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This meeting took place in 2016


Here are the related meetings in 2017:
Microbiome in Health and Disease (J8)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Gut Microbiota, Metabolic Disorders and Beyond (D4)


Organizer(s) Rémy G. Burcelin, Sven Pettersson and Tak W. Mak
April 17—21, 2016
Hyatt Regency Newport • Newport, Rhode Island USA
Discounted Abstract Deadline: Dec 17, 2015
Abstract Deadline: Jan 20, 2016
Scholarship Deadline: Dec 17, 2015
Discounted Registration Deadline: Feb 17, 2016

Sponsored by Curemark LLC, Nestlé Institute of Health Sciences and Novartis Institutes for BioMedical Research

Summary of Meeting:
The hologenome theory of evolution proposes that natural selection acts not on the individual organism but rather on the “holobiont,” which consists of the organism together with microbiome (its genes and metabolites). When a holobiont is challenged by dramatic changes, such as altered diet or reduced physical activity, it employs adaptive mechanisms in the form of reshuffling its microbiome (resident microbial communities), but the underlying mechanisms of this molecular crosstalk remain to be determined. Effective study of the holobiont requires a systems biology approach: remove one component of the holobiont to study it in reductionist style and other parts also altered will be overlooked. Decades of reductionist research aimed at understanding the mechanisms responsible for the current dramatic epidemic of man-made metabolic diseases have not considered the holobiont perspective and have consequently missed the adaptation strategies of the microbiome but have set the stage to explore the inchoate holobiont perspective. Application of a systems biology approach to decipher molecular mechanisms underlying man-made metabolic diseases presents a unique opportunity to develop novel therapies that sustain health in a personalized manner. This meeting will discuss how the gut microbiome and its metabolites influence major molecular and physiological mechanisms responsible for man-made metabolic diseases. It will therefore incorporate investigators from diverse areas such as medicine, immunology, neurobiology, endocrinology, physiology, psychiatry, systems biology and microbiology. In addition, the nutritional, surgical and pharmacological aspects of innovative therapeutic strategies will be discussed in dialogue with scientists from pharmaceutical/nutritional companies. The gut microbiome is a neuroendocrine and antigenic organ whose rediscovery is necessary for our understanding of man-made metabolic diseases in the context of the holobiont.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 21 with a closing plenary session and keynote address from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 22 in order to fully experience the meeting.

SUNDAY, APRIL 17

16:00—20:00
Arrival and Registration

Ballroom Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Foyer

MONDAY, APRIL 18

07:30—08:30
Breakfast

Rose Island
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Sven Pettersson, Karolinska Institutet, Sweden

Jeremy K. Nicholson, Imperial College London, UK
Towards Personalized Medicine and Microbiome Regulation

09:30—12:00
Gut Microbiota Biology, Microbiome and Evolution throughout Metabolic Diseases
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Rémy G. Burcelin, Institute of Molecular Medicine, France

* Matteo Serino, INSERM, France

Francois-Pierre Martin, Nestlé Institute of Health Sciences, Switzerland
The Human GI Tract and its Microbiome: From Associations to Interactions

Stephan C. Schuster, Nanyang Technological University, Singapore
Holobiont Concept and Tissue Compartment and Microbiome

Michael A. Fischbach, University of California, San Francisco, USA
Small Molecules from the Human Microbiota

Filipe De Vadder, University of Gothenburg, Sweden
Short Talk: The Gut Microbiota Induces Adult Neurogenesis in the Enteric Nervous System

Carmen A.K. Emborski, Texas Tech University, USA
Short Talk: Evidence for Metabolic Inheritance via Microbial Transfer

10:10—10:30
Coffee Break

Ballroom Foyer
12:00—14:30
On Own for Lunch

12:00—13:00
Poster Setup

Brenton Hall
13:00—22:00
Poster Viewing

Brenton Hall
14:30—16:30
Workshop 1: Microbiota-Related Biomarkers

Grand Ballroom
* Jeremy K. Nicholson, Imperial College London, UK

* Sven Pettersson, Karolinska Institutet, Sweden

Shirong Liu, Brigham and Women's Hospital/Harvard Medical School, USA
Fecal microRNAs Shape Gut Microbiota

Bailey Peck, University of North Carolina at Chapel Hill, USA
Gut Microbiota Responsive miR-375 Regulates Intestinal Epithelial Stem Cell Proliferation

Cheng-Yuan Kao, National Health Research Institutes, Taiwan
A Multi-Omics Study Reveals Insights in Gut Microbiota and Mucosal Immunity in Obesity Resistance

Sangeeta Khare, National Center for Toxicological Research-US-FDA, USA
Evaluation of the Silver Nanoparticles on Gut Virus/Phages and its Outcome on the Expression of Genes Involved in the Innate Antiviral Immune Response in Gut

Ara Koh, Gothenburg University, Sweden
Microbiota-Mediated Intestinal Cell Fate Decision Occurs Primarily in Jejunum – Use of Intestinal Organoids

Kimberly A. Krautkramer, University of Wisconsin, USA
Gut Microbiota Affect Host Epigenetic State

16:30—17:00
Coffee Available

Ballroom Foyer
17:00—19:00
Tissue Communication
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Michael A. Fischbach, University of California, San Francisco, USA

* Francois-Pierre Martin, Nestlé Institute of Health Sciences, Switzerland

James Versalovic, Texas Children's Hospital, USA
Gut Microbiome and Amino Acid Metabolism

Ruth E. Ley, Max Planck Institute for Developmental Biology, Germany
Host Genetic Regulation of the Microbiome with Consequences for Phenotype

David A. Relman, Stanford University, USA
Open Wide: Oral Microbiota in Health and Disease

Kairui Mao, NIAID, National Institute of Health, USA
Short Talk: Direct Visualization of Signaling Crosstalk Between the Microbiota and Immune System

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Brenton Hall
19:30—22:00
Poster Session 1

Brenton Hall

TUESDAY, APRIL 19

07:30—08:30
Breakfast

Rose Island
08:00—08:30
Poster Setup

Brenton Hall
08:30—17:00
Poster Viewing

Brenton Hall
08:30—11:45
Early Development – Maternal Life, Brain and Metabolic Development
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Ruth E. Ley, Max Planck Institute for Developmental Biology, Germany

* Stephan C. Schuster, Nanyang Technological University, Singapore

Kjersti Marie Aagaard, Baylor College of Medicine, USA
Unexpected Beginnings: Role of Pregnancy and Parturition in Establishing our Microbiome

Bernard Thorens, University of Lausanne, Switzerland
Glucose Signaling: Is There a Room for Microbiota?

Berengere Coupe, Vaiomer, France
Tissue Microbiota-Derived Therapeutic Strategies in Metabolic Disease

Martin J. Blaser, New York University School of Medicine, USA
Early Life Microbiota Development affects Long-Term Metabolic and Immunologic Consequences

Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Short Talk: Maternal Transplantation of High-Fat Diet/Obesity Shaped Gut Microbiota Affects Offspring Cognitive and Emotional Behavior in a Sex-Specific Manner

Taylor Kristina Soderborg, University of Colorado Denver, USA
Short Talk: Maternal Obesity and Gestational Diabetes Alters 2 Week Human Infant Microbiome and Drives Metabolic Processes in Germ-Free Mice

09:50—10:10
Coffee Break

Ballroom Foyer
11:45—12:30
Lunch

Brenton Hall
12:00—14:30
Poster Session 2

Brenton Hall
14:30—16:30
Workshop 2: Novel Mechanisms of Microbiota Regulated Metabolic Functions

Grand Ballroom
* Martin J. Blaser, New York University School of Medicine, USA

* Rémy G. Burcelin, Institute of Molecular Medicine, France

Paola Tognini, University of California, Irvine, USA
Intestinal Microbiota Influences Circadian Clock Function and Homeostasis in the Liver upon Food Stress

Suzanne Devkota, Cedars-Sinai Medical Center, USA
Feast or Famine: Sustained Reshaping of the Gut Microbiota in Response to Fasting and Re-Feeding

Mukul Prasad, National University of Singapore, Singapore
T-Cell Specific Signaling Molecule Themis in Development of Metabolic Disorder

Shiho Fujisaka, Joslin Diabetes Center and Harvard Medical School, USA
Antibiotic Effects on Gut Microbiota, Insulin Signaling and Bile Acid Metabolism is Dependent on Host Genetic Background

Edina Hot, European Institute of Oncology, Italy
Effects of Concurrent Administration of OCA and MCD Diet on NASH and Gut Vascular Barrier Permeability in Mice

Sean Davies, Vanderbilt University, USA
Inhibiting Obesity with Engineered Therapeutic Bacteria

Hasinika Gamage, Macquarie University, Australia
Fibre Products Derived from Sugarcane, Wheat Dextrin and Psyllium Husk Influence the Gut Microbiota in vitro

Diana E. Roopchand, Rutgers University, USA
Gut Microbiota: A Missing Link for the Bioactivity of Dietary Polyphenols

16:30—17:00
Coffee Available

Ballroom Foyer
17:00—19:15
Therapeutic Strategies
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Filipe De Vadder, University of Gothenburg, Sweden

* Charles R. Mackay, Monash University, Australia

Max Nieuwdorp, Academic Medical Center, University of Amsterdam, Netherlands
Fecal Transplantation – Ongoing Trials Pros and Cons

Filipe J. Gomes Cabreiro, University College London, UK
Host-Microbial Metabolic Complementation Modulates the Effects of Fluoropyrimidines in C. elegans Survival and Longevity

Elaine Holmes, Imperial College London, UK
Bariatric Surgery and Microbial Metabolites

Hao Wu, University of Gothenburg, Sweden
Short Talk: Insights into Metformin-Microbiota Interactions in Treatment of T2D: A Placebo-Controlled, Double-Blinded, and Treatment-Naïve Study

Emma D'Agostino, University of North Carolina at Chapel Hill, USA
Short Talk: The Human GI Microbial GUSome, a Constellation of Drug Targets in the Microbiome

19:15
On Own for Dinner


WEDNESDAY, APRIL 20

07:30—08:30
Breakfast

Rose Island
08:30—11:45
Small Intestine Liver Function, Bile Acids, Therapy
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Max Nieuwdorp, Academic Medical Center, University of Amsterdam, Netherlands

* Elaine Holmes, Imperial College London, UK

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Circadian Regulation of Intestinal Host-Microbe Interactions

Lotta Stenman, DuPont Nutrition and Health, Finland
Therapeutic Efficacy and Mechanisms of Probiotics and Prebiotics in Metabolic Disease

Fredrik Bäckhed, University of Gothenburg, Sweden
Gut Microbial Regulation of Bile Acids and FXR Signaling in Metabolic Disease

Paolo Sassone-Corsi, University of California, Irvine, USA
Molecular Mechanisms Linking the Gut Microbiota to the Circadian Clock

Kristien Bouter†, University of Amsterdam, Academic Medical Center, Netherlands
Short Talk: Oral Butyrate Treatment has Differential Effects on Insulin Sensitivity in Healthy Versus Metabolic Syndrome Subjects

Youngji (Helen) Cho, Harvard University, USA
Short Talk: Bile Acid Metabolism, Gut Microbiota, and Pulmonary Responses to Ozone

09:50—10:10
Coffee Break

Ballroom Foyer
11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Brenton Hall
13:00—22:00
Poster Viewing

Brenton Hall
16:30—17:00
Coffee Available

Ballroom Foyer
17:00—19:15
Immunity and Metabolism
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Filipe J. Gomes Cabreiro, University College London, UK

Gérard Eberl, Institut Pasteur, France
The Regulation of Type 2 and Type 3 Immunity by Microbiota

* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Low Grade Inflammation and Impact on Metabolic Circuits

Rémy G. Burcelin, Institute of Molecular Medicine, France
Gut Microbiota-impaired Intestinal Immune Defense and Diabetes

Maayan Levy, Weizmann Institute of Science, Israel
Short Talk: Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

Chrysothemis Brown, Kings College London, UK
Short Talk: Retinoic Acid: A Metabolic Checkpoint during CD4+ T Cell Differentiation

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Brenton Hall
19:30—22:00
Poster Session 3

Brenton Hall

THURSDAY, APRIL 21

07:30—08:30
Breakfast

Rose Island
08:30—11:45
Fat Muscle Function, Therapeutic Aging, Immunity
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Lora V. Hooper, University of Texas Southwestern Medical Center, USA

* Paolo Sassone-Corsi, University of California, Irvine, USA

Diane J. Mathis, Harvard Medical School, USA
Diabetes-Protective HLA/MHC Alleles Operate via the Microbiota

Jorge L. Ruas, Karolinska Institutet, Sweden
Skeletal Muscle Kynurenine Metabolism in Metabolic and Psychiatric Diseases

Charles R. Mackay, Monash University, Australia
Diet, Bacterial Metabolites and "Western Lifestyle" Inflammatory Diseases

José Manuel Fernández-Real, Biomedical Research Institute of Girona - IDIBGI, Spain
Iron, Microbiota and NASH

Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Short Talk: Muscle Wasting Protection Mediated by Microbiome E. coli Involves Inflammasome and IGF-1 Signaling

John Kirby, University of Iowa, USA
Short Talk: Risperidone Treatment Alters Bacteria and Phage Populations in the Gut to Suppress Metabolic Rates Leading to Weight Gain

09:50—10:10
Coffee Break

Ballroom Foyer
11:45—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Foyer
17:00—18:00
Gut Immunity, Barrier Function and Effects on Metabolism
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Diane J. Mathis, Harvard Medical School, USA

* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada

Dan R. Littman, HHMI/New York University School of Medicine, USA
The Gut Microbiota to Immune System Molecular Crosstalk

Sven Pettersson, Karolinska Institutet, Sweden
Bidirectional Communication Pathways between the Gut Microbiome and its Host Influencing Host Physiology in an Age-Dependent Manner

18:00—18:45
Closing Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grand Ballroom
* Dan R. Littman, HHMI/New York University School of Medicine, USA

Lewis C. Cantley, Weill Cornell Medicine, USA
Gut Microbiota Biology, Microbiome and Evolution throughout Metabolic Diseases

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Grand Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Brenton Hall
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Brenton Hall

FRIDAY, APRIL 22

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Curemark LLC Nestlé Institute of Health Sciences
Novartis Institutes for BioMedical Research
 

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

ACS Sensors Research Diets, Inc.
Seres Therapeutics
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK108621-01

Funding for this conference was made possible (in part) by 1 R13 DK108621-01 from NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



DuPont Nutrition and Health


Nestlé Institute of Health Sciences


Vaiomer


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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