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This meeting took place in 2018
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Tumor Metabolism (A5)
Organizer(s) Heather Christofk, Christian Metallo and Alec Kimmelman
January 21—25, 2018
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Sep 26, 2017
Abstract Deadline: Oct 24, 2017
Scholarship Deadline: Sep 26, 2017
Discounted Registration Deadline: Nov 27, 2017
Sponsored by BioLegend, Inc., Cancer Research UK, Cell Research, EMD Serono Research and Development Institute Inc., Incyte Corporation and Merck & Co., Inc.
Summary of Meeting:
This conference brings together experts in the tumor metabolism field to discuss new concepts in the regulation and role of cancer metabolism in tumor growth, as well as strategies for targeting tumor metabolism for therapeutic benefit. However, even though research and knowledge have grown in this field, there still remain many questions to be answered such as what is the role of mitochondria in promotion of cancer metabolic phenotypes, how does the influence of the microenvironment contribute to tumor metabolism, and what is the impact of tumor metabolism on the epigenetic state of cancer cells? This Keystone Symposia meeting will address such areas. In addition, the meeting aims to:1) Discuss these gaps in knowledge surrounding the influence of mitochondria and microenvironment on tumor metabolism as well as the influence of cancer metabolism on epigenetics; 2) Explore different approaches for identifying promising tumor metabolism drug targets; 3) Evaluate the best ways to model and quantify tumor metabolism in vivo; and 4) Provide a conceptual framework to trainees and non-experts in the field on the regulation and role of tumor metabolism in cancer biology. Anticipated outcomes include generation of new ideas and scientific knowledge, promotion of new collaborations, and enhanced use of correct methodologies for measuring tumor metabolism. This symposium is the premier conference for learning about the most important unpublished data in the tumor metabolism field and is invaluable to enhance accelerated discovery and development of new therapeutic approaches to target cancer metabolism.
View Scholarships/Awards
This conference brings together experts in the tumor metabolism field to discuss new concepts in the regulation and role of cancer metabolism in tumor growth, as well as strategies for targeting tumor metabolism for therapeutic benefit. However, even though research and knowledge have grown in this field, there still remain many questions to be answered such as what is the role of mitochondria in promotion of cancer metabolic phenotypes, how does the influence of the microenvironment contribute to tumor metabolism, and what is the impact of tumor metabolism on the epigenetic state of cancer cells? This Keystone Symposia meeting will address such areas. In addition, the meeting aims to:1) Discuss these gaps in knowledge surrounding the influence of mitochondria and microenvironment on tumor metabolism as well as the influence of cancer metabolism on epigenetics; 2) Explore different approaches for identifying promising tumor metabolism drug targets; 3) Evaluate the best ways to model and quantify tumor metabolism in vivo; and 4) Provide a conceptual framework to trainees and non-experts in the field on the regulation and role of tumor metabolism in cancer biology. Anticipated outcomes include generation of new ideas and scientific knowledge, promotion of new collaborations, and enhanced use of correct methodologies for measuring tumor metabolism. This symposium is the premier conference for learning about the most important unpublished data in the tumor metabolism field and is invaluable to enhance accelerated discovery and development of new therapeutic approaches to target cancer metabolism.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 25 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 26 in order to fully experience the meeting.
SUNDAY, JANUARY 21
MONDAY, JANUARY 22
TUESDAY, JANUARY 23
WEDNESDAY, JANUARY 24
THURSDAY, JANUARY 25
FRIDAY, JANUARY 26
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 25 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 26 in order to fully experience the meeting.
SUNDAY, JANUARY 21
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
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Heather Christofk,
University of California, Los Angeles, USA
Karen H. Vousden,
Crick Institute, UK
p53 Pathways and Cancer Cell Metabolism
p53 Pathways and Cancer Cell Metabolism
09:00—11:30
Mitochondrial Impact on Cancer Metabolism
Meeting has ended...abstracts no longer viewable online.
*
Alec Kimmelman,
New York University Langone Medical Center, USA
Navdeep S. Chandel,
Northwestern University, USA
Mitochondria as Signaling Organelles
Mitochondria as Signaling Organelles
Coffee Break
Laurent Le Cam,
Institut de Recherche en Cancérologie de Montpellier, France
p53 Pathway & Metabolism: Implications in Tissue Homeostasis, Aging and Carcinogenesis
p53 Pathway & Metabolism: Implications in Tissue Homeostasis, Aging and Carcinogenesis
Jared Rutter,
University of Utah, USA
Mitochondria, Metabolism and Cellular Decisions
Mitochondria, Metabolism and Cellular Decisions
David B. Shackelford,
University of California, Los Angeles, USA
Short Talk: PET Imaging Mitochondrial Bioenergetics in Lung Cancer
Short Talk: PET Imaging Mitochondrial Bioenergetics in Lung Cancer
14:30—16:30
Workshop 1: Newcomers
*
Ralph J. DeBerardinis,
University of Texas Southwestern Medical Center, USA
Donita C. Brady,
University of Pennsylvania, USA
Tracing Copper Utilization by Kinase Signal Transduction Pathways: Implications for Cancer Cell Metabolic Processes
Tracing Copper Utilization by Kinase Signal Transduction Pathways: Implications for Cancer Cell Metabolic Processes
Issam Ben-Sahra,
Northwestern University, USA
Stimulation of de novo Serine Synthesis upon Purine Depletion
Stimulation of de novo Serine Synthesis upon Purine Depletion
Andrew G. Cox,
Peter MacCallum Cancer Centre, Australia
Yap Regulates Anabolic Glucose Metabolism to Enable Optimal Organ Growth
Yap Regulates Anabolic Glucose Metabolism to Enable Optimal Organ Growth
Maria Diaz-Meco,
Sanford Burnham Prebys Institute, USA
ATF4-Induced Metabolic Reprograming, a Synthetic Vulnerability of the p62-Deficient Tumor Stroma
ATF4-Induced Metabolic Reprograming, a Synthetic Vulnerability of the p62-Deficient Tumor Stroma
Brooke M. Emerling,
Sanford Burnham Prebys Medical Discovery Institute, USA
Non-Canonical Phosphatidylinositol Kinases in the Control of Cellular Lipid Metabolism and Autophagy
Non-Canonical Phosphatidylinositol Kinases in the Control of Cellular Lipid Metabolism and Autophagy
Ayelet Erez,
Weizmann Institute of Science, Israel
Urea Cycle Dysregulation in Cancer Results in an Oncogenic Mutation Bias Associated with Enhanced Response to Immune Checkpoint Inhibitors
Urea Cycle Dysregulation in Cancer Results in an Oncogenic Mutation Bias Associated with Enhanced Response to Immune Checkpoint Inhibitors
Sumin Kang,
Emory University, USA
GDH1 Promotes Anoikis Resistance & Tumor Metastasis through CAMKK2 in Lung Cancer
GDH1 Promotes Anoikis Resistance & Tumor Metastasis through CAMKK2 in Lung Cancer
Richard L. Possemato,
New York University School of Medicine, USA
NFS1 Undergoes Positive Selection in Lung Tumors and Protects Cells from Ferroptosis
NFS1 Undergoes Positive Selection in Lung Tumors and Protects Cells from Ferroptosis
17:00—19:00
Metabolic Drivers of Tumor Growth
Meeting has ended...abstracts no longer viewable online.
*
Nika N. Danial,
Dana-Farber Cancer Institute, USA
David M. Sabatini,
Whitehead Institute for Biomedical Research, USA
Genetic Screens to Study Metabolism
Genetic Screens to Study Metabolism
Daniel K. Nomura,
University of California, Berkeley, USA
Redefining Druggability using Chemoproteomic Platforms
Redefining Druggability using Chemoproteomic Platforms
Heather Christofk,
University of California, Los Angeles, USA
Metabolic Transitions in Cancer: Regulation by Cell-Extrinsic Cues
Metabolic Transitions in Cancer: Regulation by Cell-Extrinsic Cues
Ruiting Lin,
Emory University School of Medicine, USA
Short Talk: Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-Tumor Effects on BRAF V600E Melanoma
Short Talk: Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-Tumor Effects on BRAF V600E Melanoma
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Oncogenic Control of Cancer Metabolism
Meeting has ended...abstracts no longer viewable online.
*
M. Celeste Simon,
University of Pennsylvania, USA
Lewis C. Cantley,
Weill Cornell Medicine, USA
PI 3-Kinase and Cancer Metabolism
PI 3-Kinase and Cancer Metabolism
Brendan D. Manning,
Harvard School of Public Health, USA
The PI3K-mTOR Network and Control of Anabolic Tumor Metabolism
The PI3K-mTOR Network and Control of Anabolic Tumor Metabolism
Coffee Break
Reuben J. Shaw,
The Salk Institute for Biological Studies, USA
AMPK: Cancer Fighter, Cancer Supporter
AMPK: Cancer Fighter, Cancer Supporter
Thales Papagiannakopoulos,
New York University School of Medicine, USA
Uncovering Metabolic Bottlenecks in Lung Cancer
Uncovering Metabolic Bottlenecks in Lung Cancer
Gina DeNicola,
Moffitt Cancer Center, USA
Short Talk: Cysteine Dioxygenase Is a Metabolic Liability for Non-Small Cell Lung Cancers
Short Talk: Cysteine Dioxygenase Is a Metabolic Liability for Non-Small Cell Lung Cancers
Krushna C. Patra,
Massachusetts General Hospital, Harvard Medical School, USA
Short Talk: Oncogenic cAMP Signaling Network Reprograms Lipid Metabolism and Drives Pancreatic Cancer
Short Talk: Oncogenic cAMP Signaling Network Reprograms Lipid Metabolism and Drives Pancreatic Cancer
17:00—19:00
Modeling the Complexities of Tumor Metabolism
Meeting has ended...abstracts no longer viewable online.
*
Reuben J. Shaw,
The Salk Institute for Biological Studies, USA
Ralph J. DeBerardinis,
University of Texas Southwestern Medical Center, USA
Metabolic Complexity in Cancer Cells and Tumors (…and other diseases)
Metabolic Complexity in Cancer Cells and Tumors (…and other diseases)
Eyal Gottlieb,
Technion Integrated Cancer Center, Israel
Metabolic Vulnerabilities of Cancer
Metabolic Vulnerabilities of Cancer
Christian Metallo,
University of California, San Diego, USA
Tracing the Interplay between Amino Acid and Lipid Metabolism in Cancer Cell Growth
Tracing the Interplay between Amino Acid and Lipid Metabolism in Cancer Cell Growth
Oliver Jonas,
Brigham & Women's Hospital, USA
Short Talk: Using Local Perturbations from Implantable Micro Devices to Dissect Metabolism of Cancer and Immune Cells in Tumors
Short Talk: Using Local Perturbations from Implantable Micro Devices to Dissect Metabolism of Cancer and Immune Cells in Tumors
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Metabolic Scavenging and the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.
*
Jared Rutter,
University of Utah, USA
Eileen P. White,
Rutgers University, USA
Autophagy, Metabolism, and Cancer
Autophagy, Metabolism, and Cancer
Jorge Moscat,
Sanford Burnham Prebys Institute, USA
p62: Metabolism in the Tumor Micro- and Macro-Environment
p62: Metabolism in the Tumor Micro- and Macro-Environment
Coffee Break
M. Celeste Simon,
University of Pennsylvania, USA
Metabolic Symbioses in the Tumor Microenvironment
Metabolic Symbioses in the Tumor Microenvironment
Alec Kimmelman,
New York University Langone Medical Center, USA
Identifying Metabolic Dependencies in Pancreatic Cancer
Identifying Metabolic Dependencies in Pancreatic Cancer
Boyi Gan,
MD Anderson Cancer Center, USA
Short Talk: Glutamate/Cystine Antiporter SLC7A11/xCT Regulates Glucose Dependency
Short Talk: Glutamate/Cystine Antiporter SLC7A11/xCT Regulates Glucose Dependency
Jurre J. Kamphorst,
CR-UK Beatson Institute and University of Glasgow, UK
Short Talk: Paracrine Lipid Flux from Stromal Fibroblasts Promotes Pancreatic Tumor Growth
Short Talk: Paracrine Lipid Flux from Stromal Fibroblasts Promotes Pancreatic Tumor Growth
17:00—19:00
Influence of Metabolism on the Epigenome
Meeting has ended...abstracts no longer viewable online.
*
Oliver Maddocks,
University of Glasgow, UK
Siavash K. Kurdistani,
University of California, Los Angeles, USA
A Novel Function of Histones in Copper Homeostasis
A Novel Function of Histones in Copper Homeostasis
Christian Frezza,
Hutchison/MRC Research Centre, UK
Fumarate Hydratase and Cancer: Oncometabolites and Beyond
Fumarate Hydratase and Cancer: Oncometabolites and Beyond
Mattia Falcone,
German Cancer Research Center, Germany
Short Talk: BCAT1 Restricts αKG Levels in AML Stem Cells Leading to IDHmut-like DNA Hypermethylation
Short Talk: BCAT1 Restricts αKG Levels in AML Stem Cells Leading to IDHmut-like DNA Hypermethylation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Targeting Cancer Metabolism
Meeting has ended...abstracts no longer viewable online.
*
Brendan D. Manning,
Harvard School of Public Health, USA
Gromoslaw Smolen,
Agios Pharmaceuticals, USA
Strategies for Identifying Metabolic Vulnerabilities of Cancer Cells
Strategies for Identifying Metabolic Vulnerabilities of Cancer Cells
Francesco Parlati,
Calithera Biosciences, USA
Anti-Tumor Activity of Glutaminase Inhibitor CB-839 in Combination with Clinical Anti-Cancer Agents
Anti-Tumor Activity of Glutaminase Inhibitor CB-839 in Combination with Clinical Anti-Cancer Agents
Coffee Break
Susan E. Critchlow,
AstraZeneca, UK
New Developments in Targeting Monocarboxylate Transporters
New Developments in Targeting Monocarboxylate Transporters
Nika N. Danial,
Dana-Farber Cancer Institute, USA
Causes and Consequences of Metabolic Fuel Choice in Cancer
Causes and Consequences of Metabolic Fuel Choice in Cancer
Divya Bezwada,
University of Texas Southwestern Medical Center, USA
Short Talk: Comparing Metabolic Labeling of Human Tumors at Different Anatomic Sites
Short Talk: Comparing Metabolic Labeling of Human Tumors at Different Anatomic Sites
Naama Kanarek,
Whitehead Institute, USA
Short Talk: Histidine Catabolism Is a Major Determinant of Methotrexate Sensitivity
Short Talk: Histidine Catabolism Is a Major Determinant of Methotrexate Sensitivity
14:30—16:30
Workshop 2: Therapeutic Targeting of Cancer Metabolism
*
Brooke M. Emerling,
Sanford Burnham Prebys Medical Discovery Institute, USA
Liron Bar-Peled,
The Scripps Research Institute, USA
Identification of Druggable and Redox Vulnerabilities in Lung Cancer
Identification of Druggable and Redox Vulnerabilities in Lung Cancer
Kristin Kate Brown,
Peter MacCallum Cancer Centre, Australia
Adaptive Reprogramming of de novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer
Adaptive Reprogramming of de novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer
Gregory S. Ducker,
Princeton University, USA
Glycine Restriction, One-Carbon Metabolism and Cancer Proliferation
Glycine Restriction, One-Carbon Metabolism and Cancer Proliferation
Javier Garcia-Bermudez,
Rockefeller University, USA
Squalene Accumulation Protects Lymphomas Auxotrophic for Cholesterol from Ferroptosis and Generates Therapeutic Liabilities
Squalene Accumulation Protects Lymphomas Auxotrophic for Cholesterol from Ferroptosis and Generates Therapeutic Liabilities
Evan Chen Lien,
Massachusetts Institute of Technology, USA
Impact of Diet on Tumor Metabolism and Progression
Impact of Diet on Tumor Metabolism and Progression
Samuel McBrayer,
Dana-Farber Cancer Institute, USA
BCAT Inhibition by 2HG Causes Glutaminase Dependence in IDH1 Mutant Gliomas During Oxidative Stress
BCAT Inhibition by 2HG Causes Glutaminase Dependence in IDH1 Mutant Gliomas During Oxidative Stress
Florian Muller,
University of Texas MD Anderson Cancer Center, USA
Collateral Deletion of Glycolysis Genes Generates Selective Vulnerabilities to Inhibitors of Oxidative Phosphorylation
Collateral Deletion of Glycolysis Genes Generates Selective Vulnerabilities to Inhibitors of Oxidative Phosphorylation
Cristina Muñoz-Pinedo,
Institut d'Investigacio Biomedica de Bellvitge, Spain
Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors
Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors
17:00—18:45
Immunometabolism
Meeting has ended...abstracts no longer viewable online.
*
Christian Metallo,
University of California, San Diego, USA
Janelle S. Ayres,
The Salk Institute for Biological Studies, USA
Micronutrient Regulation of Insulin Sensitivity Promotes Healthy Host-Bacterial Interactions
Micronutrient Regulation of Insulin Sensitivity Promotes Healthy Host-Bacterial Interactions
Douglas R. Green,
St. Jude Children's Research Hospital, USA
Targeting LAP: LC3-Associated Phagocytosis and Anti-Cancer Immunity
Targeting LAP: LC3-Associated Phagocytosis and Anti-Cancer Immunity
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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