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This meeting took place in 2001



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Mechanisms of Eukaryotic Transcriptional Regulation (C5)


Organizer(s) Beverly M. Emerson and Joan W. Conaway
February 26—March 4, 2001
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Oct 26, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 27, 2000

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
Transcriptional regulation is a multi-step process that involves modulation of chromatin structure to facilitate the interaction of RNA polymerase and transcription factors with the DNA template, as well as direct regulation of polymerase during the preinitiation, initiation, and elongation stages of transcription. Recently, high-resolution crystallographic and NMR structures of the nucleosome, RNA polymerase, and complexes that regulate transcriptional activation, elongation, and histone acetylation have been determined. The information from these structural studies, together with ongoing biochemical analyses of transcriptional initiation and elongation, are providing an ever-clearer picture of the molecular interactions underlying transcriptional control. Additionally, the discovery and subsequent characterization of protein complexes and enzymatic activities that function as chromatin remodeling machines, co-activators, co-repressors, or mediators of transcription factors are unraveling many of the sophisticated regulatory mechanisms that integrate physiological signals within higher organisms. The focus of this meeting is to examine each major level of transcriptional regulation in detail and develop a coherent understanding of how specificity of gene expression is achieved in a chromosomal context.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, FEBRUARY 26

14:00—19:00
Registration

Promenade
18:15—19:15
Welcome

Promenade
19:15—19:30
Orientation

Mesa Ballroom
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Gary Felsenfeld, NIDDK, National Institutes of Health, USA
The Establishment and Maintenance of Chromatin Domain Boundaries


TUESDAY, FEBRUARY 27

06:30—08:00
Breakfast

Chamisa/ Pinon Grill
08:00—11:15
Structure of Transcriptional Activators and Chromatin Complexes
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
Colin M. Garvie, Johns Hopkins School of Medicine, USA
Structural Studies of Combinatorial Regulation

Seth A. Darst, Rockefeller University, USA
Structural Studies of Prokaryotic RNA Polymerases

* Carl O. Pabo, Sangamo Therapeutics, Inc., USA
Structure and Design of DNA-Binding Proteins

Karolin Luger, Colorado State University, USA
DNA Access in the Nucleosome Probed with Minor Groove Binding Ligands

Eric N. Olson, University of Texas Southwestern Medical Center, USA
Control of Muscle Development by Signal-Dependent Nuclear Export of Histone Deacetylases

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa C/Ortiz/Aspen
13:00—18:30
Poster Viewing

Mesa C/Ortiz/Aspen
14:30—16:30
Workshop 1

Mesa A
* Patrick G. Quinn, Pennsylvania State College of Medicine, USA

Arik Dvir, Oakland University, USA

Murali Palangat, NCI, National Institutes of Health, USA

David R. Setzer†, University of Missouri, USA

Ali Shilatifard, Northwestern University, USA

16:30—18:30
Poster Session 1: Structure of Transcriptional Activators and Chromatin Complexes/Transcriptional Activation Mechanisms I

Mesa C/Ortiz/Aspen
17:30—18:30
Social Hour

Promenade
20:00—21:00
Coffee Available

Promenade
20:00—22:15
Transcriptional Activation Mechanisms I
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Nouria T. Hernandez, Cold Spring Harbor Laboratory, USA
Transcription of Human Small Nuclear RNA Genes by RNA Polymerases II and III

E. Peter Geiduschek, University of California, San Diego, USA
Role of Transcription Factor IIIB in RNA Polymerase III Initiation

Averell Gnatt, University of Maryland, USA
Structure of RNA Polymerase II Transcription Complexes

Donal S. Luse, Cleveland Clinic Foundation, USA
Short Talk: The Relationship of Transcript Length and Transcript Sequence to Promoter Clearance by RNA Polymerase II


WEDNESDAY, FEBRUARY 28

06:30—08:00
Breakfast

Chamisa/ Pinon Grill
08:00—11:15
Transcriptional Activation Mechanisms II
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Robert G. Roeder, Rockefeller University, USA
Transcriptional Coactivators: Diversity, Synergy and Mechanism of Action

Richard N. Freiman, Brown University, USA
Functional Analysis of a Tissue Selective TAF in Mice

Jean-Marc Egly, Institut de Genetique et de Biologie Moleculaire Cellulaire, France
TFIIH, a Key Player in Transcription and in the Cellular Response to DNA Damage

Danny F. Reinberg, HHMI/New York University, USA
From Transcription to Chromatin and Development

Tom K. Kerppola, University of Michigan, USA
Short Talk: Architecture and Dynamics of Fos-Jun and NFAT Transcription Regulatory Complexes

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa C/Ortiz/Aspen
13:00—18:30
Poster Viewing

Mesa C/Ortiz/Aspen
16:30—18:30
Poster Session 2: Transcriptional Activation Mechanisms II/Regulation of Transcriptional Initiation and Elongation

Mesa C/Ortiz/Aspen
17:30—18:30
Social Hour

Promenade
20:00—21:00
Coffee Available

Promenade
20:00—22:15
Regulation of Transcriptional Initiation and Elongation
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Caroline M. Kane, University of California, Berkeley, USA
TFIIS as a Discovery Target for the Elongation Machinery

Hiroshi Handa, Tokyo Institute of Technology, Japan
Regulation of Transcription Elongation

David H. Price, University of Iowa, USA
P-TEFb, a Cyclin Dependent Kinase Controlling RNA Polymerase II Elongation Control and HIV Replication

Thomas Kodadek, The Scripps Research Institute, USA
Short Talk: The 19S Regulatory Particle of the Proteasome is Required for Efficient Elongation by RNA Polymerase II


THURSDAY, MARCH 1

06:30—08:00
Breakfast

Chamisa/ Pinon Grill
08:00—11:15
Chromatin Structure and Transcription I
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Carl Wu, National Cancer Institute, NIH, USA
ATP-Driven Chromatin Remodeling Complexes

Jerry L. Workman, Stowers Institute for Medical Research, USA
Recruitment of SWI/SNF and HAT Complexes in Chromatin

Shilpa B. Kadam, Novartis Institutes for BioMedical Research, USA
Regulation of Tissue-Specific Gene Expression by Chromatin Remodeling Complexes

Peter Verrijzer, Erasmus University Medical Center, Netherlands
Targeting of Trithorax Group and Polycomb Group Proteins

Anthony N. Imbalzano, University of Massachusetts Medical School, USA
Short Talk: Mammalian SWI/SNF Chromatin Remodeling Complexes Promote MyoD-Mediated Muscle Differentiation

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa C/Ortiz/Aspen
13:00—18:30
Poster Viewing

Mesa C/Ortiz/Aspen
14:30—16:30
Workshop 2

Mesa A
* Jerry L. Workman, Stowers Institute for Medical Research, USA

Michelle C. Barton, University of Texas MD Anderson Cancer Center, USA

Masami Horikoshi, University of Tokyo, Japan

Jeremy M. Boss, Emory University, USA

Frederick J. Schaufele, University of California, San Francisco, USA

Francois Robert, Whitehead Institute for Biomedical Research, USA

Fyodor D. Urnov, Altius Institute for Biomedical Sciences, USA

Stephen A. Liebhaber, University of Pennsylvania, USA

16:30—18:30
Poster Session 3: Chromatin Structure and Transcription

Mesa C/Ortiz/Aspen
17:30—18:30
Social Hour

Promenade
20:00—21:00
Coffee Available

Promenade
20:00—22:15
Chromatin Structure and Transcription II
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* James T. Kadonaga, University of California, San Diego, USA
Studies of the Regulation of Transcription by RNA Polymerase II

Robert E. Kingston, Massachusetts General Hospital, USA
Regulation of Chromatin Structure by SWI/SNF and Polycomb

Debu Chakravarti, Northwestern University, Feinberg School of Medicine, USA
Short Talk: Regulation of Histone Acetylation and Transcription by a Novel Human Cellular Complex, INHAT


FRIDAY, MARCH 2

06:30—08:00
Breakfast

Chamisa/ Pinon Grill
08:00—11:15
Transcriptional Regulation by Epigenetic Programming and Higher-Order Chromatin Structure
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* John C. Lucchesi, Emory University, USA
Targeting, Spreading and Chromatin Acetylation by the MSL Complex at its Sites of Action on the X Chromosome of Drosophila Males

Daniel Reines, Emory University School of Medicine, USA
Histone Acetylation and DNA Methylation at FMR1 in the Fragile X Syndrome

Peter P. Cheung, University of Virginia, USA
Signaling to Chromatin Through Histone Modifications

Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Transcriptional Repression by Polycomb-Group Proteins: Implications for Cell Cycle Regulation

Niall Dillon, Medical Research Council, UK
Short Talk: Transcription Factor Dosage Affects Higher Order Chromatin Structure and Transcription of a Heterochromatic Gene

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa C/Ortiz/Aspen
13:00—18:30
Poster Viewing

Mesa C/Ortiz/Aspen
16:30—18:30
Poster Session 4: Transcriptional Regulation by Epigenetic Programming and Higher-Order Chromatin Structure/Transcriptional Regulation by Proteolysis/Transcriptional Regulatory Pathways

Mesa C/Ortiz/Aspen
17:30—18:30
Social Hour

Promenade
20:00—21:00
Coffee Available

Promenade
20:00—22:15
Transcriptional Regulation by Proteolysis
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Joan W. Conaway, Stowers Institute for Medical Research, USA

Yong Chi, California Institute of Technology, USA
Negative Regulation of Transcription Factors by Srb10 CDK

Stefan P. Jentsch, Max Planck Institute for Biochemistry, Germany
Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing

Frank Sauer, Zentrum fur Molekulare Biologie der Universit├Ąt Heidelberg, Germany
Short Talk: Ubiquitin-Activating/Conjugating Activity of TAFII250 Mediates Activation of Gene Expression in Drosophila


SATURDAY, MARCH 3

06:30—08:00
Breakfast

Chamisa/ Pinon Grill
08:00—11:15
Transcriptional Regulatory Pathways I
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Elaine V. Fuchs, HHMI/Rockefeller University, USA
Transcriptional Control of Skin Development

Katherine A. Jones, The Salk Institute, USA
Transcriptional Regulation by LEF1 and Beta-Catenin

David L. Levens, National Cancer Institute, National Institutes of Health, USA
Activators, Repressors, TFIIH, ssDNA, and the c-Myc Promoter

Mark Groudine, Fred Hutchinson Cancer Research Center, USA
What Do Locus Control Regions Activity Control?

Thomas Moss, Universite Laval, Canada
Short Talk: Competitive Recruitment of CBP and Rb-HDAC and ERK Phosphorylation Regulates UBF Activation of Ribosomal Transcription via Enhanceosome Topology

09:20—09:40
Coffee Break

Promenade
15:00—16:00
Coffee Available

Promenade
15:00—17:15
Transcriptional Regulatory Pathways II
Meeting has ended...abstracts no longer viewable online.

Mesa Ballroom
* Richard A. Young, Whitehead Institute for Biomedical Research, USA
Transcriptional Regulatory Circuitry in Yeast and Human Systems

Toshio Tsukiyama, Fred Hutchinson Cancer Research Center, USA
The in vivo Functions of Isw2 Chromatin Remodeling Complex

Jesper Q. Svejstrup, Francis Crick Institute, UK
Short Talk: Recruitment of Sir Proteins and Transcriptional Repression by Histone Hypoacetylation in vivo

Bradley R. Cairns, HHMI/University of Utah, USA
Short Talk: New Roles for RSC Revealed by a Rsc3/Rsc30 Zinc Cluster Heterodimer

Fyodor D. Urnov, Altius Institute for Biomedical Sciences, USA
Targeted Control of Endogenous Chromosomal Human Genes

19:00—20:00
Social Hour

Promenade
20:00—22:00
Banquet

Mesa Ballroom
21:00—00:00
Entertainment

Mesa Ballroom

SUNDAY, MARCH 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA91512-01




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