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NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.
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NOTES:
This meeting occurs in 2019.
This meeting will be conducted in English.
All programs are subject to change. Check this site for updates.
Download Flyer
This meeting occurs in 2019.
This meeting will be conducted in English.
All programs are subject to change. Check this site for updates.
Download Flyer
Molecular Approaches to Vaccines and Immune Monitoring (J5)
joint with the meeting on B Cell-T Cell Interactions (J6)Scientific Organizers: Peter D. Kwong, Brandon DeKosky and Jeffrey B. Ulmer
February 10—14, 2019
Keystone Resort, Keystone, Colorado, USA
Supported by the Directors' Fund
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.
Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.
Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.
DEADLINES:
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Deadline: Oct 9, 2018 [details]
Discounted Abstract Deadline: Oct 9, 2018 [details]
Abstract Deadline: Nov 7, 2018 [details]
Discounted Registration Deadline: Dec 6, 2018 [details]
Click here to view Cancellation Policy
Discounted Abstract Deadline: October 9, 2018
*All deadlines end at 11:59 PM US Mountain Standard TimeAbstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register
Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.
Submitting your abstract early allows us to:
- submit your abstract to organizers to be considered for a short talk
- accept your abstract online
- include your abstract on our website and in our secure mobile app
- reserve your space at the meeting for a poster presentation.**
(The Abstract Deadline: is November 7, 2018)
Global Health Travel Award Deadline:
*All deadlines end at 11:59 PM US Mountain Standard Time
Global Health Travel Award Details:
You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline
and complete the other required steps (verify your contact information and submit a recommendation letter)
to be considered for a travel award.
Click here to learn more about Global Health Travel Awards.
Scholarship Deadline: October 9, 2018
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Details:
You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.
Abstract Deadline: November 7, 2018
*All deadlines end at 11:59 PM US Mountain Standard Time
Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register
Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.
Submitting your abstract by the Abstract Deadline allows us to:
- submit your abstract to organizers to be considered for a short talk
- include your abstract on our website and in our secure mobile app
- reserve your space at the meeting for a poster presentation.**
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.
(Discounted Abstract Deadline: is October 9, 2018)
Discounted Registration Deadline: December 6, 2018
*All deadlines end at 11:59 PM US Mountain Standard Time
Registration Fee: 845.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 620.00 USD* (must complete student verification form)
*Includes 50.00 USD of your abstract submission fee
After the Discounted Registration Deadline:
Registration Fee: 1045.00 USD*
Student Registration Fee: 820.00 USD* (must complete student verification form)
*Includes 50.00 USD of your abstract submission fee
Registration spaces are limited and may fill prior to discounted registration deadline.
Please be advised that a few meeting participants have received calls and emails from a number of different housing services -
"Exhibitors Housing Services", "Global Housing", etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not
authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling and seek to take
your lodging reservation and obtain your credit card number. We highly recommend that you not make a reservation with these
companies or any other housing service! These companies' representations to participants have been misleading. Please report
to Keystone Symposia any calls or correspondence you might have received and book only through the lodging link on our website,
an established travel agency, or directly with the hotel.
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 15 in order to fully experience the meeting.
SUNDAY, FEBRUARY 10
MONDAY, FEBRUARY 11
TUESDAY, FEBRUARY 12
WEDNESDAY, FEBRUARY 13
THURSDAY, FEBRUARY 14
FRIDAY, FEBRUARY 15
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 15 in order to fully experience the meeting.
SUNDAY, FEBRUARY 10
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Antonio Lanzavecchia,
Institute for Research in Biomedicine, Switzerland
The B Cell Immune Response to Infection and Vaccination
The B Cell Immune Response to Infection and Vaccination
09:00—11:15
Targeting Appropriate Immune Responses for Structure-based Design
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
Dennis R. Burton,
The Scripps Research Institute, USA
From Antibody to Vaccine
From Antibody to Vaccine
Coffee Break
George Georgiou,
University of Texas at Austin, USA
Molecular Definition of Protective Serum Responses from Vaccination and for Immune Monitoring
Molecular Definition of Protective Serum Responses from Vaccination and for Immune Monitoring
Peter D. Kwong,
NIAID, National Institutes of Health, USA
Principles of Structure-Based Vaccine Design
Principles of Structure-Based Vaccine Design
Short Talk(s) Chosen from Abstracts
09:00—11:15
Carola G. Vinuesa,
Australian National University, Australia
Human Tfh Biology
Human Tfh Biology
Coffee Break
Hai Qi,
Tsinghua University, China
Guidance Cues for Tfh Cells
Guidance Cues for Tfh Cells
Shane Crotty,
La Jolla Institute for Allergy and Immunology, USA
Tfh Cell and Germinal Center B Cell Responses in the Context of Vaccines
Tfh Cell and Germinal Center B Cell Responses in the Context of Vaccines
Short Talk(s) Chosen from Abstracts
14:30—16:30
Workshop 1: Molecular Features of Serum Responses Appropriate as Vaccine Templates
Short Talks Chosen from Abstracts
14:30—16:30
Workshop 1: B Cell Biology in T-Dependent Responses
Short Talks Chosen from Abstracts
17:00—19:00
Clinical Results from Structure-based Vaccines
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
Sumana Chandramouli,
GSK Vaccines, USA
From Pentamer Structure to HCMV Vaccine
From Pentamer Structure to HCMV Vaccine
Amy S. Espeseth,
Merck & Co., Inc., USA
Immunological Responses to an RSV F Vaccine
Immunological Responses to an RSV F Vaccine
Barney S. Graham,
NIAID, National Institutes of Health, USA
Clinical Results from the Prefusion-Stabilized RSV F (DS-Cav1) Subunit Vaccine
Clinical Results from the Prefusion-Stabilized RSV F (DS-Cav1) Subunit Vaccine
Short Talk Chosen from Abstracts
17:00—19:00
Andre Ballesteros-Tato,
University of Alabama at Birmingham, USA
Regulation of IL-2 Responses in the GC
Regulation of IL-2 Responses in the GC
Short Talk Chosen from Abstracts
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Antibody Responses and Antibodies
Antibody Responses and Antibodies
09:00—11:15
B Cell Ontogenies as Vaccine Templates
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
Lynn Morris,
National Institute for Communicable Diseases, South Africa
Ontogenies of Broadly Neutralizing Antibodies from the CAPRISA Cohort
Ontogenies of Broadly Neutralizing Antibodies from the CAPRISA Cohort
Coffee Break
William Schief,
IAVI and The Scripps Research Institute, USA
Germline-Targeting Vaccine Design
Germline-Targeting Vaccine Design
Frederick W. Alt,
Boston Children's Hospital, USA
Mouse Models for Lineage-Based Vaccines
Mouse Models for Lineage-Based Vaccines
Short Talk(s) Chosen from Abstracts
09:00—11:15
Gabriel D. Victora,
Rockefeller University, USA
Clonal Dynamics of the Antibody Response
Clonal Dynamics of the Antibody Response
Coffee Break
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
Guidance Cues in the B Cell Response
Guidance Cues in the B Cell Response
Tomohiro Kurosaki,
WPI Immunology Frontier Research Center, Osaka University, Japan
Memory Cell Differentiation in the Germinal Center
Memory Cell Differentiation in the Germinal Center
Short Talk(s) Chosen from Abstracts
14:30—16:30
Workshop 2: Antibody Isolation and B Cell Sequencing
Short Talks Chosen from Abstracts
14:30—16:30
Workshop 2: Tfh/Tfr Differentiation and Function
Short Talks Chosen from Abstracts
17:00—19:00
Tackling Difficult Pathogens with Antibody-Based Vaccine Design
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
Ian A. Wilson,
The Scripps Research Institute, USA
Towards a Universal Influenza Virus Vaccine: Is it Better to Target the HA Head or Stem?
Towards a Universal Influenza Virus Vaccine: Is it Better to Target the HA Head or Stem?
Sarah F. Andrews,
National Institutes of Health, USA
Identifying Common Antibody Lineages to Evaluate Clinical Responses to Influenza Vaccination
Identifying Common Antibody Lineages to Evaluate Clinical Responses to Influenza Vaccination
Erica Ollmann Saphire,
The Scripps Research Institute, USA
Vaccine Design from a Prefusion-Stabilized Lassa Virus Trimer Structure
Vaccine Design from a Prefusion-Stabilized Lassa Virus Trimer Structure
Short Talk Chosen from Abstracts
17:00—19:00
Federica Sallusto,
Università della Svizzera Italiana & ETH Zurich, Switzerland
Antigen-specific Tfh Cells in Humans
Antigen-specific Tfh Cells in Humans
Casey T. Weaver,
University of Alabama at Birmingham, USA
Programming the Early Bifurcation of Tfh and Non-Tfh Effector Responses
Programming the Early Bifurcation of Tfh and Non-Tfh Effector Responses
Philippa C. Marrack,
HHMI/National Jewish Health, USA
Tfh Memory
Tfh Memory
Short Talk Chosen from Abstracts
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Rafi Ahmed†,
Emory University School of Medicine, USA
Extending the Durability of Protective B Cell Vaccines
Extending the Durability of Protective B Cell Vaccines
Hedda Wardemann,
German Cancer Research Center, Germany
Development and Clonal Evolution of Human Memory B Cell Antibody Responses
Development and Clonal Evolution of Human Memory B Cell Antibody Responses
Coffee Break
09:50—11:15
Immune Monitoring of B Cell Responses
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
Michael Joseph Mina,
Brigham and Women's Hospital, USA
Reading the Record of Immunity: Profiling the Anti-Virome Antibody Repertoire with Phage Display and Deep Neural Networks
Reading the Record of Immunity: Profiling the Anti-Virome Antibody Repertoire with Phage Display and Deep Neural Networks
Margaret Ellen Ackerman,
Dartmouth College, USA
Measuring and Mining Serum Antibody Responses to Understand Protection from Infection
Measuring and Mining Serum Antibody Responses to Understand Protection from Infection
Short Talk(s) Chosen from Abstracts
09:50—11:15
B Cell Responses in Infectious Disease
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
Patrick C. Wilson,
University of Chicago, USA
The B Cell Response to Influenza and Vaccination
The B Cell Response to Influenza and Vaccination
Frances E. Lund,
University of Alabama at Birmingham, USA
T Cell Dependent Memory B Cell Responses in Influenza Infection and Vaccination
T Cell Dependent Memory B Cell Responses in Influenza Infection and Vaccination
Short Talk(s) Chosen from Abstracts
14:30—16:30
Workshop 3: Molecular Approaches to Probe the Elicited Vaccine Response
Short Talks Chosen from Abstracts
14:30—16:30
Workshop 3: B Cell-T Cell Interactions in Disease
Short Talks Chosen from Abstracts
17:00—19:00
Neil P. King,
University of Washington, USA
Atomic-Level Design to Increase the Magnitude of B Cell Responses
Atomic-Level Design to Increase the Magnitude of B Cell Responses
Günther Staffler,
AFFiRiS AG, Austria
Towards a Heart Attack Vaccine: PCSK9 as a Immunogen
Towards a Heart Attack Vaccine: PCSK9 as a Immunogen
Jaap Goudsmit,
Harvard T.H. Chan School of Public Health, USA
New Vaccines against Alzheimer's
New Vaccines against Alzheimer's
Short Talk Chosen from Abstracts
17:00—19:00
Marc K. Jenkins,
University of Minnesota Medical School, USA
Memory T and B Cell Responses
Memory T and B Cell Responses
Mark J. Shlomchik,
University of Pittsburgh School of Medicine, USA
Memory B Cell Subsets
Memory B Cell Subsets
Marion Pepper,
University of Washington, USA
Memory B Cells in Plasmodium Infection
Memory B Cells in Plasmodium Infection
Short Talk Chosen from Abstracts
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Vaccines: Better, Faster, and Less Expensive!
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
Rino Rappuoli,
GlaxoSmithKline Vaccines, Italy
Developing Vaccines against Pandemics and for the Developing World
Developing Vaccines against Pandemics and for the Developing World
Laura M. Walker,
Adimab, USA
Rapid Antibody Identification to Speed Pandemic Responses
Rapid Antibody Identification to Speed Pandemic Responses
Coffee Break
Brandon DeKosky,
University of Kansas, USA
Paired Heavy-Light Chain Sequencing and Display to Optimize Immune Readout from Vaccination and for Immune Monitoring
Paired Heavy-Light Chain Sequencing and Display to Optimize Immune Readout from Vaccination and for Immune Monitoring
Julie Ledgerwood,
NIAID, National Institutes of Health, USA
Immune Monitoring to Increase the Likelihood of Phase 2 Success
Immune Monitoring to Increase the Likelihood of Phase 2 Success
Short Talk(s) Chosen from Abstracts
08:00—11:00
Humoral Autoimmunity and Allergic Responses
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
Rachel Ettinger,
MedImmune, USA
Antibody-based Treatments for Autoimmune Disease
Antibody-based Treatments for Autoimmune Disease
Michael C. Carroll,
Boston Children's Hospital, Harvard Medical School, USA
Epitope Spreading in Autoimmune Germinal Centers
Epitope Spreading in Autoimmune Germinal Centers
Coffee Break
Maria A. Curotto de Lafaille,
NYU School of Medicine, USA
Biology of IgE Affinity Maturation
Biology of IgE Affinity Maturation
Christopher C. Goodnow,
Garvan Institute of Medical Research, Australia
Redemption of Self-Reactive B Cells in the Germinal Center
Redemption of Self-Reactive B Cells in the Germinal Center
Short Talk(s) Chosen from Abstracts
14:30—16:30
Workshop 4: Molecular Approaches for Rapid Identification/Optimization of Target Antigens
Short Talks Chosen from Abstracts
17:00—18:45
Jeffrey B. Ulmer,
GSK Vaccines, USA
Molecular Approaches to Streamlining Vaccine Discovery and Development
Molecular Approaches to Streamlining Vaccine Discovery and Development
Katalin Karikó,
BioNTech RNA Pharmaceuticals, Germany
Advantages of an mRNA Vaccine Approach
Advantages of an mRNA Vaccine Approach
Gary J. Nabel,
Sanofi, USA
How Appropriate Choice of a Human Antibody Template Reduces Vaccine Development Risks
How Appropriate Choice of a Human Antibody Template Reduces Vaccine Development Risks
17:00—18:45
Klaus Rajewsky,
Max Delbrück Center for Molecular Medicine, Germany
Transcriptional Programming of GC B Cell Differentiation
Transcriptional Programming of GC B Cell Differentiation
Meinrad Busslinger,
Research Institute of Molecular Pathology, Austria
Transcriptional Programming of Plasma Cell Differentiation
Transcriptional Programming of Plasma Cell Differentiation
Robert Brink,
Garvan Institute of Medical Research, Australia
Differentiation of Plasma Cells from the GC
Differentiation of Plasma Cells from the GC
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 01/10/2019
Registered attendees can view abstracts starting on 01/10/2019
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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