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This meeting took place in 2016
Here are the related meetings in 2017:
Transcriptional and Epigenetic Control in Stem Cells (J1)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Stem Cells and Regeneration in the Digestive Organs (X6)
Organizer(s) Linheng Li, Martín G. Martín, James M. Wells and Markus Grompe
March 13—17, 2016
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Nov 12, 2015
Abstract Deadline: Dec 15, 2015
Scholarship Deadline: Nov 12, 2015
Discounted Registration Deadline: Jan 14, 2016
Sponsored by Merck & Co., Inc.
Joint Meeting:
Islet Biology: From Cell Birth to Death (X5)
Summary of Meeting:
The gastrointestinal, pancreatic and hepatobiliary systems serve many essential functions, and stem cell (SC)-based tissue regeneration holds promise for treating diseases of the digestive system (DS). Recent advances in the field include differentiation of pluripotent SCs (ESCs, iPSCs) into intestinal, pancreatic and hepatic cells that may someday be used to replace defective cell types. However, a gap remains between these achievements in basic research and translation into clinical treatment. Among the barriers to overcome include: 1) An incomplete understanding of stemness under homeostasis and stressed conditions; 2) Failure of SC in vitro to extend to in vivo conditions; 3) Questions of SC subpopulation; 4) Reversion of progenitor cells (PC) to SC; and 5) Effects of the microenvironment on SC and PC. This meeting is the first to bring together a broad representation of scientists researching SC from the interrelated fields of the DS. With open and vigorous discussion, the meeting will “cross boundaries” and capitalize on the common principles and unique features of the three systems. Specific aims of the meeting are to: 1) Facilitate characterization of the properties of DS SC in vivo; 2) Address how the heterogeneity of the microenvironment influences the state and fate of SCs/PCs; 3) Narrow the gap between findings of in vitro and in vivo identification; and 4) Explore applications for converting stem into functional DS cell systems to overcome disease. The meeting should result in new scientific methods, insights, collaborations and technical capabilities for the entire DS, and facilitate further clinical advances.
View Scholarships/Awards
The gastrointestinal, pancreatic and hepatobiliary systems serve many essential functions, and stem cell (SC)-based tissue regeneration holds promise for treating diseases of the digestive system (DS). Recent advances in the field include differentiation of pluripotent SCs (ESCs, iPSCs) into intestinal, pancreatic and hepatic cells that may someday be used to replace defective cell types. However, a gap remains between these achievements in basic research and translation into clinical treatment. Among the barriers to overcome include: 1) An incomplete understanding of stemness under homeostasis and stressed conditions; 2) Failure of SC in vitro to extend to in vivo conditions; 3) Questions of SC subpopulation; 4) Reversion of progenitor cells (PC) to SC; and 5) Effects of the microenvironment on SC and PC. This meeting is the first to bring together a broad representation of scientists researching SC from the interrelated fields of the DS. With open and vigorous discussion, the meeting will “cross boundaries” and capitalize on the common principles and unique features of the three systems. Specific aims of the meeting are to: 1) Facilitate characterization of the properties of DS SC in vivo; 2) Address how the heterogeneity of the microenvironment influences the state and fate of SCs/PCs; 3) Narrow the gap between findings of in vitro and in vivo identification; and 4) Explore applications for converting stem into functional DS cell systems to overcome disease. The meeting should result in new scientific methods, insights, collaborations and technical capabilities for the entire DS, and facilitate further clinical advances.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, March 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 17 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 18 in order to fully experience the meeting.
SUNDAY, MARCH 13
MONDAY, MARCH 14
TUESDAY, MARCH 15
WEDNESDAY, MARCH 16
THURSDAY, MARCH 17
FRIDAY, MARCH 18
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, March 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 17 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 18 in order to fully experience the meeting.
SUNDAY, MARCH 13
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.
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Klaus H. Kaestner,
University of Pennsylvania School of Medicine, USA
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Linheng Li,
Stowers Institute for Medical Research, USA
Hiromitsu Nakauchi,
Stanford University, USA
Interspecific Blastocyst Complementation: Can Patient-Specific Islets of Langerhans Be Generated in Pigs?
Interspecific Blastocyst Complementation: Can Patient-Specific Islets of Langerhans Be Generated in Pigs?
09:30—11:30
GI Lineages from Pluripotent Stem Cells
Meeting has ended...abstracts no longer viewable online.
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Stephen A. Duncan,
Medical University of South Carolina, USA
Gordon M. Keller,
University Health Network, MaRS Centre, Canada
Patterning Human Pluripotent Stem Cell-Derived Endoderm
Patterning Human Pluripotent Stem Cell-Derived Endoderm
Paul Gadue,
Children's Hospital of Philadelphia, USA
GATA6 Regulation of Endoderm and Pancreatic Development from Human Pluripotent Stem Cells
GATA6 Regulation of Endoderm and Pancreatic Development from Human Pluripotent Stem Cells
James M. Wells,
Cincinnati Children's Hospital Research Foundation, USA
Human Pluripotent Stem Cell-Derived Tissues as New Models to Study Development and Disease of the Digestive Tract
Human Pluripotent Stem Cell-Derived Tissues as New Models to Study Development and Disease of the Digestive Tract
Alexander Kleger,
Ulm University, Germany
Short Talk: Human Pluripotent Stem Cell-Derived Pancreatic Organoids to Study Cystic Fibrosis in a Dish
Short Talk: Human Pluripotent Stem Cell-Derived Pancreatic Organoids to Study Cystic Fibrosis in a Dish
09:30—11:45
Developmental and Regenerative Biology of the Endocrine Pancreas
Meeting has ended...abstracts no longer viewable online.
*
Lori Sussel,
University of Colorado, USA
Anne Grapin-Botton,
University of Copenhagen, Denmark
Progenitor Heterogeneity as a Driver of Pancreas Development
Progenitor Heterogeneity as a Driver of Pancreas Development
Christopher V. Wright,
Vanderbilt University, USA
Intra-Islet Endocrine-Cell Communication and the Control of Beta-Cell Number and Replication State
Intra-Islet Endocrine-Cell Communication and the Control of Beta-Cell Number and Replication State
Seung K. Kim,
Stanford University, USA
Signaling Regulation of Islet Morphogenesis
Signaling Regulation of Islet Morphogenesis
Caitlin Braitsch,
University of Texas Southwestern Medical Center, USA
Short Talk: Hippo-Warts Pathway Regulation of Pancreatic Epithelial Architecture and Progenitor Cell Fate
Short Talk: Hippo-Warts Pathway Regulation of Pancreatic Epithelial Architecture and Progenitor Cell Fate
Alireza Rezania,
ViaCyte, USA
Short Talk: In vitro Generation of Insulin-producing Cells with Insulin Secretion Dynamics and Mitochondrial Metabolism Similar to Adult Human Islets
Short Talk: In vitro Generation of Insulin-producing Cells with Insulin Secretion Dynamics and Mitochondrial Metabolism Similar to Adult Human Islets
14:30—16:30
Workshop and Panel Discussion 1: Tissue Engineering
*
Mo Ebrahimkhani,
Arizona State University, USA
Engineering Self-Organization of Human Pluripotent Stem Cells to a Fetal Liver-Like Tissue
Engineering Self-Organization of Human Pluripotent Stem Cells to a Fetal Liver-Like Tissue
Bruce M. Wang,
Stanford University, USA
Self-Renewing Diploid Axin2+ Cells Fuel Homeostatic Renewal of the Liver
Self-Renewing Diploid Axin2+ Cells Fuel Homeostatic Renewal of the Liver
Joseph J. Lancman,
Sanford Burnham Presbys Medical Discovery Institute, USA
Induced in vivo Cell Reprogramming of Muscle into Endoderm Lineages
Induced in vivo Cell Reprogramming of Muscle into Endoderm Lineages
Kay Wiebrands,
Hubrecht Institute, Netherlands
Single-Cell RNA Sequencing Reveals Divergence of Lgr5+ Stem Cells during Development of the Gastrointestinal Tract
Single-Cell RNA Sequencing Reveals Divergence of Lgr5+ Stem Cells during Development of the Gastrointestinal Tract
Alan Cyril Mullen,
Harvard Medical School, USA
DIGIT is a Conserved Long Noncoding RNA that Regulates Goosecoid Expression to Control Endoderm Differentiation of Human Embryonic Stem Cells
DIGIT is a Conserved Long Noncoding RNA that Regulates Goosecoid Expression to Control Endoderm Differentiation of Human Embryonic Stem Cells
*
Jan Jensen,
Lerner Research Institute, USA
Understanding Multi-Lineage Differentiation of Endodermal Progenitor Cells using a Systems Developmental Biology Approach
Understanding Multi-Lineage Differentiation of Endodermal Progenitor Cells using a Systems Developmental Biology Approach
14:30—16:30
Workshop 1: Pancreatic Islet Cell Development, Growth and Regeneration
*
Doris A. Stoffers,
Perelman School of Medicine, University of Pennsylvania, USA
Yunus Alpagu,
IMB-ASTAR, Singapore
Modelling Mitchell-Riley Syndrome in vitro using iPS Cells Derived from a RFX6 Mutant Patient
Modelling Mitchell-Riley Syndrome in vitro using iPS Cells Derived from a RFX6 Mutant Patient
Caitlin Collin,
University of Copenhagen, Denmark
The Function of Notch Ligands in Pancreas Development
The Function of Notch Ligands in Pancreas Development
Nidheesh Dadheech,
University of Alberta, Canada
GLP-1 Induces Neurog3 Re-expression and Beta-Cell Neogenesis in Adult Mice
GLP-1 Induces Neurog3 Re-expression and Beta-Cell Neogenesis in Adult Mice
Benjamin Neal Ediger,
University of Pennsylvania, USA
Ldb1 Maintains the Terminally Differentiated State of Pancreatic Beta-cells through a Functional Interaction with Isl-1
Ldb1 Maintains the Terminally Differentiated State of Pancreatic Beta-cells through a Functional Interaction with Isl-1
Katie L. Sinagoga,
Cincinnati Children's Hospital Medical Center, USA
mTOR Regulates Postnatal Morphogenesis, Maturation, and Function of Murine Islets
mTOR Regulates Postnatal Morphogenesis, Maturation, and Function of Murine Islets
Francesca M. Spagnoli,
Max Delbrück Center for Molecular Medicine, Germany
Axon Guidance Signaling Controls Pancreatic Cell Identity
Axon Guidance Signaling Controls Pancreatic Cell Identity
Amita Tiyaboonchai,
University of Pennsylvania, USA
GATA6 in Human Endoderm and Pancreatic Development from Human Pluripotent Stem Cells
GATA6 in Human Endoderm and Pancreatic Development from Human Pluripotent Stem Cells
Pei Wang,
University of Texas Health Science Center at San Antonio, USA
Investigating the Role of the Hippo Signaling Pathway in Pancreatic Endocrine Cell Development and Beta Cell Proliferation
Investigating the Role of the Hippo Signaling Pathway in Pancreatic Endocrine Cell Development and Beta Cell Proliferation
17:00—19:00
Disease Modeling
Meeting has ended...abstracts no longer viewable online.
*
Gordon M. Keller,
University Health Network, MaRS Centre, Canada
Stephen A. Duncan,
Medical University of South Carolina, USA
Disease Modeling with ESC/iPSCs-Derived Hepatocyte-Like Cells
Disease Modeling with ESC/iPSCs-Derived Hepatocyte-Like Cells
Holger Willenbring,
University of California, San Francisco, USA
Liver Cell Therapy with Hepatocytes Derived from Pluripotent Stem Cells
Liver Cell Therapy with Hepatocytes Derived from Pluripotent Stem Cells
Tobias Cantz,
Hannover Medical School, Germany
Short Talk: Patient-Specific iPS Cell-Based Hepatic Cells Allow Modeling of Transthyretin-Related Familial Amyloid Polyneuropathy
Short Talk: Patient-Specific iPS Cell-Based Hepatic Cells Allow Modeling of Transthyretin-Related Familial Amyloid Polyneuropathy
17:00—19:00
Controlling Beta-Cell Function
Meeting has ended...abstracts no longer viewable online.
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Alvin C. Powers,
Vanderbilt University School of Medicine, USA
Doris A. Stoffers,
Perelman School of Medicine, University of Pennsylvania, USA
Mining the Pdx1 Cistrome for Novel Insights into Diabetes
Mining the Pdx1 Cistrome for Novel Insights into Diabetes
Christopher J. Rhodes,
MedImmune, USA
CNS Control of Pancreatic Islet-Cell Function
CNS Control of Pancreatic Islet-Cell Function
Cristina M. Rondinone,
MedImmune, Inc., USA
Novel Direct and Indirect Ways to Improve Beta Cell Health
Novel Direct and Indirect Ways to Improve Beta Cell Health
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Identity and Function of GI Stem and Progenitor Cells
Meeting has ended...abstracts no longer viewable online.
*
Hans C. Clevers,
Hubrecht Institute, Netherlands
Frédéric Lemaigre,
de Duve Institute and Université Catholique de Louvain, Belgium
Dynamics of Hepatic Cell Differentiation Depend on microRNA-Dependent Regulatory Motifs
Dynamics of Hepatic Cell Differentiation Depend on microRNA-Dependent Regulatory Motifs
Stuart Forbes,
University of Edinburgh, UK
The Role of Hepatic Progenitor Cells in Liver Regeneration
The Role of Hepatic Progenitor Cells in Liver Regeneration
Timothy C. Wang,
Columbia University, USA
Gastric Stem Cells and Their Niches
Gastric Stem Cells and Their Niches
Linheng Li,
Stowers Institute for Medical Research, USA
Characterization of Drug-resistant Quiescent Stem Cells in Intestine
Characterization of Drug-resistant Quiescent Stem Cells in Intestine
Nicholas R. Smith,
Oregon Health & Science University, USA
Short Talk: Bmi1-Expressing Intestinal Stem Cells Drive Emergency Re-Epithelialization
Short Talk: Bmi1-Expressing Intestinal Stem Cells Drive Emergency Re-Epithelialization
08:00—11:15
Beta-Cell Growth and Proliferation
Meeting has ended...abstracts no longer viewable online.
*
Andrew F. Stewart,
Mount Sinai School of Medicine, USA
Yuval Dor,
Hebrew University-Hadassah Medical School, Israel
The Genetic Program of Replicating beta Cells
The Genetic Program of Replicating beta Cells
Heiko Lickert,
Institute of Diabetes and Regeneration, Germany
Identification of Proliferative and Mature B-cells in the Islet of Langerhans
Identification of Proliferative and Mature B-cells in the Islet of Langerhans
Klaus H. Kaestner,
University of Pennsylvania School of Medicine, USA
The Epigenome during Beta-Cell Maturation
The Epigenome during Beta-Cell Maturation
Jorge Ferrer,
Imperial College London, UK
Long Noncoding RNAs in Beta-Cells
Long Noncoding RNAs in Beta-Cells
Justin P. Annes,
Stanford University, USA
Short Talk: Multi-ligand Targeting of DYRK1A/B and Casein Kinase1gamma2 Promotes beta-cell Replication
Short Talk: Multi-ligand Targeting of DYRK1A/B and Casein Kinase1gamma2 Promotes beta-cell Replication
Bethany A. Carboneau,
Vanderbilt University, USA
Short Talk: Regulation of Beta-Cell Mass Expansion by Prostaglandin E2 Signaling
Short Talk: Regulation of Beta-Cell Mass Expansion by Prostaglandin E2 Signaling
14:30—16:30
Workshop 2: Pancreatic Beta-Cell Death and Survival
*
Guy A. Rutter,
Imperial College London, UK
Michal Aharoni-Simon,
University of British Columbia, Canada
Anti-Apoptotic Bcl-2 Regulates Reactive Oxygen Species Signaling and a Redox-Sensitive Mitochondrial Proton Leak in Mouse Pancreatic beta-Cells
Anti-Apoptotic Bcl-2 Regulates Reactive Oxygen Species Signaling and a Redox-Sensitive Mitochondrial Proton Leak in Mouse Pancreatic beta-Cells
Lukas Adrian Berchtold,
University of Copenhagen, Denmark
Pannexin-2 is an Anti-Apoptotic Protein in Pancreatic beta-Cells
Pannexin-2 is an Anti-Apoptotic Protein in Pancreatic beta-Cells
Anne Close,
University of Alberta, Canada
The Nuclear Receptor Nor1/Nr4a3 Mediates Cytokines-induced beta-cell Apoptosis and Regulates beta-cell Mass
The Nuclear Receptor Nor1/Nr4a3 Mediates Cytokines-induced beta-cell Apoptosis and Regulates beta-cell Mass
Yong Kyung Kim,
Chungnam National University, South Korea
Disruption of Mitochondrial Crif1 (CR6-interacting factor-1) in Mouse beta Cells Leads to Diabetes with Progressive beta Cell Failure
Disruption of Mitochondrial Crif1 (CR6-interacting factor-1) in Mouse beta Cells Leads to Diabetes with Progressive beta Cell Failure
Amelia K. Linnemann,
University of Wisconsin-Madison, USA
Interleukin-6 Stimulates Autophagy in Pancreatic beta-cells and Protects against Apoptosis
Interleukin-6 Stimulates Autophagy in Pancreatic beta-cells and Protects against Apoptosis
Michelle E. Kimple,
University of Wisconsin, Madison, USA
G-protein-mediated Mechanisms Linking Beta-cell Death, Dysfunction, and Decompensation in Diabetes
G-protein-mediated Mechanisms Linking Beta-cell Death, Dysfunction, and Decompensation in Diabetes
Jason M. Tonne,
Mayo Clinic, USA
Nestin-positive Pericytes Facilitate beta-cell-protection through Prevention of Excessive beta-cell-targeted Immune Reactions and Promotion of beta-cell Regeneration in Insulitis
Nestin-positive Pericytes Facilitate beta-cell-protection through Prevention of Excessive beta-cell-targeted Immune Reactions and Promotion of beta-cell Regeneration in Insulitis
Brett S. Peterson,
Duke University, USA
Delayed Apoptosis Allows Islet beta-cells to Implement an Autophagic Mechanism to Promote Cell Survival
Delayed Apoptosis Allows Islet beta-cells to Implement an Autophagic Mechanism to Promote Cell Survival
17:00—19:00
Programmed or Reprogrammed Regeneration
Meeting has ended...abstracts no longer viewable online.
*
Holger Willenbring,
University of California, San Francisco, USA
Lijian Hui,
Shanghai Institutes of Biological Sciences, China
Direct Reprogramming of Human Fibroblasts to Functional Hepatocyte-Like Cells
Direct Reprogramming of Human Fibroblasts to Functional Hepatocyte-Like Cells
Louise Laurent,
University of California, San Diego, USA
Using Single-Cell Transcriptomics to Discover Cellular Reprogramming Factors for Autologous Cell Replacement Therapy for Type 1 Diabetes
Using Single-Cell Transcriptomics to Discover Cellular Reprogramming Factors for Autologous Cell Replacement Therapy for Type 1 Diabetes
Markus Grompe,
Oregon Health & Science University, USA
Tissue Regeneration in Liver: Plasticity or Stem Cells?
Tissue Regeneration in Liver: Plasticity or Stem Cells?
Claude Gérard,
Université Catholique de Louvain, Belgium
Short Talk: A Mathematical Model for the Transcription Factor Network Driving Hepatocyte Differentiation
Short Talk: A Mathematical Model for the Transcription Factor Network Driving Hepatocyte Differentiation
17:00—19:00
Other Islet Cell Types: Major Contributor to Glucose Homeostasis and Health?
Meeting has ended...abstracts no longer viewable online.
*
Nils Billestrup,
University of Copenhagen, Denmark
Alvin C. Powers,
Vanderbilt University School of Medicine, USA
Interactions of Endothelial Cells, Macrophages, and Islet Cells
Interactions of Endothelial Cells, Macrophages, and Islet Cells
Patrik Rorsman,
Oxford Centre for Diabetes, Endocrinology and Metabolism, UK
ATP-Regulated Potassium Channels in the Regulation of Glucagon Secretion
ATP-Regulated Potassium Channels in the Regulation of Glucagon Secretion
Per-Olof Berggren,
Karolinska Institutet, Sweden
Insight Into Pancreatic Islet Cell Physiology/Pathology
Insight Into Pancreatic Islet Cell Physiology/Pathology
Guy A. Rutter,
Imperial College London, UK
Short Talk: Deletion of the Type 2 Diabetes-associated Gene StarD10 in Mice Impairs Insulin Secretion and Action
Short Talk: Deletion of the Type 2 Diabetes-associated Gene StarD10 in Mice Impairs Insulin Secretion and Action
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Adult Pancreatic Stem Cells (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Catherine Lee May,
University of Pennsylvania, USA
*
Markus Grompe,
Oregon Health & Science University, USA
Matthias Hebrok,
University of California, San Francisco, USA
Cellular Plasticity in the Adult Pancreas
Cellular Plasticity in the Adult Pancreas
Qiao Zhou,
Harvard Stem Cell Institute, USA
Renewable Generation of Functional Insulin+ Cells from Gastric Tissues
Renewable Generation of Functional Insulin+ Cells from Gastric Tissues
Lori Sussel,
University of Colorado, USA
Regulation of Pancreatic Beta Cell Identity
Regulation of Pancreatic Beta Cell Identity
Maike Sander,
University of California, San Diego, USA
Chromatin State in Beta cell Development and Function
Chromatin State in Beta cell Development and Function
Stephanie A. Campbell,
Child and Family Research Institute, Canada
Short Talk: Trithorax Group Complexes are Essential for Pancreatic Endocrine and Exocrine Cell Specification
Short Talk: Trithorax Group Complexes are Essential for Pancreatic Endocrine and Exocrine Cell Specification
17:00—19:00
Stem and Progenitor Cells in Homeostasis and Diseases
Meeting has ended...abstracts no longer viewable online.
*
Linheng Li,
Stowers Institute for Medical Research, USA
Maureen Gannon,
Vanderbilt University, USA
Expansion of Functional Pancreatic beta-Cell Mass Using Connective Tissue Growth Factor (CTGF)
Expansion of Functional Pancreatic beta-Cell Mass Using Connective Tissue Growth Factor (CTGF)
Calvin Kuo,
Stanford University, USA
Regulation of Intestinal Stem Cell Self-Renewal
Regulation of Intestinal Stem Cell Self-Renewal
Ben Z. Stanger,
University of Pennsylvania Perelman School of Medicine, USA
Cellular Plasticity in the Liver
Cellular Plasticity in the Liver
Mark Lewis,
Washington University in St. Louis, USA
Short Talk: The Role of IFRD1 in Reprogramming Secretory Cells
Short Talk: The Role of IFRD1 in Reprogramming Secretory Cells
17:00—19:00
Beta-Cell Stress
Meeting has ended...abstracts no longer viewable online.
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Ernesto Bernal-Mizrachi,
University of Miami Miller School of Medicine, USA
Miriam Cnop,
Universite Libre de Bruxelles, Belgium
Mechanisms of Pancreatic Beta-cell Death in Type 2 Diabetes
Mechanisms of Pancreatic Beta-cell Death in Type 2 Diabetes
Marc Y. Donath,
University Hospital Basel, Switzerland
Physiology of Pro-Inflammatory Cytokines in Metabolism: Therapeutic Consequences
Physiology of Pro-Inflammatory Cytokines in Metabolism: Therapeutic Consequences
Roland W. Stein,
Vanderbilt University Medical Center, USA
Examining How the MAFA and MAFB Transcription Factors Regulate Human Islet Beta Cell Function
Examining How the MAFA and MAFB Transcription Factors Regulate Human Islet Beta Cell Function
Maria S. Remedi,
Washington University Medical School, USA
Short Talk: Plasticity of Pancreatic beta-cells: Dedifferentiation in Diabetes and Re-differentiation after Insulin Therapy
Short Talk: Plasticity of Pancreatic beta-cells: Dedifferentiation in Diabetes and Re-differentiation after Insulin Therapy
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Markus Grompe,
Oregon Health & Science University, USA
09:00—11:15
Developmental Origin of Stem Cells
Meeting has ended...abstracts no longer viewable online.
*
James M. Wells,
Cincinnati Children's Hospital Research Foundation, USA
Jason R. Spence,
University of Michigan Health System, USA
Pluripotent Stem Cell Derived Organoid Models to Study Human Development
Pluripotent Stem Cell Derived Organoid Models to Study Human Development
Atsushi Suzuki,
Medical Institute of Bioregulation, Kyushu University, Japan
Stem Cell Systems in the Liver
Stem Cell Systems in the Liver
Olivia G. Kelly,
Viacyte, Inc., USA
Stem-Cell Derived, Macroencapsulated Islet Replacement for Type 1 Diabetes
Stem-Cell Derived, Macroencapsulated Islet Replacement for Type 1 Diabetes
Somdutta Mukherjee,
University of Pennsylvania, USA
Short Talk: Investigating the Role of TBX3 in Endodermal Progenitor Cell Maintenance and Differentiation
Short Talk: Investigating the Role of TBX3 in Endodermal Progenitor Cell Maintenance and Differentiation
08:00—11:15
Targeting Novel Drugs to the Islet
Meeting has ended...abstracts no longer viewable online.
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Carina Ammala,
AstraZeneca, Sweden
Shalev Itzkovitz,
Weizmann Institute of Science, Israel
EMBO Young Investigator Lecture: Single Molecule Approaches for Studying Gene Expression in Intact Mammalian Tissues
EMBO Young Investigator Lecture: Single Molecule Approaches for Studying Gene Expression in Intact Mammalian Tissues
Andrew F. Stewart,
Mount Sinai School of Medicine, USA
Progress and Hurdles in Human Beta Cell Regeneration for Diabetes
Progress and Hurdles in Human Beta Cell Regeneration for Diabetes
Robert A. Screaton,
Sunnybrook Research Institute, Canada
Functional Genomics and the Human Pancreatic Beta Cell
Functional Genomics and the Human Pancreatic Beta Cell
Jesper Gromada,
Regeneron Pharmaceuticals, USA
Single Islet Cell RNAseq for Target Discovery
Single Islet Cell RNAseq for Target Discovery
Christian Helker,
Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Whole Organism Secretome-wide Screen to Identify Novel Regulators of Pancreatic Beta-Cell Function
Short Talk: Whole Organism Secretome-wide Screen to Identify Novel Regulators of Pancreatic Beta-Cell Function
Samuel B. Stephens,
Duke University Medical Center, USA
Short Talk: Loss of the Pro-hormone VGF Decreases beta-cell Function via Reduced Insulin Secretory Granule Biogenesis
Short Talk: Loss of the Pro-hormone VGF Decreases beta-cell Function via Reduced Insulin Secretory Granule Biogenesis
14:30—16:30
Workshop and Panel Discussion 2: Hurdles to Translation
*
Martín G. Martín,
David Geffen School of Medicine at UCLA, USA
Shinichiro Ogawa,
McEwen Centre for Regenerative Medicine, Canada
Modeling Cystic Fibrosis Biliary Disease with hPSC-Derived Cholangiocyte
Modeling Cystic Fibrosis Biliary Disease with hPSC-Derived Cholangiocyte
Casey Allison Rimland,
Cambridge University, UK
Progenitor Cells in the Human Extrahepatic Biliary Tree and Gallbladder
Progenitor Cells in the Human Extrahepatic Biliary Tree and Gallbladder
Ken Woo,
University of Western Australia, Australia
Liver Progenitor Cells Derived from Pluripotent Stem Cells
Liver Progenitor Cells Derived from Pluripotent Stem Cells
Christopher Heinen,
University of Connecticut Health, USA
The DNA Mismatch Repair-Dependent Damage Response in Human Embryonic Stem Cell-Derived Intestinal Organoids
The DNA Mismatch Repair-Dependent Damage Response in Human Embryonic Stem Cell-Derived Intestinal Organoids
Maelle Lorvellec,
University College London, UK
Differentiation of human Embryonic Stem Cells and Induced Pluripotent Stem Cells into Hepatocytes-like Cells in a Mouse Decellularized Liver Scaffold
Differentiation of human Embryonic Stem Cells and Induced Pluripotent Stem Cells into Hepatocytes-like Cells in a Mouse Decellularized Liver Scaffold
Li-Fang Chu,
University of Wisconsin-Madison, USA
Single-cell RNA-seq Reveals Novel Regulators of Human Embryonic Stem Cell Differentiation to Definitive Endoderm
Single-cell RNA-seq Reveals Novel Regulators of Human Embryonic Stem Cell Differentiation to Definitive Endoderm
14:30—16:30
Workshop 3: Novel Insight into Beta-Cell Functions and Dysfunctions
*
Christopher V. Wright,
Vanderbilt University, USA
Aimee Bastidas Ponce,
Helmholtz Zentrum Munich, Germany
Analysis of the Role of Synaptotagmin 13 in Pancreatic Beta-cell Function and Islet Architecture
Analysis of the Role of Synaptotagmin 13 in Pancreatic Beta-cell Function and Islet Architecture
Esther Marie Bolanis,
Indiana University School of Medicine, USA
Posttranslational Modification of the Factor eIF5A is Required for the Adaptive Response of the Islet Beta Cell During Insulin Resistance
Posttranslational Modification of the Factor eIF5A is Required for the Adaptive Response of the Islet Beta Cell During Insulin Resistance
Gitte Lund Christensen,
University of Copenhagen, Denmark
Pancreatic beta-cells Dysfunction Induced by Prolonged Exposure to Low Dose IL1beta or Bmp2 is associated with beta-cell De-differentiation
Pancreatic beta-cells Dysfunction Induced by Prolonged Exposure to Low Dose IL1beta or Bmp2 is associated with beta-cell De-differentiation
Jennifer L. Estall,
Institut de Recherches Cliniques de Montréal, Canada
Pgc-1 Coactivators in beta-cells are Essential for Glycerolipid Metabolism and Insulin Secretion Coupled to Fatty Acids
Pgc-1 Coactivators in beta-cells are Essential for Glycerolipid Metabolism and Insulin Secretion Coupled to Fatty Acids
Amanda M. Ackermann,
Children's Hospital of Philadelphia, USA
Integration of ATAC-seq and RNA-seq Identifies Human Alpha Cell and Beta Cell Signature Genes
Integration of ATAC-seq and RNA-seq Identifies Human Alpha Cell and Beta Cell Signature Genes
Aharon Helman,
Harvard University, USA
p16Ink4a-induced Senescence of Pancreatic beta-cells Enhances Insulin Secretion
p16Ink4a-induced Senescence of Pancreatic beta-cells Enhances Insulin Secretion
Aida Martinez-Sanchez,
Imperial College London, UK
Disallowance of Acot7 in Beta-cells is Required for Normal Insulin Secretion and Glucose Tolerance
Disallowance of Acot7 in Beta-cells is Required for Normal Insulin Secretion and Glucose Tolerance
Lu Zhu,
NIDDK, National Institutes of Health, USA
Beta-Arrestin-2 is an Essential Regulator of Pancreatic beta-cell Function
Beta-Arrestin-2 is an Essential Regulator of Pancreatic beta-cell Function
17:00—18:45
Translational and Clinical Applications
Meeting has ended...abstracts no longer viewable online.
*
Jill L. Carrington,
National Institute of Diabetes and Digestive and Kidney Diseases, USA
Tsutomu Chiba,
Kyoto University, Japan
Double Cortin-Like Kinase 1 (Dclk1) Marks PanIN-initiating Cells in Acinar-to-Ductal Metaplasia (ADM)
Double Cortin-Like Kinase 1 (Dclk1) Marks PanIN-initiating Cells in Acinar-to-Ductal Metaplasia (ADM)
William Proctor,
Genentech, Inc., USA
Role of PI3Kalpha and mTOR Inhibition in Endoderm Differentiation as a First Step toward Personalized Toxicology
Role of PI3Kalpha and mTOR Inhibition in Endoderm Differentiation as a First Step toward Personalized Toxicology
Martín G. Martín,
David Geffen School of Medicine at UCLA, USA
Intestinal Stem Cells - Bench to Bedside, and Future Challenges
Intestinal Stem Cells - Bench to Bedside, and Future Challenges
17:00—18:45
Type-1 Diabetes: The Beta-Cell Immune System Interface
Meeting has ended...abstracts no longer viewable online.
*
Miriam Cnop,
Universite Libre de Bruxelles, Belgium
Mark A. Atkinson,
University of Florida, USA
The Pathogenesis of Human Type 1 Diabetes - A Disease of the Immune System, Beta Cells and Pancreas
The Pathogenesis of Human Type 1 Diabetes - A Disease of the Immune System, Beta Cells and Pancreas
Carla J. Greenbaum,
Benaroya Research Institute at Virginia Mason, USA
T1D Therapeutic Approaches
T1D Therapeutic Approaches
Rene Maehr,
University of Massachusetts Medical School, USA
Towards a Human Pluripotent Stem Cell-Based Disease Model for Autoimmune Diabetes
Towards a Human Pluripotent Stem Cell-Based Disease Model for Autoimmune Diabetes
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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