy

Christine E. Seidman, Harvard Medical School, USA
Genetic (and Other) Antidotes for Cardiomyopathy

Richard L. Moss, University of Wisconsin, Madison, USA
Modulation of Sarcomeres via MYBPC3

Leslie A. Leinwand, University of Colorado, Boulder, USA
Myosin Myopathies: Pathogenesis and Potential Therapeutics

Hugh Watkins, University of Oxford, UK
Sequencing Sarcomeric (and Other Genes) in Cardiomyopathy

08:00—11:15
Cardiac Morphogenesis and Regeneration
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Benoit G. Bruneau, Gladstone Institute of Cardiovascular Disease, USA

Jonathan A. Epstein, University of Pennsylvania, USA
Nuclear Architecture and Cardiac Development

Eldad Tzahor, Weizmann Institute of Science, Israel
Novel Insights into Cardiac Regeneration

Kristy Red-Horse, Stanford University, USA
Growth and Patterning of Coronary Arteries

Neil C. Chi, University of California, San Diego, USA
Cellular and Genetic Dissection of Cardiovascular Development and Regeneration

Ignacio Flores, Centro Nacional de Investigaciones Cardiovasculares, Spain
Short Talk: Telomerase is Essential for Zebrafish Heart Regeneration

Tilde Eskildsen, Odense University Hospital, Denmark
Short Talk: Defining the Earliest Step of Cardiovascular Development Using CRISPR Genome Editing Technology

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Systems Dissection of Cardiac Failure
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Yigal M. Pinto, University of Amsterdam, Netherlands

Norbert Hubner, Max Delbrück Center for Molecular Medicine, Germany
Dissecting the Genetic Basis of Translational Regulation in Heart Failure

Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Towards a Structural Basis of Complex Disorders of the Heart: Calcium Leak and Mitochondria

17:00—19:00
Differentiation and Characterization of Cardiomyocytes from Pluripotent Stem Cells
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Martina Brueckner, Yale University School of Medicine, USA

David A. Elliott, Murdoch Childrens Research Institute, Australia
Generating Cellular Diversity during Human Cardiovascular Development

Bernd K. Fleischmann, Bonn University, Germany
Assessing Plasticity of Cardiomyocytes Using Pluripotent ES-Cell and Mouse Models

Godfrey Smith, University of Glasgow, UK
The Pharmacology of iPS-Derived Cardiomyocytes

Sanjay Sinha, University of Cambridge, UK
Short Talk: Human Pluripotent Stem Cell-Derived Epicardium Promotes Cardiomyocyte Maturation and Contraction in Tissue-Engineered Cardiac Constructs

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 2

Primrose

WEDNESDAY, APRIL 6

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Aging Hearts
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Leslie A. Leinwand, University of Colorado, Boulder, USA

* Gerald W. Dorn, II, Washington University School of Medicine, USA

Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA
Interplay of Proteotoxicity, Heart Failure and Autophagy

Richard T. Lee, Harvard University, USA
Systemic Factors and Cardiac Aging

Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Genetic Lineage Tracing Defines Myofibroblast Origin and Function in the Injured Heart

Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Autophagy and Heart Disease

Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: Preserving Heart Function despite Obesity, Aging and Parental Diet

Eleonora Adami, Max Delbrück Center for Molecular Medicine, MDC, Germany
Short Talk: Ribo-Seq Provides a Genome-Wide View of Translational Control in the Diseased Human and Rat Heart

08:00—11:15
Human Pluripotent Stem Cells as Models of Cardiovascular Disease
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Stacey L. Rentschler, Washington University School of Medicine, USA

Joseph C. Wu, Stanford University School of Medicine, USA
Cardiac iPSCs for Disease Modeling and Drug Discovery

Lior Gepstein, Technion-Israel Institute of Technology, Israel
iPS Modeling of Cardiac Disease: Arrhythmias and Heart Failure

Christine L. Mummery, Leiden University Medical Center, Netherlands
Human iPS Cell Models of Heart and Blood Vessel Disease

Kiran Musunuru, University of Pennsylvania, USA
Genome Editing of Human Pluripotent Stem Cells to Generate Human Cellular Disease Models

Zhen Ma, University of California, Berkeley, USA
Short Talk: Biomaterial-Guided Isogenic iPS Disease Modeling of Hypertrophic Cardiomyopathy

Yuta Yamamoto, Kyoto University, Japan
Short Talk: Modeling of Long-QT Syndrome Associated with a Calmodulin Mutation using Human Induced Pluripotent Stem Cells

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:15
Molecular Aspects of Muscle Cell Contractility and Relaxation
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Jeffrey Robbins, Cincinnati Children's Hospital Medical Center, USA

* Stefan Engelhardt, Institut for Pharmacologie & Toxicologie der TUM, Germany

Wolfgang A. Linke, Ruhr University Bochum, Germany
Titin Elasticity Impacts Diastolic and Systolic Function

David Warshaw, University of Vermont, USA
Molecular Mechanics of MYBPC3

Gerald W. Dorn, II, Washington University School of Medicine, USA
Mitochondrial Triage: Dynamism Determines Quality Control

Nina de Groot, University of Amsterdam, Netherlands
Short Talk: Rbm24 Influences the force-Ca2+ Relation in Heart Muscle

Ryan L. Boudreau, University of Iowa, USA
Short Talk: The Cardiac microRNA-target Interactome Reveals a Novel miR-24:SCN5A:SNP Interaction Associating with Non-Arrhythmic Death in Heart Failure

17:00—19:15
Vascular Development and Disease
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Anne C. Eichmann, Yale University School of Medicine, USA
Signalling in Vascular Development and Function

Zoltan P. Arany, University of Pennsylvania, USA
Vascular Metabolism and Disease

Stefanie Dimmeler, University of Frankfurt, Germany
Non-Coding RNAs in Cardiovascular Repair

Alexandria Afonso, McMaster University, Canada
Short Talk: Modeling Genetic Determinants of Early-Onset Coronary Artery Disease using Patient-Derived Induced Pluripotent Stem Cells

Naoko Koyano-Nakagawa, University of Minnesota, USA
Short Talk: Feedback Mechanisms Regulate Ets variant 2 (Etv2) Gene Expression and Hematoendothelial Lineages

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 3

Primrose

THURSDAY, APRIL 7

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Novel Therapeutic Approaches to Fix Broken Hearts (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Joseph C. Wu, Stanford University School of Medicine, USA

Paul R. Riley, University of Oxford, UK
Developmental Programming of the Cardiac Lymphatics towards Heart Repair

Kenneth D. Poss, Duke University Medical Center, USA
Endogenous Heart Regeneration Programs

Charles E. Murry, University of Washington, USA
Cardiogenesis with Human Pluripotent Stem Cells

Karl Tryggvason, Karolinska Institutet, Sweden
Using Laminins to Generate Therapeutic Cardiomyocytes from hES Cells

Anna Blice-Baum, Johns Hopkins University, USA
Short Talk: Titered FOXO Overexpression Maintains Cardiac Proteostasis and Ameliorates Age-Associated Functional Decline

Palmer Yu, Gladstone Institutes, USA
Short Talk: Regeneration of Cardiomyocytes in vivo Using Human Cardiac Reprogramming Factors in a Pig Model

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—18:45
Epigenetics and miRNAs: Muscle Failure and Arrhythmia Predisposition
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Esther E. Creemers, Academic Medical Center, Netherlands

* Joseph A. Hill, University of Texas Southwestern Medical Center, USA

Stefan Engelhardt, Institut for Pharmacologie & Toxicologie der TUM, Germany
MiRNAs from Non-Muscle Cells

Roger Foo, Genome Institute of Singapore, Singapore
What Single Cell Genomics Can Tell Us About Heart Failure

Yigal M. Pinto, University of Amsterdam, Netherlands
Role of Cardiac Specific RNA Binding Proteins in Regulating miRNA Function

17:00—18:45
Cardiomyocyte Maturation, Proliferation and Cardiac Remodeling
Meeting has ended...abstracts no longer viewable online.

Ballroom 2
* Bernd K. Fleischmann, Bonn University, Germany

Anthony J. Muslin, Sanofi, USA
Signal Transduction Pathways Related to Cardiac Hypertrophy

Jose Luis de la Pompa, Centro Nacional de Investigaciones Cardiovasculares, Spain
Notch Signaling in Ventricular Chamber Development and Disease

Thomas Braun, , Germany
The Role of Dedifferentiated Cardiomyocytes in the Diseased Myocardium

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Ballroom 1
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Ballroom 2
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 2-3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 2-3

FRIDAY, APRIL 8

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Bayer HealthCare Pharmaceuticals Pfizer Inc.
Takeda Pharmaceutical Company Limited
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:


American Heart Association's Council on Functional Genomics and Translational Biology

Bethyl Laboratories, Inc. Cytokinetics, Inc.

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13HL131204-01

Funding for this conference was made possible (in part) by 1R13HL131204-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676