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This meeting took place in 2017



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Frontiers of NMR in Life Sciences (C5)


Organizer(s) Kurt Wüthrich, Michael Sattler and Stephen W. Fesik
March 12—16, 2017
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Nov 15, 2016
Abstract Deadline: Dec 13, 2016
Scholarship Deadline: Nov 15, 2016
Discounted Registration Deadline: Jan 13, 2017

Sponsored by Merck & Co., Inc.

Summary of Meeting:
The NMR principle is widely applied in structural biology, biomedical research and clinical diagnosis. This conference will highlight progress in solution and solid state NMR methods and recent advances in selected NMR applications in metabolic profiling, drug research, protein/ nucleic acid interactions, in-cell NMR, intrinsically disordered proteins and the study of membrane proteins. Attendees will obtain an overview of the principal advances made during the last four years with the use of NMR techniques in structural biology and biomedical research, and receive guidance on anticipated mid-term and long-term future advances with NMR applications in molecular and cell biology.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 12 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 17 in order to fully experience the meeting.

SUNDAY, MARCH 12

16:00—20:00
Arrival and Registration

Longs Peak Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Longs Peak Foyer

MONDAY, MARCH 13

07:00—08:00
Breakfast

Shavano/Torreys
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Kurt Wüthrich, ETH Zürich, Switzerland / The Scripps Research Institute, USA

Lewis E. Kay, University of Toronto, Canada
NMR: Why Bother?

09:00—11:15
Innovative Solution NMR Methods for Studying Biological Macromolecules
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Michael Sattler, Helmholtz Zentrum München & Technische Universität München, Germany

Dominique P. Frueh, Johns Hopkins University School of Medicine, USA
Invited Short Talk: Overcoming Challenges in NMR Studies of Large and Dynamic Nonribosomal Peptide Synthetases

Wolfgang Peti, University of Arizona, USA
Invited Short Talk: Using Dynamics and Structure to Understand Allostery in Signaling Enzymes

Coffee Break

Haribabu Arthanari, Harvard Medical School, USA
Invited Short Talk: Increasing Resolution of Backbone Experiments: Thinking Beyond the Nyqvist Grid

Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany
NMR-Based Structural Biology in Immunity and Neurodegeneration/Protectoin

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Use of NMR in Metabolic Profiling
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Jane Dyson, The Scripps Research Institute, USA

Teresa W. M. Fan, University of Kentucky Markey Cancer Center, USA
Metabolic Network Mapping by Stable Isotope Resolved Metabolomics (SIRM)

Rafael Brüschweiler, Ohio State University, USA
NMR and NMR/MS Hybrid Approaches for Targeted and Untargeted Metabolomics

Michael A. Kennedy, Miami University, USA
NMR-Based Metabolic Profiling of Human Diseases

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 1

Shavano/Torreys

TUESDAY, MARCH 14

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Protein-Nucleic Acid Interactions
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Robert Kaptein, University of Utrecht, Netherlands

Frédéric H.T. Allain, ETH Zurich, Switzerland
Structures of Protein RNA Complexes using Hybrid Structural Approaches

Hashim M. Al-Hashimi, Duke University, USA
Visualizing Transient Watson-Crick Mispairs in DNA and RNA Duplexes

Coffee Break

Pedro Serrano-Navarro, The Scripps Research Institute, USA
Invited Short Talk: In vitro Studies of Arginine-Serine-Rich Domains

Teresa Carlomagno, Universität Hannover, Germany
Invited Short Talk: ssNMR of RNA and RNP Complexes

Michael Sattler, Helmholtz Zentrum München & Technische Universität München, Germany
Conformational Dynamics of Biomolecular Recognition in Gene Regulation

11:00—14:30
On Own for Lunch

11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—16:30
Workshop 1: Automation in Protein NMR Structure Determination and Other Hot Topics

Grays Peak
* Martin Billeter, University of Gothenburg, Sweden

Kristaps Jaudzems, Institut des Sciences Analytiques, France
Solution NMR Conquers Solids with Fast MAS: de novo NMR Structure Determination of a 2.5 MDa Capsid

Silke Andrea Wieninger, Institut Pasteur, France
Identification of Incompatible NOE Restraints for Partial Ensemble Structure Determination in ARIA

Marielle Aulikki Wälti, National Institutes of Health, USA
Fast Determination of 3D Complex Structures with Low Affinity Binders

William J. Placzek, University of Alabama at Birmingham, USA
NMR Studies of Ubc9 Mutant Identify Structural Basis for SUMO Target Selection

Joshua D. Brown, University of Maryland, Baltimore County, USA
Influence of the 5' Transcription Start Site Heterogeneity on HIV RNA Structure and Fate

Shin Isogai, Biozentrum, Basel University, Switzerland
Backbone Solution NMR of GPCRs: A Case Study of the Engineered Beta1-Adrenergic receptor

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Integrative Structural Biology
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* John L. Markley, University of Wisconsin-Madison, USA

Andrej Sali, University of California, San Francisco, USA
Integrative Modeling of Biomolecular Assembly Structures and Pathways

Juli Feigon, University of California, Los Angeles, USA
Integrative Structural Biology of Telomerase

Michael Nilges, Institut Pasteur, France
Integrative Structural Biology of a Type II Secretion Pseudopilus

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 2

Shavano/Torreys

WEDNESDAY, MARCH 15

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
NMR in Drug Research
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA

Maurizio Pellecchia, University of California, Riverside, USA
NMR-Guided Discovery of Novel Pharmacological Tools and Therapeutics

Dorothee Kern, Brandeis University, HHMI, USA
Exploiting Protein Dynamics for Novel Strategies in Drug Design

Coffee Break

Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Cancer Drug Discovery Using Fragment-Based Methods

Robert G. Brinson, National Institute of Standards and Technology, USA
Practical NMR Applications for Structural Assessment of Monoclonal Antibody Therapeutics

11:00—14:30
On Own for Lunch

11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:00
Poster Viewing

Shavano/Torreys
14:30—15:30
Workshop 2: NMR in Integrative Structural Biology Projects and Other Hot Topics

Grays Peak
* Ad Bax, NIDDK, National Institutes of Health, USA
Following Protein Folding in Real Time by Fast Pressure Jump NMR

Daniel Stöppler, Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany
Dynamic Nuclear Polarization Provides New Insights into Chromophore Structure in Phytochrome Photoreceptors

Tobias Madl, Medical University of Graz, Austria
Structural Characterization of Biomolecules using Solvent-Accessibility Data

Nikolaos G. Sgourakis, University of California, Santa Cruz, USA
An Allosteric Site in the T Cell Receptor beta-Chain Constant Domain Plays a Critical Role in T Cell Signaling

15:30—16:30
Panel: NMR in Integrative Structural Biology Projects

Grays Peak
* Ad Bax, NIDDK, National Institutes of Health, USA

Frédéric H.T. Allain, ETH Zurich, Switzerland

Jonathan Pritz, Dana-Farber Cancer Institute, Boston, USA

Andrej Sali, University of California, San Francisco, USA

Ian A. Wilson, The Scripps Research Institute, USA

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Advances in Solid State NMR Methods in Biology
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Arthur G. Palmer, III, Columbia University, USA

Bernd Reif, Technische Universität München, Germany
Soluble Protein Complexes Investigated by MAS Solid-State NMR

Marc Baldus, Utrecht University, Netherlands
Cellular Solid-State NMR Applied to Membrane Protein Complexes

Paul Schanda, Institut de Biologie Structurale, France
Invited Short Talk: Functional Dynamics in a Half-Megadalton Large Enzyme Complex as Seen by Solid-State NMR

Christopher P. Jaroniec, Ohio State University, USA
Invited Short Talk: Structural Studies of Y145Stop Prion Protein Amyloids

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
19:30—22:00
Poster Session 3

Shavano/Torreys

THURSDAY, MARCH 16

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
In-Cell NMR and Intrinsically Disordered Proteins
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Astrid Gräslund, Stockholm University, Sweden

Ichio Shimada, University of Tokyo, Japan
Studying Proteins inside Eukaryotic Cells in NMR

Richard W. Kriwacki, St. Jude Children's Research Hospital, USA
Structure and Dynamics of IDPs from NMR; Applications from Small Molecule Interactions to Phase Separation

Coffee Break

Peter E. Wright, The Scripps Research Institute, USA
NMR Characterization of Intrinsically Disordered Regulatory Proteins

Martin Blackledge, Institut de Biologie Structurale, France
Large-Scale Conformational Dynamics and Biomolecular Function from NMR

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:45
Solution NMR Studies of Membrane Proteins
Meeting has ended...abstracts no longer viewable online.

Grays Peak
* Stephen W. Fesik, Vanderbilt University School of Medicine, USA

Kurt Wüthrich, ETH Zürich, Switzerland / The Scripps Research Institute, USA
NMR Studies of G Protein-coupled Receptors (GPCR) in Solution

Daniel Nietlispach, University of Cambridge, UK
Invited Short Talk: Investigating the Dynamic Landscape of GPCRs

Katherine A. Henzler-Wildman, University of Wisconsin-Madison, USA
Invited Short Talk: The Small Multidrug Resistance Transporter EmrE Sacrifices Efficiency to Achieve Promiscuity

Gerhard Wagner, Harvard Medical School, USA
Membrane Protein Studies in Micelles and Nanodiscs

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Grays Peak
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Shavano/Torreys
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Shavano/Torreys

FRIDAY, MARCH 17

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Merck & Co., Inc.

We gratefully acknowledge additional support for this conference from:

Bruker BioSpin
New Era Enterprises, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676