Taos Convention Center (meeting only) Floorplan

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This meeting took place in 2001



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Obesity and the Regulation of Energy Homeostasis (C4)


Organizer(s) Jeffrey S. Flier and Barbara B. Kahn
February 24—March 1, 2001
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Oct 24, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 21, 2000

Sponsored by Hoffmann-La Roche, Inc.

Summary of Meeting:
Our understanding of the regulation of energy balance, and defects in this system that result in obesity, has undergone dramatic progress in recent years. Insights gained from identifying the genetic basis of several monogenic obesities in rodents and humans have allowed us to define the existence of a novel regulated physiologic system by which the status of energy balance and energy stores in peripheral tissues is communicated to central nervous system circuits that regulate hunger, energy expenditure and neuroendocrine function. Critical areas of recent discovery involve the adipocyte hormone leptin, the mechanism for leptin signaling and action both within and outside the CNS, identification of a coordinated group of leptin target neurons in the hypothalamus, including the melanocortin pathway that involves antagonistic ligands and several receptors, mapping of downstream targets in the CNS, and elucidation of effector pathways, including those that influence energy expenditure by regulating mitochondrial coupling. The goal of this Keystone Symposium is to bring together investigators from diverse aspects of this field, including neurobiologists, geneticists, physiologists and pharmacologists, to integrate and provide new directions for this rapidly moving field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, FEBRUARY 24

14:00—19:00
Registration

Rio Grande D
18:15—19:15
Welcome

Rio Grande ABC
19:15—19:30
Orientation

Bataan
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Bataan
Jeffrey M. Friedman, Rockefeller University, USA
Leptin and the Regulation of Body Weight


SUNDAY, FEBRUARY 25

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Neural Integration of Energy Balance I
Meeting has ended...abstracts no longer viewable online.

Bataan
Paul E. Sawchenko, The Salk Institute, USA
The Organization of Neural Systems Underlying Energy Balance

* Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
Central Pathways Underlying the Endocrine, Behavioral, and Autonomic Effects of Leptin

Michael W. Schwartz, University of Washington, USA
Anabolic and Catabolic Pathways Underlying Energy Homeostasis

Richard D. Palmiter, HHMI/University of Washington, USA
Gene Knockouts and Energy Balance

William F. Colmers, University of Alberta, Canada
Short Talk: A Neural Substrate of the Adipostat

Michael A. Cowley, Monash University, Australia
Short Talk: Leptin Increases the Activity of Accurate POMC Neurons by Two Mechanisms

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
16:30—18:30
POSTER SESSION 1: Neural Integration of Energy Balance/Human Genetics

Rio Grande
17:30—18:30
Social Hour

Rio Grande
18:30—19:30
Coffee Available

Hallway
18:30—20:30
Neural Integration of Energy Balance II
Meeting has ended...abstracts no longer viewable online.

Bataan
* Suzanne Lee Dickson, Sahlgrenska Academy, Gothenburg University, Sweden

Roger D. Cone, University of Michigan, USA
Mechanisms of Melanocortin Action in the CNS

Gregory S. Barsh, Stanford University Medical Center, USA
Genetic and Genomic Approaches to Hypothalmic Regulation of Energy Homeostasis

Laurence H. Tecott, University of California, San Francisco, USA
Late Onset Obesity and Abnormal Feeding Behavior in 5HT2C Receptor Mutant Mice


MONDAY, FEBRUARY 26

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Neural Integration of Energy Balance III
Meeting has ended...abstracts no longer viewable online.

Bataan
* Robert Steiner, University of Washington, USA

Chien Li, The Salk Institute, USA
Corticotropin-releasing Factor Family Peptides and Their Receptors

Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA
Update on the MCH System and Energy Homeostasis

Masashi Yanagisawa, University of Tsukuba, Japan
To Eat or Sleep? Roles of the Orexin Pathway in Coordination of Feeding and Vigilance

Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
A Role for Ghrelin in the Control of Energy Homeostasis

Eduardo A. Nillni, Brown University, Rhode Island Hospital, USA
Short Talk: Leptin Stimulates the Expression and Biosynthesis of prohormone Convertases 1 and 2 (PC1 and PC2) in Hypothalamic Neurons

Hubert C. Chen, Pfenex Inc., USA
Short Talk: Increased Leptin Sensitivity in DGAT-Deficient Mice

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
16:30—18:30
POSTER SESSION 2: The Adipocyte and Energy Balance/Molecular Basis for Energy Expenditure

Rio Grande
17:30—18:30
Social Hour

Rio Grande
18:30—19:30
Coffee Available

Hallway
18:30—20:30
The Adipocyte and Energy Balance
Meeting has ended...abstracts no longer viewable online.

Bataan
* Juleen R. Zierath, Karolinska Institutet, Sweden

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
The Influence of Adipocytes on Energy Balance: Insights from Tissue Specific Knockout of Glucose Transporters

Marc L. Reitman, NIDDK, National Institutes of Health, USA
Physiology of Fatless Mice

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
New Insights into the Regulation of Obesity and Energy Homeostasis from Tissue Specific Knockout Mice


TUESDAY, FEBRUARY 27

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Molecular Basis for Energy Expenditure
Meeting has ended...abstracts no longer viewable online.

Bataan
* Eric Ravussin, Louisiana State University, Pennington Biomedical Research Center, USA

Martin D. Brand, Medical Research Council, UK
Mitochondrial Uncoupling and Energy Expenditure

Bruce M. Spiegelman, Harvard Medical School, USA
Regulation of Adipogenesis and Energy Expenditure Through PPARgamma and PGC-1

Bradford B. Lowell, Beth Israel Deaconess Medical Center, USA
Uncoupling Proteins 2 and 3: Regulators of Intracellular Energy Metabolism in Health and Disease

Daniel Ricquier, Centre National de la Recherche Scientifique, France
Uncoupling Proteins: Biochemical and Physiological Studies

Ville Wallenius, Sahlgrenska University Hospital, Sweden
Short Talk: Interleukin-6 Knockout Causes Obesity in Mice

Bruce A. Witthuhn, University of Minnesota, USA
Short Talk: Upregulation of Bone Morphogenetic Protein GDF-3/Vgr-2 Expression in Adipose Tissue of FABP4 Null Mice

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
16:30—18:30
POSTER SESSION 3: Leptin/Genetics of Obesity/New Therapeutics for Obesity

Rio Grande
17:30—18:30
Social Hour

Rio Grande
18:30—19:30
Coffee Available

Hallway
18:30—20:30
Leptin and Novel Adipocyte Secreted Proteins
Meeting has ended...abstracts no longer viewable online.

Bataan
Luciano Rossetti, Merck Research Laboratories, USA
Hypothalamic Regulation of Insulin Action

* Jeffrey Flier, Harvard University, USA
Leptin Signaling and Leptin Resistance

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Resistin

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Short Talk: The Adipocyte-Specific Protein Acrp30 Acts as a Hepatic Insulin Sensitizer

Takashi Kadowaki, University of Tokyo, Japan
Short Talk: Adiponectin and Diabetes


WEDNESDAY, FEBRUARY 28

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Genetics of Obesity
Meeting has ended...abstracts no longer viewable online.

Bataan
* Harriet Wallberg-Henriksson, Karolinska Institutet, Sweden

I. Sadaf Farooqi, University of Cambridge, UK
Lessons from Monogenic Human Obesity Syndromes

Philippe Froguel, Imperial College of London, UK
Genes Involved in the Regulation of Energy Homeostasis

Anthony Comuzzie, Southwest Foundation for Biomedical Research, USA
The Emerging Pattern of the Genetic Contribution to Human Obesity: Evidence from Genome Scans

Martin G. Myers, Jr., University of Michigan, USA
Short Talk: Leptin Receptor-STAT3 Signaling Integrates Energy Balance and Metabolic Homeostasis

Kevin D. Niswender, University of Washington, USA
Short Talk: Hypothalamic Phosphoinositide 3-Kinase Activity is Required for Leptin-Induced Anorexia

Peter R. Shepherd, University of Auckland, New Zealand
Short Talk: Macrophages as a Novel Target for Leptin Ation

09:20—09:40
Coffee Break

Rio Grande
15:00—16:00
Coffee Available

Hallway
15:00—17:00
New Targets for Obesity Treatment
Meeting has ended...abstracts no longer viewable online.

Bataan
* Timothy A. Stewart, Genentech, USA

George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA
CNTF Acts Via a Leptin-like Pathway to Suppress Hunger Signals and Cause Weight Loss

Constantine Londos, National Institutes of Health, USA
The Perilipin Knock-Out Mouse Confirms a Central Role for Perilipin in the Management of Adipocyte Lipid Stores

Salih J. Wakil, Baylor College of Medicine, USA
The Role of Acetyl-CoA Carboxylase 2 in Energy Balance

Effie Tozzo, Millennium Pharmaceuticals, USA
Short Talk: Melanocortin Receptor Agonists for the Treatment of Syndrome X

19:00—20:00
Social Hour

Rio Grande
20:00—22:00
Banquet

Bataan
21:00—00:00
Entertainment

Bataan

THURSDAY, MARCH 1

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK58917-01




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