Granlibakken Tahoe Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

Ubiquitin Signaling (A8)

Scientific Organizers: David Komander and Sylvie Urbé


January 28—February 1, 2018

Granlibakken Tahoe, Tahoe City, California, USA


Sponsored by Cell Research


Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

DEADLINES:
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Deadline: Oct 2, 2017 [details]
Discounted Abstract Deadline: Oct 2, 2017 [details]
Abstract Deadline: Oct 31, 2017 [details]
Discounted Registration Deadline: Dec 1, 2017 [details]

Click here to view Cancellation Policy

Register Yourself Deadlines and Fees

Rates and Deadlines listed below are for the 2018-A8 "Ubiquitin Signaling" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On October 2, 2017 100.00 USD*
- 50.00 USD discount
Abstract Deadline
More details
After October 2, 2017 until December 17, 2017 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
October 2, 2017 n/a
Discounted NON-STUDENT Registration
More details
Before and On December 1, 2017 820.00 USD
(includes 200.00 discount)
Regular NON-STUDENT Registration
More details
After December 1, 2017 1020.00 USD
Discounted STUDENT Registration
More details
Before and On December 1, 2017 595.00 USD
(includes 200.00 discount)
Regular STUDENT Registration
More details
After December 1, 2017 795.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will accept no liability for money loss through bank charges, transfers or currency fluctuations.




Discounted Abstract Deadline: October 2, 2017

*All deadlines end at 11:59 PM US Mountain Standard Time

Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is October 31, 2017)

Global Health Travel Award Deadline:

*All deadlines end at 11:59 PM US Mountain Standard Time


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: October 2, 2017

*All deadlines end at 11:59 PM US Mountain Standard Time


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: October 31, 2017

*All deadlines end at 11:59 PM US Mountain Standard Time


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:

  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is October 2, 2017)

Discounted Registration Deadline: December 1, 2017

*All deadlines end at 11:59 PM US Mountain Standard Time


Registration Fee: 820.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 595.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 1020.00 USD*
Student Registration Fee: 795.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that a few meeting participants have received calls and emails from a number of different housing services - "Exhibitors Housing Services", "Global Housing", etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling and seek to take your lodging reservation and obtain your credit card number. We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report to Keystone Symposia any calls or correspondence you might have received and book only through the lodging link on our website, an established travel agency, or directly with the hotel.
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 28 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, February 1 with a closing plenary session from 17:00 to 19:15, followed by dinner and entertainment. We recommend return travel on Friday, February 2 in order to fully experience the meeting.

SUNDAY, JANUARY 28

16:00—20:00
Arrival and Registration

Pre Function
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Granhall
18:00—20:00
Light Meal - Provided by Granlibakken

Granhall

MONDAY, JANUARY 29

07:00—08:00
Breakfast

Granhall
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
* David Komander, MRC Laboratory of Molecular Biology, UK

Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Celebrating 20 Years of Cullin Neddylation

09:00—11:30
The Ubiquitin Code I - Ubiquitin Chains
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
* David Komander, MRC Laboratory of Molecular Biology, UK

Nicolas H. Thomä, Friedrich Miescher Institute for Biomedical Research, Switzerland
How Thalidomide Analogues Recruit Zinc-Finger Degrons to the CRL4-CRBN Ubiquitin Ligase

Coffee Break

David Toczyski, University of California, San Francisco, USA
Genetic Analysis Reveals Functions of Atypical Polyubiquitin Chains

Steve Cappell, NCI, National Institutes of Health, USA
Short Talk: Emi1 Switches from being a Substrate to an Inhibitor of APC/C-Cdh1 to Start the Cell Cycle

Achim Werner, NIDCR, National Institutes of Health, USA
Short Talk: Multisite Phosphorylation Regulates Ubiquitin-dependent Neural Crest Formation

Raymond J. Deshaies, California Institute of Technology and Cleave Biosciences
Vms1/Ankzf1: A Novel Peptidyl-tRNA Hydrolase that Releases Nascent Chains from Stalled Ribosomes

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop 1: New Methods

Mountain/Lake
* Ingrid E. Wertz, Genentech, Inc., USA
Reactive Site-centric Chemoproteomics Identifies a Structurally Distinct Class of Deubiquitinase Enzymes

Norihito Shibata, National Institute of Health Sciences, Japan
Strategy for Protein Degradation against Oncoprotein BCR-ABL

Kristin Riching, Promega Corporation, USA
Monitoring Functional Mechanisms of Protein Degradation in Living Cells

Yu Ye, University of Cambridge, UK
Targeting Protein Aggregates with the Proteasome in vitro and in vivo

Itay Koren, Harvard Medical School, USA
Discovering Degrons using a Synthetic Human Peptidome

* Benedikt M. Kessler, University of Oxford, UK
Expanding the Cancer Cell DUBome for Small Molecule Drug Profiling using Advanced Chemoproteomics

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
The Ubiquitin Code II - Ub/Ubl Modifications
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
* Sylvie Urbé, University of Liverpool, UK

Christopher D. Lima, Memorial Sloan Kettering Cancer Center, USA
Ubiquitin-like Protein Conjugation Complexes and Genome Integrity

Jon Huibregtse, University of Texas at Austin, USA
The Extracellular Signaling Function of ISG15 and Cytokine Secretion

Neil Hunter, University of California, Davis, USA
Short Talk: Delineation and Analysis of the SUMO-Modified Proteome during Meiosis

Mark W. Hochstrasser, Yale University, USA
Distinct Toxin-Antidote Modules Underlie Reproductive Manipulation of Insect Hosts by Intracellular Wolbachia Bacteria

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour

Bay

TUESDAY, JANUARY 30

07:00—08:00
Breakfast

Granhall
08:00—11:15
Ubiquitin in the Host's Response to Infection
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
* Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany

Vishva M. Dixit, Genentech, Inc., USA
Ubiquitin in Inflammation

Mads Gyrd-Hansen, University of Oxford, UK
Deubiquitinases in Innate Immune Signalling

Coffee Break

Catherine L. Day, University of Otago, New Zealand
TRAFs and the Assembly of Ubiquitin Chains

Nicolas Bidère, INSERM, France
Short Talk: Regulation of Ciliogenesis and Cell Death by CYLD and Centriolar Satellites

Fuminori Tokunaga, Osaka City University, Japan
Short Talk: Characterization of a Novel LUBAC Inhibitor, HOIPIN-1

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
Ubiquitin in Host Responses

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Genetic Disorders
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
* Agata Smogorzewska, Rockefeller University, USA

Ivona Aksentijevich, NHGRI, National Institutes of Health, USA
NF-kappaB Pathway in Autoinflammatory Diseases: Ubiquitination meets Autoinflammation

Ryan Potts, St. Jude Children's Research Hospital, USA
MAGE Proteins in Cancer

Alessandra Rufini, University of Rome Tor Vergata, Italy
Short Talk: The E3 Ligase RNF126 as a New Therapeutic Target for Friedreich Ataxia

Miratul Muqit, University of Dundee, UK
Parkinson’s Disease Ubiquitin Signaling Pathways in Mice and Man

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 2

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

WEDNESDAY, JANUARY 31

07:00—08:00
Breakfast

Granhall
08:00—11:15
Protein Degradation in Diseases
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
* Mark W. Hochstrasser, Yale University, USA

Daniel J. Finley, Harvard University and Proteostasis, Inc.
Reciprocal Regulation between Ubp6 and the Proteasome

Andreas Matouschek, University of Texas at Austin, USA
Selecting Proteins for Proteasomal Degradation

Coffee Break

Leo James, MRC Laboratory of Molecular Biology, UK
Trim-Away: Targeted Degradation of Pathogens and Proteins by the Cytosolic Antibody Receptor TRIM21

Sumana Sanyal, Hong Kong University-Pasteur Institut, Hong Kong
Short Talk: Host Cellular Ubiquitylation Profiling Reveals a Critical Role for Lipid Droplet Metabolism during Flavivirus Infections

John Hanna, Harvard Medical School, USA
Short Talk: Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity

Craig M. Crews, Yale University and Arvinas, Inc.
PROTACs: Induced Protein Degradation as a Therapeutic Strategy

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay
14:30—16:30
Workshop 2: Drug Discovery

Mountain/Lake
* Lawrence R. Dick, Takeda, USA
Targeting the Proteasome for Antimalarial Drug Discovery

Thomas Kodadek, The Scripps Research Institute, USA
Mining DNA-Encoded Combinatorial Libraries of Electrophilic Compounds for Selective, Covalent Inhibitors of Deubiquitylases

Peter Tsvetkov, Whitehead Institute, USA
A New Way Cancer Cells Cope with Proteotoxic Stress

Panagiotis Ntziachristos, Northwestern University, USA
USP7 Cooperates with Oncogenes to Drive the Oncogenic Transcriptional Program in Acute Lymphoblastic Leukemia

Marjolein Kikkert, Leiden University Medical Center, Netherlands
Potent and Selective Inhibition of MERS Coronavirus Papain-like Protease by Engineered Ubiquitin Variants

* Jeanine Harrigan, Mission Therapeutics, UK
Development of DUB Inhibitors for the Treatment of Human Disease

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Regulation of Autophagy and Mitophagy by Ubiquitin
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
* Miratul Muqit, University of Dundee, UK

Sylvie Urbé, University of Liverpool, UK
Regulation of Basal Mitophagy by Deubiquitylases

J. Wade Harper, Harvard Medical School, USA
Digitizing Ubiquitin Signaling for Mitophagy

Kalle Gehring, McGill University, Canada
Short Talk: Parkin and PINK1 at the Crossroads of Cell Signaling by Phosphorylation and Ubiquitination

Richard J. Youle, NINDS, National Institutes of Health, USA
Synthetic Phenotypes in Mice Lacking PINK1 and Parkin-Mediated Mitophagy

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 3

Bay
20:00—21:00
Social Hour
No registration fees are used to fund alcohol served at this function.

Bay

THURSDAY, FEBRUARY 1

07:00—08:00
Breakfast

Granhall
08:00—11:15
Nuclear Roles of Ubiquitin
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
* Christine Katrin Schmidt, University of Manchester, UK

Titia K. Sixma, Netherlands Cancer Institute, Netherlands
Finding the Right Target

Niels Mailand, University of Copenhagen, Denmark
Regulation of Chromatin Ubiquitylation in the DNA Damage Response

Coffee Break

Agata Smogorzewska, Rockefeller University, USA
Ubiquitin Shuttle Proteins and the Stress Response at the Replication Fork

John L. Nitiss, University of Illinois, USA
Short Talk: Ubiquitylation Regulates Repair of Topoisomerase Induced DNA Damage

Lorenza Penengo, University of Zurich, Switzerland
Short Talk: The Ubiquitin-Dependent DNA Damage Response Factors RNF8/RNF168/53BP1 Are Essential Modulators of DNA Replication Fork Progression and Remodeling

Cynthia Wolberger, Johns Hopkins University School of Medicine, USA
Mechanistic Insights into Histone Deubiquitination

11:15—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
New Paradigms in Ubiquitin Modification(s)
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
* Sylvie Urbé, University of Liverpool, UK

Ivan Dikic, Goethe University Medical School, Germany
Catalysis and Inhibition of Phosphoribosyl-Dependent Ubiquitination

Yuxin Mao, Cornell University, USA
Short Talk: The Molecular Mechanism of Phosphoribosyl-ubiquitination Mediated by a Single Legionella Effector

Satpal Virdee, University of Dundee, UK
A New Class of Threonine-specific E3 Ligase

David Komander, MRC Laboratory of Molecular Biology, UK
New Tools to Study Ubiquitin Chain Architecture

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 12/28/2017

Mountain/Lake
19:15—20:15
Dinner

Granhall
19:15—20:15
Social Hour
No registration fees are used to fund alcohol served at this function.

Granhall
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Granhall

FRIDAY, FEBRUARY 2

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Cell Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Genentech, Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676