Snowbird Resort Floorplan

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This meeting took place in 2018


Here are the related meetings in 2019:
Tumor Metabolism (B5)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Tumor Metabolism (A5)


Organizer(s) Heather Christofk, Christian Metallo and Alec Kimmelman
January 21—25, 2018
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Sep 26, 2017
Abstract Deadline: Oct 24, 2017
Scholarship Deadline: Sep 26, 2017
Discounted Registration Deadline: Nov 27, 2017

Sponsored by BioLegend, Inc., Cancer Research UK, Cell Research, EMD Serono Research and Development Institute Inc., Incyte Corporation and Merck & Co., Inc.

Summary of Meeting:
This conference brings together experts in the tumor metabolism field to discuss new concepts in the regulation and role of cancer metabolism in tumor growth, as well as strategies for targeting tumor metabolism for therapeutic benefit. However, even though research and knowledge have grown in this field, there still remain many questions to be answered such as what is the role of mitochondria in promotion of cancer metabolic phenotypes, how does the influence of the microenvironment contribute to tumor metabolism, and what is the impact of tumor metabolism on the epigenetic state of cancer cells? This Keystone Symposia meeting will address such areas. In addition, the meeting aims to:1) Discuss these gaps in knowledge surrounding the influence of mitochondria and microenvironment on tumor metabolism as well as the influence of cancer metabolism on epigenetics; 2) Explore different approaches for identifying promising tumor metabolism drug targets; 3) Evaluate the best ways to model and quantify tumor metabolism in vivo; and 4) Provide a conceptual framework to trainees and non-experts in the field on the regulation and role of tumor metabolism in cancer biology. Anticipated outcomes include generation of new ideas and scientific knowledge, promotion of new collaborations, and enhanced use of correct methodologies for measuring tumor metabolism. This symposium is the premier conference for learning about the most important unpublished data in the tumor metabolism field and is invaluable to enhance accelerated discovery and development of new therapeutic approaches to target cancer metabolism.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 25 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 26 in order to fully experience the meeting.

SUNDAY, JANUARY 21

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, JANUARY 22

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Heather Christofk, University of California, Los Angeles, USA

Karen H. Vousden, Crick Institute, UK
p53 Pathways and Cancer Cell Metabolism

09:00—11:30
Mitochondrial Impact on Cancer Metabolism
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Alec Kimmelman, New York University Langone Medical Center, USA

Navdeep S. Chandel, Northwestern University, USA
Mitochondria as Signaling Organelles

Coffee Break

Laurent Le Cam, Institut de Recherche en Cancérologie de Montpellier, France
p53 Pathway & Metabolism: Implications in Tissue Homeostasis, Aging and Carcinogenesis

Jared Rutter, University of Utah, USA
Mitochondria, Metabolism and Cellular Decisions

David B. Shackelford, University of California, Los Angeles, USA
Short Talk: PET Imaging Mitochondrial Bioenergetics in Lung Cancer

Kay F. Macleod, University of Chicago, USA
Short Talk: Mitophagy and Cancer

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
14:30—16:30
Workshop 1: Newcomers

Ballroom 1-3
* Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA

Donita C. Brady, University of Pennsylvania, USA
Tracing Copper Utilization by Kinase Signal Transduction Pathways: Implications for Cancer Cell Metabolic Processes

Issam Ben-Sahra, Northwestern University, USA
Stimulation of de novo Serine Synthesis upon Purine Depletion

Andrew G. Cox, Peter MacCallum Cancer Centre, Australia
Yap Regulates Anabolic Glucose Metabolism to Enable Optimal Organ Growth

Maria Diaz-Meco, Sanford Burnham Prebys Institute, USA
ATF4-Induced Metabolic Reprograming, a Synthetic Vulnerability of the p62-Deficient Tumor Stroma

Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA
Non-Canonical Phosphatidylinositol Kinases in the Control of Cellular Lipid Metabolism and Autophagy

Ayelet Erez, Weizmann Institute of Science, Israel
Urea Cycle Dysregulation in Cancer Results in an Oncogenic Mutation Bias Associated with Enhanced Response to Immune Checkpoint Inhibitors

Sumin Kang, Emory University, USA
GDH1 Promotes Anoikis Resistance & Tumor Metastasis through CAMKK2 in Lung Cancer

Richard L. Possemato, New York University School of Medicine, USA
NFS1 Undergoes Positive Selection in Lung Tumors and Protects Cells from Ferroptosis

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Metabolic Drivers of Tumor Growth
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Nika N. Danial, Dana-Farber Cancer Institute, USA

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Genetic Screens to Study Metabolism

Daniel K. Nomura, University of California, Berkeley, USA
Redefining Druggability using Chemoproteomic Platforms

Heather Christofk, University of California, Los Angeles, USA
Metabolic Transitions in Cancer: Regulation by Cell-Extrinsic Cues

Ruiting Lin, Emory University School of Medicine, USA
Short Talk: Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-Tumor Effects on BRAF V600E Melanoma

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 1

Superior/Superior Lobby/Wasatch

TUESDAY, JANUARY 23

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Oncogenic Control of Cancer Metabolism
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* M. Celeste Simon, University of Pennsylvania, USA

Lewis C. Cantley, Weill Cornell Medicine, USA
PI 3-Kinase and Cancer Metabolism

Brendan D. Manning, Harvard School of Public Health, USA
The PI3K-mTOR Network and Control of Anabolic Tumor Metabolism

Coffee Break

Reuben J. Shaw, The Salk Institute for Biological Studies, USA
AMPK: Cancer Fighter, Cancer Supporter

Thales Papagiannakopoulos, New York University School of Medicine, USA
Uncovering Metabolic Bottlenecks in Lung Cancer

Gina DeNicola, Moffitt Cancer Center, USA
Short Talk: Cysteine Dioxygenase Is a Metabolic Liability for Non-Small Cell Lung Cancers

Krushna C. Patra, Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: Oncogenic cAMP Signaling Network Reprograms Lipid Metabolism and Drives Pancreatic Cancer

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Modeling the Complexities of Tumor Metabolism
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Reuben J. Shaw, The Salk Institute for Biological Studies, USA

Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, USA
Metabolic Complexity in Cancer Cells and Tumors (…and other diseases)

Eyal Gottlieb, Technion - Israel Institute of Technology, Israel
Metabolic Vulnerabilities of Cancer

Christian Metallo, University of California, San Diego, USA
Tracing the Interplay between Amino Acid and Lipid Metabolism in Cancer Cell Growth

Oliver Jonas, Brigham & Women's Hospital, USA
Short Talk: Using Local Perturbations from Implantable Micro Devices to Dissect Metabolism of Cancer and Immune Cells in Tumors

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 2

Superior/Superior Lobby/Wasatch

WEDNESDAY, JANUARY 24

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Metabolic Scavenging and the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Jared Rutter, University of Utah, USA

Eileen P. White, Rutgers University, USA
Autophagy, Metabolism, and Cancer

Jorge Moscat, Sanford Burnham Prebys Institute, USA
p62: Metabolism in the Tumor Micro- and Macro-Environment

Coffee Break

M. Celeste Simon, University of Pennsylvania, USA
Metabolic Symbioses in the Tumor Microenvironment

Alec Kimmelman, New York University Langone Medical Center, USA
Identifying Metabolic Dependencies in Pancreatic Cancer

Boyi Gan, MD Anderson Cancer Center, USA
Short Talk: Glutamate/Cystine Antiporter SLC7A11/xCT Regulates Glucose Dependency

Jurre J. Kamphorst, CR-UK Beatson Institute and University of Glasgow, UK
Short Talk: Paracrine Lipid Flux from Stromal Fibroblasts Promotes Pancreatic Tumor Growth

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Superior/Superior Lobby/Wasatch
13:00—22:00
Poster Viewing

Superior/Superior Lobby/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Influence of Metabolism on the Epigenome
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Oliver Maddocks, University of Glasgow, UK

Benjamin Tu, University of Texas Southwestern Medical Center, USA
Metabolic Functions for Histones

Siavash K. Kurdistani, University of California, Los Angeles, USA
A Novel Function of Histones in Copper Homeostasis

Christian Frezza, Hutchison/MRC Research Centre, UK
Fumarate Hydratase and Cancer: Oncometabolites and Beyond

Mattia Falcone, German Cancer Research Center, Germany
Short Talk: BCAT1 Restricts αKG Levels in AML Stem Cells Leading to IDHmut-like DNA Hypermethylation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Superior Lobby/Wasatch
19:30—22:00
Poster Session 3

Superior/Superior Lobby/Wasatch

THURSDAY, JANUARY 25

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:15
Targeting Cancer Metabolism
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-3
* Brendan D. Manning, Harvard School of Public Health, USA

Gromoslaw Aleksander Smolen, Celsius Therapeutics, USA
Strategies for Identifying Metabolic Vulnerabilities of Cancer Cells

Francesco Parlati, Calithera Biosciences, USA
Anti-Tumor Activity of Glutaminase Inhibitor CB-839 in Combination with Clinical Anti-Cancer Agents

Coffee Break

Susan E. Critchlow, AstraZeneca, UK
New Developments in Targeting Monocarboxylate Transporters

Nika N. Danial, Dana-Farber Cancer Institute, USA
Causes and Consequences of Metabolic Fuel Choice in Cancer

Divya Bezwada, University of Texas Southwestern Medical Center, USA
Short Talk: Comparing Metabolic Labeling of Human Tumors at Different Anatomic Sites

Naama Kanarek, Whitehead Institute, USA
Short Talk: Histidine Catabolism Is a Major Determinant of Methotrexate Sensitivity

11:15—17:00
On Own for Lunch

14:30—16:30
Workshop 2: Therapeutic Targeting of Cancer Metabolism

Ballroom 1-2
* Brooke M. Emerling, Sanford Burnham Prebys Medical Discovery Institute, USA

Liron Bar-Peled, The Scripps Research Institute, USA
Identification of Druggable and Redox Vulnerabilities in Lung Cancer

Kristin Kate Brown, Peter MacCallum Cancer Centre, Australia
Adaptive Reprogramming of de novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer

Gregory S. Ducker, University of Utah, USA
Glycine Restriction, One-Carbon Metabolism and Cancer Proliferation

Javier Garcia-Bermudez, Rockefeller University, USA
Squalene Accumulation Protects Lymphomas Auxotrophic for Cholesterol from Ferroptosis and Generates Therapeutic Liabilities

Evan Chen Lien, Massachusetts Institute of Technology, USA
Impact of Diet on Tumor Metabolism and Progression

Samuel McBrayer, Dana-Farber Cancer Institute, USA
BCAT Inhibition by 2HG Causes Glutaminase Dependence in IDH1 Mutant Gliomas During Oxidative Stress

Florian Muller, University of Texas MD Anderson Cancer Center, USA
Collateral Deletion of Glycolysis Genes Generates Selective Vulnerabilities to Inhibitors of Oxidative Phosphorylation

Cristina Muñoz-Pinedo, Institut d'Investigacio Biomedica de Bellvitge, Spain
Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—18:45
Immunometabolism
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-2
* Christian Metallo, University of California, San Diego, USA

Jeffrey C. Rathmell, Vanderbilt University, USA
Fueling T Cells in Inflammation and Cancer

Janelle S. Ayres, The Salk Institute for Biological Studies, USA
Micronutrient Regulation of Insulin Sensitivity Promotes Healthy Host-Bacterial Interactions

Douglas R. Green, St. Jude Children's Research Hospital, USA
Targeting LAP: LC3-Associated Phagocytosis and Anti-Cancer Immunity

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Ballroom 1-2
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 2-3
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Ballroom 2-3

FRIDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

BioLegend, Inc. Cancer Research UK
Cell Research EMD Serono Research and Development Institute, Inc.
Incyte Corporation Merck & Co., Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

HypOxygen
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13CA221318-01

Funding for this conference was made possible (in part) by 1R13CA221318-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

Agilent

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Agios Pharmaceuticals


AstraZeneca


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676