The Westin Miyako Kyoto Floorplan
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This meeting took place in 2015
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Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies (T2)
Organizer(s) Takashi Kadowaki, Juleen R. Zierath, Nobuya Inagaki and Barbara B. Kahn
October 25—29, 2015
The Westin Miyako Kyoto • Kyoto, Japan
Discounted Abstract Deadline: Jun 25, 2015
Abstract Deadline: Jul 23, 2015
Scholarship Deadline: Jun 25, 2015
Discounted Registration Deadline: Aug 25, 2015
Lead Sponsor: Takeda Pharmaceutical Company Ltd. Other Sponsors: Astellas Pharma Inc., Journal of Molecular Cell Biology (JMCB), Novo Nordisk A/S and Sanofi-Aventis Deutschland GmbH
Summary of Meeting:
The prevalence of type 2 diabetes is rising to epidemic proportions worldwide. Type 2 diabetes is a complex disease caused by dysfunction of multiple organ systems, and disease susceptibility is profoundly influenced by both genetic and environmental factors. It is essential to bring leading professionals in the academic and pharmaceutical communities together with various specialties in diabetes research to share new approaches and research paradigms. The meeting will present the latest discoveries in diabetes research, highlighting essential aspects of diabetes, as well as emerging themes that are likely to provide novel therapeutic approaches. The major topics of the meetings are: Islet Dysfunction; Gut Biology and Systemic Metabolism; CNS Control of Metabolism; Adipocyte Biology; Insulin Resistance; Genetics and Epigenetics; Diabetes and Healthy Lifespan and Regenerative Medicine. The ultimate goal for the meeting is to provide a forum that encourages attendees to communicate and exchange ideas to facilitate an integrative understanding of pathogenesis and development of therapeutic strategies for prevention and treatment of diabetes.
View Scholarships/Awards
The prevalence of type 2 diabetes is rising to epidemic proportions worldwide. Type 2 diabetes is a complex disease caused by dysfunction of multiple organ systems, and disease susceptibility is profoundly influenced by both genetic and environmental factors. It is essential to bring leading professionals in the academic and pharmaceutical communities together with various specialties in diabetes research to share new approaches and research paradigms. The meeting will present the latest discoveries in diabetes research, highlighting essential aspects of diabetes, as well as emerging themes that are likely to provide novel therapeutic approaches. The major topics of the meetings are: Islet Dysfunction; Gut Biology and Systemic Metabolism; CNS Control of Metabolism; Adipocyte Biology; Insulin Resistance; Genetics and Epigenetics; Diabetes and Healthy Lifespan and Regenerative Medicine. The ultimate goal for the meeting is to provide a forum that encourages attendees to communicate and exchange ideas to facilitate an integrative understanding of pathogenesis and development of therapeutic strategies for prevention and treatment of diabetes.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, October 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, October 29 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, October 30 in order to fully experience the meeting.
SUNDAY, OCTOBER 25
MONDAY, OCTOBER 26
TUESDAY, OCTOBER 27
WEDNESDAY, OCTOBER 28
THURSDAY, OCTOBER 29
FRIDAY, OCTOBER 30
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, October 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, October 29 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, October 30 in order to fully experience the meeting.
SUNDAY, OCTOBER 25
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—08:40
Welcome Remarks
Meeting has ended...abstracts no longer viewable online.
Takashi Kadowaki,
University of Tokyo, Japan
08:40—11:30
Islet Dysfunction in Diabetes
Meeting has ended...abstracts no longer viewable online.
*
Domenico Accili,
Columbia University, USA
Roland W. Stein,
Vanderbilt University Medical Center, USA
Identification and Characterization of Transcriptional Coregulators of MafA and Pdx1
Identification and Characterization of Transcriptional Coregulators of MafA and Pdx1
Nobuya Inagaki,
Kyoto University Graduate School of Medicine, Japan
Non-Invasive Pancreatic Beta-Cell Imaging Using Radiolabeled Exendin Probe
Non-Invasive Pancreatic Beta-Cell Imaging Using Radiolabeled Exendin Probe
Nadeeja T. Wijesekara,
University of Toronto, Canada
Short Talk: Amyloid beta Induced Insulin Resistance Leads to Diabetes and Severe Neurodegeneration in Transgenic Mice
Short Talk: Amyloid beta Induced Insulin Resistance Leads to Diabetes and Severe Neurodegeneration in Transgenic Mice
Andrew Parker,
GeNeuro SA, Switzerland
Short Talk: Human Endogenous Retrovirus Type W Is Strongly Upregulated in T1D Pancreas and Dysregulates Insulin Production in vitro and in vivo
Short Talk: Human Endogenous Retrovirus Type W Is Strongly Upregulated in T1D Pancreas and Dysregulates Insulin Production in vitro and in vivo
C.K. Wong,
University of British Columbia, Canada
Short Talk: p300 Regulates Glucose Homeostasis by Maintaining Islet Mass
Short Talk: p300 Regulates Glucose Homeostasis by Maintaining Islet Mass
14:00—16:00
Workshop 1: Islet, Brain and Gut Biology
*
Bei B. Zhang,
Pfizer Inc., USA
*
Hisamitsu Ishihara,
Nihon University School of Medicine, Japan
Yau-Sheng Tsai,
National Cheng Kung University, Taiwan
Egr-1 Deficiency Sensitizes Pancreatic beta-Cells to Palmitate-Induced ER Stress and Apoptosis
Egr-1 Deficiency Sensitizes Pancreatic beta-Cells to Palmitate-Induced ER Stress and Apoptosis
Eitan M. Akirav,
Winthrop University Hospital, USA
Demethylating Cytosine Analogs Reverse T1D and Improve beta-Cell Function
Demethylating Cytosine Analogs Reverse T1D and Improve beta-Cell Function
Yuichi Tsuchiya,
Nara Institute of Science and Technology, Japan
Physiological Activation of IRE1a Upregulates a Subset of Insulin Folding Enzymes in Pancreatic b Cells
Physiological Activation of IRE1a Upregulates a Subset of Insulin Folding Enzymes in Pancreatic b Cells
Yasuhiko Minokoshi,
National Institute for Physiological Sciences, Japan
AMP-Activated Protein Kinase in CRH Neurons in the PVH Controls Food Selection Behavior
AMP-Activated Protein Kinase in CRH Neurons in the PVH Controls Food Selection Behavior
Hua V. Lin,
Eli Lilly & Co., USA
Stimulation of Insulin and Incretin Secretion by Tryptophan Is Mediated by GPR142
Stimulation of Insulin and Incretin Secretion by Tryptophan Is Mediated by GPR142
Olga Rudenko,
Copenhagen University, Denmark
Agonists for the Aromatic Amino Acid Receptor GPR142 Provides a Broad, Balanced Stimulation of Pancreatic and Gut Hormones Strongly Stimulating Glucose Disposal
Agonists for the Aromatic Amino Acid Receptor GPR142 Provides a Broad, Balanced Stimulation of Pancreatic and Gut Hormones Strongly Stimulating Glucose Disposal
16:15—17:15
Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Nobuya Inagaki,
Kyoto University Graduate School of Medicine, Japan
Shinya Yamanaka,
Center for iPS Cell Research and Application, Kyoto University, Gladstone Institutes, Japan
Recent Progress in iPS Cell Research toward Regenerative Medicine
Recent Progress in iPS Cell Research toward Regenerative Medicine
17:15—19:15
Regenerative Medicine in Diabetes
Meeting has ended...abstracts no longer viewable online.
*
Kohjiro Ueki,
University of Tokyo, Graduate School of Medicine, Japan
Laura C. Alonso,
University of Massachusetts Medical School, USA
Homeostatic Control of beta Cell Proliferation by Insulin Demand via the Unfolded Protein response
Homeostatic Control of beta Cell Proliferation by Insulin Demand via the Unfolded Protein response
*
James M. Wells,
Cincinnati Children's Hospital Research Foundation, USA
Human Pluripotent Stem Cell-derived Tissues as New Models to Study Development, Digestive Diseases and Diabetes
Human Pluripotent Stem Cell-derived Tissues as New Models to Study Development, Digestive Diseases and Diabetes
Noriko Kodani,
Keio University, Japan
Short Talk: Foxo1 CoRepressor (FCoR) Regulates alpha-Cell Mass and Maintain beta-Cell Identity in Cooperation with Foxo1
Short Talk: Foxo1 CoRepressor (FCoR) Regulates alpha-Cell Mass and Maintain beta-Cell Identity in Cooperation with Foxo1
08:30—11:45
CNS Control of Metabolism
Meeting has ended...abstracts no longer viewable online.
*
Yasuhiko Minokoshi,
National Institute for Physiological Sciences, Japan
Jens C. Brüning,
Max Planck Institute for Metabolism Research, Germany
CNS-dependent Control of Metabolism
CNS-dependent Control of Metabolism
*
Joel K. Elmquist,
University of Texas Southwestern Medical Center, USA
SF-1 in the Hypothalamus: A Molecular Link Between Energy Balance Regulation and Exercise
SF-1 in the Hypothalamus: A Molecular Link Between Energy Balance Regulation and Exercise
Michael Krashes,
NIDDK, National Institutes of Health, USA
A neural basis for melanocortin-4 receptor regulated appetite
A neural basis for melanocortin-4 receptor regulated appetite
Scott M. Sternson,
HHMI/Janelia Research Campus, USA
Molecular and Systems Neuroscience of Weight Loss
Molecular and Systems Neuroscience of Weight Loss
Stephanie M. Correa,
University of California, San Francisco, USA
Short Talk: Sex-Specific Metabolic Roles of Estrogen Receptor alpha Signaling in the Mediobasal Hypothalamus
Short Talk: Sex-Specific Metabolic Roles of Estrogen Receptor alpha Signaling in the Mediobasal Hypothalamus
Lotte Bjerre Knudsen,
Novo Nordisk A/S, Denmark
Short Talk: Acylated GLP-1 Receptor Agonists Effectively Lower Body Weight and Directly Access POMC/CART Neurons in the Mouse Hypothalamus
Short Talk: Acylated GLP-1 Receptor Agonists Effectively Lower Body Weight and Directly Access POMC/CART Neurons in the Mouse Hypothalamus
17:00—19:00
Gut Biology and Systemic Metabolism
Meeting has ended...abstracts no longer viewable online.
Nathalie Delzenne,
Université Catholique de Louvain, Belgium
Gut Microbiota as a Tool in the Nutritional Management of Metabolic Disorders and Inflammation.
Gut Microbiota as a Tool in the Nutritional Management of Metabolic Disorders and Inflammation.
*
Yutaka Seino,
Kansai Electric Power Medical Research Institute, Japan
Incretin-Based Therapies for Type 2 Diabetes: Focus on East Asian Perspectives and Hypoglycemia
Incretin-Based Therapies for Type 2 Diabetes: Focus on East Asian Perspectives and Hypoglycemia
*
Daniel J. Drucker,
Lunenfeld-Tanenbaum Research Institute, Canada
Mechanisms of Incretin Action-A Molecular Approach
Mechanisms of Incretin Action-A Molecular Approach
Erina Joo,
Graduate School of Medicine, Kyoto University, Japan
Short Talk: Inhibition of GIP Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Improves Hepatic Steatosis in High Fat Diet-Induced Obesity
Short Talk: Inhibition of GIP Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Improves Hepatic Steatosis in High Fat Diet-Induced Obesity
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Novel Insights into Adipocyte Biology
Meeting has ended...abstracts no longer viewable online.
*
Toshimasa Yamauchi,
University of Tokyo, Japan
*
Bruce M. Spiegelman,
Harvard Medical School, USA
Transcriptional Control of Brown and Beige Fat: Toward a New Generation of Therapeutics
Transcriptional Control of Brown and Beige Fat: Toward a New Generation of Therapeutics
Yu-Hua Tseng,
Joslin Diabetes Center/Harvard Medical School, USA
Functional and Clonal Analyses of Human Brown and White Fat Progenitors
Functional and Clonal Analyses of Human Brown and White Fat Progenitors
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
Diabetes, Obesity and the Central Role of the Adipocyte in Maintaining Systemic Homeostasis
Diabetes, Obesity and the Central Role of the Adipocyte in Maintaining Systemic Homeostasis
Naja Zenius Jespersen,
Rigshospitalet, Denmark
Short Talk: Human Perirenal Fat Display a Location-Dependent Brown Fat Phenotype
Short Talk: Human Perirenal Fat Display a Location-Dependent Brown Fat Phenotype
Mary N. Teruel,
Stanford University, USA
Short Talk: Controlling Low Rates of Adipogenesis through Noise, Ultra-High Feedback and Sensing Circadian Rhythms
Short Talk: Controlling Low Rates of Adipogenesis through Noise, Ultra-High Feedback and Sensing Circadian Rhythms
Yuta Hiraike,
Graduate School of Medicine, University of Tokyo, Japan
Short Talk: NFIA Controls the Brown Fat Gene Program by Co-Localizing with PPARgamma at Cell-Type-Specific Enhancers
Short Talk: NFIA Controls the Brown Fat Gene Program by Co-Localizing with PPARgamma at Cell-Type-Specific Enhancers
Kei Sakamoto,
Nestlé Institute of Health Sciences, Switzerland
Short Talk: Mechanism of Action of Metformin- Insights from an AMP-Insensitive FBP1 Knockin Mouse Model
Short Talk: Mechanism of Action of Metformin- Insights from an AMP-Insensitive FBP1 Knockin Mouse Model
17:00—19:00
Molecular Mechanisms Underlying Insulin Resistance
Meeting has ended...abstracts no longer viewable online.
*
Takashi Kadowaki,
University of Tokyo, Japan
*
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Discovery of a Novel Class of Lipids with Anti-Diabetic and Anti-Inflammatory Effects
Discovery of a Novel Class of Lipids with Anti-Diabetic and Anti-Inflammatory Effects
David E. James,
University of Sydney, Australia
Molecular Mapping of Insulin Action and Insulin Resistance
Molecular Mapping of Insulin Action and Insulin Resistance
Masato Kasuga,
National Center for Global Health and Medicine, Japan
Insulin Signaling Network for Understanding Diabetes
Insulin Signaling Network for Understanding Diabetes
Yun Sok Lee,
University of California, San Diego, USA
Short Talk: Saturated Fatty Acids and Mitochondrial Dysfunction Initiates Inflammation and Insulin Resistance in Obesity
Short Talk: Saturated Fatty Acids and Mitochondrial Dysfunction Initiates Inflammation and Insulin Resistance in Obesity
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Genetics and Epigenetics of Diabetes
Meeting has ended...abstracts no longer viewable online.
*
Masato Kasuga,
National Center for Global Health and Medicine, Japan
Linong Ji,
Peking University People’s Hospital, China
Genetic Study and Management of Diabetes: Asian Perspective
Genetic Study and Management of Diabetes: Asian Perspective
Philippe Froguel,
Imperial College of London, UK
The Genetic Link between Nutrients, the Gut Microbiome and Metabolism
The Genetic Link between Nutrients, the Gut Microbiome and Metabolism
*
Juleen R. Zierath,
Karolinska Institutet, Sweden
Exercise as a Medicine to Improve Insulin Sensitivity in Type 2 Diabetes
Exercise as a Medicine to Improve Insulin Sensitivity in Type 2 Diabetes
Marcelo Nobrega,
University of Chicago, USA
Regulatory Variants and Metabolic Diseases
Regulatory Variants and Metabolic Diseases
Koshi Hashimoto,
Tokyo Medical and Dental University, Japan
Short Talk: DNA Methylation Status in Early Life as an Epigenetic Memory and Its Physiological Significance in Later Life
Short Talk: DNA Methylation Status in Early Life as an Epigenetic Memory and Its Physiological Significance in Later Life
Yurong Xin,
Regeneron Pharmaceuticals, Inc., USA
Short Talk: Single-cell RNA Sequencing of Healthy and Type 2 Diabetes Pancreatic Islet Cells
Short Talk: Single-cell RNA Sequencing of Healthy and Type 2 Diabetes Pancreatic Islet Cells
14:30—16:30
Workshop 2: Insulin Resistance, Healthy Lifespan and Genetics of Diabetes
*
Yu-Hua Tseng,
Joslin Diabetes Center/Harvard Medical School, USA
*
Iichiro Shimomura,
Osaka University Graduate School of Medicine, Japan
Guang Yang,
University of Sydney, Australia
Characterization of RagC Phosphorylation Sites Reveals Self-Regulation of mTOR Complex 1
Characterization of RagC Phosphorylation Sites Reveals Self-Regulation of mTOR Complex 1
Natasha Chaudhary,
Weill Cornell Medical College, USA
RAB22A, a Regulator of Menkes Copper Transporter ATP7A Trafficking, Functions in Insulin-Stimulated GLUT4 Trafficking
RAB22A, a Regulator of Menkes Copper Transporter ATP7A Trafficking, Functions in Insulin-Stimulated GLUT4 Trafficking
Tetsuya Kimura,
Immunology Frontier Research Center, Osaka University, Japan
Prevention of Obesity, Fatty Liver and Diabetes by Macrophages
Prevention of Obesity, Fatty Liver and Diabetes by Macrophages
Sang Won Park,
Boston Childrens Hospital, USA
Regulation of Glucose Homeostasis through brd7-p85 Interaction
Regulation of Glucose Homeostasis through brd7-p85 Interaction
Essi M. Havula,
University of Helsinki and Institute of Biotechnology, Finland
ChREBP/Mondo-Mlx Mediates Organismal Sugar sensing through Gli-Similar Transcription Factor Sugarbabe
ChREBP/Mondo-Mlx Mediates Organismal Sugar sensing through Gli-Similar Transcription Factor Sugarbabe
Markus Jabs,
German Cancer Research Center, Germany
The Endothelium Actively Balances Glucose and Fatty Acid Metabolism
The Endothelium Actively Balances Glucose and Fatty Acid Metabolism
Yibo Wu,
Institute of Molecular Systems Biology, ETH Zurich, Switzerland
Systems Proteomics and Trans Omic Data Integration – Uncovering Novel Diabetic Genes
Systems Proteomics and Trans Omic Data Integration – Uncovering Novel Diabetic Genes
17:00—18:45
Diabetes and Healthy Lifespan
Meeting has ended...abstracts no longer viewable online.
*
Philippe Froguel,
Imperial College of London, UK
*
Masaomi Nangaku,
University of Tokyo School of Medicine, Japan
Ulf Smith,
Göteborg University, UGOT, Sweden
The Roles of Wnt and BMP Signaling in Insulin Resistance and Obesity
The Roles of Wnt and BMP Signaling in Insulin Resistance and Obesity
Gary Krishnan,
Eli Lilly and Company, USA
Efficient Remodeling of Skeletal Muscle Is Crucial for Recovery after Exercise and Relies on Innate Lymphoid Cells
Efficient Remodeling of Skeletal Muscle Is Crucial for Recovery after Exercise and Relies on Innate Lymphoid Cells
Takashi Kadowaki,
University of Tokyo, Japan
Adiponectin Receptor and Metabolic Syndrome: Pathophysiology and Therapeutic Strategy
Adiponectin Receptor and Metabolic Syndrome: Pathophysiology and Therapeutic Strategy
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Nobuya Inagaki,
Kyoto University Graduate School of Medicine, Japan
Takashi Kadowaki,
University of Tokyo, Japan
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Juleen R. Zierath,
Karolinska Institutet, Sweden
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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