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This meeting took place in 2016



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Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication (E4)


Organizer(s) Richard A. Cerione and Xandra O. Breakefield
June 19—22, 2016
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Feb 18, 2016
Abstract Deadline: Mar 17, 2016
Scholarship Deadline: Feb 18, 2016
Discounted Registration Deadline: Apr 19, 2016

Supported by the Directors' Fund

Summary of Meeting:
An emerging area of great excitement in the cell biology and pharmaceutical/biotech communities involves the release and subsequent uptake of membrane-enclosed packets of information, often referred to as extracellular vesicles. These non-traditional vesicles contain a potent array of cargo, including hundreds of proteins such as growth factors and receptors, metabolic enzymes, transcription factors and a large variety of RNA transcripts as well as DNA. Extracellular vesicles span a range of sizes from 50 nm to 1 micron and comprise a heterogenous set, including exosomes and microvesicles that appear to be generated through distinct mechanisms. Extracellular vesicles are thought to serve as a means of cell-to-cell communication and contribute to a number of disease states, including cancer and neurodegeneration, thus offering new targets for therapeutic intervention and novel possibilities for diagnostic biomarkers. However, a number of important questions need to be answered. What are the regulatory cues that determine content and release of these vesicles from ”donor” cells? How many different types of extracellular vesicles are there and do they vary among cell types? Are there specific uptake mechanisms of vesicles into ”recipient cells” and is the cargo functional in these cells? The time is right for a Keystone Symposia meeting that covers this exciting area and aims to bring together investigators from different disciplines and areas of interest to present their newest findings concerning the biogenesis of extracellular vesicles, how they are shed and dock onto target cells, and the biological and disease consequences of their functions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, June 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, June 22 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Thursday, June 23 in order to fully experience the meeting.

SUNDAY, JUNE 19

16:00—20:00
Arrival and Registration

Keystone Lodge Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Keystone Lodge-Bighorn Bar

MONDAY, JUNE 20

07:30—08:30
Breakfast

Crestone
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Richard A. Cerione, Cornell University, USA

Xandra O. Breakefield, Massachusetts General Hospital, USA
The Language of Extracellular Vesicles

09:30—12:00
Extracellular Vesicles and Cargo
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Jan Lötvall, University of Gothenburg, Sweden
Extracellular Vesicles and their RNA Cargo

Coffee Break

* Louise Laurent, University of California, San Diego, USA
ExRNAs as Biomarkers of Placental Function

Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
The Biology and Function of Exosomes in Cancer

Jennifer C. Jones, NCI, National Institutes of Health, USA
Short Talk: NanoFACS: A Tool to Enable Extracellular Vesicle Subset Sorting for Personalized Medicine

Valery Combes, University of Technology Sydney, Australia
Short Talk: Identification of a Novel Intracellular Actin-Based Structure Implicated in Endothelial Vesiculation

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Crestone
13:00—22:00
Poster Viewing

Crestone
14:30—16:30
Workshop

Red Cloud/Shavano
Chulhee Choi, Korea Advanced Institute of Science and Technology, South Korea
Efficient intra-cellular Delivery of Therapeutic Proteins via Opto-genetically Engineered Exosomes

Deepak Nagrath, Rice University, USA
Tumor Microenvironment Derived Exosomes: A Major Player Regulating Cancer Cell Metabolism

Paul Coats, University of Strathclyde, UK
Mitochondrial Regulation of Exosomal MicroRNA Cargo in Vascular Smooth Muscle Cell Proliferation

* Carole A. Parent, NCI, National Institutes of Health, USA
Exosomes as Key Regulators of Signal Relay during Chemotaxis

Ryan Middleton, Cedars-Sinai Medical Center, USA
Newt Exosomes are Bioactive on Mammalian Heart, Enhancing Proliferation of Rat Cardiomyocytes and Improving Recovery after Myocardial Infarction

Anaïs Soula, Interdisciplinary Institute for Neurosciences, France
Involvement of Exosomal miRNAs in the Mechanisms of Neuronal Plasticity

Michela Marcatti, University of Texas Medical Branch, USA
Damaged Mitochondrial DNA as a Potent Inducer of Lung Inflammation

Leonid Margolis, NICHD, National Institutes of Health, USA
Extracellular Vesicles in HIV Infection: Analysis and Function

16:30—17:00
Coffee Available

Crestone Foyer
17:00—19:00
Extracellular Vesicle Biogenesis
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Guillaume van Niel, Institute Curie, France
Exosomes Shed new Light on Endosomal Sorting and Functional Amyloid Formation

Richard A. Cerione, Cornell University, USA
Signals that Lead to Microvesicle Formation

* Stephen J. Gould, Johns Hopkins University School of Medicine, USA
Exosome Biogenesis: Models, Predictions and Results

Ann M. Wehman, University of Würzburg, Germany
Short Talk: PAD-1 Activates the Phospholipid Flippase TAT-5 to Prevent Extracellular Vesicle Release in C. elegans

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Crestone
19:30—22:00
Poster Session 1

Crestone

TUESDAY, JUNE 21

07:30—08:30
Breakfast

Crestone
08:30—11:45
Extracellular Vesicle Release and Docking
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
Marc Antonyak, Cornell University, USA
Embryonic Stem Cell Microvesicles and Their Roles in Early Development

* Crislyn D'Souza-Schorey, University of Notre Dame, USA
Extracellular Microvesicles Mediate Tumor Cell Invasion

Coffee Break

Phyllis I. Hanson, Washington University School of Medicine, USA
ESCRTs, Endosomal Trafficking, and Extracellular Vesicle Biogenesis

Hakho Lee, Massachusetts General Hospital, USA
Nanotechnology Platforms for Quantitative Analyses of Extracellular Vesicles

Andrew Ross Nager, Stanford University School of Medicine, USA
Short Talk: Actin-Dependent Ectocytosis and BBSome/beta-Arrestin2-Mediated Retrieval Drive the Removal of Activated GPCRs from Cilia

Chungen Pan, Dalhousie University, Canada
Short Talk: Fusogenic Nonenveloped Reoviruses are Released as Highly Infectious Vesicle-Encapsulated Nonenveloped Virus (VENEV) Particles Inside Fusogenic Exosomes

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Crestone
13:00—22:00
Poster Viewing

Crestone
16:30—17:00
Coffee Available

Crestone Foyer
17:00—19:00
Extracellular Vesicles as Biomarkers and Therapeutic Vehicles
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Johan Skog, Exosome Diagnostics, Inc., USA
Exosome Based Liquid Biopsy for Cancer Screening, Patient Stratification and Monitoring

Richard Simpson, La Trobe University, Australia
Comparative Proteome and RNA Analyses of Extracellular Vesicle Subtypes

Anastasia Khvorova, University of Massachusetts Medical School, USA
Exosomes as Therapeutic RNA Delivery Vehicles

Andrew Michael Breglio, NIDCD, National Institutes of Health, USA
Short Talk: Exosomes Protect Inner Ear Hair Cells from Aminoglycoside-Induced Death

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Crestone
19:30—22:00
Poster Session 2

Crestone

WEDNESDAY, JUNE 22

07:30—08:30
Breakfast

Crestone
08:30—11:45
Extracellular Vesicles in Cancer
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Janusz Rak, McGill University, Canada
Intercellular Trafficking of Oncogenic Macromolecules as Cargo of Extracellular Vesicles in Cancer – Pathways and Barriers

Ayuko Hoshino, Weill Cornell Medicine, USA
Tumor Exosome Integrins Initiate Pre-Metastatic Niches

Coffee Break

E. Antonio Chiocca, Brigham and Women's Hospital, USA
Role of Microvesicles in Glioblastoma

Alissa M. Weaver, Vanderbilt University Medical Center, USA
Role of Exosomes in Promoting Directional Migration of Cancer Cells

Sónia A. Melo, i3S - Instituto de Investigação e Inovação em Saúde, Portugal
Short Talk: ExoNet: Exosomes-Mediate Intra-Tumor Communication in Pancreatic Cancer

Maria Laura Tognoli, University of Oxford, UK
Short Talk: RASSF1C Promotes Tumor Invasiveness via Exosome Release

11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Crestone Foyer
17:00—18:45
Extracellular Vesicles in Other Aspects of Biology and Disease
Meeting has ended...abstracts no longer viewable online.

Red Cloud/Shavano
* Leonid Margolis, NICHD, National Institutes of Health, USA

Mercedes Tkach, Institut Curie, France
Extracellular Vesicles in Immune Response

Kaushik Choudhuri, University of Michigan Medical School, USA
Microvesicle Release in T Cell Communication

Andrew Hill, La Trobe University, Australia
Role of Extracellular Vesicles in Neurodegenerative Diseases

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions

Red Cloud/Shavano
Richard A. Cerione, Cornell University, USA

Xandra O. Breakefield, Massachusetts General Hospital, USA

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Crestone
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Crestone

THURSDAY, JUNE 23

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
Office of the Director (OD)

Grant No. 1R13CA206166-01

Funding for this conference was made possible (in part) by 1R13CA206166-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Exosome Diagnostics, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676