Santa Fe Community Convention Center Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

NOTES:
This meeting will be conducted in English.

All programs are subject to change. Check this site for updates.


Download Flyer

Twitter hashtag for this meeting: #KSdna

DNA Replication and Recombination (Z2)

joint with the meeting on Genomic Instability and DNA Repair (Z1)

Scientific Organizers: John F.X. Diffley, Anja Groth and Scott Keeney


April 2—6, 2017

Santa Fe Community Convention Center, Santa Fe, New Mexico, USA


Sponsored by Editas Medicine, Inc.


IT’S NOT TOO LATE TO SUBMIT YOUR ABSTRACT. Abstracts received can no longer be considered for oral short talks; poster display opportunities remain open.
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.

DEADLINES:
Scholarship Deadline: Dec 5, 2016 [details]
Discounted Abstract Deadline: Dec 5, 2016 [details]
Abstract Deadline: Jan 12, 2017 [details]
Discounted Registration Deadline: Feb 2, 2017 [details]

Click here to view Cancellation Policy

Submit an Abstract Register Yourself Deadlines and Fees

Rates and Deadlines listed below are for the 2017-Z2 "DNA Replication and Recombination" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On December 5, 2016 100.00 USD*
- 50.00 USD discount
Abstract Deadline
More details
After December 5, 2016 until February 27, 2017 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
December 5, 2016 n/a
Discounted NON-STUDENT Registration
More details
Before and On February 2, 2017 795.00 USD
(includes 150.00 discount)
Regular NON-STUDENT Registration
More details
After February 2, 2017 945.00 USD
Discounted STUDENT Registration
More details
Before and On February 2, 2017 570.00 USD
(includes 150.00 discount)
Regular STUDENT Registration
More details
After February 2, 2017 720.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will accept no liability for money loss through bank charges, transfers or currency fluctuations.




Discounted Abstract Deadline: December 5, 2016


Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is January 12, 2017)

Global Health Travel Award Deadline:


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: December 5, 2016


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: January 12, 2017


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is December 5, 2016)

Discounted Registration Deadline: February 2, 2017


Registration Fee: 795.00 USD* (includes 150.00 USD discount)
Student Registration Fee: 570.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 945.00 USD*
Student Registration Fee: 720.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that a few meeting participants have received calls and emails from a number of different housing services - "Exhibitors Housing Services", "Global Housing", etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling and seek to take your lodging reservation and obtain your credit card number. We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report to Keystone Symposia any calls or correspondence you might have received and book only through the lodging link on our website, an established travel agency, or directly with the hotel.
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 2 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 6 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 7 in order to fully experience the meeting.

SUNDAY, APRIL 2

16:00—20:00
Arrival and Registration

Sweeney Ballroom Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sweeney F

MONDAY, APRIL 3

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—09:30
Welcome and Keynote Session (Joint)
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-E
Tatsuya Hirano, RIKEN, Japan
Condensin-Based Chromosome Organization

Johannes C. Walter, Harvard Medical School, USA
Mechanisms of Replication-Coupled Repair

Coffee Break

09:50—12:00
Replication/Repair Structure and Function
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom C-E
Michael E. O'Donnell, Rockefeller University, USA
Structure and Function of the Eukaryotic Replisome

Tyler H. Stanage, University of Wisconsin - Madison, USA
Short Talk: The Escherichia coli RarA Protein is Involved in the Switch between DNA Replication and Translesion Synthesis in vivo

Karlene A. Cimprich, Stanford University, USA
When RNA Meets DNA: Dangerous Liaisons in the Genome

Alessandro Costa, Francis Crick Institute, UK
Cryo-EM Approaches to Understanding the Eukaryotic Replisome

Matthew L. Bochman, Indiana University, USA
Short Talk: Hrq1, The Yeast Homolog of RecQ4, Inhibits Telomerase Activity on Long Telomeres


Following Session is for Genomic Instability and DNA Repair (Z1)

09:50—12:00
Mechanisms of DNA Repair
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-B
Wei Yang, NIDDK, National Institutes of Health, USA
Structural Insights into Translesion DNA Polymerases

James E. Haber, Brandeis University, USA
Short Talk: Rad51-Mediated Double-Strand Break Repair and Mismatch Correction of Highly Diverged Substrates

Joseph J. Loparo, Harvard Medical School, USA
Short Talk: Single-Molecule Imaging of Non-Homologous End Joining

Michael D. Stone, University of California, Santa Cruz, USA
Mechanical Transitions in Long Duplex Telomere DNA Molecules

Fena Ochs, University of Copenhagen, Denmark
Short Talk: Dynamic Chromatin Superstructures Safeguard Integrity of Nuclear Compartments Challenged by DNA Breakage

Cecilia Cotta-Ramusino, Editas Medicine, USA
Short Talk: Characterization of the Interplay between DNA Repair and CRISPR/Cas9-Induced DNA Lesions at an Endogenous Locus

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
14:30—16:30
Workshop 1: Recombination and Repair

Sweeney Ballroom C-E
Tracey E Beyer, Biotech Research and Innovation Centre, Denmark
Ontogeny of Genome Rearrangements in Budding Yeast

Simon N. Powell, Memorial Sloan Kettering Cancer Center, USA
Replication Fork Cleavage Occurs within 100bp from Local ATM Signaling of Site-Specific DNA Replication Block in Human Cells

Sneha Saxena, Indian Institute of Science, India
ATR Signaling Uncouples Role of XRCC2 in Homologous Recombination and Replication Stress Response

Erin Hannah Sybouts, University of Texas Health Science Center at San Antonio, USA
Recombination and BLM Helicase Compensate for Replication Fork Defects in the Absence of 53BP1 Protein

Shane McDevitt, Temple University, USA
Mechanism of RNA Transcript-Mediated DNA Recombinational Repair

Susanne S. C. Bantele, Max Planck Institute of Biochemistry, Germany
Regulation of the Conserved Chromatin Remodeler Fun30SMARCAD1 at DNA Double-Strand Breaks

Walter J. Chazin†, Vanderbilt University, USA
Mechanisms for Counting and Handoff by Human DNA Primase- A Role for the 4Fe-4S Cluster?

Holger Puchta, Karlsruhe Institute of Technology, Germany
The RTR Complex Partner RMI2 and the DNA Helicase RTEL1 Are Both Independently Involved in Preserving the Stability of 45S rDNA Repeats in Arabidopsis thaliana


Following Session is for Genomic Instability and DNA Repair (Z1)

14:30—16:30
Workshop 1: Genome Instability and DNA Repair I

Sweeney Ballroom A-B
Elena Balkanska-Sinclair†, Duke University, USA
The BRD4-NUT Fusion Protein from Nut-Midline Carcinoma modulates DNA Damage Signaling and Ionizing Radiation Response

Michael M. Cox, University of Wisconsin-Madison, USA
Ionizing Radiation Resistance in Experimentally Evolved Escherichia coli Populations

Qing Li, Peking University, China
Chaperoning RPA during DNA Replication

Ryan M. Baxley, University of Minnesota, USA
Progressive Genomic Instability and Telomere Erosion in Human Cells following Inactivation of a Single MCM10 Allele

Michael H. Hauer, Friedrich Miescher Institute for Biomedical Research, Switzerland
Histone Degradation in Response to DNA Damage Enhances Chromatin Dynamics and Recombination Rates

Mariano Labrador-San Jose, University of Tennessee, USA
Components of the DNA Damage Response Pathway, ATR and ATM, Modulate Chromatin Insulator Activity through Phosphorylation of Histone H2Av at Insulator Sites

Mitch McVey, Tufts University, USA
Coordination of ATPase and Polymerase Activities of Drosophila DNA Polymerase Theta during Interstrand Crosslink and Alternative End-Joining Repair of Double-Strand Breaks

Hilda A. Pickett, Children's Medical Research Institute, Australia
BLM and SLX4 Play Opposing Roles in Recombination-Dependent Replication at Human Telomeres

16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
Starting Recombination
Registered attendees can view abstracts starting on 03/02/2017
Covering meiotic initiation, somatic lesion formation, DSB processing.

Sweeney Ballroom C-E
Scott Keeney, HHMI/Memorial Sloan Kettering Cancer Center, USA
Breaking and Chewing DNA during Meiosis

Florencia M. Pratto†, NIDDK, National Institutes of Health, USA
Coordination between Replication and Meiotic Recombination Initiation in Mouse

Kara A. Bernstein, University of Pittsburgh School of Medicine, USA
Short Talk: The Function of the Shu Complex and the Rad51 Paralogs in Repair of Replication Intermediate by Promotion of Rad51 Presynaptic Filament Assembly

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Protecting the Genome by Homologous Recombination

Sofija Mijic, Institute of Molecular Cancer Research, Switzerland
Short Talk: Replication Fork Reversal Triggers Fork Degradation in BRCA2-Defective Cells


Following Session is for Genomic Instability and DNA Repair (Z1)

17:00—19:00
RNA Metabolism and Genome Stability
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-B
Vihandha Wickramasinghe, Peter MacCallum Cancer Centre, Australia
Effects of Altered RNA Processing on Genome Stability and the Proteome

Frédéric L. Chedin†, University of California, Davis, USA
Short Talk: R-Loop Formation is a Hallmark of Active Early Replication Origins in Mammalian Genomes

Julius Brennecke, IMBA - Institut für Molekulare Biotechnologie GmbH, Austria
An RNA-Based Genome Immune System Safeguards Genome Stability

Eric A. Hunt†, New England Biolabs, USA
Short Talk: Prokaryotic Argonautes and their Potential as New Molecular Tools

Richard T. Pomerantz†, Temple University Lewis Katz School of Medicine, USA
Short Talk: A High-Fidelity Mechanism of RNA Transcript-Mediated DNA Repair

Francesca Storici, Georgia Institute of Technology, USA
Short Talk: Double-Strand Break Repair by Transcript RNA Is Stimulated by Rad52 and Requires Limited End Resection

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 1

Sweeney F, Main Level Breakouts

TUESDAY, APRIL 4

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:15
Interplay between Chromatin Structure and DNA Replication/Repair (Joint)
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-E
Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Shaping Chromatin in the Nucleus, the Bricks and the Architects

Gary Karpen, Lawrence Berkeley National Laboratory, University of California, Berkeley, USA
Regulation of DNA Repair in Heterochromatin and Euchromatin

Francesca Mattiroli, HHMI/Colorado University Boulder, USA
Short Talk: DNA-Mediated Association of Two Histone-Bound CAF-1 Complexes Drives Tetrasome Assembly in the Wake of DNA Replication

Coffee Break

Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Interface between DNA Replication and Inheritance of Heterochromatin

Bernard de Massy, Institut de Génétique Humaine, France
The Control of Initiation of Meiotic Recombination by PRDM9

Philipp Oberdoerffer, NCI, National Institutes of Health, USA
Short Talk: Replication Stress Shapes a Protective Chromatin Environment Across Fragile Genomic Regions

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts
16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
Regulating Recombination
Registered attendees can view abstracts starting on 03/02/2017
Cell cycle, site choice, partner choice, pathway choice.

Sweeney Ballroom C-E
Eva Hoffmann, University of Copenhagen, Denmark
Gene Conversion and Crossover Maps in the Human Germline

Lorraine S. Symington, Columbia University, USA
DNA End Resection and Repair Pathway Choice

Aurele Piazza, University of California, Davis, USA
Short Talk: Multi-Invasions Are Recombination Byproducts that Induce Chromosomal Rearrangements

Eric C. Greene, Columbia University, USA
Single-Molecule Studies of Recombination Pathways

Jennifer A. Cobb, University of Calgary, Canada
Short Talk: Nej1 Regulates Repair Pathway Choice by Inhibiting Dna2-Sgs1 Mediated Resection


Following Session is for Genomic Instability and DNA Repair (Z1)

17:00—19:00
Cell Cycle Regulation of DNA Damage Response
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-B
Tanya T. Paull, University of Texas at Austin, USA
Double-Strand Break Repair Factors and R-Loop-Mediated Genomic Instability

David Cortez, Vanderbilt University School of Medicine, USA
Regulation of Replication Fork Stability by Single-Stranded DNA Binding Proteins

Kyle M. Miller, University of Texas at Austin, USA
Chromatin Regulation of the DNA Damage Response

Michael P. Sheetz, Mechanobiology Institute, National University of Singapore, Singapore
Short Talk: DNA Damage Causes¬ Rapid Accumulation of Phosphoinositides to Recruit ATR but not ATM

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 2

Sweeney F, Main Level Breakouts

WEDNESDAY, APRIL 5

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
07:30—08:00
Poster Setup

Sweeney F, Main Level Breakouts
08:00—17:00
Poster Viewing

Sweeney F, Main Level Breakouts
08:00—11:00
Replication Fork Progression and Restart
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom C-E
Karim Labib, University of Dundee, UK
The End of Chromosome Replication

Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
Imaging Individual Replisomes Reveals Independence and Decoupling of Polymerases During Replication

Alberto Ciccia, Columbia University, USA
Short Talk: Restoration of Fork Stability in BRCA1- and BRCA2-Deficient Cells

Coffee Break

Xiaolan Zhao, Memorial Sloan Kettering Cancer Center, USA
The Effects of Cancer-Associated DNA Polymerase Epsilon Mutations on Replication

Anja Groth, University of Copenhagen, Denmark
Chromatin Replication and Epigenome Maintenance

Carl L. Schildkraut†, Albert Einstein College of Medicine, USA
Short Talk: Visualizing DNA Replication in Telomeres in Real Time in Living Cells


Following Session is for Genomic Instability and DNA Repair (Z1)

08:00—11:00
Nuclear Dynamics and Genome Stability
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-B
Marco F. Foiani, Instituto FIRC di Oncologia Molecolare, Italy
An Integrated ATR, ATM and mTOR-Mechanical Network Controlling Nuclear Plasticity and Cell Migration

Angela Taddei, Institut Curie, France
Nuclear Organization and Chromatin Status Modulate Homologous Recombination Efficiency and Outcome

Irene Chiolo, University of Southern California, USA
Short Talk: Highways for Repair: Nuclear Myosins and Actin Filaments Relocalize Heterochromatic DNA Breaks to the Nuclear Periphery

Coffee Break

Martin W. Hetzer, The Salk Institute, USA
How the Nuclear Membrane Controls Genome Function

Emmanuelle Fabre, Hopital St Louis, France
Short Talk: DNA Damage Increases Chromatin Stiffening in Budding Yeast

Neil T. Umbreit†, Dana-Farber Cancer Institute, USA
Short Talk: Chromosome Bridge Resolution Requires Mechanical Forces from Actin-Based Contractility

Peter Ly, Ludwig Institute for Cancer Research, University of California at San Diego, USA
Short Talk: Mitotic Errors Promote Chromosome Shattering and DNA Break Repair by Non-Homologous End Joining

11:00—12:00
Lunch

Sweeney F, Main Level Breakouts
12:00—14:30
Poster Session 3

Sweeney F, Main Level Breakouts
16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
Replication Initiation Mechanisms
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom C-E
Stephen P. Bell, Massachusetts Institute of Technology, USA
Mechanism and Timing of Mcm2-7 Ring Closure during Origin Licensing

Stephen D. Bell, Indiana University, USA
DNA Replication in Archaea

Heath Murray, Newcastle University, UK
Short Talk: A New Bacterial Replication Origin Element Specifies Single-Strand Initiator Binding

Anne D. Donaldson, University of Aberdeen, UK
The Conserved role of Rif1 as a Substrate-Targeting Subunit of Protein Phosphatase 1

Dominik Boos†, University of Duisburg-Essen, Germany
Short Talk: MTBP Is an Essential Replication Initiation Factor with Vertebrate-Specific and Sld7-Like Features


Following Session is for Genomic Instability and DNA Repair (Z1)

17:00—19:00
DNA Repair and Human Diseases
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-B
Agnel Sfeir, New York University School of Medicine, USA
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion

André Nussenzweig, NCI, National Institutes of Health, USA
DNA Breaks and End-Resection Measured Genome-Wide by End Sequencing (END-seq)

Simon J. Boulton, London Research Institute, Clare Hall Laboratories, UK
Mechanistic Insights into Telomere Dysfunction Disorders

Madalena Tarsounas, University of Oxford, UK
Short Talk: MUS81 Nuclease Activity Is Essential for Replication Stress Tolerance and Chromosome Segregation in BRCA2-Deficient Cells

Janet Partridge, St Jude Children's Research Hospital, USA
Short Talk: Histone H3G34R Mutation Causes Replicative Stress, Defective Homologous Recombination and Genomic Instability in Fission Yeast

19:00
On Own for Dinner


THURSDAY, APRIL 6

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:00
Replication Fork Establishment and Replication-Coupled Repair (Joint)
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-E
James M. Berger, Johns Hopkins University School of Medicine, USA
Physical Mechanisms for Initiating DNA Replication in Cells

Agata Smogorzewska, Rockefeller University, USA
Stress Response at the Replication Fork

Eric J. Brown, Perelman School of Medicine, University of Pennsylvania, USA
Short Talk: Characterizing Replisome Ubiquitination upon Fork Stalling

Coffee Break

Virginia A. Zakian, Princeton University, USA
Adaptation to Heat Stress Results in Reversible Telomere Shortening, Reduced Telomerase, and Shelterin Rearrangement

Helle D. Ulrich, Institute of Molecular Biology, Germany
Coordination of DNA Damage Bypass with Genome Replication and Checkpoint Signaling

Stephane Koundrioukoff, Institute Gustave Roussy, France
Short Talk: DNA Replication Compensation: A Two Steps Mechanism

11:00—17:00
On Own for Lunch

14:30—16:30
Workshop 2: Replication

Sweeney Ballroom C-E
* Linda B. Bloom, University of Florida, USA
Active Sliding Clamp Opening in Three Steps

Joseph Yeeles, MRC Laboratory of Molecular Biology, UK
How the Eukaryotic Replisome Responds to DNA Damage in the Leading- and Lagging-Strand Templates

Christopher Sansam, Oklahoma Medical Research Foundation, USA
DNA Replication Timing during Development Anticipates Transcriptional Programs and Parallels Enhancer Activation

Boris Pfander, Max Planck Institute of Biochemistry, Germany
Robust Replication Control by Temporal Gaps between Licensing and Firing Phases

Hasan Yardimci, Francis Crick Institute, UK
Super-Resolution Fluorescence Imaging of DNA Replication Intermediates

Jon Baxter, University of Sussex, UK
Transcription Promotes Replication Fork Rotation and Double-Stranded DNA Intertwining via a Cohesin-Dependent Pathway

Ivan Psakhye, IFOM, the FIRC Institute of Molecular Oncology, Italy
DDK-Mediated Regulation of the deSUMOylating Enzyme Ulp2 Facilitates DNA Replication Initiation

Joseph L. Stodola†, Washington University School of Medicine, USA
Kinetic Analysis of Lagging Strand Replication and Okazaki Fragment Maturation


Following Session is for Genomic Instability and DNA Repair (Z1)

14:30—16:30
Workshop 2: Genome Instability and DNA Repair II

Sweeney Ballroom A-B
Katharina Schlacher, MD Anderson Cancer Center, USA
Epigenetics-Enabled MRE11 Replication Restart by p53 Promotes Replication Pathway Homeostasis to Suppress Opportunistic Transcription Reprogramming

Kristijan Ramadan, University of Oxford, UK
SPRTN Is a Novel Mammalian Protease with the Central Role in DNA Replication-Coupled DNA-Protein Crosslink Repair

Jason Sheltzer, Cold Spring Harbor Laboratory, USA
Single-Chromosome Aneuploidy Commonly Functions as a Tumor Suppressor but Can Drive Genome Evolution

Manuel Stucki, University of Zurich, Switzerland
TOPBP1 Cooperate with TCOF1/Treacle in the Nucleolar Response to DNA Double-Strand Breaks

Maria Teresa Teixeira, CNRS – UMR 8226, France
Telomere Replication in the Absence of Telomerase: Failure, Repair and Adaptation

Hemmo Meyer†, University Duisburg-Essen, Germany
The AAA-ATPase VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair

Catherine H. Freudenreich, Tufts University, USA
Cytosine Deamination Mediates R-Loop Dependent CAG Repeat Fragility and Instability

Muwen Kong, University of Pittsburgh, USA
Auto-PARylation Switches PARP1 Search Mechanism from Three-Dimensional Diffusion to Anomalous One-Dimensional Sliding

16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—18:45
Finishing Recombination
Registered attendees can view abstracts starting on 03/02/2017
Homology search, strand exchange, dealing with DNA joint molecules.

Sweeney Ballroom C-E
Stephen C. Kowalczykowski, University of California, Davis, USA
Molecular Functions and Single Molecule Studies of BRCA1, BRCA2, and RAD51 Paralogs

Petr Cejka, University of Zurich, Switzerland
Processing of DNA Double-Strand Breaks for Repair by Homologous Recombination

Ralph Scully, Beth Israel Deaconess Medical Center, USA
Short Talk: Microhomology-Mediated Tandem Duplications form at Tus/Ter-Stalled Replication Forks in BRCA1 Mutant Cells

Stephen C. West, Francis Crick Institute, UK
Unresolved Recombination Intermediates as a Source of DNA Breaks and Chromosome Aberration


Following Session is for Genomic Instability and DNA Repair (Z1)

17:00—18:45
Telomeres and Centromeres
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-B
Titia de Lange, Rockefeller University, USA
How Shelterin Solves the Telomere End-Protection Problem  

Kerry S. Bloom, University of North Carolina at Chapel Hill, USA
The Molecular Basis for the Centromere Spring

Julia Promisel Cooper, NCI, National Institutes of Health, USA
Control of Mitotic and Meiotic Centrosomes by Telomeres and Centromeres

Nausica Arnoult, The Salk Institute for Biological Studies, USA
Short Talk: Regulation of DNA Repair Pathway Choice in S/G2 by the NHEJ Inhibitor CYREN

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom C-E

Following Session is for Genomic Instability and DNA Repair (Z1)

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 03/02/2017

Sweeney Ballroom A-B
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F, Main Level Breakouts
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sweeney F

FRIDAY, APRIL 7

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Editas Medicine, Inc.

We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

eLife Genomic Vision
March of Dimes Foundation, Grant No. 4-FY16-317
 

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Assistant Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676