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This meeting took place in 2001



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Frontiers of NMR in Molecular Biology VII (A6)


Organizer(s) Angela M. Gronenborn, James H. Prestegard and Stanley J. Opella
January 20—26, 2001
Big Sky Resort • Big Sky, Montana USA
Abstract Deadline: Sep 20, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 20, 2000

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
NMR is playing an increasingly important role in the determination of macromolecular structures and the study of protein and nucleic acid dynamics. This growing importance of NMR in structural biology is powerfully illustrated by the number of novel structures of biological macromolecules determined by this technique over the last few years, with approximately 250 new NMR structures deposited in the PDB each year. But NMR is not only a technique for structure determination, it is also able to provide a wealth of information which is complementary to the structural data. NMR data on dynamics and solvation of proteins and nucleic acids is becoming available, as well as NMR characterization of partially folded or unfolded protein and polypeptide states. A major research goal is to increase the size of the protein or macromolecular complex that can be analyzed by NMR. This requires the development of even higher-field spectrometers, which will yield higher sensitivity and better resolution, thereby improving the quality of structures of all sizes. Hand in hand with these instrument developments will be methodological approaches to overcome or minimize the correlation time problem. Despite major advances, NMR data collection still represents a substantial investment in real time and in equipment time and may require several months for one structure. Avenues for increasing the number of NMR structures are sought though high throughput approaches or streamlining experiments. NMR is one of very few techniques which will be able to provide structural and dynamical data on partially folded and heterogeneous protein systems, i.e., amyloids. Studies on these will have major implications for pathology and disease. The meeting will be the forum to present the newest structures of important proteins, nucleic acids and complexes thereof, illuminating key functional questions in molecular biology. Methodological and functional discussions will be given equal weight.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, JANUARY 20

14:00—19:00
Registration

Firehole Lounge
18:15—19:15
Welcome

Gallatin/Lower Atrium
19:15—19:30
Orientation

Jefferson/Madison
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
Ad Bax, NIDDK, National Institutes of Health, USA
NMR of Weakly Aligned Macromolecules


SUNDAY, JANUARY 21

06:30—08:00
Breakfast

Gallatin/Lake-Canyon
08:00—11:00
New NMR Methods for Structure Determination I. Session Sponsored in part by Bruker Instruments, Inc.
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Ad Bax, NIDDK, National Institutes of Health, USA

Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany
Angular Projection Restraints for the Determination of Structure and Dynmics of Biomolecules

Kurt Wüthrich, ETH Zürich, The Scripps Research Institute, Switzerland
New Results from Solution NMR with Large Structures

James H. Prestegard, University of Georgia, USA
Rapid Protein Structure Determination Using Residual Dipolar Couplings

A. Joshua Wand, University of Pennsylvania, USA
NMR Spectroscopy of Encapsulated Proteins in Low Viscosity Fluids

09:20—09:40
Coffee Break

Gallatin/Lower Atrium
11:00—13:00
Poster Setup

Gallatin
16:00—18:00
POSTER SESSION 1: New NMR Methods for Structure Determination I/Unfolded and Partially Folded States of Proteins and Protein Dynamics

Gallatin
17:00—18:00
Social Hour with Lite Bites

Gallatin/Lower Atrium
20:00—21:00
Coffee Available

Gallatin/Lower Atrium
20:00—22:30
Unfolded and Partially Folded States of Proteins and Protein Dynamics
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Jane Dyson, The Scripps Research Institute, USA

Peter E. Wright, The Scripps Research Institute, USA
Structural Characterization of Myoglobin Folding Pathways and Intermediates

Christopher M. Dobson, University of Cambridge, UK
NMR Approaches to Studying Folding and Misfolding of Proteins

Angela M. Gronenborn, University of Pittsburgh, USA
Structure and Functional Studies on Cyanovirin-N, a Potent HIV Inactivating Protein

Arthur G. Palmer, III, Columbia University, USA
Probing Protein Dynamics by NMR


MONDAY, JANUARY 22

06:30—08:00
Breakfast

Gallatin/Lake-Canyon
08:00—11:00
New and Interesting Proteins
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Gerhard Wagner, Harvard Medical School, USA

Mitsuhiko Ikura, University of Toronto, Canada
NMR and Crystallographic Studies of Macromolecular Complexes

Rolf Boelens, Utrecht University, Department of Chemistry, Netherlands
NMR Studies of Ribosomal Translation Initiation Factors

Michael K. Rosen, University of Texas Southwestern Medical Center, USA
Signaling from GTPases to the Cytoskeleton

Brian D. Sykes, University of Alberta, Canada
Antifreeze Proteins: Diverse Structures for a Single Function?

09:20—09:40
Coffee Break

Gallatin/Lower Atrium
11:00—13:00
Poster Setup

Gallatin
14:00—16:00
WORKSHOP 1: Structural Genomics - Past, Present and Future Contributions of NMR

Jefferson/Madison
* Gaetano Thomas Montelione, Rutgers University, USA
The International Structural Genomics Initiatives

Gregory Farber, NIMH, National Institutes of Health, USA
The Future of NMR in Structural Genomics

Robert Powers, Wyeth Pharmaceuticals, USA
Low Resolution NMR Structures and Structure Based Drug Design

Thomas Szyperski, SUNY at Buffalo, USA
Reduced-Dimensionality NMR Spectroscopy: An Approach Comes of Age

Bennett T. Farmer, II, Boehringer Ingelheim, USA
Drug Discovery in a Genomics Era: Roles for Protein NMR

16:00—18:00
POSTER SESSION 2: New and Interesting Proteins/New NMR Methods for Structure Determination II

Gallatin
17:00—18:00
Social Hour with Lite Bites

Gallatin/Lower Atrium
20:00—21:00
Coffee Available

Gallatin/Lower Atrium
20:00—22:00
New NMR Methods for Structure Determination II
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Christian Griesinger, Max Planck Institute for Biophysical Chemistry, Germany

David Cowburn, Albert Einstein College of Medicine, USA
Approaches to Multi-Domain Structures

David A. Case, Rutgers University, USA
Density Functional Calculations of Chemical Shifts and Spin-Spin Coupling in Protein Fragments

G. Marius Clore, NIDDK, National Institutes of Health, USA
Structures of Complexes in the Bacterial Phosphotransferase Pathway (PTS) Using New Methodology for the Rapid Determination of Macromolecular Complexes by NMR


TUESDAY, JANUARY 23

06:30—08:00
Breakfast

Gallatin/Lake-Canyon
08:00—11:00
New Methods for Assignment, Structure Determination and Refinement. Session Sponsored in part by Cambridge Isotope Laboratories, Inc.
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* James H. Prestegard, University of Georgia, USA

Gaetano Thomas Montelione, Rutgers University, USA
Protein NMR in Structural Genomics

Hans Robert Kalbitzer, University of Regensburg, Germany
Automated Structure Calculation of Proteins from NMR Data

John L. Markley, University of Wisconsin-Madison, USA
BMRB Data and Their Use in Biomolecular Structure-Function Investigations

Masatsune Kainosho, Nagoya University, Japan
Advanced Isotope-Labeling Technology for Structural Studies of Larger Proteins

09:20—09:40
Coffee Break

Gallatin/Lower Atrium
11:00—13:00
Poster Setup

Gallatin
16:00—18:00
POSTER SESSION 3: New Methods for Assignment, Structure Determination and Refinement/Hydrogen Bonding and Hydration

Gallatin
17:00—18:00
Social Hour with Lite Bites

Gallatin/Lower Atrium
20:00—21:00
Coffee Available

Gallatin/Lower Atrium
20:00—22:00
Hydrogen Bonding and Hydration
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Kurt Wüthrich, ETH Zürich, The Scripps Research Institute, Switzerland

Stephan Grzesiek, University of Basel, Switzerland
H-Bond Scalar Couplings in Nucleic Acids and Proteins - High Resolution NMR of Macromolecules in Gels

Bertil Halle, Lund University, Sweden
Hydration of Native and Denatured Proteins


WEDNESDAY, JANUARY 24

06:30—08:00
Breakfast

Gallatin/Lake-Canyon
08:00—11:00
New Results for Proteins in the Solid State
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Dennis A. Torchia, National Institutes of Health, USA

Stanley J. Opella, University of California, San Diego, USA
Structural Biology of the Bacterial Mercury Detoxification System

Robert G. Griffin, Massachusetts Institute of Technology, USA
Structural Studies of Membrane Proteins with Solid State NMR

Robert Tycko, NIDDK, National Institutes of Health, USA
Probing the Structure of Amyloid Fibrils by Solid State NMR

Anne S. Ulrich, Universität Karlsruhe, Germany
Structure Determination of Polypeptides in Biomembranes by Solid State 19F-NMR

09:20—09:40
Coffee Break

Gallatin/Lower Atrium
11:00—13:00
Poster Setup

Gallatin
14:00—16:00
WORKSHOP 2: NMR of Metalloproteins

Jefferson/Madison
* Ivano Bertini, University of Florence, Italy
Self Orientation in Magnetic Fields of Paramagnetic Metalloproteins

Walter J. Chazin, Vanderbilt University, USA
Towards the Design of Functional Ca2+ Sites in Proteins

Juliette T.J. Lecomte, Pennsylvania State University, USA
Exercises in Heme Coordination

Wolfgang Jahnke, Novartis Institutes for BioMedical Research, Switzerland
NMR Screening Using Spin Labels

16:00—18:00
POSTER SESSION 4: New Results for Proteins in the Solid State/Interesting Drug Targets and Drug Development/Folded Nucleic Acid Structures/Macromolecular Complexes

Gallatin
17:00—18:00
Social Hour with Lite Bites

Gallatin/Lower Atrium
20:00—21:00
Coffee Available

Gallatin/Lower Atrium
20:00—22:30
Interesting Drug Targets and Drug Development
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Angela M. Gronenborn, University of Pittsburgh, USA

Stephen W. Fesik, Vanderbilt University School of Medicine, USA
NMR as a Tool in Drug Discovery

Jonathan M. Moore, Vertex Pharmaceuticals Incorporated, USA
Recent Advances in SHAPES-based NMR Screening

Dennis A. Torchia, National Institutes of Health, USA
Structural Dynamics of HIV Protease, Free and Bound to Potent Inhibitors

Tracy M. Handel, University of California, San Diego, USA
Structural-Function Studies of Chemokine- Receptor Interactions


THURSDAY, JANUARY 25

06:30—08:00
Breakfast

Gallatin/Lake-Canyon
08:00—11:00
Folded Nucleic Acid Structures
Meeting has ended...abstracts no longer viewable online.

Jefferson/Madison
* Walter J. Chazin, Vanderbilt University, USA

Joseph D. Puglisi, Stanford University, USA
RNA and Translation

Juli Feigon, University of California, Los Angeles, USA
Structures of RNA and RNA-Protein Complexes

James R. Williamson, The Scripps Research Institute, USA
1H-31P Heteronuclear Residual Dipolar Couplings in RNA

Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Folding Topologies and Recognition of Multi-stranded DNA Architectures

09:20—09:40
Coffee Break

Gallatin/Lower Atrium
17:00—18:00
Coffee Available

Lower Atrium
17:00—19:00
Macromolecular Complexes
Meeting has ended...abstracts no longer viewable online.

Jefferson
* Peter E. Wright, The Scripps Research Institute, USA

Gerhard Wagner, Harvard Medical School, USA
NMR Studies of Protein Complexes

Michael F. Summers, HHMI/University of Maryland, Baltimore County, USA
Protein-RNA Interactions in Retroviral Genome Packaging

Jun Qin, Lerner Research Institute, USA
Structural and Dynamical Elucidation of Double-Stranded RNA Mediated Activation Mechanism for Antiviral Kinase PKR

19:00—20:00
Social Hour with Lite Bites

Madison

FRIDAY, JANUARY 26

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA88925-01




National Institutes of Health
Department of Energy Nat'l Nuclear Security Administration (DOE)

Grant No. DE-FG03-00ER63043




National Science Foundation (NSF)

Grant No. MCB-003850




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