Hyatt Regency Monterey Floorplan

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This meeting took place in 2016


Here are the related meetings in 2017:
B Cells and T Follicular Helper Cells – Controlling Long-Lived Immunity (D2)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

T Follicular Helper Cells and Germinal Centers (B4)


Organizer(s) Shane Crotty and Carola G. Vinuesa
February 26—March 1, 2016
Hyatt Regency Monterey • Monterey, California USA
Discounted Abstract Deadline: Oct 27, 2015
Abstract Deadline: Nov 30, 2015
Scholarship Deadline: Oct 27, 2015
Discounted Registration Deadline: Jan 5, 2016

Sponsored by BioLegend, Inc.

Summary of Meeting:
Follicular helper CD4 T cells (Tfh) are the specialized providers of B cell help and are essential for germinal centers and most antibody responses. Germinal centers are the engines of rapid B cell evolution and have exquisitely complex cellular dynamics. Tfh differentiation is a multistage, multifactorial process. Tfh cells have recently emerged as major players in protective immunity to pathogens, and generation of high-affinity and long-term antibody responses to vaccines, autoimmune diseases, allergies and even cancer. However, there are major gaps in our understanding of Tfh differentiation, Tfh function, germinal center function and the biological selection of high-affinity antibody responses in vivo in a variety of relevant anti-pathogen and autoimmune contexts. This conference will bring together scientists and physicians from a range of disciplines and disease models to elaborate the complex biology of Tfh cells and germinal centers and discuss emerging avenues to manipulate them in clinical settings.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Friday, February 26 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 1 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Wednesday, March 2 in order to fully experience the meeting.

FRIDAY, FEBRUARY 26

16:00—20:00
Arrival and Registration

Regency IV-VI
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Regency IV-VI

SATURDAY, FEBRUARY 27

07:30—08:30
Breakfast

Regency IV-VI
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Regency Main I-III
* Shane Crotty, La Jolla Institute for Allergy and Immunology, USA

Chen Dong, Tsinghua University, China
Transcription in the germinal center: a tale of twin factors

09:30—12:00
Tfh Differentiation
Meeting has ended...abstracts no longer viewable online.

Regency Main I-III
* Carola G. Vinuesa, Australian National University, Australia

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Pathways of Tfh Differentiation and Function

John J. O'Shea, NIAMS, National Institutes of Health, USA
Epigenetics and MicroRNAs in Tfh Differentiation

Arlene H. Sharpe, Harvard Medical School, USA
Control of Tfh Cells by T follicular regulatory cells

Sunil Kannanganat, Houston Methodist Research Institute, USA
Short Talk: Regulation of T Helper Fate Decisions by Dynamic Control of IRF4

Hui Hu, University of Alabama at Birmingham, USA
Short Talk: A Multi-Level Control of T Follicular Helper Cell Differentiation by Transcription Factor Foxp1

10:10—10:30
Coffee Break

Regency Foyer Terrace
12:00—13:00
Poster Setup

Regency IV-VI
13:00—22:00
Poster Viewing

Regency IV-VI
12:00—14:30
On Own for Lunch

14:30—16:30
Workshop 1

Regency Main I-III
* Nicolas Fazilleau, Center of Pathophysiology of Toulouse-Purpan, France

* John J. O'Shea, NIAMS, National Institutes of Health, USA

Chen Yao, University of Minnesota, USA
Skin DC Induce Follicular Helper T Cells and Protective Humoral Immune Responses

Seung-Chul Choi, University of Florida, USA
The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation

Yoontae Lee, POSTECH, South Korea
Capicua Regulates Follicular Helper T Cell Differentiation and Autoimmunity through Repression of Pea3 Group Gene Expression

Hidehiro Yamane, NIAID, National Institutes of Health, USA
The Gamma-Secretase Complex Co-Operates with TCR Signals to Regulate Tfh Differentiation by Modulating the IL-2R Pathway

Michela Locci, La Jolla Institute for Allergy and Immunology, USA
Activin A Orchestrates the Gene Program of Human Tfh Cells

Anastassia Alexandrovna Tselikova, National Institutes of Health, USA
Two-step Regulation of Tfh Differentiation by E-box Binding Proteins

Masashi Watanabe, NCI, National Institutes of Health, USA
Costimulatory Pathways Mediating T-Dependent Germinal Center Responses: Distinct Cellular Requirements for CD40 and B7 Costimulation

Maria D. Lopez-Ocasio, National Institutes of Health, USA
T Follicular Regulatory (TFR) Cells Suppress Germinal Center (GC) B Cell Differentiation by Targeting TF Helper (TFH) Cells

16:30—17:00
Coffee Available

Regency Foyer Terrace
17:00—19:00
Tfh Functions and B Cell Functions
Meeting has ended...abstracts no longer viewable online.

Regency Main I-III
* Shane Crotty, La Jolla Institute for Allergy and Immunology, USA

Carola G. Vinuesa, Australian National University, Australia
A FOXP3-Negative Follicular Regulatory T Cell Subset, “Tfr2”, that Controls Germinal Center Antibody Responses in Humans

Facundo D. Batista, Ragon Institute of MGH, MIT and Harvard, USA
Visualizing the Early Events of Antigen Recognition by B Cells

Pamela L. Schwartzberg, NHGRI, National Institutes of Health, USA
Signaling Pathways and Molecules Affecting Tfh Differentiation and Function

Yu Kato, University of Melbourne, Australia
Short Talk: Clec9A-mediated Induction of Tfh and B Cell Responses

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Regency IV-VI
19:30—22:00
Poster Session 1

Regency IV-VI

SUNDAY, FEBRUARY 28

07:30—08:30
Breakfast

Regency IV-VI
08:00—08:30
Poster Setup

Regency IV-VI
08:30—17:00
Poster Viewing

Regency IV-VI
08:30—11:45
Germinal Center B Cell Biology and Selection: T Cell Help
Meeting has ended...abstracts no longer viewable online.

Regency Main I-III
* Michel C. Nussenzweig, HHMI/Rockefeller University, USA

Gabriel D. Victora, Rockefeller University, USA
Clonal Dynamics in Germinal Centers

Hai Qi, Tsinghua University, China
Tfh Interactions with B Cells in vivo

Michelle Angela Linterman, Babraham Institute, UK
Formation and Function of Follicular Regulatory T Cells

Jason G. Cyster, HHMI/University of California, San Francisco, USA
Requirements for Germinal Center organization and function

Stefan Feske, New York University School of Medicine, USA
Short Talk: Store-Operated Ca2+ Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity

Andrea Radtke, NIAID, National Institutes of Health, USA
Short Talk: Multi-plexed, Quantitative Imaging of Germinal Center Reaction Reveals Profound Impact of Adjuvants on Cell Fate Decisions in situ

09:50—10:10
Coffee Break

Regency Foyer Terrace
11:45—12:30
Lunch

Regency IV-VI
12:00—14:30
Poster Session 2

Regency IV-VI
14:30—16:30
Workshop 2

Regency Main I-III
* Beatriz León, University of Alabama at Birmingham, USA

* Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA

Alexander Dent, Indiana University School of Medicine, USA
Follicular Regulatory T Cells Act on Multiple Facets of the Germinal Center Response

Cristian G. Beccaria, Facultad de Cs. Químicas, Universidad Nacional de Córdoba, Argentina
Galectin-3 Restrains Spontaneous Germinal Centers Formation Preventing Autoimmunity

Ilenia Papa, Australian National University, Australia
Tfh-derived Dopamine: An ‘Immunetransmitter’ in the Germinal Center

Irina Grigorova, University of Michigan Medical School, USA
Production of CCL3,4 Chemokines by Germinal Center B Cells Promote their Direct Interactions and Control by Follicular Regulatory T Cells

Ana Raquel Maceiras, University of Lisbon, Portugal
Different TCR-Specificity Requirements in T Follicular Helper and T Follicular Regulatory Cells from the Same Germinal Centers

Andre Ballesteros-Tato, University of Alabama, Birmingham, USA
Interleukin-2 (IL-2) Prevent Foxp3+ T Follicular Regulatory (TFR) Cell Responses During Influenza Virus

Keiko Sakamoto, Kyoto University, Japan
Osteopontin Produced by CD153+ Follicular T Cells Suppresses Apoptotic Cell-engulfment by Tingible Body Macrophages in Germinal Centers to Accelerate SLE in NZB/W F1 Mice

Shirdi E. Schmiel, University of Minnesota, USA
Activation of Adenosine 2A Receptor on CD4 T Cells Promotes Tolerance by Reducing Germinal Center Follicular Helper T Cells and Pathogenic B Cells

16:30—17:00
Coffee Available

Regency Foyer Terrace
17:00—19:00
Tfh and GCs in Infections and Vaccines
Meeting has ended...abstracts no longer viewable online.

Regency Main I-III
* Jason G. Cyster, HHMI/University of California, San Francisco, USA

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
The Importance of GC Biology in HIV Vaccine Development

Elina I. Zuniga, University of California, San Diego, USA
T follicular Helper Cell Regulation By Gp130 Signaling Cytokines

Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA
Human T Follicular Helper Cell Subsets

Isabela Pedroza-Pacheco, University of Oxford, UK
Short Talk: Perturbations in Regulatory and Helper CD4+ T Cell Subsets in HIV 1-infected Individuals Producing Broadly Reactive Neutralizing Antibodies: Relevance to HIV-1 Vaccine Design

19:00
On Own for Dinner


MONDAY, FEBRUARY 29

07:30—08:30
Breakfast

Regency IV-VI
08:30—11:45
Human Tfh and GCs and Lessons from Human Diseases
Meeting has ended...abstracts no longer viewable online.

Regency Main I-III
* Joseph E. Craft, HHMI, Yale University, USA

Mark M. Davis, Stanford University, USA
Human T Cell Response to Influenza Vaccines

Di Yu, Monash University, Australia
Monitoring and Modulation of Tfh cell activity: a tale of two cytokines

Riccardo Dalla-Favera, Columbia University, USA
Transcriptional Regulation of Germinal Center Development and its Mutational Deregulation in B Cell Lymphoma

Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Tfh and B Cell Memory: Lessons from Human Genetic Diseases

Karen Willard-Gallo, Universite Libre de Bruxelles, Belgium
Short Talk: CXCL13-producing Tfh Cells Link Immune Suppression and Adaptive Immunity in Human Breast Cancer

Daniel E. Kaufmann, University of Montreal, Canada
Short Talk: Germinal Center Hyperactivity and HIV-associated Residual Immune Dysregulation Syndrome

09:50—10:10
Coffee Break

Regency Foyer Terrace
11:45—13:00
Poster Setup

Regency IV-VI
13:00—22:00
Poster Viewing

Regency IV-VI
11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Regency Foyer Terrace
17:00—19:00
Tfh and GCs in Autoimmunity and Allergy/Type 2 Responses
Meeting has ended...abstracts no longer viewable online.

Regency Main I-III
* Stuart G. Tangye, Garvan Institute of Medical Research, Australia

Joseph E. Craft, HHMI, Yale University, USA
Regulation of Tfh Cell Development and Differentiation

Cecile King, Garvan Institute of Medical Research, Australia
To MAVS and MAVS not: Cytoplasmic nucleic acid sensors and adaptive immunity

Frances E. Lund, University of Alabama at Birmingham, USA
Tuning Antibody Production by Modulating the Blimp1/Bcl6 Balance in B cells

Hsin-Jung Wu, University of Arizona, USA
Short Talk: Gut Microbiota Drives Autoimmune Arthritis by Unleashing the Tfh Response

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Regency IV-VI
19:30—22:00
Poster Session 3

Regency IV-VI

TUESDAY, MARCH 1

07:30—08:30
Breakfast

Regency IV-VI
08:30—11:30
Complexities of Tfh and GC Regulation: Molecules, Cells and Systems
Meeting has ended...abstracts no longer viewable online.

Regency Main I-III
* Chen Dong, Tsinghua University, China

Ari M. Melnick, Weill Cornell Medical College, USA
Bcl6 Functions in Tfh and GC B Cells

Sidonia Fagarasan, RIKEN Research Center for Allergy and Immunology, Japan
Follicular Dendritic Cells (FDC) as Regulators of GC B Cells and Tfh Cells

Bali Pulendran, Emory University, USA
Systems-based approaches to vaccine development

Akshay T. Krishnamurty, University of Washington, USA
Short Talk: Somatically Hypermutated Plasmodium-specific IgM+ Memory B Cells Are Optimally Responsive to a Secondary Blood Stage Malaria Infection

Fabio Grassi, Institute for Research in Biomedicine, Switzerland
Short Talk: Regulation of T Follicular Helper Cells by ATP-gated Ionotropic P2X7 Receptor

09:50—10:10
Coffee Break

Regency Foyer Terrace
11:30—14:30
On Own for Lunch

14:30—16:30
Workshop 3

Regency Main I-III
* Brian J. Laidlaw, University of California, San Francisco, USA

* Bali Pulendran, Emory University, USA

Jodi Gullicksrud, University of Iowa, USA
TCF1 Long Isoforms are Critical for Secondary Tfh Responses

Tobias Boettler, University Hospital Freiburg, Germany
Follicular T Helper Cell Signatures on Virus-Specific CD4 T Cells during Acute and Chronic HCV Infection

Nicolas Riteau, NIAID, National Institutes of Health, USA
Dual Roles for Myd88 and Type I Interferon in Adjuvant Induced Tfh Polarization

Colin Havenar-Daughton, La Jolla Institute of Allergy and Immunology, USA
Longitudinal Analysis of Tfh and Germinal Center B Cells by Lymph Node Fine Needle Aspirates (FNA) after HIV Envelop Trimer Immunizations

Laura Garcia Ibanez, University of Birmingham, UK
The CCL19/CCL21 Axis Regulates Memory B Cell Appearance and Migration

Yang Yang, Stanford University School of Medicine, USA
Expression of CTLA4 in B-1 Cells Plays a Key Role in Regulating B Cell Homeostasis

Kristen Valentine, University of California, Merced, USA
Dysregulated CD8 T Cells Resemble Tfh-like Cells and Promote B Cell Activation during Autoimmunity

Faith I. Uwadiae, Imperial College London, UK
Chronic Exposure to Inhaled Allergen Results in Sustained T Follicular Helper Cell Generation in Both the Lungs and Peripheral Lymph Nodes, which Potentially Contributes to Allergic Airway Disease

Mohammad M. Sajadi, University of Maryland School of Medicine, USA
The HIV Env Humoral Response: A Paucity of Epitopes and Antibodies

16:30—17:00
Coffee Available

Regency Foyer Terrace
17:00—19:15
Memory and its Regulation
Meeting has ended...abstracts no longer viewable online.

Regency Main I-III
* Shane Crotty, La Jolla Institute for Allergy and Immunology, USA

Marc K. Jenkins, University of Minnesota Medical School, USA
Insights into CD4+ T Cell Differentiation and Memory from Analysis of Single Cells

Michael G. McHeyzer-Williams, The Scripps Research Institute, USA
Deconstructing B Cell Memory at the Single Cell Level

David M. Tarlinton, Monash University, Australia
Generation of Memory B Cells

Rafi Ahmed, Emory University School of Medicine, USA
Tfh Cell Memory

19:15—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Regency Main I-III
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Regency IV-VI
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Regency IV-VI

WEDNESDAY, MARCH 2

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

BioLegend, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:


Kyowa Kirin Pharmaceutical Research, Inc.


NIAID, Division of AIDS


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI122341-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Phone:+1 970-262-2690

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