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This meeting took place in 2016



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Epigenetic and Metabolic Regulation of Aging and Aging-Related Diseases (E1)


Organizer(s) Anne Brunet, David M. Sabatini and Shelley L. Berger
May 1—5, 2016
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Jan 5, 2016
Abstract Deadline: Feb 2, 2016
Scholarship Deadline: Jan 5, 2016
Discounted Registration Deadline: Mar 1, 2016

Sponsored by Journal of Molecular Cell Biology (JMCB)

Summary of Meeting:
Aging poses formidable scientific, medical and societal challenges. Old age is the single most important risk factor for a constellation of diseases, including cardiovascular disease, cancer, diabetes and a range of neurodegenerative disorders such as Alzheimer’s disease. Aging is also one of the greatest fundamental mysteries in biology, and arguably its next frontier. Long thought to be inexorable, aging has in fact been shown to be malleable due to specific changes in genes or environment. This Keystone Symposia meeting will cover the most exciting questions at the forefront of the field: How can external stimuli delay aging in a long-lasting, yet reversible, manner? Does the integration of external stimuli to modulate aging differ among cells with vastly diverse functions – somatic maintenance, tissue regeneration and the “immortal” germline? Is aging a synchronous process, and how do the different cells and systems communicate? How do diseases of aging develop, and what can be done to prevent or reverse them? To address these questions, the symposium will gather investigators from completely different areas to bring an interdisciplinary approach to aging. The meeting will focus on the emerging nexus between two key aging regulators – epigenetic states of the genome and metabolic status – and will highlight innovative technologies and the newest discoveries in aging and diseases. This symposium will also address questions from different perspectives, taking advantage of model organisms with drastically divergent lifespans and aging strategies. Importantly, this meeting will particularly discuss human aging and its associated traits – frailty, susceptibility to diseases – and potential aging therapeutics.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 5 with a closing plenary session from 17:00 to 20:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 6 in order to fully experience the meeting.

SUNDAY, MAY 1

16:00—20:00
Arrival and Registration

Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Canyon

MONDAY, MAY 2

07:30—08:30
Breakfast

Pecos/Canyon
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mesa A-B
Linda Partridge, Max Planck Institute for Biology of Ageing, Germany
Manipulating Nutrient-Sensing Signaling to Improve Health During Ageing

09:30—12:00
Epigenetic Regulation of Aging
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mesa A-B
* Anne Brunet, Stanford University, USA

Shelley L. Berger, University of Pennsylvania, USA
Acetyl-coA Metabolism by ACSS2 Regulates Neuronal Histone Acetylation and Long-term Memory

Andrew G. Dillin, University of California, Berkeley, USA
Epigenetic Control of Mitochondrial Stress Response

Weiwei Dang, Baylor College of Medicine, USA
Short Talk: H3K36me3 Promotes Longevity by Suppressing Age-Associated Intragenic Cryptic Transcription

Steve Horvath, University of California, Los Angeles, USA
Short Talk: Recent Updates on the Epigenetic Clock

Peter D. Adams, Beatson Institute for Cancer Research, UK
Epigenetics of Cancer and Aging: Mechanisms , interventions and Therapeutic

10:10—10:30
Coffee Break

Canyon
12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Mesa C
13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee Available

Canyon
17:00—19:15
Transcriptional and Noncoding RNA Networks in Aging
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mesa A-B
* Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain

Coleen T. Murphy, Princeton University, USA
The tissue Specific Roles of Insulin/IGF-1 Like Signaling in Quality of Life

Ramin Shiekhattar, University of Miami, USA
Integrator in Signaling and Enhancer Function

Irina M. Bochkis, Broad Institute, USA
Short Talk: Reorganization of Lamin B1 Genomic Regions in Aged Liver Alters Binding of Pioneer Factor Foxa2

Ashley E. Webb, Brown University, USA
Short Talk: Elucidation of Direct FOXO Networks that Promote Stem Cell Preservation during Aging

Ali Shilatifard, Northwestern University, USA
Enhancer Malfunction in Cancer

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pecos/Canyon
19:30—22:00
Poster Session 1

Mesa C

TUESDAY, MAY 3

07:30—08:30
Breakfast

Pecos/Canyon
08:00—08:30
Poster Setup

Mesa C
08:30—17:00
Poster Viewing

Mesa C
08:30—11:45
Epigenetic and Metabolic Regulation of Aging Stem Cells
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mesa A-B
* David M. Sabatini, Whitehead Institute for Biomedical Research, USA

Thomas A. Rando, Stanford University School of Medicine, USA
Epigenetic Mechanisms of Stem Cell Aging and Rejuvenation

Marcia C. Haigis, Harvard Medical School, USA
Rethinking Mitochondrial Biogenesis

Salvador Aznar Benitah, ICREA and Institute for Research in Biomedicine, Spain
Short Talk: Adult Stem Cells Undergo Diet-Dependent Circadian Reprogramming during Ageing

David A. Sinclair, Harvard Medical School, USA
Is Loss of Epigenetic Resilience a Driver of Aging?

Isabel Beerman, Harvard University, USA
Short Talk: Age-Associated Clonal Dominance of Myeloid-Biased HSC is Underwritten by Unique Transcriptional and Epigenetic Alterations

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Clec11a Is an Osteogenic Factor that Is Necessary for the Maintenance of the Adult Skeleton during Aging

10:10—10:30
Coffee Break

Canyon
11:45—12:30
Lunch

Pecos/Canyon
12:00—14:30
Poster Session 2

Mesa C
14:30—16:30
Workshop 1: New Animal Models and Rejuvenation

Mesa A-B
* Danica Chen, University of California, Berkeley, USA
Mitochondrial Regulation of Hematopoietic Stem Cell Aging and Rejuvenation

Itamar Harel, Stanford University, USA
Prion-Like Spread of Protein Aggregates in a New Aging Vertebrate Model: The Turquoise Killifish

Nora D. Yucel, Stanford University, USA
Metabolic Regulation of Muscle Stem Cell Acetylation Landscape during Regeneration

Carsten Merkwirth, University of California, Berkeley, USA
Epigenetic Control of Longevity in Response to Mitochondrial Dysfunction

Geraldine Gontier, University of California, San Francisco, USA
Role of TET2 in Regulating Neurogenesis and Cognition during Aging

Wenke Wang, Cornell University, USA
The Functions of SET-9 and SET-26 in Longevity and the Germline

Jae-Hyun Yang, Harvard Medical School, USA
Evidence for Epigenomic Change as a Cause of Mammalian Aging

Michael Todhunter, Lawrence Berkeley National Laboratory, USA
Studying Aging via Reconstituted Human Organoid Arrays

16:30—17:00
Coffee Available

Canyon
17:00—19:15
The Immortal Germline: Reprogramming and Transgenerational Inheritance
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mesa A-B
* Malene Hansen, Sanford Burnham Prebys Institute, USA

Adam Antebi, Max Planck Institut für Biologie des Alterns, Germany
Mondo Complexes Regulate TFEB via TOR Inhibition to Promote Longevity in Response to Gonadal Signals

Anne Brunet, Stanford University, USA
Long-Lasting Epigenetic Regulation of Aging in Germline and Soma

Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: Preserving Heart Function despite Obesity, Aging and Parental Diet

Eric L. Greer, Harvard Medical School, Boston Children's Hospital, USA
Short Talk: DNA Methylation on N6-Adenine in C. elegans

Steven E. Artandi, Stanford University, USA
Immortality in Germline Stem Cells and Somatic Stem Cells

19:15
On Own for Dinner


WEDNESDAY, MAY 4

07:30—08:30
Breakfast

Pecos/Canyon
08:30—12:00
Autophagy, "Inflammaging" and Metabolism
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mesa A-B
* J. Andrew Pospisilik, Max Planck Institute for Immunobiology and Epigenetics, Germany

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
mTOR Pathway in Metabolism and Aging

Malene Hansen, Sanford Burnham Prebys Institute, USA
Cellular Recycling: Role of Autophagy in Aging and Disease

Theodore T. Ho, University of California, San Francisco, USA
Short Talk: Activation of Autophagy During Aging Maintains Hematopoietic Stem Cell Metabolism and Functional Capacity

Leanne Jones, University of California, Los Angeles, USA
Mechanisms Underlying Loss of Intestinal Homeostasis with Age

Darren J. Baker, Mayo Clinic, USA
Short Talk: Naturally Occurring p16Ink4a-Positive Cells Shorten Healthy Lifespan

Riekelt H. Houtkooper, Academic Medical Center, Netherlands
Short Talk: A Sensitive Mass-Spectrometry-Based Platform Identifies Metabolic Changes of Life History Traits in C. elegans

Vishva M. Dixit, Genentech, Inc., USA
Inflammation and Aging

10:10—10:30
Coffee Break

Canyon
12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Mesa C
13:00—22:00
Poster Viewing

Mesa C
16:30—17:00
Coffee Available

Canyon
17:00—19:15
Systemic Regulation of Aging
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mesa A-B
* Thomas A. Rando, Stanford University School of Medicine, USA

Tony Wyss-Coray, Stanford University School of Medicine, USA
Systemic Regulation of Brain Aging and Neurodegeneration

Amy J. Wagers, Harvard University, USA
Reversing Dysfunction in Aging Tissues through Systemic Mediators

Louis R. Lapierre, Brown University, USA
Short Talk: Limiting Lipid Secretion Promotes Lipophagy and Longevity

Constanza J. Cortes, University of California, San Diego, USA
Short Talk: Skeletal Muscle Control of Systemic Metabolism: A Role for Transcription Factor E-B (TFEB) Signaling

Amita Sehgal, University of Pennsylvania Perelman School of Medicine, USA
Circadian Rhythms and Aging

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pecos/Canyon
19:30—22:00
Poster Session 3

Mesa C

THURSDAY, MAY 5

07:30—08:30
Breakfast

Pecos/Canyon
08:30—11:45
Epigenetics of Age-Related Diseases
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mesa A-B
* Lauren Booth, Stanford University, USA

Li-Huei Tsai, Massachusetts Institute of Technology, USA
Demystifying Innate Immune Response in Alzheimer's Like Neurodegeneration

Tony Kouzarides, University of Cambridge, UK
Role of ncRNAs in Transcription and Cancer

J. Andrew Pospisilik, Max Planck Institute for Immunobiology and Epigenetics, Germany
Epigenetic Determinants of Phenotypic Variation and Metabolic Disease: Intergenerational and Stochastic Effects

James Dowell, Wisconsin Institutes for Discovery, USA
Short Talk: Aberrant H3.3 Methylation and H2A.Z Acetylation in Alzheimer’s Disease

Christin A. Glorioso, Massachusetts Institute of Technology, USA
Short Talk:Brain Aging and APOE4 are Independent Additive Predictors of Neurological Function and Alzheimer’s Disease

Margaret A. Goodell, Baylor College of Medicine, USA
Epigenetic Alterations and Aging of Hematopoietic Stem Cells

09:50—10:10
Coffee Break

Canyon
11:45—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Therapeutic Approaches and Aging Biomarkers

Mesa A-B
Shahaf Peleg, Ludwig Maximilian University, Germany
The Metabolism-Chromatin Connectivity during Ageing

Brian H. Chen, National Institute on Aging, USA
Longitudinal Changes in DNA Methylation Levels at Epigenetic Clock Loci

Berenice Anath Benayoun, Stanford University, USA
Epigenomes and Transcriptomes across Tissues during Mouse Aging

Hongbo Zhang, École Polytechnique Fédérale de Lausanne, Switzerland
Improving Mitochondrial Function by NAD+ Repletion Rejuvenates Adult Stem Cells and Enhances Lifespan

Lauren Hillary Kodroff, Tulane University, USA
Impact of Microbiome Manipulation on Age-Related Inflammation and Immune System Dysfunction

Erik Ben van den Akker, Leiden University Medical Center, Netherlands
Uncompromised Ten-Year Survival of Oldest Old Carrying Somatic Mutations in DNMT3A and TET2

Aaron Mark Robitaille, University of Washington, USA
Identification of Small Molecules that Target Conserved Regulators of Lifespan

* Duygu Ucar, The Jackson Laboratory, USA
An Epigenomic Signature of Human Immune Aging in Circulating Lymphocytes/Leukocytes

16:30—17:00
Coffee Available

Promenade
17:00—19:00
Human Aging and Therapeutics
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Mesa A-B
* Shelley L. Berger, University of Pennsylvania, USA

P. Eline Slagboom, Leiden University Medical Center, Netherlands
Determinants of Human Lifespan

Trey Ideker, University of California, San Diego, USA
Epigenetic Prediction of Aging and Aging Acceleration for HIV+ Individuals

Joseph M. Castellano, Stanford University School of Medicine, USA
Short Talk: Human Umbilical Cord Plasma Proteins Revitalize Hippocampal Function in Aged Mice

Cynthia Kenyon, Calico, USA
How can Nature Counteract Aging?

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Mesa A-B
20:00—21:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Promenade/Mesa Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Mesa Ballroom

FRIDAY, MAY 6

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Journal of Molecular Cell Biology (JMCB)

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Zymo Research Corporation

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AG052264-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676