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This meeting took place in 2001



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Regulation of Immunity and Autoimmunity (A2)


Organizer(s) Pamela S. Ohashi, Andrew C. Chan and Christopher C. Goodnow
January 10—16, 2001
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Sep 11, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 10, 2000

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Many new molecules have been recently identified that have the potential to regulate lymphocyte survival, activation or apoptosis. Current research has also examined membrane bound and intracellular molecules that negatively regulate immune receptor triggering and lymphocyte activation. Further examination of the functional properties of these molecules may reveal new insights into the underlying mechanisms that maintain tolerance, or enhance immunity or autoimmunity. This meeting will focus upon the molecular and cellular events that regulate lymphocyte homeostasis and activation, and how these mechanisms act in concert to maintain tolerance and prevent autoimmunity. The goal of this meeting is to highlight current research in immunity and autoimmunity to provide a framework for an overall understanding of the requirements for the induction of self reactive cells, and the regulatory events that generally keep this process intact.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, JANUARY 10

14:00—19:00
Registration

Shavano Foyer
18:15—19:15
Welcome

Shavano Foyer
19:15—19:30
Orientation

Crestone/Red Cloud
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Philippa C. Marrack, HHMI/National Jewish Health, USA
Life and Death of T cells


THURSDAY, JANUARY 11

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Signaling Molecules Regulating Lymphocyte Activation
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Andrew C. Chan, Genentech, Inc., USA
Lymphocyte Signaling

Alexander Tarakhovsky, Rockefeller University, USA
Mechanisms of src-PTK Regulation by Csk and Its Role in Lymphocyte Signaling

James C. Stone, University of Alberta, Canada
Ras Signaling in T Cells and Thymocytes: Get a GRP

Cox Cornelis Terhorst, Beth Israel Deaconess Medical Center, USA
X-Linked Lymphoproliferative Disease, a Progressive Immunodeficiency

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:30
Poster Viewing

Shavano/Torreys
14:00—16:00
Workshop 1: Signals Influencing Lymphocyte Differentiation and Activation

Crestone
* Andrew C. Chan, Genentech, Inc., USA

Traci Zell, University of Minnesota, USA
In vivo Analysis of Proximal Signal Transduction in Antigen-Stimulated CD4 T Cells

Helena Mancebo, Multispan, Inc., USA
Cloning of a Novel Inhibitor of Antigen-Receptor Signaling Using a Retroviral-Based Functional Screen

Jeff Allen Yoder, Washington University School of Medicine, USA
Requirement for the SLP-76 Adaptor GADS in T Cell Development

Kun Bi, Life Technologies, USA
Translocation of PKC0 to Membrane Rafts Upon T Cell Activation

John David Colgan, University of Iowa, USA
Cyclosporine Resistance and Altered Effector CD4 T Cell Function in Cells Lacking Cyclophilin A

Wei Li, University of Minnesota, USA
Regulation of Elk-1 Transativation by the Coactivators P300/ Creb-Binding Protein (CBP) During T Cell Activation

Robyn Starr, St. Vincent's Institute, Australia
Mice Lacking Suppressor of Cytokine Singaling-1 (SOCS-1) are Hypersensitive to Interferon y

Yun-Cai Liu, La Jolla Institute for Allergy and Immunology, USA
Cbl-b, a RING-Type E3 Ubiquitin Ligase, Targets PI3 Kinase for Ubiquitination in T Cells

14:00—16:00
Workshop 2: Lymphocyte Tolerance, Apoptosis and Survival

Red Cloud
* Ronald H. Schwartz, NIAID, National Institutes of Health, USA

Joyce T. Tan, The Scripps Research Institute, USA
Homeostasis of Naive Mature T Cells is Regulated by IL-7

Jeffrey C. Rathmell, Vanderbilt University, USA
In the Absence of Extrinsic Signals, Nutrient Utilization by Lymphocytes is Insufficient to Maintain Immunologic Function

Daniel Chui, University of California, San Diego, USA
Homeostatic Regulation of CD8+ T Cells in vivo is Controlled by Expression of the ST3Gal-I Sialyltranserase

Martin Villalba, La Jolla Institute for Allergy and Immunology, USA
PKC0 Mediates a Selective T Cell Survival Singal via Phosphorylation of BAD

Rebecca J. Greenwald, Brigham and Women's Hospital, USA
CTLA-4 Regulates Peripheral T Cell Tolerance in vivo

Tracy Leigh Vanasek, University of Minnesota, USA
Regulation of T Cell Clonal Anergy by Cell-Cycle Progression

Matthew Christopher Walsh, University of Pennsylvania, USA
Signaling Through CD28 and CTLA4 Control Two Distinct Forms of T Cell Anergy

Katsuyuki Yui, Nagasaki University, Japan
Maintenance of T Cell Anergy by Activation of p38 MAP Kinase

19:00—20:00
Coffee Available

Shavano Foyer
19:00—20:30
Apoptosis Versus Survival
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Tadaaki Miyazaki, Sanford-Burnham Medical Research Institute, USA
Caspase Activation and Signal Transduction by TNF-Family Death Receptors

Michael J. Lenardo, NIAID, National Institutes of Health, USA
Molecular Regulation of Fas and TNF Receptor Signaling in the Healthy and Diseased Immune System

20:30—22:30
Poster Session 1: Molecular Signals Regulating Lymphocyte Activation, Tolerance, Apoptosis and Survival

Shavano/Torreys
20:30—21:30
Social Hour

Shavano/Torreys

FRIDAY, JANUARY 12

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Innate Immunity
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Ralph M. Steinman, Rockefeller University, USA
DC Activation and Migration

Ken Shortman, Walter and Eliza Hall Institute of Medical Research, Australia
Dendritic Cell Heterogeneity in Origin and Function

Martin F. Bachmann, Cytos Biotechnology AG, Switzerland
Cross-Talk Between Innate and Specific Immunity: From Opsonisation to Molecular Mimicry

Yong-Jun Liu, Sanofi, USA
Natural Interferon-alpha/beta-Producing Cells Link Innate and Adaptive Immunity

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:30
Poster Viewing

Shavano/Torreys
14:00—16:00
Workshop 3: APCs, Migration and Inflammation

Crestone I-II
* Jason G. Cyster, HHMI/University of California, San Francisco, USA

Jennifer L. Gommerman, University of Toronto, Canada
The Lymphotoxin Pathway and Dendritic Cell Migration - Implications for Autoimmunity

Sigrid R. Ruuls, Genmab, Netherlands
Membrane vs. Soluble TNF in Autoimmunity

Andreas Limmer, Zentrum für Molekulare Biologie, Germany
Liver Endothelial Cells Constitute a New Type of Organ-Resident Antigen Presenting Cell Promoting Peripheral Immune Tolerance: Molecular Mechanisms and Implications for Control of the Systemic Immuen Response

Angus Gordon Thompson, University of Queensland, Australia
Dendritic Cells are Present in Normal Lymphoid Tissue and Autoimmune Peripheral Tissue

Tetsuya Yamagata, Tempero Pharmaceuticals, USA
Dominant-Negative GATA-3 Affects T Cell Survival and Homing to Secondary Lymphoid Organs

Dominic van Essen, Max Planck Institute for Immunobiology, Germany
A Novel Chemokine Implicated in B Cell - T Cell Interactions

Leonid Izikson, Brigham and Women's Hospital, USA
Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the CC Chemokine Receptor (CCR) 2

14:00—16:00
Workshop 4: T Cell Differentiation and Activation

Crestone III-IV
* Philippa C. Marrack, HHMI/National Jewish Health, USA

Gilbert J. Kersh, Emory University, USA
Expresion of the Transcriptional Regulator Egr-1 Controls the Threshold of Thymoctye Positive Selection

Hisse Martien Van Santen, Joslin Diabetes Center, USA
Specificity and Avidity of TCR-MHC/ Peptide Interactions During T Cell Differentiation

Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
The Molecular Mechanism of T Cell Receptor: CD3 Complex Downmodulation

Linda Oberg, Karolinska Institute, Sweden
Expression of Ly49A on T Cells Alters the Threshold for T Cell Responses

Tarek M. Fahmy, Yale University, USA

Laura Carter, Wyeth Pharmaceuticals, USA
Inhibition of T Cell Function Upon Engagement of the Immuno-Inhibiory Receptor PD-1 with New B7- Family Member PD-L1

Thomas R. Malek, University of Miami School of Medicine, USA
Broad Programming by IL-2 Recetor Signaling for Extended Growth to Multiple Cytokines and Functional Maturation fo Antigen-Activated T Cells

Lucile E. Wrenshall, Wright State University, USA
Regulation of T Cell Responses by Heparan Sulfate-Bound IL-2

Sarah E. Townsend, University of British Columbia, Canada
Mechanisms of B-Cell -Mediated Cross-Presentation

14:00—16:00
Workshop 5: Immune Deviation, Cytokines and Autoimmunity

Red Cloud
* Anne O'Garra, Francis Crick Institute, UK

Sumeena Bhatia, National Cancer Institute, National Institutes of Health, USA
Scavenger Receptor-Specific Delivery of House Dust Mite Allergen, Der p I Reprograms Established Th2-Dominated Responses to a Non-Allergic Response

Daniel J. Cua, Merck Research Laboratories, USA
Cellular Mechanism of IL-10 Inhibition of Autoimmune Enephalomyeltis

Petya Dimitrova, University of Erlangen-Nuernberg, Germany
Leflunomide Inhibits Proliferation of th1 Effectors and Biases for Th2 Cell Peptide Epitopes

Mark Larché, McMaster University, Canada
Induction of T Cell Hyporesponsiveness in Human Allergic Asthma using T Cell Peptide Epitopes

Megan K. Levings, University of British Columbia, Canada
IFN-alpha Synergizes with IL-10 to Induce the Differentiation of Type 1 T Regulatory Cells

Alistair Noble, Rayne Institute, UK
Donor and Host CD8 T Cells Regulate Immune Deviation and Autoantibody Production in a Graft-versus-Host Reaction

19:00—20:00
Coffee Available

Shavano Foyer
19:00—20:30
Lymphocyte Migration
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Jason G. Cyster, HHMI/University of California, San Francisco, USA
Chemokines and Cell Migration in Secondary Lymphoid Organs

Marc K. Jenkins, University of Minnesota Medical School, USA
In vivo Analysis of Peripheral Tolerance Induced by Injection of Peptide Antigen

20:30—22:30
Poster Session 2: Dendritic Cells/Lymphoctye Inflammation/Migration

Shavano/Torreys
20:30—21:30
Social Hour

Shavano/Torreys

SATURDAY, JANUARY 13

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Genetic Approaches to Understanding Immunity
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Costimulatory Molecules and Activation

Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Genetic Analysis of Checkpoints Controlling Self-Reactive Lymphocytes

Josef M. Penninger, Institute of Molecular Biotechnology GmbH, Austria
Role of Cbl-b in Autoimmunity

Richard A. Flavell, HHMI/Yale University School of Medicine, USA
The Regulation of T Cell Differentiation

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:30
Poster Viewing

Shavano/Torreys
14:00—17:00
Special Topics: Autoimmune Diseases: Genetics and Clinical Trials
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Linda S. Wicker, University of Cambridge, UK
Autoimmunity Genes

Ji-Won Yoon, Chicago Medical School, USA
Late Breaking Short Talk: Permanent Remission of Autoimmune Diabetes by a Novel Gene Therapy Using a Single Chain Insulin Analogue in NOD Mice

Dennis A. Carson, University of California, San Diego, USA
New Therapeutic Approaches for Rheumatoid Arthritis

Richard K. Burt, Northwestern University, USA
Hematopoietic Stem Cell Transplantation of Autoimmune Disease

R. Paul Robertson, Pacific Northwest Research Institute, USA
Autoimmune Diabetes: Update on Pancreatic Islet Transplantation in Humans

14:00—15:00
Coffee Available

Shavano Foyer
19:00—20:30
Immunity
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Steven F. Ziegler, Benaroya Research Institute, University of Washington School of Medicine, USA
The Role of Scurfin, the Gene Mutated in scurfy Mutant Mice, in T Cell Development and Function

* Laurie H. Glimcher, Dana-Farber Cancer Institute, USA
Subset-Specific Transcription Factors that Direct Cytokine Expression

20:30—22:30
Poster Session 3: Lymphocyte Differentiation and Activation

Shavano/Torreys
20:30—21:30
Social Hour

Shavano/Torreys

SUNDAY, JANUARY 14

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Role of Cytokines in Immunity and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Gene Regulation by NFAT

Anne O'Garra, Francis Crick Institute, UK
In vitro Generation of Regulatory T Cells Using a Combination of Immunosuppressive Drugs

Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Interleukin-10 and Immune Regulation

09:20—09:40
Coffee Break

Shavano Foyer
11:00—13:00
Poster Setup

Shavano/Torreys
13:00—22:30
Poster Viewing

Shavano/Torreys
14:00—16:00
Workshop 6: Mechanisms of Induction and Progression of Autoimmune Disease

Crestone
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Mechanisms of Inductions of Selective Tolerance in T Cells

Adnane Achour, Karolinska Institute, Sweden
The Crystal Structures of an Immunodominat Peptide from LCMV in Complex with H-2D Beta and H-2K Beta And of a Cross-Reactive Self Ligand Involved in Virus-Mediated Autoimmunity in Complex iwth H-2D beta

Sylvie Lesage, John Curtin School of Medical Research, Australia
T Cell Tolerance in a Transgenic Mouse Model for Autoimmune Diabetes

Mayumi Naramura, National Institutes of Health, USA
T Cell-Specific Deletion of c-Cbl/Cbl-b Leads to Generalized Lymphoid Activation and Severe Vasculitis in Mice

Part Peterson, University of Tampere Medical School, Finland
AIRE< Gene Defective in APECED as Guardian of Immune Tolerance

Daniel J. Powell, University of Pennsylvania, USA
The Role of The RET/PTC3 Oncogene in Thryoid Carcinoma and Autoimmune Disease

Marie Wahren-Herlenius, Karolinska Institute, Sweden
A Leucine Zipper Motif is the Target for Antibodies Correlated with Development of Passively Acquired Autoimmune Congential Heartblock

14:00—16:00
Workshop 7: Modulation of Immunity and Autoimmunity

Red Cloud
* Shimon Sakaguchi, Osaka University, Japan

Franck J. Barrat, Hospital for Special Surgery, USA
A Combination of Vitamin D3 and Dexamethasone Induces the Development of IL-10 Producing Regluatory CD4+ T Cells

Leigh A. Stephens, University of Edinburgh, UK
Characterization of Thymus-Derived CD4+CD5+ Regulatory T Cells in Humans

Bonnie Nelson Dittel, Blood Center of Wisconsin, USA
Recovery from Acute Experimental Autoimmune Enephalomyelitis (EAE) is Perturbed in Mice Deficient in Gamma/Delta T Cells

Victor H. Engelhard, University of Virginia, USA
Multiple Mechansims Maintain Tolerance to the Melanoma Associated Antigen Tyrosinase in HLA-A2 Transgenic Mice

Ann Herman, Genentech, USA
Blockade of Inducible Co-Stimulator (ICOS) Promotes Diabetes in a Mouse Model of Type I Diabetes

Takeshi Tsubata, Tokyo Medical and Dental University, Japan
Ectopic Expression of CD40L on B Cells Abrogates Self-Tolerance and Induces Lupus-Like Autoimmune Disease

19:00—20:00
Coffee Available

Shavano Foyer
19:00—20:30
Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Hamish S. Scott, Walter and Eliza Hall Institute of Medical Research, Australia
The Autoimmune Regulator Gene (AIRE) Mutated in a Monogenic Disease, Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED); Clues to Self Tolerance

* Christophe Benoist, Harvard Medical School, USA
Autoimmune Animal Models

20:30—22:30
Poster Session 4: Autoimmunity

Shavano/Torreys
20:30—21:30
Social Hour

Shavano/Torreys

MONDAY, JANUARY 15

07:00—08:00
Breakfast

Shavano/Torreys
08:00—11:00
Regulation of Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Shimon Sakaguchi, Osaka University, Japan
Immunologic Self-Tolerance Maintained by CD25+ CD4+ Regulatory T Cells

Kenneth S. Tung, University of Virginia, USA
Endogenous Antigen and Regulatory T Cells in Autoimmune Disease

Benoit L. Salomon, University Pierre et Marie Curie, France
and Regulation of Autoimmunity

Günter J. Hämmerling, German Cancer Research Center, Germany
Regulation of Peripheral Tolerance and Organ-Specific Autoimmunity by the Microenvironment

09:20—09:40
Coffee Break

Shavano Foyer
15:00—16:00
Coffee Available

Shavano Foyer
16:00—18:00
Induction of Autoimmune Disease
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* William R. Heath, University of Melbourne, Australia
Cross-Presentation and Induction of Autoimmunity

Michael Demetriou, University of California, Irvine, USA
Negative Regulation of T Cell Activation and Autoimmunity by Mgat5 N-Glycosylation

Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
The Role of PKB/Akt in Survival and Autoimmunity

19:00—20:00
Social Hour

Shavano Foyer
20:00—22:00
Banquet

Shavano/Torreys
21:00—00:00
Entertainment

Shavano/Torreys

TUESDAY, JANUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI48531-01




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