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This meeting took place in 2018



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B Cells: Mechanisms in Immunity and Autoimmunity (E4)


Organizer(s) Lars Nitschke, Michael Reth, Roberta Pelanda and David M. Tarlinton
June 17—21, 2018
Maritim Hotel & International Congress Center Dresden • Dresden, Germany
Discounted Abstract Deadline: Feb 14, 2018
Abstract Deadline: Mar 14, 2018
Scholarship Deadline: Feb 14, 2018
Discounted Registration Deadline: Apr 17, 2018

Sponsored by Genentech, Inc., MSD, and Roche

Summary of Meeting:
B cells play an important role in immunity and immunology research. New findings about the relevance and contribution of B cells to autoimmunity have rejuvenated interest in B cell immunology research. B cell functions unrelated to the production of antibodies have also been recently uncovered, indicating B cells operate in the context of both humoral and cellular adaptive immune responses. These B cell properties have stimulated a plethora of studies aimed at discovering the molecular mechanisms of B cell development and diversification, B cell activation, B cell memory responses and B cell tolerance induction. Affinity maturation of antibodies within the germinal center is now considered to be more complex than previously thought. The generation of broadly neutralizing antibodies against viruses in a few, but not all individuals, and the generation of autoantibodies during germinal center responses, have challenged existing dogmas. B cell metabolism and its intersection with the microbiome are stimulating and exciting areas only now beginning to be explored. Antibody-independent functions of B cells, for example in secreting inflammatory or regulatory cytokines, suggest B cells are relevant in many inflammatory and allergic diseases. This conference aims to address the mechanisms of B cell activation, B cell differentiation and B cell responses, and the contribution of B cells to the development of autoimmune diseases. Potential new treatment options for these diseases will also be covered.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, June 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 21 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, June 22 in order to fully experience the meeting.

SUNDAY, JUNE 17

16:00—20:00
Arrival and Registration

Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Foyer

MONDAY, JUNE 18

08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Roberta Pelanda, University of Colorado Denver, USA

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Germinal Centers and Memory B Cells

09:30—12:00
B Cell Differentiation
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Lill Martensson, University of Gothenburg, Sweden

* Anja Erika Hauser, Charité-Universitätsmedizin, Germany

Martin Turner, Babraham Institute, UK
Regulation of B Cell Development by RNA Binding Proteins

Coffee Break

Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Suppression of Autoimmunity by the Transcription Factor Ikaros

Marion Pepper, University of Washington, USA
Memory B Cells in Malaria Infections

Anselm Enders, John Curtin School of Medical Research, Australia
Short Talk: Deregulation of PAX5 Causes Abnormal B Cell Lymphopoiesis and Spontaneous Precursor B Cell Lymphoma Development in Mice

Klaus D. Fischer, Medical Faculty Magdeburg, Germany
Short Talk: The Opposing Forces of Shear Flow and Sphingosine-1-Phosphate Control Marginal Zone B Cell Shuttling

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Saal 3
13:00—22:00
Poster Viewing

Saal 3
14:30—16:30
Workshop 1: Signals Driving Development of Conventional and Innate B Cells

Saal 4/5
* Joao Pereira, Yale University School of Medicine, USA

* Nicole Baumgarth, University of California, Davis, USA

Duane R. Wesemann, Brigham and Women's Hospital, Harvard Medical School, USA
Stochastic B Cell Diversification in Germinal Centers

Meihong Deng, University of Pittsburgh, USA
TLR9 Regulates Host Defense via Modulation of Peritoneal B1 Cell Pathobiology during Intra-Abdominal Sepsis

Stijn Vanhee, Lund University, Sweden
B Cell Positive Selection Is Developmentally Regulated during Ontogeny by the Heterochronic Protein Lin28b

Wenxia Song, University of Maryland, USA
BCR-Antigen Interaction Causes Wounding and Repair of the B Cell Membrane, Promoting BCR Activation

Sandra Eva Zehentmeier, Yale School of Medicine, USA
Get Your Motor Runnin’: Control of B Cell Receptor Signaling through Gαi Protein-Mediated Chemoattractant Sensing

Carolin Ulbricht, Charité Universitätsmedizin Berlin, Germany
Tracking B Cell Receptor Signaling during Germinal Center Reactions in vivo

Daniela Giordano, University of Washington, USA
Expression of and Requirement for B Cell Activating Factor (BAFF) during West Nile Virus (WNV) and Salmonella Infection

Simar Pal Singh, Erasmus MC, Netherlands
T Cells Shape the Immunoglobulin Repertoire of Murine Chronic Lymphocytic Leukemia while B Cell Receptor Signaling Strength Controls Age of Onset

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Innate Functions of B Cells
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Michelle A. Linterman, Babraham Institute, UK

* Randall S. Davis, University of Alabama, Birmingham, USA

Nicole Baumgarth, University of California, Davis, USA
Regulation of B-1 Cell Functions

Simon Fillatreau, Institut Necker Enfants Malades, France
Regulatory Roles of B Cells in Autoimmune and Infectious Diseases

Claudia Mauri, University College London, UK
How Regulatory B Cells Bridge the Innate and the Adaptive Immune Response

Yoontae Lee, Pohang University of Science and Technology, South Korea
Short Talk: Transcriptional Regulation of B-1 and B-2 Cell Fates by Capicua

Marc Seifert, University of Duisburg-Essen, Germany
Short Talk: Molecular and Functional Characterization of Human B-1a Cells

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Terrassen Foyer
19:30—22:00
Poster Session 1

Saal 3

TUESDAY, JUNE 19

08:00—08:30
Poster Setup

Saal 3
08:30—17:00
Poster Viewing

Saal 3
08:30—11:45
Checkpoint Control of B Cell Signaling
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Raul M. Torres, University of Colorado School of Medicine, USA

* Victor L.J. Tybulewicz, Francis Crick Institute, UK

Julia Jellusova, University of Freiburg, Germany
The Role of the B Cell Receptor in Regulating Metabolic Fitness

Michael Reth, Albert-Ludwigs University Freiburg, Germany
The Nanoscale Organization of the BCR and the B Cell Membrane

Coffee Break

Jürgen Wienands, Georg August University of Goettingen, Germany
The Scaffolding Protein CIN85 Controls BCR Responsiveness and Subsequent Antibody Responses in Humans

Markus Müschen, Beckman Research Institute, USA
Autoimmunity Checkpoints in B Cell Malignancies

Kerstin Nündel, University of Massachusetts Medical School, USA
Short Talk: Divergent Roles for TLR7 and TLR9 in Modulating the NFkB Pathway in B Cells

Susana Minguet, Biology III and BIOSS, Germany
Short Talk: Caveolin-1-Dependent Nanoscale Organization of the BCR Regulates B Cell Tolerance

11:45—12:30
Lunch

Terrassen Foyer
12:00—14:30
Poster Session 2

Saal 3
14:30—16:30
Workshop 2: Germinal Centers and Humoral Immune Response

Saal 4/5
* Kai-Michael Toellner, University of Birmingham Medical School, UK

* Hedda Wardemann, German Cancer Research Center, Germany

Michelle A. Mintz, University of California, San Francisco, USA
The HVEM-BTLA Interaction Restrains the Germinal Center Response

Floriana Cremasco, Università Vita Salute San Raffaele, Italy
Autophagy-Independent Control of the Germinal Center Reaction by the Adapter SQSTM1/p62

Michelle A. Linterman, Babraham Institute, UK
Type I Interferon Induces CXCL13-Driven B Cell Recruitment to the Lung to Enable Tertiary Germinal Centre Formation

Imogen Moran, Garvan Institute of Medical Research, Australia
Where and How Memory Cells Are Reactivated in the Secondary Antibody Response in the Lymph Node

Dessi Malinova, Francis Crick Institute, UK
Genome-Wide CRISPR/Cas9 Screens Identify Components of B Cell Antigen Internalization

Yuezhou Chen, Brigham and Women's Hospital, USA
Primary Ig Repertoire Control as a Demand-Driven Process

Kim Good-Jacobson, Monash University, Australia
Histone-Modifying Complexes Differentially Regulate B Cell Fate Decisions during Acute and Chronic Infection

Ian A. Cockburn, Australian National University, Australia
New Approaches to Track B Cells Specific for a Major Malaria Vaccine Candidate

16:30—17:00
Coffee Available

Foyer
17:00—19:15
Diversification of Antibodies and Humoral Immune Response
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Gabriel D. Victora, Rockefeller University, USA

* Berit Jungnickel, Friedrich Schiller University Jena, Germany

Javier M. Di Noia, Institut de Recherches Cliniques de Montreal, Canada
Structure-Function of AID Uncovers a Licensing Step for Antibody Gene Diversification

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
Fate Decision of Germinal Center B Cells

Daisuke Kitamura, Tokyo University of Science, Japan
Regulatory Mechanisms for Memory B Cell Development and Function

Robert Abbott, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

Berit Jungnickel, Friedrich Schiller University Jena, Germany
Short Talk: Regulation of AID Activity and DNA Repair during Somatic Hypermutation

19:15
On Own for Dinner


WEDNESDAY, JUNE 20

08:30—11:45
Germinal Centers and B Cell Memory Formation
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Marion Pepper, University of Washington, USA

* Oliver Bannard, University of Oxford, UK

Gabriel D. Victora, Rockefeller University, USA
Clonal and Cellular Dynamics of Germinal Center Selection

Carola G. Vinuesa, Australian National University, Australia
T Follicular Helper Cells in the Germinal Center

Coffee Break

David M. Tarlinton, Monash University, Australia
Germinal Center-Derived Plasma Cells

Shannon J. Turley, Genentech, Inc., USA
Fibroblastic Reticular Cells and the Maintenance of B Cell Follicles

Ziv Shulman, Weizmann Institute, Israel
Short Talk: Germinal Centers: Arrivals, Departures and the T Cell Border Control

Hedda Wardemann, German Cancer Research Center, Germany
Short Talk: The Role of Clonal Selection Versus Affinity Maturation in the Human B Cell Response to a Repetitive Malaria Parasite Antigen

11:45—13:00
Poster Setup

Saal 3
11:45—17:00
On Own for Lunch

13:00—22:00
Poster Viewing

Saal 3
16:30—17:00
Coffee Available

Foyer
17:00—19:15
B Cell Metabolism and Intersection with the Microbiome
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Ziv Shulman, Weizmann Institute, Israel

* Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA

Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany
Regulation of Intestinal TGFß and IgA by a Distinct Microbiota

Joseph E. Craft, Yale University, USA
The Role of Tfh Cells in B-Cell Selection

Nicola L. Harris, Monash University, Australia
B Cell-Stomal Cell Interactions Drive Lymphoid Remodeling and Are Required for Efficient Adaptive Immune Responses against Intestinal Helminths

Lieselotte S.M. Kreuk, University of California, Berkeley, USA
Short Talk: B Cell Receptor and Toll-Like Receptor Signaling Integrate to Control B1-Derived Anti-Commensal IgM, IgG, and IgA

Romain Ballet, Stanford University, USA
Short Talk: CD22 Positively Controls α4β7-Dependent B Cell Homing to the Peyer’s Patches

19:15—20:15
Social Hour with Lite Bites

Terrassen Foyer
19:30—22:00
Poster Session 3

Saal 3

THURSDAY, JUNE 21

08:30—11:45
B Cell Tolerance and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* Julie Zikherman, University of California, San Francisco, USA

* Lars Nitschke, University of Erlangen, Germany

Roberta Pelanda, University of Colorado Denver, USA
Dual Antibody B Cells in Lupus, Mice and Humans

Takeshi Tsubata, Tokyo Medical and Dental University, Japan
The Inhibitory B Cell Co-Receptor CD72 Regulates Tolerance to Self Nucleic Acids Crucial for Development of Systemic Lupus Erythematosus

Coffee Break

Julie Zikherman, University of California, San Francisco, USA
Regulation of B Cell Tolerance by Nur77

Lars Nitschke, University of Erlangen, Germany
CD22 and Siglec-G Are Inhibitory Receptors on B Cells and Prevent Autoimmunity

Jeremy F. Brooks, University of Queensland, Australia
Short Talk: Characterizing Self-Reactive B Cell Responses in a Polyclonal Repertoire

Joanne H. Reed, Garvan Institute of Medical Research, Australia
Short Talk: Single Cell Analysis of Self-Reactive B Cells in Autoimmune Disease

11:45—17:00
On Own for Lunch

14:30—16:30
Workshop 3: Autoimmunity

Saal 4/5
* John C. Cambier, University of Colorado, USA

* Simon Fillatreau, Institut Necker Enfants Malades, France

Betsy J. Barnes, Feinstein Institute for Medical Research, USA
Targeting IRF5 Hyper-Activation in SLE B Cells Inhibits Disease Onset and Severity

Chih-Yeh Chen, Regensburg Center for Interventional Immunology, Germany
Bone Marrow Aire-Expressing Plasma Cells Ectopically Express Tissue-Restricted Self-Antigens and Drive Peripheral Tolerance by Inducing Autoreactive Regulatory T Cells

Amanda E. Agazio, University of Colorado Anschutz Medical Campus, USA
The Contribution of Anergic B Cells to Protective Immunity

Carlos Castrillon, Institut Pasteur, France
A Novel Technology to Follow Antibody Affinity Maturation during Autoimmunity

Roza I. Nurieva, MD Anderson Cancer Center, USA
Role of E3 Ubiquitin Ligase GRAIL in B Cell Activation and Tolerance

Zia Rahman, Penn State Hershey Medical College, USA
Crosstalk between TLR7 and IFNg Signaling via STAT1 in B Cells Controls Spontaneous Germinal Center and Autoimmune Responses

Jamie van Langelaar, Erasmus University Medical Center, Netherlands
Human T-bet+ B Cells: Induction and Effector Functions from a Multiple Sclerosis Perspective

Yang Yang, Stanford University School of Medicine, USA
Expression of CTLA4 in B-1 B Cells Acts as A Key Regulating Mechanism in Maintaining the Immune Homeostasis

16:30—17:00
Coffee Available

Foyer
17:00—18:45
B Cells in Autoimmune Diseases and Targeting Strategies
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
* David M. Tarlinton, Monash University, Australia

* Roberta Pelanda, University of Colorado Denver, USA

Reinhard E. Voll, University Freiburg, Germany
Targeting Plasma Cells in Systemic Lupus by Proteasome Inhibitors: From Mice to Men

Deborah L. Burnett, Garvan Institute of Medical Research, Australia
Short Talk: Antibodies Cross-Reacting with Self and Foreign Proteins Evolve on Consistent Trajectories to Shed Self-Binding, then Enhance Foreign-Binding

John C. Cambier, University of Colorado, USA
Loss of Anergy in Human Autoimmunity; Underlying Mechanisms

Nicholas Sanderson, University of Basel, Switzerland
Short Talk: High Dimensional Characterization of Cell Phenotypes, Soluble Signaling Molecules and Antibodies in the Cerebrospinal Fluid of Patients with Multiple Sclerosis

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.

Saal 4/5
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Terrassen Foyer
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Terrassen Foyer

FRIDAY, JUNE 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

Genentech, Inc. MSD
Roche
 

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13AI138574-01

Funding for this conference was made possible (in part) by 1R13AI138574-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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Phone:+1 970-262-2690

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