Taos Convention Center (meeting only) Floorplan

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This meeting took place in 2001



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Cell Cycle 2001 (J1)


Organizer(s) William G. Kaelin, Jr. and Helen Piwnica-Worms
January 9—14, 2001
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Sep 8, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 9, 2000

Sponsored by Novartis Pharmaceuticals Corporation


Summary of Meeting:
Understanding cell-cycle control is central to understanding diseases characterized by abnormal cellular proliferation such as cancer. Recent developments in this area relate to molecular pathways that govern whether cells proceed through the cell cycle, as well as to the mechanics of DNA replication and mitosis. Timely changes in protein phosphorylation at the hands of specific kinases/phosphatases, as well as changes in protein stability mediated by specific ubiquitin ligases, play central roles in these processes. Finally, ‘checkpoints’ exist to monitor the fidelity and completion of these events. Activation of checkpoints leads to cell-cycle arrest or death and perturbations in checkpoint pathways is characteristic of cancers. Current problems include understanding how the molecular pathways alluded to above network with one another, determining how cell-cycle exit is coupled to cell fate decisions, and understanding of the biochemistry of both DNA replication and mitosis in higher eukaryotes. The goal of this meeting is to facilitate communication among a diverse group of investigators who apply genetic, biological and biochemical approaches to understand cell cycle regulation in a variety of model organisms. A secondary goal will be to ask whether there are specific therapeutic opportunities related to the cell cycle based on our current state of knowledge.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 9

14:00—19:00
Registration

Rio Grande D
18:15—19:15
Welcome

Bataan
19:15—19:30
Orientation

Rio Grande ABC
19:30—21:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Rio Grande ABC
* Karen H. Vousden, Crick Institute, UK

Charles J. Sherr, St. Jude Children's Research Hospital, USA
G1 Phase Progression and Cancer

Gerard I. Evan, University of Cambridge, UK
Apoptosis and Cancer


WEDNESDAY, JANUARY 10

07:00—08:00
Breakfast

Bataan
08:00—11:00
DNA Replication
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
* Bruce W. Stillman, Cold Spring Harbor Laboratory, USA
Inheritance of DNA and Chromatin

Stephen P. Bell, Massachusetts Institute of Technology, USA
ORC-Dependent Nucleosome Positioning Stimulates the Initiation of DNA Replication

Michael Botchan, University of California, Berkeley, USA
Targeting the Drosophila ORC to DNA

Ronald A. Laskey, Hutchison/MRC Research Centre, UK
Control of DNA Replication in Normal and Neoplastic Cells

08:00—11:00
Apoptosis/Death Receptors
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Gerard I. Evan, University of Cambridge, UK

Avi Ashkenazi, Genentech, Inc., USA
Death Receptors: Signaling and Modulation

J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Regulating the Pro- and Anti-Apoptotic Functions of Bcl-2 Family Proteins

Hermann Steller, Rockefeller University, USA
Control of Apoptosis in Drosophila

David Ching Huang, Walter and Eliza Hall Institute of Medical Research, Australia
BH3-Only Proteins, Essential Initiators of Apoptotic Cell Death

09:20—09:40
Coffee Break

Bataan
11:00—13:00
Poster Setup

Bataan
16:30—18:30
POSTER SESSION 1

Bataan
17:30—18:30
Social Hour

Bataan
18:30—19:30
Coffee Available

Hallways
18:30—20:30
Cell-Cycle Transitions I
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
* Douglas Dean, Washington University School of Medicine, USA
Mechanism of Action of the Rb Tumor Suppressor

Terry L. Orr-Weaver, Massachusetts Institute of Technology, USA
Developmental Regulation of DNA Replication

J. Wade Harper, Harvard Medical School, USA
Control of S-phase Events by Cyclin E/Cdk2

18:30—20:30
Survival Signals/Growth Signals
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Christopher Marshall, Institute of Cancer Research, UK
Signaling Through Ras and Rho

Michael Karin, University of California, San Diego, USA
Pro- and Anti-Apoptotic Activity of the JNK and IKK Signaling Pathways

Gerard I. Evan, University of Cambridge, UK
Apoptosis and Cancer


THURSDAY, JANUARY 11

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Checkpoints and Cancer (Joint)
Meeting has ended...abstracts no longer viewable online.

Bataan
Joseph R. Nevins, Duke University Medical Center, USA
Synergy in Pathways that Regulate G1 Cell Cycle Progression

* Helen Piwnica-Worms, Washington University School of Medicine, USA
Checkpoint Control in Normal and Cancer Cell Cycles

Michael B. Kastan, St. Jude Children's Research Hospital, USA
Multiple Cellular Functions for ATM

Jerry W. Shay, University of Texas Southwestern Medical Center, USA
The Role of Telomeres in Cell Cycle Checkpoint Responses

09:00—09:20
Coffee Break

Rio Grande BCD
11:00—13:00
Poster Setup

Rio Grande
16:30—18:30
POSTER SESSION 2

Rio Grande
17:30—18:30
Social Hour

Rio Grande
18:30—19:30
Coffee Available

Hallways
18:30—21:00
Tumor Suppression (Joint)
Meeting has ended...abstracts no longer viewable online.

Bataan
* Carol L. Prives, Columbia University, USA
Regulation of p53 and its Relatives

Karen H. Vousden, Crick Institute, UK
Regulation and Function of MDM2

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Screens in Zebrafish for Genes Related to the Cell Cycle and Cancer

Edward Harlow, Constellation Pharmaceuticals, USA
Nuclear Organization of DNA Replication in Primary Mammalian Cells


FRIDAY, JANUARY 12

07:00—08:00
Breakfast

Bataan
08:00—11:00
Cell-Cycle Transitions II
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Control of Cell Death and Differentiation by the Retinoblastoma Protein

* Steven I. Reed, The Scripps Research Institute, USA
Cell Cycle Control, Proteolysis, and Genetic Instability

Angelika Amon, Massachusetts Institute of Technology, USA
Regulation of Exit from Mitosis in Yeast

Jan-Michael Peters, Research Institute of Molecular Pathology, Austria
Regulation of Anaphase by the APC-Separase Pathway

08:00—11:00
Signaling
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
Ann Marie Pendergast, Duke University Medical Center, USA
Novel Roles of ABL Tyrosine Kinases and Associated Adaptors

Anita B. Roberts, National Institutes of Health, USA
Role of the Smad Pathway in Pathogenetic Mechanisms Dependent on TGF-beta

Stanley J. Korsmeyer, Harvard University, USA
Integrating the Cell Death Pathway

* Moshe Oren, Weizmann Institute of Science, Israel
Signaling to the p53 Pathway

09:20—09:40
Coffee Break

Bataan
11:00—13:00
Poster Setup

Bataan
16:30—18:30
POSTER SESSION 3

Bataan
17:30—18:30
Social Hour

Bataan
18:30—19:30
Coffee Available

Hallways
18:30—20:30
Cell-Cycle Transitions III
Meeting has ended...abstracts no longer viewable online.

Rio Grande A-B
Mark Winey, University of California Davs, USA
MPS1 Family Kinases Regulate Centrosome Duplication

* David Pellman, Dana-Farber Cancer Institute, USA
Spindle Attachments and Chromosomal Stability

Stephen A. Osmani, Geisinger Clinic, USA
Location of Protein Kinases and Mitosis

18:30—20:30
Regulation of Gene Expression by Oncogenes/Tumor Suppressors
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
Robert N. Eisenman, Fred Hutchinson Cancer Research Center, USA
The Mad Protein Family: Biological Functions and the Structural Basis for Transcription Repression

Joan W. Conaway, Stowers Institute for Medical Research, USA
Elongin BC and the VHL Tumor Suppressor Complex

Tony Kouzarides, University of Cambridge, UK
Histone Methylation and Transcriptional Silencing


SATURDAY, JANUARY 13

07:00—08:00
Breakfast

Rio Grande
08:00—11:00
Therapeutic Opportunities (Joint)
Meeting has ended...abstracts no longer viewable online.

Bataan
* Allen Ira Oliff, DuPont Pharmaceuticals Company, USA
Molecular Targets Versus Empirical Cytotoxics

Julian Adams, Vedantra Pharmaceuticals, Inc., USA
Therapeutic Opportunities Related to Ubiquitination Pathways

Leisa K. Johnson, Genentech, Inc., USA
Adenoviruses Targeting Deregulation of the RB Tumor Suppressor Pathway in Cancer Cells Demonstrate Potent Anti-Tumor Activity

Nicholas B. Lydon, , USA
Structure-Based Approaches to the Discovery and Optimization of Selective Protein Kinase Inhibitors

09:20—09:40
Coffee Break

Rio Grande BCD
15:00—16:00
Coffee Available

Hallways
15:00—17:00
Proteolysis
Meeting has ended...abstracts no longer viewable online.

Rio Grande A - B
* Raymond J. Deshaies, Amgen, Inc., USA
Standing at the Intersection of Cell Cycle Control and Ubiquitin-Dependent Proteolysis

Michael Tyers, University of Montreal, Canada
Multi-Site Phosphorylation of a CDK Inhibitor Sets a Threshold for S-Phase Onset

Wilhelm Krek, Institute of Molecular Health Sciences, ETH Zürich, Switzerland
Roles of the F-Box Protein Skp2 in Cell Cycle Control

15:00—17:00
Tumor Progression
Meeting has ended...abstracts no longer viewable online.

Rio Grande C-D
* Terry A. Van Dyke, National Cancer Institute, National Institutes of Health, USA
Modeling Cancer Mechanisms in the Mouse

Allan Balmain, University of California, San Francisco, USA
Genetic Control of Tumor Susceptibility in the Mouse

George F. Vande Woude, Van Andel Research Institute, USA
Met-HGF/SF: Tumorigenesis, Invasion and Metastasis

19:00—20:00
Social Hour

Rio Grande
20:00—22:00
Banquet

Bataan
21:00—00:00
Entertainment

Rio Grande

SUNDAY, JANUARY 14

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA88825-01




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