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This meeting took place in 2001



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Dendritic Cells: Interfaces with Immunobiology and Medicine (D4)


Organizer(s) Ralph M. Steinman, Anne O'Garra and Jacques Banchereau
March 12—18, 2001
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Nov 13, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 12, 2001

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
DCs are recognized as the key controllers of the immune system, including immune aspects of clinical medicine. DC biology continues to develop in significant and surprising ways. There are new subsets of DCs with different functions; new maturation stimuli that control the initiation of immunity; new markers to visualize DCs in lymphoid tissues and pathologic states; new molecular mechanisms that control DC migration and lifespan; and new therapies aimed at manipulating DC physiology. Therefore it is straightforward to devote an entire meeting to DCs themselves. However, it is additionally important to emphasize the developments in DC biology that interface with other active areas of immunobiology and medicine. The main interfaces of this multidisciplinary meeting comprise 1) the cell biology of antigen presentation, including the regulated function of intracellular MHC II compartments, the exogenous pathway for presentation on MHC class I, and nonclassical presenting molecules like CD1; 2) T cell costimulation, including the clustering of MHC and accessory molecules to form the immunological synapse; 3) the role of DCs in the regulation of T cell function, including Th1/Th2 subsets, regulatory T cells, and peripheral tolerance; 4) the interaction of infectious agents with DCs, including emerging viral vectors for expression of recombinant genes; and 5) human immunotherapy, using DCs as adjuvants. The meeting will highlight the participation of younger scientists through the inclusion of longer talks by rising new investigators, shorter presentations selected from the abstracts, and several workshops in critical areas. The program and the breadth of participation will make this meeting a must for the many students and postdocs who are now providing the advances in this field.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


MONDAY, MARCH 12

14:00—19:00
Registration

Foyer
18:15—19:15
Welcome

Rio Grande A-C
19:15—19:30
Orientation

Bataan

TUESDAY, MARCH 13

07:00—08:00
Breakfast

Rio Grande
08:00—11:30
Immunotherapy of Human Cancer
Meeting has ended...abstracts no longer viewable online.

Bataan
A. Karolina Palucka, Tha Jackson Laboratory for Genomic Medicine, USA
Presentation of Tumor Antigens by Dendritic Cells Loaded with Killed Human Tumor Cells

Eli Gilboa, University of Miami, Miller School of Medicine, USA
Tumor RNA Transfected Dendritic Cells; From Vaccine to Antigen Discovery

Lawrence Fong, University of California, San Francisco, USA
Short Talk: Human Tumor Immunotherapy with an Altered Carcinoembryonic Antigen Derived Epitope Loaded on Flt3L Expanded Dendritic Cells

Romina S. Goldszmid, NCI, National Institutes of Health, USA
Short Talk: Immunization with Dendritic Cells Loaded with B16F1 Melanoma Apoptotic Cells Induces Protection Against Tumor Development in C57BL6 Mice.

* Gerold Schuler, University Hospital of Erlangen, Germany
Immunotherapy with Monocyte-Derived Dendritic Cells

Cornelis J. M. Melief, Leiden University Medical Center, Netherlands
CD4+ and DC Requirements for Optimal CD8+ CTL Induction Against Tumors

Nicole Selenko, University of Vienna, Austria
Short Talk: Dendritic Cells Take Up IDEC-C2B8 (RITUXIMAB(R)) Treated Lymphoma Cells and Cross-Prime CD8+CTL Against Lymphoma Cell-Associated Antigens

Dean L. Mann, University of Maryland Medical School, USA
Short Talk: Dendritic Cells Armed with PSA-Anti PSA (Antigen-Antibody) Complexes Generate Both CD4+ and CD8+ T Cell Response in vitro

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
14:30—16:30
Workshop 1: DC-Mediated Cancer Therapy

Bataan
* Olivera J. Finn, University of Pittsburgh School of Medicine, USA

* Philip D. Greenberg, University of Washington, USA

Pia Björck, Apexigen, USA

Magali de Heusch, Universite Libre de Bruxelles, Belgium

Mariolina Salio, Weatherall Institute of Molecular Medicine, UK

Victor H. Engelhard, University of Virginia, USA

LiQi Li, Karolinska Institute, Sweden

Grégoire Lauvau, Albert Einstein College of Medicine, USA

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

John Matthew Timmerman, Stanford University, USA

16:30—18:30
Poster Session 1: Immunotherapy of Human Cancer/Control of CD4+ T Cell Differentiation

Rio Grande
17:30—18:30
Social Hour with Lite Bites

Rio Grande
18:30—19:30
Coffee Available

Rio Grande
18:30—20:30
Control of CD4+ T Cell Differentiation
Meeting has ended...abstracts no longer viewable online.

Bataan
* Anne O'Garra, Francis Crick Institute, UK
Control of T Cell Differentiation

Muriel Moser, Université Libre de Bruxelles, Belgium
Dendritic Cell Regulation of Th1/Th2 Development

Caetano Reis e Sousa, Francis Crick Institute, UK
Short Talk: Regulation of Dendritic Cell Function in vivo by Microbial and T Cell-Derived Stimuli

Luigina Romani, University di Perugia, Italy
Skewing of Th Differentiation During the DC-Microbe Interaction

Steffen Jung, Weizmann Institute of Science, Israel
Short Talk: A Transgenic Mouse Model Allowing Inducible in vivo Dendritic Cell Ablation


WEDNESDAY, MARCH 14

07:00—08:00
Breakfast

Rio Grande
08:00—11:30
Peripheral Tolerance and Regulatory T Cells
Meeting has ended...abstracts no longer viewable online.

Bataan
* William R. Heath, University of Melbourne, Australia
Tolerance to Pancreatic Beta Cell Autoantigens

Linda A. Sherman, The Scripps Research Institute, USA
Tolerance to Pancreatic Beta Cell Autoantigens

Anand Gautam, Novo Nordisk, Denmark
Short Talk: Cognate CD4 T Cell Help ?Breaks? Cytotoxic T Lymphocyte (CTL) Tolerance Against Self-Antigens

Peta J. O'Connell, University of Pittsburgh, USA
Short Talk: Differential Regulation of Organ Allograft Survival by Lymphoid-Related and Myeloid Dendritic Cell Subsets

Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Regulatory T Cells

Manfred B. Lutz, University of Erlangen, Germany
Short Talk: Induction of Regulatory T-Cells by Dendritic Cells Leads to Complete Protection of Mice from Experimental Autoimmune Encephalomyelitis

Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Role of the APC in the Induction of Tolerance, Autoimmunity and Tumor Immunity

Yonghong Wan, McMaster University, Canada
Short Talk: Uncoupling of Antitumor and Autoimmune Responses Using Dendritic Cell Vaccines

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
14:30—16:30
Workshop 2: DC Subsets

Bataan
* Kayo Inaba, Kyoto University, Japan

* Brian L. Kelsall, NIAID, National Institutes of Health, USA

Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA

Omid Akbari, University of Southern California, USA

Karim Y. Vermaelen, Ghent University Hospital, Belgium

Helmut Jonuleit, University of Mainz, Germany

Huirong Jiang, Aberdeen University Medical School, UK

Matthew L. Albert, Genentech, Inc., USA

Kim Campbell, Therakos, Inc., USA

Habib Zaghouani, University of Missouri School of Medicine, USA

Li-Yun Coty Huang, U.S. Food and Drug Administration, USA

Andrew Blauvelt, Oregon Health & Science University, USA

16:30—18:30
Poster Session 2: Peripheral Tolerance and Regulatory T Cells/T Cell Activation

Rio Grande
17:30—18:30
Social Hour with Lite Bites

Rio Grande
18:30—19:30
Coffee Available

Rio Grande
18:30—20:30
T Cell Activation
Meeting has ended...abstracts no longer viewable online.

Bataan
* Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
The Dynamics of T Lymphocyte Activation

Michael L. Dustin, University of Oxford, UK
Molecular Dynamics in the Immunological Synapse

Carl G. Figdor, Radboud University Medical Center, Netherlands
Molecular Characterisation of Dendritic Cells

Pawel Kalinski, University of Pittsburgh, USA
Short Talk: T Helper Function of CD8+ T Cells

Kelly David Smith, University of Washington, USA
Short Talk: The Role of Toll-Like Receptors in Macrophage Activation


THURSDAY, MARCH 15

07:00—08:00
Breakfast

Rio Grande
08:00—11:30
DC Development and Subsets
Meeting has ended...abstracts no longer viewable online.

Bataan
Ken Shortman, Walter and Eliza Hall Institute of Medical Research, Australia
Dendritic Cell Diversity

Joke M. M. den Haan, VU Medical Center, Netherlands
Short Talk: Lymphoid-Related But Not Myeloid-Related Dendritic Cells Cross-Prime CD8+ T Cells in vivo

Yong-Jun Liu, Sanofi, USA
IPC/pre-DC2, an Anti-Viral Innate Effector and a Bridge Between Innate and Adaptive Immunity

Andre Boonstra, Erasmus Medical Center, Netherlands
Short Talk

Markus G. Manz, University Hospital Zürich, Switzerland
Short Talk: Dendritic Cell Development from Lineage Committed Hematopoietic Progenitors

Yu-Min Huang, Karolinska Institute, Sweden
Short Talk: Interferon-beta Induces the Development of Type 2 Dendritic Cells

* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Interplay Between Dendritic Cell Subsets in Systemic Lupus Erythematosus

Shigeo Koyasu, Keio University School of Medicine, Japan
Production of Interferon-gamma by Subsets of Dendritic Cells

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
14:30—16:30
Workshop 3: Cell and Molecular Markers of DC Differentiation

Bataan
* Sem Saeland, DermImmune, France

* Paola Ricciardi-Castagnoli, Toscana Life Science Foundation, Italy

Kevin Scott Gorski, 3M Pharmaceuticals, USA

Maria Rescigno, European Institute of Oncology, Italy

Blandine De Saint-Vis, Schering-Plough, France

Tao Wan, Second Military Medical University, China

Tsuneyasu Kaisho, RIKEN Research Center for Allergy and Immunology, Japan

Stefania Gallucci, Temple University, USA

Julio Aliberti, NIAID, National Institutes of Health, USA

Alexander Steinkasserer, University of Erlangen, Germany

Nir Hacohen, Massachusetts General Hospital, USA

Francesca Granucci, University of Milano-Bicocca, Italy

Martin Zenke, Institute for Bioemdical Engineering, Germany

Bali Pulendran, Stanford University School of Medicine, USA

16:30—18:30
Poster Session 3: DC Development and Subsets/Antigen Presenting Cells in Lymphoid and Nonlymphoid Tissues

Rio Grande
17:30—18:30
Social Hour with Lite Bites

Rio Grande
18:30—19:30
Coffee Available

Rio Grande
18:30—20:30
Antigen Presenting Cells in Lymphoid and Nonlymphoid Tissues
Meeting has ended...abstracts no longer viewable online.

Bataan
* G. Gordon MacPherson, University of Oxford, UK
Antigen Transport by Lymph Dendritic Cells

Clemens Scheinecker, University of Vienna, Austria
Short Talk: Dendritic Cells Draining the Target Organ Present Tissue Specific Autoantigen

V. Hugh Perry, University of Southampton, UK
Dendritic Cells in the Central Nervous System

Alain P. Vicari, Schering-Plough, France
Dendritic Cell Recruitment by Chemokines Toward Strategies to Elicit Anti-Tumor Immunity

Maria Rosa Bono, University of Chile, Chile
Short Talk: Peyer's Patches-Derived Dendritic Cells Preferentially Induce the Mucosa-Specific Homing Integrin alpha4beta7 on Murine TCR Transgenic T Cells

Bart N. Lambrecht, VIB, Ghent University, Belgium
Short Talk: Bone Marrow and Airway DCs in a Murine Model of Asthma


FRIDAY, MARCH 16

07:00—08:00
Breakfast

Rio Grande
08:00—11:30
TNF and B7 Family Members on DCs
Meeting has ended...abstracts no longer viewable online.

Bataan
Yasunori Yamaguchi, Kyowa Hakko Kirin California, USA
Short Talk: BDCA-2, a Novel Plasmacytoid Dendritic Cell-Specific Transmembrane Protein: Molecular Cloning and Functional Characterization

Lieping Chen, Yale University, USA
T Cell Costimulatory Network

* Arlene H. Sharpe, Harvard Medical School, USA
B7 Family of Costimulators

Yongwon Choi, University of Pennsylvania, USA
TNFR Family - Mediated Signaling in DCs

Edward A. Clark, University of Washington, USA
Short Talk: Regulation of Dendritic Cells by Osteoprotegerin (OPG), a Secreted Member of the TNF Receptor Family

Bertrand Huard, Centre Medical Universitaire, Switzerland
Short Talk: A TNF Family Member Expressed by Dendritic Cells and Newly Identified as Costimulatory for T Cells

09:20—09:40
Coffee Break

Rio Grande
11:00—13:00
Poster Setup

Rio Grande
14:30—16:30
Workshop 4: Genetic Modification of DCs and Vaccine Strategies

Bataan
* Margaret A. Liu, ProTherImmune and Karolinska Institutet, USA

* Angela Granelli-Piperno, Rockefeller University, USA

Noemi Sevilla, Centro de Investigación en Sanidad Animal (INIA),, Spain

Christiane Ruedl, Basel Institute, Switzerland

Laura B. Bungener, University Medical Center Groningen, Netherlands

Yan Cui, Louisianna State University Health Sciences Center, USA

Naotaka Shibagaki, National Cancer Institute, National Institutes of Health, USA

Amy R. Tvinnereim, University of Iowa, USA

Marc Grégoire, INSERM, France

Simon M. Barratt-Boyes, University of Pittsburgh, USA

Heather Zwickey, National College of Naturopathic Medicine, USA

Lee Leserman, Centre d'Immunologie de Marseille-Luminy, France

Jose A. Villadangos, University of Melbourne, Australia

16:30—18:30
Poster Session 4: TNF and B7 Family Members on DCs/Chemokines and Chemokine Receptors/Antigen Processing and Presentation (MHC I, MHC II, CD1)/Antigen Receptors and Antigen Targeting for DCs

Rio Grande
17:30—18:30
Social Hour with Lite Bites

Rio Grande
18:30—19:30
Coffee Available

Rio Grande
18:30—20:30
Chemokines and Chemokine Receptors
Meeting has ended...abstracts no longer viewable online.

Bataan
* Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
The Role of Chemokines and Chemokine Receptors in Primary, Effector and Memory Immune Responses

Martin Lipp, Max-Delbrueck-Center, MDC, Germany
Role of Homeostatic Chemokines in the Function of Lymphoid Tissues

Reinhold Förster, Hannover Medical School, Germany
Short Talk: Distinct Stages of Dendritic Cell Mobilization and Localization are Controlled by CC Chemokine Receptor 7

Andreas Cornelius Renkl, University of Freiburg, Germany
Short Talk: Osteopontin (OPN) Deficient Mice are Impaired in Their Function to Attract Dendritic Cells to Lymph Nodes Which Correlates with a Reduced Cutaneous Contact Hypersensitivity (CHS) Response

Gwendalyn J. Randolph, Washington University, USA
Multidrug Resistance Transporters and Dendritic Cell Mobilization to Lymph Nodes


SATURDAY, MARCH 17

07:00—08:00
Breakfast

Rio Grande
08:00—11:30
Antigen Processing and Presentation (MHC I, MHC II, CD1)
Meeting has ended...abstracts no longer viewable online.

Bataan
* Sebastian Amigorena, Institut Curie, France
Endocytic Transport and Antigen Presentation in Dendritic Cells

Steven A. Porcelli, Albert Einstein College Of Medicine, USA
Specialized Roles of CD1 Molecules in Antigen Presentation

Laurence Zitvogel, Institut Gustave Roussy, France
Short Talk: Dendritic Cell (DC) Maturation Overrules H-2D-Mediated NKT Cell Inhibition: A Critical Role of B7 in CD1d-Dependent NKT Cell IFNgamma Production

Atsushi Kumanogoh, Osaka University, Japan
Short Talk: CD100 has a Critical Costimulatory Role in Cellular Immunity via Dendritic Cells

Mary Jo Wick, University of Gothenburg, Sweden
Dendritic Cells and Anti-Salmonella Immunity

Elizabeth Ingulli, University of Minnesota, USA
Short Talk: Myeloid and Not Lymphoid Dendritic Cells (DC) Present Soluble Antigen to Naive T Cells in vivo

Ira Mellman, Genentech, Inc., USA
Developmental Regulation of Antigen Processing and MHC Function in Dendritic Cells

Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France
Short Talk: Cysteine Proteases, MHC Class II, H2-DM and Ii Chain, Guilt by Association in Dendritic Cells

09:20—09:40
Coffee Break

Rio Grande
17:00—18:00
Coffee Available

Rio Grande
17:00—19:00
Antigen Receptors and Antigen Targeting for DCs
Meeting has ended...abstracts no longer viewable online.

Bataan
* Nina Bhardwaj, Icahn School of Medicine at Mt Sinai, USA
Presentation of Dying Cells by DCs

Jan Paul Medema, Academic Medical Center, Netherlands
Short Talk: Expression of the Serpin SPI-6 Protects Dendritic Cells from Cytotoxic T Lymphocyte-Induced Apoptosis; Differential Modulation by T-Helper Type 1 and Type 2 Cells

Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
New Molecules Expressed by Dendritic Cells and Their Application in Amplifying Vaccine Potency

Daniel Hawiger, Rockefeller University, USA
Short Talk: A Method for Efficient Antigen Targeting to Dendritic Cells in vivo

Ralph M. Steinman, Rockefeller University, USA
Emerging Areas of Dendritic Cell Biology

19:00—20:00
Social Hour with Lite Bites

Rio Grande
20:00—23:00
Entertainment

Rio Grande

SUNDAY, MARCH 18

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI48918-01




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