Keystone Resort Floorplan

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This meeting took place in 2016


Here are the related meetings in 2017:
New Developments in Our Basic Understanding of Tuberculosis (A5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Tuberculosis Co-Morbidities and Immunopathogenesis (B6)


Organizer(s) Hardy Kornfeld, Sarah M. Fortune and Thomas R. Hawn
February 28—March 3, 2016
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 29, 2015
Abstract Deadline: Dec 1, 2015
Scholarship Deadline: Oct 29, 2015
Discounted Registration Deadline: Jan 5, 2016

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation.

Summary of Meeting:
Tuberculosis remains one of the most significant infectious disease threats to global health despite the availability of effective antimicrobials for more than 50 years. The focus of this Keystone Symposia meeting is on co-morbidities that are major driving factors in the TB pandemic and that may cause informative perturbations of immunity. This symposium explores metabolic disorders, environmental exposures, co-infections, age and genetic variants that influence host-pathogen interactions in TB. Plenary sessions will combine rather than separate topics focused on the host and the pathogen, and perspectives from laboratory and field studies. Speakers are encouraged to challenge existing dogma and offer new paradigms as a basis for more effective approaches to TB prevention and treatment.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, February 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 3 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 4 in order to fully experience the meeting.

SUNDAY, FEBRUARY 28

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, FEBRUARY 29

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Metabolism and Co-Morbidity I
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Eric J. Rubin, Harvard School of Public Health, USA

Gökhan S. Hotamisligil, Harvard University, USA
Immunometabolic Homeostasis and Metaflammation in Health and Disease

Larry S. Schlesinger, Ohio State University, USA
A Convergence of Macrophage Inflammation and Metabolism

Kyu Y. Rhee, Weill Cornell Medical College, USA
Bacterial Metabolism in a Changing Host Environment

Sarah A. Stanley, University of California, Berkeley, USA
An Immune-Metabolic Program Regulated by HIF-1alpha and Nitric Oxide is Required for Control of M. tuberculosis

Noton K. Dutta, Johns Hopkins School of Medicine, USA
Short Talk: Statin Adjunctive Therapy Shortens the Duration of Tuberculosis Treatment in Mice

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:00—14:30
On Own for Lunch

14:30—16:30
Workshop 1: TB Risk Factors

Grays Peak
* Georgiana Purdy, Oregon Health & Sciences University, USA

Abul K. Azad, Ohio State University, USA
Defining the Genetic Basis for Biological Variation Among Donors in Human Macrophage Responses to Mycobacterium Tuberculosis

Anthony Michael Cadena, University of Pittsburgh School of Medicine, USA
Barcoding Mycobacterium Tuberculosis Reveals Local in vivo Infection Dynamics in the Macaque Model of Tuberculosis

Mark Hatherill, University of Cape Town, South Africa
A Phase 2 Randomized Controlled Trial of Safety and Immunogenicity of MVA85A and Selective, Delayed Bacille Calmette-Guerin (BCG) Vaccination in Infants of HIV Infected Mothers

David J. Horne, University of Washington, USA
Human ULK1 Variation and Susceptibility to Latent Tuberculosis Infection

Nuria Martinez, University of Massachusetts Medical School, USA
Impaired Innate Recognition of Mycobacterium tuberculosis by Alveolar Macrophages from Diabetic Mice

Juan I. Moliva, Ohio State University, USA
Age-Associated Oxidation of Innate Immune Proteins in the Lung Mucosa Alters the Host Response to Mycobacterium tuberculosis

Ruijuan Zheng, Tongii University School of Medicine, China
Induction of Notch4 Negatively Regulate the Inflammatory responses to Mycobacterium Tuberculosis Infection

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Genetic Variation: A Different Type of Co-Morbidity?
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Ann M. Ginsberg, Aeras, USA

Thomas R. Hawn, University of Washington, USA
Innate Resistance to Mtb Infection

Igor B. Kramnik, Boston University, USA
Control of Lung Damage and Carcinogenesis in TB: Genes Meet the Microenvironment

Sarah M. Fortune, Harvard School of Public Health, USA
Identifying the Drivers of Genetic Variation in Clinical Isolates of Mycobacterium tuberculosis

Maria Lerm, Linkoping University, Sweden
Short Talk: Epigenetic Reprogramming of Peripheral Blood Mononuclear Cells in BCG-Vaccinated Individuals

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, MARCH 1

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
HIV/TB Co-Morbidity
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Michael Stephen Glickman, Memorial Sloan-Kettering Institute, USA

Robert J. Wilkinson, University of Cape Town, South Africa
Understanding and Intervening in HIV-Associated Tuberculosis

Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA
Time is of the Essence: Lessons from the CAMELIA Trial

Keertan Dheda, University of Cape Town, South Africa
New Insights into the Pathogenesis of Drug-Resistant TB and Implications for Clinical Management

Philana Ling Lin, University of Pittsburgh, USA
Lesion Dynamics in SIV/TB Co-Infection

Elisa Nemes, University of Cape Town, South Africa
Short Talk: Host Correlates of Risk of Bacille Calmette-Guerin (BCG) Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV+ Children Starting Antiretroviral Therapy (ART)

Robert Blomgran, Linköping University, Sweden
Short Talk: HIV Interferes with Mycobacterium Tuberculosis Antigen Presentation in Human Dendritic Cells

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—13:00
Poster Setup

Longs/Quandary Peaks
11:30—12:15
Tips for Writing NIH Grant Applications: Navigating NIH Peer Review

Grays Peak
* Raymond R. Schleef, NIAID, National Institutes of Health, USA

13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:15—14:30
On Own for Lunch

14:30—16:30
Workshop 2: Host-Pathogen Interactions

Grays Peak
* David M. Tobin, Duke University Medical Center, USA

Eusondia Arnett, Ohio State University, USA
Characterization of Virulence-Dependent AIM2 Expression, a PPAR-gamma effector in Human Macrophages During Mycobacterium Infection

Claire Dodd, Ohio State University, USA
Scavenger Receptor CD36 Mediates Uptake of Surfactant Lipids by Human Macrophages and Regulates Intracellular Growth of M. tuberculosis

Jan Philipp Korte, Heinrich-Heine University Düsseldorf, Germany
Trehalose-6-Phosphate Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium Tuberculosis in vitro and in mice

Lenette Lu, Partners HealthCare, USA
Unique Functional Antibody Profiles in Latent and Active Tuberculosis Infection

Amanda J. Martinot, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
“Fat is not Fit”: Targeting Lipid Transport in Drug Discovery for Mycobacterium tuberculosis

Amira Refai, Institut Pasteur de Tunis, Tunisia
Discrepancy Around Biological Functions of Mycobacterium tuberculosis Virulent factor ESAT-6 is due to two Distinct Conformational States of the Protein

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Pediatrics: Is Immaturity a Co-Morbidity?
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Thomas J. Scriba, University of Cape Town, South Africa

Theodore H. Cohen, Yale School of Public Health, USA
Within-host Heterogeneity of M. tuberculosis Infection

Deborah Lewinsohn, Oregon Health & Science University, USA
Pediatric Immunity in TB

Helen McShane, Jenner Institute, UK
Vaccine Immunogenicity and Correlates of Protection in Infants and Adults

Michael Shiloh, University of Texas Southwestern Medical Center, USA
Short Talk: Airway Microfold Cells Translocate Mycobacterium Tuberculosis to Initiate Infection

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, MARCH 2

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Impact of Co-Infections on TB Pathogenesis
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Shabaana Khader, Washington University School of Medicine, USA

Alessandro Sette, La Jolla Institute for Allergy & Immunology, USA
Comprehensive Immunophenotyping and Immunoprofiling of Epitope-Specific Responses.

Subash S. Babu, National Institutes of Health - ICER, India
Modulation of Immune and Inflammatory Responses in Active Pulmonary Tuberculosis by Co-Incidental Helminth Infections

Padmini Salgame, Rutgers University, USA
Helminth/TB Co-Infection: Th2 Cytokines

Maziar Divangahi, McGill University, Canada
Influenza and Tuberculosis

Jannike Blank, Research Center Borstel, Germany
Short Talk: One Episode of Self-resolving Plasmodium yoelii Infection Transiently Exacerbates Chronic Mycobacterium tuberculosis Infection

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks
11:00—14:30
On Own for Lunch

14:30—16:30
Workshop 3: Host-Directed Therapy

Grays Peak
* Alan Sher, NIAID, National Institutes of Health, USA

Anna-Maria Andersson, Linköping University, Sweden
Autophagy Enhances Mycobacterium tuberculosis Replication in Latently and HIV Co-Infected Human Macrophages

Shashank Gupta, Johns Hopkins University, USA
ONTAK, a Recombinant Toxin, as a Host-Directed Therapy for Tuberculosis in the Mouse Model

Stefan Oehlers, Duke University Medical Center, USA
Interception of Host Angiogenic Signaling Limits Mycobacterial Growth

Joseph Edward Qualls, Cincinnati Children's Hospital Medical Center, USA
Macrophage L-citrulline Metabolism Improves Anti-Mycobacterial Host Defense in vivo

Robindra Basu Roy, MRC Unit The Gambia, Gambia
Evaluation of ibuprofen with Novel Whole Blood BCG GFP-luciferase Full Operon Assay

Javeed Ali Shah, University of Washington, USA
TOLLIP Deficiency is Associated with Increased Mycobacterium tuberculosis-specific Anti-Microbial Monocyte Responses and Protection from Pediatric Tuberculosis in South Africa

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:15
Metabolism and Co-Morbidity II
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Blanca I. Restrepo, University of Texas Health Science Center, USA

Megan Murray, Harvard Medical School, USA
Diabetes and Environmental Co-Morbidities with TB

Hazel M. Dockrell, London School Hygiene & Tropical Medicine, UK
Tuberculosis and Diabetes: Learning in TANDEM

Hardy Kornfeld, University of Massachusetts Medical School, USA
Cellular Immunology of TB Susceptibility with Metabolic Co-Morbidities

Satyanarayana Swamy Cheekatla, University of Texas Health N.E., USA
Short Talk: Nk-dc Crosstalk in Diabetes Enhances il-6 Mediated Inflammation during Tuberculosis Infection

Anil Kumar Ojha, Wadsworth Center/University at Albany, USA
Short Talk: Ribosomal Heterogeneity Determines Biofilm Development and Drug Tolerance in Mycobacteria

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, MARCH 3

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:15
Host-Pathogen Interactions
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Priscille Marie Brodin, CIIL Institut Pasteur, France
Small Molecules Targeting Host Against M. tuberculosis

Shabaana Khader, Washington University School of Medicine, USA
Neutrophils in TB: The Good, the Bad and the Ugly

Jeffery S. Cox, University of California, Berkeley, USA
Discrimination of Pathogens from Non-Pathogens by Innate Immune Cells

Joseph Keane, St. James's Hospital and Trinity College Dublin, Ireland
Effects of Cigarette Smoke on the Macrophage-Pathogen Interaction

Jacqueline M. Kimmey, Washington University, USA
Short Talk: Unique Role for ATG5 in PMN-Mediated Immunopathology during M. tuberculosis Infection

Joanne Turner, Ohio State University, USA
Short Talk: A Mouse Model of Age-Associated Tuberculosis Reactivation Positions KLRG1 as a Modulator of Disease Progression

09:20—09:40
Coffee Break

Longs Peak Foyer
11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Host-Directed Therapeutics: Co-Opting Treatment of Co-Morbidities
Meeting has ended...abstracts no longer viewable online. Purchase an Abstract Book from this meeting

Grays Peak
* Anna K. Coussens, Institute of Infectious Disease and Molecular Medicine, South Africa

Amit Singhal, Singapore Immunology Network, Singapore
Intervening Host Immunometabolic Program: Potential for TB HDT

Guy Edward Thwaites, Oxford University Clinical Research Unit, Vietnam
Personalised Adjunctive Anti-Inflammatory Therapy for Tuberculosis

Adrian Martineau, Queen Mary University of London, UK
Vitamin D and Phenylbutyrate as Potential Host-Directed Therapies

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Grays Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Longs/Quandary Peaks
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Longs/Quandary Peaks

FRIDAY, MARCH 4

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI122627-01

Funding for this conference was made possible (in part) by 1 R13 AI 122627 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676