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This meeting took place in 2016



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Nuclear Receptors: Full Throttle (J1)


Organizer(s) Carol A. Lange, Jennifer K. Richer and Karen E. Knudsen
January 10—14, 2016
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Sep 23, 2015
Abstract Deadline: Oct 22, 2015
Scholarship Deadline: Sep 23, 2015
Discounted Registration Deadline: Nov 12, 2015

Sponsored by Intercept Pharmaceuticals, Inc.


Summary of Meeting:
Nuclear receptors (NRs) represent a large superfamily of ligand-dependent transcription factor “sensors” for a diverse set of fat-soluble hormones, vitamins and dietary lipids. NRs orchestrate genetic response programs critical for normal homeostasis, and are required for reproduction, development, metabolism and immune function. For this reason, NRs have been investigated for over 30 years as promising targets for drugs to treat a broad spectrum of diseases including cancer, diabetes and other endocrine or metabolic disorders, obesity, cardiovascular disease, hypertension, inflammation and cholestasis. Research on NRs has led to numerous successful therapies for deadly diseases that have improved both longevity and quality of life. However, significant hurdles remain that involve further detailed understanding of the major gene regulatory networks regulated by NRs, how these differ in normal relative to pre-disease and disease states, and the complex problems associated with targeting tissue-specific effects (to reduce side effects) and circumventing mechanisms of resistance. Thus, further insight into the full range of NR functions and interactions with co-regulatory molecules and signaling pathways is necessary for combinatorial approaches involving NRs in health and disease, and development of next-generation therapies. This meeting on “Nuclear Receptors: Full Throttle” continues the Keystone Symposia tradition of bringing together a diverse array of our leading scientists, including senior and junior investigators and their trainees, from academic, clinical and pharmaceutical settings, to showcase the latest science, highlight the use of innovative and emerging technologies, explore new directions, and develop collaborative and synergistic efforts in the exciting field of NR biology.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 14 with a closing plenary session and keynote address from 17:00 to 20:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 15 in order to fully experience the meeting.

SUNDAY, JANUARY 10

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, JANUARY 11

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Carol A. Lange, University of Minnesota, USA

* Peter Verrijzer, Erasmus University Medical Center, Netherlands

Robert T. Tjian, HHMI/University of California, Berkeley, USA
Probing Transcription Regulation by Single Molecule Imaging

09:00—11:30
Transcription and Human Disease (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
Danny F. Reinberg, HHMI/New York University, USA
Epigenetic Regulation by Polycomb Complexes

Susanne Mandrup, University of Southern Denmark, Denmark
Reorganization of the 3D Chromatin Structure during Adipocyte Differentiation

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Nuclear Receptors and the Transcriptional Regulation of Circadian Rhythms and Metabolism

Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany
Epigenetic Regulation by MOF Containing Complexes

09:40—10:00
Coffee Break

Ballroom Lobby
11:30—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
11:30—14:30
On Own for Lunch

14:30—16:30
Workshop 1: NR Interactions with DNA and the Transcriptional Machinery
NR Interactions with DNA & the Transcriptional Machinery

Ballroom 2-3
* Carolyn L. Smith, Baylor College of Medicine, USA

Sofie Johanna Desmet, Ghent University/VIB, Belgium
Cofactor Profiling Following Selective Modulation of the Glucocorticoid Receptor

Jay Gertz, University of Utah, USA
Functional Dissection of Estrogen Receptor Alpha Bound Enhancers at their Endogenous Loci

Ville Paakinaho, National Institutes of Health, USA
Single-Molecule Analysis of Glucocorticoid Receptor and Cofactor Action in Living Cells

Jing Yang, Baylor College of Medicine, USA
The Histone Demethylase PHF8, a Novel Interacting Partner of the SMRT Coregulator, Promotes Estrogen Receptor-alpha Transcriptional Activity

Dinny Graham, Westmead Millennium Institute, University of Sydney, Australia
Differential Effects of Cell Type and Nuclear Environment on Progesterone Receptor Isoform Function

Coralie Poulard, University of Southern California, USA
Crosstalk between Automethylation and Phosphorylation Tightly Regulates G9a Coactivator Function with Steroid Hormone Receptors

Bart Kolendowski, University of Western Ontario, Canada
The Role of Thymine DNA Glycosylase (TDG) in Estrogen Receptor Signalling and Enhancer RNA Regulation in Breast Cancer

Sean W. Fanning, University of Chicago, USA
Bazedoxifene Potently Inhibits Y537S and D538G ESR1 Somatic Mutants by Disrupting the Constitutively Active AF-2 Conformational State

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Co-Regulators
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA

Myles Brown, Dana-Farber Cancer Institute, USA
Hacking the Steroid Receptor Cistrome

Qianben Wang, Ohio State University, USA
Precise and Dynamic Definition of Nuclear Receptor Collaborator and Coregulator Cistromes

Carol A. Lange, University of Minnesota, USA
Stress-Responsive Gene Regulation by GR/HIF/PELP1 Complexes in Triple-Negative Breast Cancer

Timothy E. Reddy, Duke University, USA
Short Talk: Massively Parallel Reporter Assays Reveal Glucocorticoid Receptor Interaction Modules that Direct Gene Expression Responses to Corticosteroids

17:00—19:00
Epigenetics and Chromatin as a Metabolic Sensor
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics, Germany

Hans-Martin Herz, St. Jude Children's Research Hospital, USA
Short Talk: The Histone H3 Lysine 4 to Methionine (H3K4M) Mutant as a Tool to Study Enhancer-Mediated Processes

Katrin F. Chua, Stanford University Medical Center, USA
Chromatin Regulation and Genome Maintenance by Mammalian Sirtuins

Tokameh Mahmoudi, Erasmus Universiteit Rotterdam, Netherlands
Signaling to Chromatin and Viral Latency

Melanie M. Ott, University of California, San Francisco, USA
Metabolic Reprogramming of T Cells by SIRT1

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 1

Primrose

TUESDAY, JANUARY 12

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
From Chromatin to Clinic
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Scott M. Dehm, University of Minnesota, USA

Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Nuclear Receptor-DNA Repair Crosstalk: Bench to Bedside

John A. Katzenellenbogen, University of Illinois at Urbana-Champaign, USA
Novel Ligands for Estrogen Receptor and Androgen Receptor Targeted Therapies

Susan K. Logan, New York University School of Medicine, USA
Transcription Repression in Prostate Cancer

Amy Peterson, BeiGene, USA
Advances in the Use of Selective Androgen Receptor Modulators as Cancer Therapies

Yiru Chen Zhao, University of Illinois at Urbana-Champaign, USA
Short Talk: Prevention of Obesity Related Breast Cancer Using Pathway Preferential Estrogens

Lisa Greene, University of Colorado Anschutz Medical Campus, USA
Short Talk: Suppression of CD8 T-cells by Tryptophan Catabolism in Triple-Negative Breast Cancer

08:00—11:15
Signaling to Chromatin and Human Disease
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
Gerald R. Crabtree, Stanford University, USA
ATP-Dependent Chromatin Remodeling: Insights from New Methods and the Genomics of Human Disease

Irina M. Bochkis, Broad Institute, USA
Short Talk: Reorganization of Lamina-Associated Domains in Aged Liver Alters Binding of Pioneer Factor Foxa2

* Jerry L. Workman, Stowers Institute for Medical Research, USA
Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism

W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Nuclear NAD+ Signaling through DNA-dependent PARPs and the Control of Gene Expression

Juan Du, Beckman Research Institute of City of Hope, USA
Short Talk: Chromatin Variation Driven by Transposable Elements Is a Key Contributor to Liver Metabolism in Mice

Ali Shilatifard, Northwestern University, USA
Enhancer Malfunction in Cancer

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Advances in Structures, Ligands and Energetics
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Myles Brown, Dana-Farber Cancer Institute, USA

Nima Sharifi, Cleveland Clinic, USA
Feeding the Ligand Addiction in Advanced Cancers

Kendall W. Nettles, The Scripps Research Institute, USA
Predicting Phenotypic Outcomes for Estrogen Receptor Ligands

David L. Bain, University of Colorado Anschutz Medical Campus, USA
Nuclear Receptor Functional Energetics and Transcriptional Regulation

Kerry Kornfeld, Washington University Medical School, USA
Short Talk: The Nuclear Receptor HIZR-1 Mediates Zinc Homeostasis by Functioning as a Zinc Sensor and Transcription Response Effector

17:00—19:00
Metabolism and Gene Control
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Melanie M. Ott, University of California, San Francisco, USA

Jesper Q. Svejstrup, Francis Crick Institute, UK
Transcription-Associated Genome Instability

Frances M. Sladek, University of California, Riverside, USA
Short Talk: Soybean Oil Induces Obesity via Linoleic Acid, Oxylipins and Nuclear Receptor HNF4alpha

Katherine A. Jones, The Salk Institute, USA
Metabolic Role for CTD Kinases

Joaquín M. Espinosa, University of Colorado Boulder, USA
Mechanisms of Transcriptional Control by HIF1 and its Cofactors in Response to Hypoxia

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 2

Primrose

WEDNESDAY, JANUARY 13

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Rapid and Integrated Signaling (Extra-Nuclear) Actions of NRs
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Kenneth S. Korach, NIEHS, National Institutes of Health, USA

Ellis R. Levin, University of California, Irvine, USA
Membrane and Nuclear-Only ERalpha Mice Inform Phenotypes and Metabolic Functions Resulting from Estrogen Action

Cheryl L. Walker, Texas A&M Health Science Center, USA
Environmental Estrogens Activate Nongenomic ER Signaling to Developmentally Reprogram the Epigenome

Stephen R. Hammes, University of Rochester Medical Center, USA
Crosstalk between Estrogen and mTOR Signaling in Lymphangioleiomyomatosis (LAM)

Zeynep Madak-Erdogan, University of Illinois at Urbana-Champaign, USA
Systems Biology of Gene and Metabolic Regulation by Estrogen Receptors and Kinases in Breast Cancer and Metabolic Disease

Rebecca B. Riggins, Georgetown University, USA
Short Talk: The Extra-Nuclear Life of ERRbeta2: Cytoskeletal and Mitotic Functions of an Orphan Nuclear Receptor Splice Variant

Andrea R. Patterson, Ohio State University, USA
Short Talk: The Role of Stromal Estrogen Receptor in Mammary Gland Reprogramming Following in Utero BPA Exposure

08:00—11:00
Metabolism and Tumor Suppression
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Jane Mellor, University of Oxford, UK

Jennifer Jones McCann, Thomas Jefferson University, USA
Short Talk: Novel Action of p53 Gain-of-Function Mutations in Prostate Cancer Progression

Amanda G. Fisher, MRC Clinical Sciences Centre, Imperial College London, UK
Non-Invasive Imaging of Epigenetic Changes in the Developing Embryo

Adrian P. Bracken, Trinity College Dublin, Ireland
The PRC2 Complex in Cellular Proliferation and Cancer

Selma Masri, University of California, Irvine, USA
Short Talk: Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Metabolic Regulation of Epigenetics

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—13:00
Poster Setup

Primrose
13:00—22:00
Poster Viewing

Primrose
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Circadian and Metabolic Cycles (Joint)
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
Nuclear Receptors—Physiology's Architect: A 30 Year Perspective

Paolo Sassone-Corsi, University of California, Irvine, USA
Metabolic and Epigenetic Language of the Circadian Clock

Jane Mellor, University of Oxford, UK
Transcriptional Regulation of the Metabolic Cycle

Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
Nuclear Receptors and the Circadian Clock

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 3

Primrose

THURSDAY, JANUARY 14

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Paolo Sassone-Corsi, University of California, Irvine, USA

Bruce M. Spiegelman, Harvard Medical School, USA
Transcriptional Control of Brown and Beige Fat: Basic Biology and Potential Therapeutic Pathways

08:00—11:15
Nuclear Receptors in Cancer, Gender Benders and Other Advances
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Jonna Frasor, University of Illinois, Chicago, USA

Christine Louise Clarke, Westmead Millennium Institute, Australia
Progesterone Action in Normal Breast and Breast Cancer

Gail S. Prins, University of Illinois, USA
Estrogenic Regulation of Prostate Stem and Progenitor Cells: Differential Actions through ERalpha and ERbeta

Jennifer K. Richer, University of Colorado Anschutz Medical Campus, USA
Subtype-Specific AR Action in Breast Cancer

John A. Cidlowski, NIEHS, National Institutes of Health, USA
Stress Hormone Signaling and Heart Disease: The Good, the Bad, and the Deadly

Diana M. Cittelly, University of Colorado Anschutz Medical Campus, USA
Short Talk: Ovarian and Brain Estrogens Promote Brain Metastases of Triple-Negative Breast Cancer

Christopher M. McNair, Thomas Jefferson University, USA
Short Talk: RB Loss Re-Programs E2F1 and AR Cistromes in Prostate Cancer

09:00—11:15
Obesity, Diabetes and Misregulation of Gene Expression
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Paolo Sassone-Corsi, University of California, Irvine, USA

Amandine Chaix, The Salk Institute, USA
Short Talk: Time-Restricted Feeding is a Preventative and Therapeutic Intervention Against Diverse Nutritional Challenges

Carl S. Thummel, University of Utah School of Medicine, USA
Regulation of Mitochondrial Transcription and Carbohydrate Homeostasis by the HNF4 Nuclear Receptor

Shingo Kajimura, University of California, San Francisco, USA
Molecular Basis of Beige Adipocyte Maintenance and Energy Expenditure

Anders M. Näär, Harvard Medical School, USA
Transcriptional and MicroRNA Circuits in Metabolic Disorder

09:20—09:40
Coffee Break

Ballroom Lobby
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Signal Transduction and NR Actions

Ballroom 2-3
* Carol A. Lange, University of Minnesota, USA

Christy Hagan, University of Kansas Medical Center, USA
Progesterone Receptor Promotes Inflammatory Gene Programs in Breast Cancer

Lynsey M. Fettig, University of Colorado, USA
Progesterone Receptor-Retinoic Acid Receptor Crosstalk in Regulating a Breast Cancer Stem Cell Population

Michael A. Gordon, University of Colorado Anschutz Medical Campus, USA
Targeting Multiple Pathways in Breast Cancer: Androgen Receptor, HER2, and mTOR

Daniel E. Frigo, University of Houston, USA
Regulation of AMPK by Androgen Receptor Signaling and its Role in Prostate Cancer Metabolism

Zhenqi Zhou, University of California, Los Angeles, USA
ERalpha Deficiency-Induced Mitochondrial Dysfunction and Skeletal Muscle Insulin Resistance is Mediated by Imbalanced Fission-Fusion Dynamics in Females

Hari Singhal, University of Chicago, USA
Progesterone Receptor Agonists, Antagonists and Isoforms Differentially Reprogram Estrogen Signaling in Breast Cancer

Nancy R. Gough, AAAS / Science, USA
Presentation on Science Writing

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—18:00
NRs as Modulators of Immune Cell Function
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Jennifer K. Richer, University of Colorado Anschutz Medical Campus, USA

Inez Rogatsky, Weill Medical College of Cornell University, USA
Transcriptional Cofactor NCoA2/GRIP1 in Macrophage Polarization and Metabolic Control

Christopher K. Glass, University of California, San Diego, USA
Influence of Tissue Environment on Macrophage Identity and Function

17:00—19:00
Transcriptional Control of Cell Growth
Meeting has ended...abstracts no longer viewable online.

Ballroom 1
* Katherine A. Jones, The Salk Institute, USA

James T. Kadonaga, University of California, San Diego, USA
Operating Systems, Apps, and Novel Chromatin Structures for the Regulation of Our Genes

Claudio Villanueva, University of Utah School of Medicine, USA
Short Talk: TLE3 is a Gatekeeper of the Beige Transcriptional Program

Don Ayer, University of Utah, USA
c-Myc and MondoA Couple Nutrient Utilization and Availability in Tumorigenesis

Peter Verrijzer, Erasmus University Medical Center, Netherlands
Transcription Control by Nucleotide Biosynthetic Enzymes

18:00—18:45
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Joe Thornton, University of Chicago, USA
Nuclear Receptor Evolution: How NR Structures and Functions Came to Be

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Ballroom 2-3
20:00—21:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 2-3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 2-3

FRIDAY, JANUARY 15

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Intercept Pharmaceuticals, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA200226-01

Funding for this conference was made possible (in part) by 1R13CA200226-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676