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This meeting took place in 2001



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B Cell Immunobiology and Disease (E8)


Organizer(s) Jane R. Parnes, Anthony L. DeFranco and Kathryn L. Calame
April 17—22, 2001
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Dec 18, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 17, 2001

Sponsored in part by the Director's Sponsor Fund

Summary of Meeting:
B lymphocytes serve as both critical mediators of immune responses and as targets of human disease. Key advances have been made in our understanding of the molecular regulation of B cell development and activation. Recent progress has also been made in defining the molecular mechanisms responsible for the recombination events leading to formation of functional antibody genes, and the regulation of these events. It has become apparent that B cells, like T cells, undergo selective mechanisms that determine both survival and functional capacity. Proper regulation is required to ensure protective immune responses but avoid autoimmunity. Signals through the B cell receptor and regulatory coreceptors have been shown to be major determinants of the fate of developing and activated B cells. It is critical to determine how such signals integrate with other pathways to determine immunity versus tolerance. New insights should come from studies of the interaction of B cells with T lymphocytes, stromal cells and various types of dendritic cells. The mechanisms by which dysregulation of key transcription factors and signaling molecules lead to B cell malignancy are also being explored; such knowledge will lead to new opportunities for therapy of leukemia/lymphoma. The goal of this meeting is to integrate these advances in regulation of B cell development, signal transduction and responsiveness, to provide a molecular understanding of B cell function and fate in both health and disease.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, APRIL 17

14:00—19:00
Registration

Coat Room
18:15—19:15
Welcome

Golden Cliff
19:15—19:30
Orientation

Ballroom 2 - 3
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2 - 3
Frederick W. Alt, Boston Children's Hospital, USA
Molecular Mechanisms Involved in the Formation of Antibody Genes


WEDNESDAY, APRIL 18

07:00—08:00
Breakfast

Golden Cliff, Magpie
08:00—11:00
B Cell Development I: Pre-B Cells and V(D)J Recombination
Meeting has ended...abstracts no longer viewable online.

Ballroom 2 - 3
* Paul W. Kincade, Oklahoma Medical Research Foundation, USA
Early, Hormone-Sensitive Events in Lymphopoiesis

Cynthia J. Guidos, University of Toronto and Hospital for Sick Children, Canada
Short Talk: Lunatic Fringe, Notch-1 and the T/B Lineage Decision

Shiv Pillai, Massachusetts General Hospital, USA
Short Talk: The Follicular Versus Marginal Zone B Lymphocyte Cell-Fate Decision

Marjorie A. Oettinger, Massachusetts General Hospital, USA
Regulatory Mechanisms in V(D)J Recombination

Mark S. Schlissel, University of California, Berkeley, USA
Developmental Regulation of the V(D)J Recombinase: Igkappa Locus Allelic Exclusion

09:00—09:20
Coffee Break

Ballroom Lobby
11:00—13:00
Poster Setup

Maybird/Superior & Lobby
14:00—16:00
Workshop 1: B Cell Development and Lineage Choice

Ballroom 1
* Richard (Randy) Hardy, Fox Chase Cancer Center, USA

14:00—16:00
Workshop 2: B Cell Receptor Signaling

Ballroom 2-3
* Michael R. Gold, University of British Columbia, Canada

16:00—18:00
POSTER SESSION 1: B Cell Development: Pre-B Cells and V(D)J Recombination/Transcriptional Regulation

Maybird/Superior & Lobby
17:00—18:00
Social Hour

Maybird/Superior & Lobby
20:00—21:30
Coffee Available

Ballroom Lobby
20:00—22:00
B Cell Development II: Transcriptional Regulation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2 - 3
Katia Georgopoulos, Massachusetts General Hospital, USA
Regulation of Lymphocyte Activation by Ikaros-Targeted Chromatin Remodelers

Harinder Singh, Cincinnati Children's Hospital Medical Center, USA
Functions of ETS and IRF Transcription Factors in B Cell Development

* Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
The Master Regulator of Class II MHC: CIITA

Jean-Pierre de Villartay, INSERM U768, France
Short Talk: Physiopathology of V(D)J Recombination


THURSDAY, APRIL 19

07:00—08:00
Breakfast

Golden Cliff, Magpie
08:00—11:00
B Cell Activation I: Ag Receptor Signaling and Coreceptors
Meeting has ended...abstracts no longer viewable online.

Ballroom 2 - 3
Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
Regulation of Phospholipase C-gamma2 and Phosphoinositide 3-Kinase Pathways by Adaptor Molecules in B Lymphocytes

John C. Cambier, University of Colorado SOM, USA
Molecular Mechanism Underlying B Cell Anergy: Lessons from a New Model of Tolerance

Thomas F. Tedder, Duke University Medical Center, USA
CD19 and CD22 Regulate Intrinsic and BCR-Induced Signal Transduction Thresholds and Autoimmunity

* Jane R. Parnes, Amgen, USA
Negative Regulation of B Cell Responsiveness by CD72

Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan
Short Talk: A Novel Adapter Molecule BARP (BLNK-Associated Raft Protein) is Involved in preBCR Signaling

09:00—09:20
Coffee Break

Ballroom Lobby
11:00—13:00
Poster Setup

Maybird/Superior & Lobby
14:00—16:00
Workshop 3: B Cell Maturation and Survival in the Periphery

Ballroom 1
* Timothy W. Behrens, Genentech, Inc., USA

14:00—16:00
Workshop 4: Coreceptors and Regulation of B Cell Activation

Ballroom 2-3
* Edward A. Clark, University of Washington, USA

14:00—16:00
Workshop 5: V(D)J Recombination

Magpie
* Patricia Cortes, Mount Sinai School of Medicine, USA

16:00—18:00
POSTER SESSION 2: B Cell Activation: Ag Receptor Signaling and Coreceptors/Cellular Interactions and Their Consequences

Maybird/Superior & Lobby
17:00—18:00
Social Hour

Maybird/Superior & Lobby
20:00—21:30
Coffee Available

Ballroom Lobby
20:00—22:00
B Cell Activation II: Cellular Interactions and Their Consequences
Meeting has ended...abstracts no longer viewable online.

Ballroom 2 - 3
* Jason G. Cyster, HHMI/University of California, San Francisco, USA
Regulation of B Cell Migration by Chemokines

Yong-Jun Liu, Sanofi, USA
Regulation of B Cell Activation by DCs and FDCs

Jane A. Gross, Emergent Biosolutions, USA
Short Talk: TACI-Ig is a Potent Inhibitor of B Cell Development and Differentiation in vivo

William C. Sha, University of California, Berkeley, USA
Short Talk: Regulation of B7h/ICOS Interactions


FRIDAY, APRIL 20

07:00—08:00
Breakfast

Golden Cliff, Magpie
08:00—11:00
Class Switch and Somatic Mutation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2 - 3
Janet M. Stavnezer, University of Massachusetts Medical School, USA
Role of Mismatch Repair Proteins in Antibody Class Switch Recombination

* Ursula Storb, University of Chicago, USA
Molecular Basis of Somatic Hypermutation of Immunoglobulin Genes

Tasuku Honjo, Kyoto University Graduate School of Medicine, Japan
The Immune System Requires 'AID' for Class Switch Recombination and Hypermutation

David G. Schatz, Yale University School of Medicine, USA
Short Talk: DNA Double Strand Breaks in Somatic Hypermutation

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Short Talk: Measuring the Contribution of Receptor Editing to the Anitbody Repertoire

09:00—09:20
Coffee Break

Ballroom Lobby
11:00—13:00
Poster Setup

Maybird/Superior & Lobby
14:00—16:00
Workshop 6: B Cell Activation by Helper T Cells and Follicular Dendritic Cells

Ballroom 1
* Genhong Cheng, University of California, Los Angeles, USA

14:00—16:00
Workshop 7: B Cell Immunodeficiencies in Humans and Animal Models

Magpie
* Mary Ellen Conley, Rockefeller University, USA

14:00—16:00
Workshop 8: Somatic Mutation and Class Switching

Ballroom 2-3
* Patricia J. Gearhart, NIA, National Institutes of Health, USA

16:00—18:00
POSTER SESSION 3: Class Switch and Somatic Mutation/Terminal Differentiation/Tolerance and Autoimmunity/B Cell Malignancy

Maybird/Superior & Lobby
17:00—18:00
Social Hour

Maybird/Superior & Lobby
20:00—21:30
Coffee Available

Ballroom Lobby
20:00—22:00
Terminal Differentiation
Meeting has ended...abstracts no longer viewable online.

Ballroom 2 - 3
* Kathryn L. Calame, Columbia College of Physicians and Surgeons, USA
BLIMP-1 As a Critical Regulator of Plasma Cell Differentiation

Selina Chen-Kiang, Weill Medical College of Cornell University, USA
Cell Cycle and Apoptotic Control of B Cell Terminal Differentiation

Virginia Pascual, Cornell University, USA
Alterations of B Cell and Dendritic Cell Subsets in SLE


SATURDAY, APRIL 21

07:00—08:00
Breakfast

Golden Cliff, Magpie
08:00—11:00
Tolerance and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Ballroom 2 - 3
David Nemazee, The Scripps Research Institute, USA
Cellular and Molecular Analysis of Receptor Editing

* Anthony L. DeFranco, University of California, San Francisco, USA
Regulation of B Cell Activation and Tolerance by the Tyrosine Kinases Lyn and Fyn

Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Positive and Negative Regulation of Autoreactive B Cells

Betty Diamond, Feinstein Institute for Medical Research, USA
Short Talk: Models of Autoimmunity in a Non-Spontaneously Autoimmune Host

Martin G. Weigert, University of Chicago, USA
Short Talk: Editing of Anti-DNA Receptors

09:00—09:20
Coffee Break

Ballroom Lobby
13:30—15:30
Workshop 9: B Cell Tolerance and Autoimmunity

Ballroom 1
* Ann Marshak-Rothstein, University of Massachusetts Medical School, USA

13:30—16:00
Workshop 10: B Cell Malignancy

Ballroom 2-3
* Diane F. Jelinek, Mayo Clinic, USA

15:30—17:30
Coffee Available

Ballroom Lobby
16:15—18:15
B Cell Malignancy
Meeting has ended...abstracts no longer viewable online.

Ballroom 2 - 3
* Louis M. Staudt, NCI, National Institutes of Health, USA
Gene Expression Profiling of Lymphoid Malignancies Reveals New Cancer Types and Mechanisms of Malignant Transformation

Herbert C. Morse, III, NIAID, National Institutes of Health, USA
Modeling, Human Non-Hodgkins Lymphomes in Mice: The Case for MYC, And Burkitt Lymphoma

Riccardo Dalla-Favera, Columbia University, USA
Molecular Pathogenesis of Human B Cell Lymphoma

19:00—20:00
Social Hour

Ballroom Mezzanine
20:00—22:00
Banquet

Ballroom
21:00—00:00
Entertainment

Ballroom

SUNDAY, APRIL 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI48920.01




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