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This meeting took place in 2018
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Novel Aspects of Bone Biology (E3)
Organizer(s) Gerard Karsenty and David T. Scadden
June 13—16, 2018
Snowbird Resort • Snowbird, Utah USA
Discounted Abstract Deadline: Feb 27, 2018
Abstract Deadline: Mar 27, 2018
Scholarship Deadline: Feb 27, 2018
Discounted Registration Deadline: Apr 12, 2018
Supported by the Directors' Fund
Summary of Meeting:
This conference presents recent progress made in two relatively novel areas of skeletal biology not covered by other meetings. The first one is the cross-talk between bone, hematopoiesis and leukemogenesis. The second is the study of the various endocrine functions of bone and how their study impacts on our understanding of multiple degenerative diseases. Meetings of bone biology are traditionally dominated by the need to explain the basis and to propose treatments for the most frequent bone disease: osteoporosis. Aside from this very vivid field, these two other novel aspects of bone biology have developed in the last decade. A shared feature is that they link bone biology to multiple other organs and to other functions besides making bones. This conference showcases the many advances made in these two aspects of skeleton biology and how these developments have enriched our understanding of the pathogenesis of multiple degenerative diseases affecting the bone marrow, energy metabolism or the brain. Because of its very nature, this conference brings together investigators from different fields rarely afforded an opportunity to meet.
View Scholarships/Awards
This conference presents recent progress made in two relatively novel areas of skeletal biology not covered by other meetings. The first one is the cross-talk between bone, hematopoiesis and leukemogenesis. The second is the study of the various endocrine functions of bone and how their study impacts on our understanding of multiple degenerative diseases. Meetings of bone biology are traditionally dominated by the need to explain the basis and to propose treatments for the most frequent bone disease: osteoporosis. Aside from this very vivid field, these two other novel aspects of bone biology have developed in the last decade. A shared feature is that they link bone biology to multiple other organs and to other functions besides making bones. This conference showcases the many advances made in these two aspects of skeleton biology and how these developments have enriched our understanding of the pathogenesis of multiple degenerative diseases affecting the bone marrow, energy metabolism or the brain. Because of its very nature, this conference brings together investigators from different fields rarely afforded an opportunity to meet.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Wednesday, June 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, June 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, June 17 in order to fully experience the meeting.
WEDNESDAY, JUNE 13
THURSDAY, JUNE 14
FRIDAY, JUNE 15
SATURDAY, JUNE 16
SUNDAY, JUNE 17
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Wednesday, June 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, June 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Sunday, June 17 in order to fully experience the meeting.
WEDNESDAY, JUNE 13
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
*
Christa Maes,
KU Leuven, Belgium
Daniel E. Lieberman,
Harvard University, USA
An Evolutionary Medical Perspective on Bone Disease
An Evolutionary Medical Perspective on Bone Disease
09:30—12:00
The Origin of the Osteoblast
Meeting has ended...abstracts no longer viewable online.
*
Christa Maes,
KU Leuven, Belgium
Roberta Faccio,
Washington University, USA
Bone-Derived Dickkopf-Related Protein 1 (Dkk1) Exerts Immune-Suppressive Effects in Cancer
Bone-Derived Dickkopf-Related Protein 1 (Dkk1) Exerts Immune-Suppressive Effects in Cancer
Coffee Break
Siddhartha Mukherjee,
Columbia University Medical Center, USA
Definition of a Post-Natal Osteoblast Stem Cell
Definition of a Post-Natal Osteoblast Stem Cell
Henry M. Kronenberg,
Massachusetts General Hospital, USA
Sox9-Expressing Cells Are Progenitors of Osteoblasts, Stromal Cells and Chondrocytes in Mouse Bone
Sox9-Expressing Cells Are Progenitors of Osteoblasts, Stromal Cells and Chondrocytes in Mouse Bone
Shawon Debnath,
Weill Cornell Medicine, Cornell University, USA
Short Talk: Identification of a Novel Periosteal Stem Cell Population that Mediates Intramembranous Bone Formation
Short Talk: Identification of a Novel Periosteal Stem Cell Population that Mediates Intramembranous Bone Formation
Constance T. Noguchi,
NIDDK, National Institutes of Health, USA
Short Talk: Altered Erythropoietin Signaling Disrupts Bone Marrow Stromal Cell Differentiation
Short Talk: Altered Erythropoietin Signaling Disrupts Bone Marrow Stromal Cell Differentiation
17:00—19:15
The Bone Marrow Niche
Meeting has ended...abstracts no longer viewable online.
*
Sabina Sangaletti,
Fondazione IRCCS Istituto Tumori Milano, Italy
David T. Scadden,
Massachusetts General Hospital and Harvard University, USA
Defining (and applying) The Bone Marrow Niche
Defining (and applying) The Bone Marrow Niche
Sean J. Morrison,
University of Texas Southwestern Medical Center, USA
The Maintenance of the Adult Skeleton
The Maintenance of the Adult Skeleton
Paul S. Frenette,
Albert Einstein College of Medicine, USA
Neural Regulation of the Aging Bone Marrow Niche
Neural Regulation of the Aging Bone Marrow Niche
John Chute,
University of California, Los Angeles, USA
Bone Marrow Osteolineage Cells Regulate Hematopoietic Regeneration via Secretion of Dkk1
Bone Marrow Osteolineage Cells Regulate Hematopoietic Regeneration via Secretion of Dkk1
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
The Endocrine Function of the Osteoblast
Meeting has ended...abstracts no longer viewable online.
*
Mathieu Ferron,
Institut de Recherches Cliniques de Montréal, Canada
Gerard Karsenty,
Columbia University Medical Center, USA
Osteocalcin Is Necessary and Sufficient to Mount an Acute Stress Response
Osteocalcin Is Necessary and Sufficient to Mount an Acute Stress Response
Aline Bozec,
University of Erlangen, Germany
High-Fat Diet and Microbiota Control the Bone Marrow Niche and Hematopoietic Stem Cell Differentiation
High-Fat Diet and Microbiota Control the Bone Marrow Niche and Hematopoietic Stem Cell Differentiation
Coffee Break
Yihong Wan,
University of Texas Southwestern Medical Center, USA
Endocrine and Metabolic Regulation of Osteoclastogenesis
Endocrine and Metabolic Regulation of Osteoclastogenesis
Omar Al Rifai,
Clinical Research Institute of Montreal, IRCM, Canada
Short Talk: Proprotein Convertase Furin is a Novel Pleiotropic Regulator of Bone Endocrine Functions
Short Talk: Proprotein Convertase Furin is a Novel Pleiotropic Regulator of Bone Endocrine Functions
Julian Berger,
Columbia University Medical Center, USA
Short Talk: Osteocalcin Signaling in the Adrenal Cortex is Necessary for Steroid Hormones Biosynthesis and Adrenal Gland Growth
Short Talk: Osteocalcin Signaling in the Adrenal Cortex is Necessary for Steroid Hormones Biosynthesis and Adrenal Gland Growth
17:00—19:00
The Relationship between Bone and Leukemia
Meeting has ended...abstracts no longer viewable online.
*
Lev Silberstein,
Fred Hutchinson Cancer Research Center, USA
Emmanuelle Passegué,
Columbia University, USA
Aging of Stem Cells and Leukemogenesis
Aging of Stem Cells and Leukemogenesis
Stavroula Kousteni,
Columbia University, USA
The Osteoblast as an Inducer of Leukemogenesis
The Osteoblast as an Inducer of Leukemogenesis
Stéphane J. C. Mancini,
INSERM, France
Short Talk: Hematopoietic Stem Cells and Early B Cells Form Specific Interaction Networks with A Unique Peri-Sinusoidal Stromal Cell Niche in the Bone Marrow
Short Talk: Hematopoietic Stem Cells and Early B Cells Form Specific Interaction Networks with A Unique Peri-Sinusoidal Stromal Cell Niche in the Bone Marrow
Annas Al-Sharea,
Baker IDI Heart and Diabetes Institute, Australia
Short Talk: Cholinergic Regulation of Bone Marrow Vascular Microenvironment Influences Hematopoietic Stem Cell Mobilization
Short Talk: Cholinergic Regulation of Bone Marrow Vascular Microenvironment Influences Hematopoietic Stem Cell Mobilization
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Molecular Genetics of Bone Metastasis
Meeting has ended...abstracts no longer viewable online.
*
Patricia Ducy,
Columbia University, USA
Yibin Kang,
Princeton University, USA
The Role of Bone Stromal Niches in the Seeding, Outgrowth and Treatment Resistance of Bone Metastasis
The Role of Bone Stromal Niches in the Seeding, Outgrowth and Treatment Resistance of Bone Metastasis
Theresa A. Guise,
Indiana University, USA
Systemic Effects of the Tumor-Bone Microenvironment: Mechanisms and Therapeutic Approaches
Systemic Effects of the Tumor-Bone Microenvironment: Mechanisms and Therapeutic Approaches
Coffee Break
G. David Roodman,
Indiana University, USA
The Pathogenesis of Multiple Myeloma
The Pathogenesis of Multiple Myeloma
Camilla Engblom,
Massachusetts General Hospital, USA
Lung Tumors Talk to Bones and Bones Answer Back
Lung Tumors Talk to Bones and Bones Answer Back
Aaron E. Chiou,
Cornell University, USA
Short Talk: Investigating Pre-Metastatic Alterations of Bone Extracellular Matrix
Short Talk: Investigating Pre-Metastatic Alterations of Bone Extracellular Matrix
17:00—18:45
The Relationship between Bone and the Immune System
Meeting has ended...abstracts no longer viewable online.
Hiroshi Takayanagi,
University of Tokyo, Japan
Interaction between Bone and the Immune System
Interaction between Bone and the Immune System
Rheinallt M. Jones,
Emory University, USA
The Influence of the Gut Microbiota on Bone Metabolism: In Pursuit of Mechanisms
The Influence of the Gut Microbiota on Bone Metabolism: In Pursuit of Mechanisms
Ralf H. Adams,
Max Planck Institute for Molecular Biomedicine, Germany
Blood Vessel Growth, Function and Aging in the Skeletal System
Blood Vessel Growth, Function and Aging in the Skeletal System
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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