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This meeting took place in 2016


Here are the related meetings in 2017:
Autophagy Network Integration in Health and Disease (B2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Autophagy: Molecular and Physiological Mechanisms (V1)


Organizer(s) Sharon A. Tooze, Ana Maria Cuervo and Noboru Mizushima
June 5—9, 2016
Whistler Conference Centre • Whistler, British Columbia Canada
Discounted Abstract Deadline: Feb 4, 2016
Abstract Deadline: Mar 8, 2016
Scholarship Deadline: Feb 4, 2016
Discounted Registration Deadline: Apr 5, 2016

Sponsored by Novartis Institutes for BioMedical Research

Summary of Meeting:
Autophagy, an evolutionarily conserved pathway, is required for homeostasis, growth and survival in eukaryotic cells. Deregulation of autophagy is implicated in many human diseases, and mutations in autophagy genes are known to be a direct cause of severe human disorders. There are global efforts to understand the role of autophagy in disease pathogenesis and to develop therapeutic strategies to control the autophagic response. However, the latter is hampered by the lack of biomarkers, and disease-specific, selective autophagy targets. Overcoming this barrier in development of therapeutics will require a better understanding of basic autophagy biology. This meeting will specifically address the basic molecular pathway to increase our knowledge of the genes, proteins and signaling pathways involved in autophagy. The program will assemble experts in the molecular details of the diverse autophagic pathways and therefore provide clinicians and pharmaceutical companies with information to develop new, specific targets.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, June 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 9 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, June 10 in order to fully experience the meeting.

SUNDAY, JUNE 5

16:00—20:00
Arrival and Registration

Grand Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Grand Foyer

MONDAY, JUNE 6

07:30—08:30
Breakfast

Sea to Sky C
08:00—08:30
Poster Setup

Grand Foyer
08:30—17:00
Poster Viewing

Grand Foyer
08:30—11:45
Molecular Mechanisms of Autophagy I
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Vojo Deretic, University of New Mexico Health Sciences Center, USA

Tamotsu Yoshimori, Osaka University, Japan
Regulation of Membrane Dynamics in Autophagy; Its Implication in Diseases

Sharon A. Tooze, Francis Crick Institute, UK
Molecular Pathways and Vesicular Traffic during Autophagosome Formation

Coffee Break

Noboru Mizushima, University of Tokyo, Japan
The Life of the Autophagosome

Fulvio Reggiori, University Medical Centre Groningen, Netherlands
Spatial Atg8 Deconjugation Depends on the Regulation of Atg4 Function by Atg1 Phosphorylation and Phosphatidylinositol-3-Phosphate Levels

Josh Lyon Andersen, Brigham Young University, USA
Short Talk: Regulation of mAtg9A Phosphorylation by an AMPK/ULK1/LIMD1 Complex

Roarke A. Kamber, Harvard University, USA
Short Talk: Local Control of Autophagy Receptor Activation

11:45—12:30
Lunch

Sea to Sky C
12:00—14:30
Poster Session 1

Grand Foyer
14:30—16:30
Workshop 1: Selective and Non-Canonical Autophagy Pathways

Sea to Sky B
Allyson Anding, University of Massachusetts Medical School, USA
A Novel and Conserved Ubiquitin Receptor that is Required for Parkin-Dependent Mitophagy

* Li-Lin Du, National Institute of Biological Sciences, China
Fission Yeast Nbr1 Acts as a Cargo Receptor in an ESCRT-Dependent Vacuolar Targeting Pathway

Oliver Florey, Babraham Institute, UK
Novel Mechanisms of ATG16L1 Recruitment in Non-Canonical Autophagy

* Katarzyna Zientara-Rytter, University of California, San Diego, USA
New Roles of Atg37 and Pex3 in Assembly of the Pexophagic Receptor Protein Complex

Jakob Mejlvang, UiT The Arctic University of Norway, Norway
The Immediate Autophagic Response to Starvation (IARS) is Independent of Canonical Macroautophagy but Dependent on ESCRT-III and Vps4

Jin-A Lee, Hannam University, South Korea
Development of a New Autophagosome Sensor with an LC3-Interacting Region (LIR) Motif and a Hydrophobic Domain

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Molecular Mechanisms of Autophagy II
Meeting has ended...abstracts no longer viewable online.
To establish the key questions in autophagy.

Sea to Sky B
* Sascha Martens, University of Vienna, Austria

Nicholas Ktistakis, Babraham Institute, UK
Starvation-Induced and Selective Autophagy: The First 3 Minutes

Francesco Cecconi, Danish Cancer Society Research Center, Denmark
AMBRA1 Negative Control at the Crossroads among Autophagy, Cell Proliferation and Cell Death

Claudine Kraft, Max F. Perutz Laboratories, Austria
EMBO Young Investigator Lecture: Molecular Regulation of Autophagy: Signaling and Beyond

Carsten Sachse, EMBL - European Molecular Biology Laboratory, Germany
Short Talk: Higher-Order Assemblies of Polymeric and Oligomeric Cargo Receptor Complexes form the Membrane Scaffold for Selective Autophagy

19:00
On Own for Dinner


TUESDAY, JUNE 7

07:30—08:30
Breakfast

Sea to Sky C
08:30—11:45
Autophagy and Diseases of Aging
Meeting has ended...abstracts no longer viewable online.
To exchange scientific information between autophagy and aging community.

Sea to Sky B
* Alicia Melendez, Queens College - CUNY, USA

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Chaperone-mediated Autophagy in the Fight against Aging

David C. Rubinsztein, Cambridge Institute for Medical Research, UK
Autophagy, Neurodegeneration and Neurodevelopment

Coffee Break

Anne Simonsen, University of Oslo, Norway
Regulation of Autophagosome Biogenesis by Lipid-Binding Proteins

Peter C. Butler, University of California, Los Angeles, USA
Autophagy and Diabetes

Jessica Chang, Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: Spatial and Temporal Regulation of Autophagy during C. Elegans Aging

Patricia Boya, Centro de Investigaciones Biológicas, CSIC, Spain
Short Talk: Lysosomal Cell Death in Animal Models of Neurodegenerative Diseases

11:45—13:15
Chewing the Fat: Panel and Discussion about Autophagy and Future Directions of the Autophagy Field
Eric Baehrecke, Ana Maria Cuervo, Vojo Deretic and Leon Murphy met to discuss their interests in autophagy. Topics included some history, current and future areas of research interests, possible controversies, and speculation about the future directions of the autophagy field. Come enjoy a short video of their discussion, and be prepared to ask them questions.

Sea to Sky B
* Eric H. Baehrecke, University of Massachusetts Medical School, USA

* Ana Maria Cuervo, Albert Einstein College of Medicine, USA

* Vojo Deretic, University of New Mexico Health Sciences Center, USA

* Leon O. Murphy, Novartis Pharmaceuticals, USA

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Grand Foyer
13:15—22:00
Poster Viewing

Grand Foyer
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Regulation of Autophagic Processes
Meeting has ended...abstracts no longer viewable online.
To build upon session 1 and 2 data and start to explore regulation of autophagy.

Sea to Sky B
* Thomas Melia, Yale School of Medicine, USA

Hong Zhang, Chinese Academy of Sciences, China
Differential Function of the Four WIPIs in Autophagy

Leon O. Murphy, Novartis Pharmaceuticals, USA
Regulation of Selective Autophagy

Zvulun Elazar, Weizmann Institute of Science, Israel
Role of Lipids in Autophagy

Hemmo Meyer, University Duisburg-Essen, Germany
Short Talk: A Role of the Ubiquitin-directed VCP/p97 AAA-ATPase in Autophagy

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky C
19:30—22:00
Poster Session 2

Grand Foyer

WEDNESDAY, JUNE 8

07:30—08:30
Breakfast

Sea to Sky C
08:30—11:45
Molecular Reconstitution of Autophagy Machinery
Meeting has ended...abstracts no longer viewable online.
Structural and reconstitution of autophagic proteins.

Sea to Sky B
* Zvulun Elazar, Weizmann Institute of Science, Israel

Thomas Melia, Yale School of Medicine, USA
Membrane Recognition by the Atg4 Family of Proteases

Sascha Martens, University of Vienna, Austria
EMBO Young Investigator Lecture: Molecular Mechanisms of Selective Autophagy

Coffee Break

Thomas Wollert, Max Planck Institute of Biochemistry, Germany
EMBO Young Investigator Lecture: How to Make an Autophagosome – Membrane Remodeling in Autophagy

Ivan Dikic, Goethe University Medical School, Germany
Ubiquitin Regulation of Selective Autophagy

Lindsey Young, University of California, Berkeley, USA
Short Talk: Structural Insights into Autophagy Initiation by PI3K Complex I

Mary Lilly, NICHD, National Institutes of Health, USA
Short Talk: The GATOR2 Complex Regulates Lysosome Acidification and Autophagic Flux Independent of TORC1 Activity

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Grand Foyer
13:00—22:00
Poster Viewing

Grand Foyer
16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Autophagy in Conserved Homeostatic Pathways
Meeting has ended...abstracts no longer viewable online.

Sea to Sky B
* Claudine Kraft, Max F. Perutz Laboratories, Austria

Gabor Juhasz, Biological Research Center, HAS, Hungary
Autophagosome and Endosome Maturation in Drosophila

Masaaki Komatsu, School of Medicine Niigata University, Japan
Autophagy-Adaptors Regulate Cellular Metabolism through Multiple Transcription-Factor Pathways

Alicia Melendez, Queens College - CUNY, USA
Autophagy in C. elegans Development and Aging

Tamiza Nanji, University of British Columbia, Canada
Short Talk: Molecular Organization and Interactions of the Fission Yeast Atg1 Complex

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky C
19:30—22:00
Poster Session 3

Grand Foyer

THURSDAY, JUNE 9

07:30—08:30
Breakfast

Sea to Sky C
08:30—11:45
Autophagy in Human Pathophysiology
Meeting has ended...abstracts no longer viewable online.
To explore the role of autophagy in infection and immunity, and other physiological situations.

Sea to Sky B
* Anne Simonsen, University of Oslo, Norway

Janice Lee, Takeda Oncology, USA
Targeting Autophagy for Cancer Therapy

Vojo Deretic, University of New Mexico Health Sciences Center, USA
Talk and Crosstalk between Immune Response and Autophagy

Coffee Break

Katja Simon, University of Oxford, UK
Autophagy Determines Hematological Cell Fate

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
Regulation of Inflammation and Immunity by Autophagy Genes

Véronik Lachance, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Mutation of Vps11 Causes a New Class of Leukoencephalopathy and Autophagy Impairment

Rhea M. Sumpter, Jr., University of Texas Southwestern Medical Center, USA
Short Talk: Fanconi Anemia Tumor Suppressor Genes Function in Selective Autophagy, Immunity and Mitochondrial Homeostasis

11:45—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Challenges in Measuring and Manipulating Autophagy in Humans

Sea to Sky B
* Janice Lee, Takeda Oncology, USA

* Peter C. Butler, University of California, Los Angeles, USA

Joo Yun Jun, NICHD, National Institutes of Health, USA
Melanocortin 3 Receptor (MC3R), A Novel Regulator of Hepatic Autophagy in Obesity

Anatoliy I. Masyuk, Mayo Clinic, USA
Dysregulated Autophagy in Cholangiocytes Contributes to the Progression of Polycystic Liver Disease

Natalia Rodriguez Muela, Harvard University, USA
Role of Autophagy in Spinal Muscular Atrophy

Katrin Panzitt, Medical University Graz, Austria
The Autophagy Inhibitor Rubicon is a Direct Target of the Bile Acid Receptor FXR in Human Liver and is Induced in Human Cholestasis

Christos E. Zois, University of Oxford, UK
Targeting VPS34 to Enhance Anticancer Therapy

Shankar J. Chinta, Buck Institute for Research on Aging, USA
High Potency Miscible Activators of TFEB and Clearance of Toxic Alpha-Synuclein Oligomers; Implications for Parkinson’s Disease

16:30—17:00
Coffee Available

Grand Foyer
17:00—19:00
Autophagy and Cancer
Meeting has ended...abstracts no longer viewable online.
To connect the molecular aspects to human disease.

Sea to Sky B
* Ana Maria Cuervo, Albert Einstein College of Medicine, USA

Alec Kimmelman, NYU Langone Medical Center, USA
Autophagy, Metabolism and Cancer

Andrew M. Thorburn, University of Colorado AMC, USA
Autophagy and Cancer Therapy

Kevin M. Ryan, Beatson Institute for Cancer Research, UK
Mechanism of Autophagy in Cell Death and Cancer

Sharon Gorski, BC Cancer Research Centre, Canada
Short Talk: Evaluation of ATG4B Expression and Function in Breast Cancer Subtypes

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Sea to Sky B
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sea to Sky C
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sea to Sky C

FRIDAY, JUNE 10

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Novartis Institutes for BioMedical Research

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA206357-01

Funding for this conference was made possible (in part) by 1R13CA206357-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



EMBO Young Investigator Programme


Novartis Institutes for BioMedical Research


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