Eldorado Hotel & Spa Floorplan

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This meeting took place in 2016



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Cellular Stress Responses and Infectious Agents (S4)


Organizer(s) Margo A. Brinton, Sandra K. Weller and Beth Levine
December 4—8, 2016
Eldorado Hotel & Spa • Santa Fe, New Mexico USA
Discounted Abstract Deadline: Aug 4, 2016
Abstract Deadline: Sep 12, 2016
Scholarship Deadline: Aug 4, 2016
Discounted Registration Deadline: Oct 4, 2016

Supported by the Directors' Fund

Summary of Meeting:
This conference will bring together cell biologists studying various cellular stress responses and researchers interested in how various infectious agents activate and manipulate host cellular stress responses. Examples of cellular stress responses activated by infectious agents are: the stress granule response, the unfolded protein response, the DNA damage response, responses to oxidative stress and metabolic stress, autophagy, and other protein quality control responses. Many of these cellular homeostatic mechanisms function as part of innate and intrinsic defense mechanisms to counteract infections. Various infectious agents have evolved to subvert and manipulate many of these anti-pathogen mechanisms by utilizing, evading or inactivating components of these cellular pathways. The study of interactions between infectious agents and these pathways provides new insights about cellular stress responses and identifies new targets for the development of novel therapies for the treatment of infectious diseases.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, December 4 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, December 8 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, December 9 in order to fully experience the meeting.

SUNDAY, DECEMBER 4

16:00—20:00
Arrival and Registration

Eldorado Lounge
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Eldorado Lounge

MONDAY, DECEMBER 5

07:30—08:30
Breakfast

Anasazi Ballroom
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Eldorado B
* Margo A. Brinton, Georgia State University, USA

* Beth Levine, University of Texas Southwestern Medical Center, USA

David Ron, University of Cambridge, UK
Protein-Folding Homeostasis in the Endoplasmic Reticulum – Some Lessons from Microbes

09:30—12:00
Unfolded Protein Response
Meeting has ended...abstracts no longer viewable online.

Eldorado B
* Beth Levine, University of Texas Southwestern Medical Center, USA

Rockland Luke Wiseman, The Scripps Research Institute, USA
Regulating Secretory Proteostasis through the Unfolded Protein Response

Coffee Break

Timothy A.J. Haystead, Duke University, USA
Hsp90 Promotes HIV and Chikungunya Virus Replication, Hsp90 Inhibitors are Antiviral

Claudio Soto, University of Texas Medical School at Houston, USA
The Unfolded Protein Response after Prion Infection

Timothy E. Audas, Simon Fraser University, Canada
Short Talk: Adaptation to Stressors by Systemic Protein Amyloidogenesis

Ross Buchan, University of Arizona, USA
Short Talk: Endocytosis is a Key Regulator of TDP-43 Aggregation, Toxicity and Turnover

12:00—14:30
On Own for Lunch

12:00—13:00
Poster Setup

Anasazi Ballroom
13:00—22:00
Poster Viewing

Anasazi Ballroom
14:30—16:30
Workshop 1: Unfolded Protein Response and ER Stress

Eldorado B
* Timothy A.J. Haystead, Duke University, USA

Mitali Adlakha, University of Connecticut Health Center, USA
HSV-1 Immediate Early Proteins ICP0 and ICP22 Manipulate the Cellular Protein Homeostatic Machinery

Vikas Anathy, University of Vermont, USA
Activation of UPR Transducer ATF6alpha and Increases in PDIA3 is Required for Influenza Propagation and Development of Lung Pathology

Ben P. Johnston, Dalhousie University, Canada
KSHV Modulates the IRE1-XBP1 Axis of the Unfolded Protein Response during Lytic Replication

Kimberly Kline, Nanyang Technological University, Singapore
Streptolysin-Induced Endoplasmic Reticulum Stress Controls in vivo Biofilm Formation by Group A Streptococcus

Charles Grose, University of Iowa, USA
Cellular Stress, Autophagosomes, Amphisomes and Virus Trafficking during Varicella Infection

Abagail Rosen, University of Virginia, USA
A Novel, IRE1-Dependent Role for Sigma-1 Receptor in Control of Inflammatory Cytokine Production

16:30—17:00
Coffee Available

Concourse
17:00—19:00
Stress Granule Response, Modulation of Translation and Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Eldorado B
* Margo A. Brinton, Georgia State University, USA

Paul J. Anderson, Harvard Medical School, USA
Stress Granules: RNA-centric Signaling Hubs

Richard E. Lloyd, Baylor College of Medicine, USA
Cross-Talk between RNA Granules and Innate Immunity

Craig McCormick, Dalhousie University, Canada
Control of Protein Synthesis in Influenza Virus-Infected Cells

Mena Abdel-Nour, University of Toronto, Canada
Short Talk: The eIF2 alpha Kinase HRI Senses Protein Aggregation and Facilitates Signaling of Cytosolic Innate Immune Receptors

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
19:30—22:00
Poster Session 1

Anasazi Ballroom

TUESDAY, DECEMBER 6

07:30—08:30
Breakfast

Anasazi Ballroom
08:30—11:45
Regulation of Stress Responses
Meeting has ended...abstracts no longer viewable online.

Eldorado B
* James C. Alwine, University of Pennsylvania School of Medicine, USA

Carolyn-Ann Robinson, Dalhousie University, Canada
Activation of LXRalpha Inhibits Kaposi’s Sarcoma-Associated Herpesvirus Replication

Carmen Rivas, Centro Nacional de Biotecnología, Spain
Regulation of Stress Responses by SUMOylation

Coffee Break

Robert H. Silverman, Cleveland Clinic Foundation, USA
The Role of 2’,5’-Oligoadenylate Synthetases in Cellular Responses to Stress

Peter D. Nagy, University of Kentucky, USA
A Small Plant Virus Co-opts Heat Shock Protein and the Actin Cytoskeleton and Rewires Glycolytic Pathway during Infection

Walid A. Houry, University of Toronto, Canada
Short Talk: Systematic Characterization of the Chaperone Networks Required for Cellular Protein Homeostasis

Sebastian Aguirre, Mount Sinai School of Medicine, USA
Short Talk: The DNA Sensor cGAS Detects Dengue Virus Infection Collateral Damage

11:45—14:30
On Own for Lunch

11:45—13:00
Poster Setup

Anasazi Ballroom
13:00—22:00
Poster Viewing

Anasazi Ballroom
14:30—16:30
Workshop 2: RNA Granules and Regulation of Translation

Eldorado B
* Paul J. Anderson, Harvard Medical School, USA

Wei-Chih Tsai, Baylor College of Medicine, USA
Arginine Demethylation of G3BP1 Promotes Stress Granules Assembly

Bruce W. Banfield, Queen's University, Canada
Herpes Simplex Virus Type 2 Promotes Stress Granule Disassembly Via the Endoribonuclease Activity of Virion Host Shutoff Protein

Jason Mackenzie, University of Melbourne, Australia
Norovirus Translation: Control at the Stress Granule-PKR-p-elf2alpha Axis

Huib Rabouw, Utrecht University, Netherlands
Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

Ji-Young Youn, Lunefeld Tanenbaum Research Institute, Canada
Identification of Novel Protein Components of Stress Granules and Processing Bodies using BioID Approach

Alessia Ruggieri, University of Heidelberg, Germany
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

16:30—17:00
Coffee Available

Concourse
17:00—19:00
Infectious Agents and Oxidative Stress
Meeting has ended...abstracts no longer viewable online.

Eldorado B
* Robert H. Silverman, Cleveland Clinic Foundation, USA

Sandra K. Weller, University of Connecticut School of Medicine, USA
Herpes Simplex Virus Manipulates Cellular Oxidative Stress Responses to Promote Lytic Infection

Christopher F. Basler, Georgia State University, USA
Marburg Virus VP24 Protein Interacts with Keap1 to Engage the Antioxidant Response Pathway

Margo A. Brinton, Georgia State University, USA
Resistance of Flavivirus-infected Cells to Arsenite-induced Stress Granule Formation is Mediated by Activation of the Cell Antioxidant Pathway.

Eric Skaar, Vanderbilt University, USA
Short Talk: Dietary Manganese Supplementation Influences the Oxidative Stress Response to Staphylococcus Aureus during Infection of the Heart

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
19:30—22:00
Poster Session 2

Anasazi Ballroom

WEDNESDAY, DECEMBER 7

07:30—08:30
Breakfast

Anasazi Ballroom
08:30—11:45
Autophagy and Host Defense Against Infectious Agents
Meeting has ended...abstracts no longer viewable online.

Eldorado B
* Sara R. Cherry, University of Pennsylvania School of Medicine, USA

Beth Levine, University of Texas Southwestern Medical Center, USA
Conserved Mechanisms for Autophagic Removal of Mitochondria and Microbes

Herbert (Skip) W. Virgin, Washington University School of Medicine, USA
Regulation of Tissue Inflammation by Autophagy Genes through Multiple Mechanisms

Coffee Break

Felix Randow, MRC Laboratory of Molecular Biology, UK
How Autophagy Defends the Cytosol Against Bacterial Invasion

Jae U. Jung, Keck School of Medicine of USC, USA
Viral Manipulation of Autophagy for Viral Lifecycle

Chiara Calabrese, University of Cologne, Germany
Short Talk: Salmonella Typhimurium Disrupts Sirt1/AMPK Signaling Network to Impair Autophagy

Elena Muscolino, Heinrich Pette Institute, Germany
Short Talk: Murine Cytomegalovirus Recruits the Retromer Complex to Promote NEMO Degradation by Autophagy

11:45—14:30
On Own for Lunch

11:45—13:00
Poster Setup

Anasazi Ballroom
13:00—22:00
Poster Viewing

Anasazi Ballroom
14:30—16:30
Workshop 3: Autophagy, Regulation of Stress and Metabolic Stress

Eldorado B
* Herbert (Skip) W. Virgin, Washington University School of Medicine, USA

Jennifer Corcoran, Dalhousie University, Canada
Viral Control of Autophagy to Reprogram the Host Cell Secretome

Alexandra Boeske, Forschungszentrum Jülich, Germany
GABARAPs Mediate Anterograde Transport and Secretion of HIV-1 Nef via Mechanisms Related to Unconventional Protein Secretion

Nazira El-Hage, Florida International University, USA
Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood–Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in vitro

Elizabeth Figueroa-Juárez, Instituto Nacional de Ciencias Médicas y Nutrición, S.Z., Mexico
Renal Endoplasmic Reticulum Stress and its Modulation by Resveratrol

Julien Moretti, Mount Sinai School of Medicine, USA
Vita-PAMP Sensing by STING Orchestrates Stress-Induced ER-phagy Apical to a Type-I Interferon Response

Jessica Tsalikis, University of Toronto, Canada
The Role of U snRNA Maturation and mRNA Splicing Regulation in Response to Metabolic Stress and Bacterial Infection

Teresa S. Wiley, Wiley Systems, Inc, USA
Autophagy Pathways and the Effects of Steroid Hormones

Angela M. Phillips, Massachusetts Institute of Technology, USA
Host Proteostasis Network-Mediated Modulation of Influenza Evolution

16:30—17:00
Coffee Available

Concourse
17:00—19:00
Intracellular Infectious Agents and Metabolic Stress
Meeting has ended...abstracts no longer viewable online.

Eldorado B
* Craig McCormick, Dalhousie University, Canada

Joshua C. Munger, University of Rochester Medical Center, USA
Harnessing Small Molecule Stress Pathways to Support Viral Infection

Stephen E. Girardin, University of Toronto, Canada
A Cytosolic Unfolded Protein Response Controls Innate Immune Signaling

James C. Alwine, University of Pennsylvania School of Medicine, USA
The Masterful Manipulation of Host Cell Stress Responses, Signaling and Metabolism by Human Cytomegalovirus

Andrew Timmons, Johns Hopkins Hospital, USA
Short Talk: Small Molecule Inhibition of Intrinsic Stress Pathways Substantially Reduces HIV Transcription upon T Cell Activation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
19:30—22:00
Poster Session 3

Anasazi Ballroom

THURSDAY, DECEMBER 8

07:30—08:30
Breakfast

Anasazi Ballroom
08:30—11:45
Integrated Stress Responses and Infectious Agents
Meeting has ended...abstracts no longer viewable online.

Eldorado B
Sara R. Cherry, University of Pennsylvania School of Medicine, USA
Systems Approaches to Study Antiviral Immunity

George A. Belov, University of Maryland, USA
Membrane Metabolism of Picornavirus-Infected Cells: A Little Virus Makes A Big Mess

Coffee Break

Denise A. Galloway, Fred Hutchinson Cancer Research Center, USA
Human Papillomaviruses dampen the Response to DNA Damage

* Ralph Isberg, Tufts University School of Medicine, USA
Bacterial Community Behavior in Deep Tissue Sites during Microbial Disease

Scott Espenschied, Duke University, USA
Short Talk: In vivo Analysis of Intestinal Epithelial Damage Responses in a Zebrafish Model of NSAID-Induced Enteropathy

Adam R. Renslo, University of California, San Francisco, USA
Short Talk: Discovery and Optimization of Small Molecule Antagonists of the Integrated Stress Response

11:45—14:30
On Own for Lunch

14:30—16:30
Workshop 4: Integrated Stress Responses and the DNA Damage Response

Eldorado B
* Denise A. Galloway, Fred Hutchinson Cancer Research Center, USA

Wolfram Brune, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Germany
Activation and Inhibition of Caspase-2 by Human Cytomegalovirus

Christopher Fisher, University of Florida College of Medicine, USA
HSV-1 Infection Activates ATR and Chk1, Mislocalizes the Phosphorylated Proteins, and Utilizes their Activity to Promote Viral Replication

Terri Edwards, University of Florida, USA
Rebound of Human Papillomavirus (Hpv) Dna Episomes Following Antiviral Treatment Shares Fundamental Features with Genome Amplification During the HPV Life Cycle

Priya Luthra, Georgia State University, USA
The Crosstalk Between DNA Damage and Innate Immune Responses Circumvents Ebola Virus Immune Evasion Mechanisms

Michael P. Sheetz, Columbia University, USA
DNA Damage Causes Rapid Accumulation of Phosphoinositides to Recruit ATR but not ATM

Rong Tan, University of Pittsburgh, USA
Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1

Alexander Zaika, Vanderbilt University Medical Center, USA
Bacterial Pathogen Helicobacter Pylori Modulates Cellular Responses to DNA Damage and Oncogenic Stress by Inducing Degradation of p53 Protein and Altering Expression of p53 Isoforms

16:30—17:00
Coffee Available

Concourse
17:00—18:45
Infectious Agents and the DNA Damage Response
Meeting has ended...abstracts no longer viewable online.

Eldorado B
* Sandra K. Weller, University of Connecticut School of Medicine, USA

Matthew D. Weitzman, Children's Hospital of Philadelphia, USA
DNA Damage Responses to DNA Virus Infection

Richard I. Morimoto, Northwestern University, USA
Regulation of the Heat Shock Response and Proteostasis Networks

Hugues de Thé, Hopital St. Louis, France
In vivo Sumoylation Control by PML Nuclear Bodies under Oxidative Stress

18:45—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Eldorado B
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Anasazi Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Anasazi Ballroom

FRIDAY, DECEMBER 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI126782-01

Funding for this conference was made possible [in part] by 1R13AI126782-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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Phone:+1 970-262-2676