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This meeting took place in 2002



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Genomics and Genetics of Senescence and Cancer (A5)


Organizer(s) Peter K. Vogt and Ronald A. DePinho
January 22—27, 2002
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 1, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 20, 2001

Sponsored by DNAX Research, Inc. and The Director's Sponsor Fund

Summary of Meeting:
Exciting developments in several fields are converging to offer an ever more comprehensive explanation of cancer and aging. Telomerase has emerged as a major determinant of cellular immortality. Oncogenic proteins target cell cycle controls and checkpoints for modification or inactivation. Networks of developmental and growth regulatory signals gain independence from physiological controls. New insights into DNA repair extend the role of genetic and genomic instability as initiating factor in oncogenesis; and novel mechanisms of chromatin remodeling broaden our understanding of transcriptional controls. Progress in transgenic and knock-out technologies yields animal model systems that closely mimic human cancers. The origins of genetic and genomic instability remain one of the central problems in oncogenesis. It has links to telomerase, to cell cycle controls, to signaling and to chromatin. Understanding the causes of this instability is an important goal of animal model systems. Completion of the human genome sequence and extensive expression profiling are not only generating tremendous wealth of new knowledge but are also driving the synthesis of diverse data into coherent systems of understanding.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 22

16:00—19:00
Registration

Shavano Peak Foyer
18:15—19:15
Welcome

Shavano Peak Foyer
19:15—19:30
Orientation

Shavano Peak
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Phillip A. Sharp, Massachusetts Institute of Technology, USA
RNA Interference


WEDNESDAY, JANUARY 23

07:00—08:00
Breakfast

Red Cloud
08:00—11:00
Genomic Stability. Session Sponsored in part by New England BioLabs, Inc.
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Vicki Lundblad, The Salk Institute for Biological Studies, USA
Mechanisms that Enhance Telomere Maintenance in the Absence of Telomerase

Frederick W. Alt, Boston Children's Hospital, USA
Interplay Between DNA End-Joining and Cell Cycle Check Point Pathways in Lymphogenesis and Genomic Stability

Lynda Chin, University of Texas MD Anderson Cancer Center, USA
Melanoma Genesis and Maintenance

* Jerry W. Shay, University of Texas Southwestern Medical Center, USA
Cell and Molecular Basis of Senescence: When Do Telomeres Matter?

Yvette R. Seger, Cold Spring Harbor Laboratory, USA
Short Talk: Transformation of Human Cells in the Absence of Telomerase Activation

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
04:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Cell Cycle and Checkpoints
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Michael B. Kastan, St. Jude Children's Research Hospital, USA
ATM and Cellular Signaling Pathways

Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
p53 Action in Tumor Development and Therapy

Shridar Ganesan, Cancer Institute of New Jersey: RWJMS-UMDNJ, USA
The Multifunctionality of BRCA1 Likely Contributes to its Tumor Suppressing Activity

Rudolf Beier, Bayer Schering Pharma, Germany
Short Talk: A Novel Miz-1 Interacting Transcriptional Coactivator Promotes Ubiquitination of Myc

19:00—20:00
Welcome Mixer

Torreys Peak 1-4
20:00—22:00
Poster Session 1

Torreys Peak 1-4

THURSDAY, JANUARY 24

07:00—08:00
Breakfast

Red Cloud
08:00—11:00
Pathways to Cancer and Senescence
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
A TGFbeta Cytostatic Program and its Loss in Cancer

* Charles J. Sherr, St. Jude Children's Research Hospital, USA
INK4a/ARF: RB and p53 Intersection

Lewis C. Cantley, Weill Cornell Medicine, USA
Biology and Chemistry of P13K Pathway in Normal and Neoplastic Cells

Judith Campisi, Buck Institute for Research on Aging, USA
Tumor Suppression, Aging and Cellular Senescence

Julien Sage, Stanford University, USA
Short Talk: Cellular Senescence in Mouse Embryonic Fibroblasts is a Reversible State Controlled by the Retinoblastoma Gene Family

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—19:00
Chromatin and Transcription
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Robert L. Strausberg, National Institutes of Health, USA
The Cancer Genome Anatomy Project

* Ronald M. Evans, HHMI/The Salk Institute, USA
Nuclear Receptors: The Physiology of Transcription

Don Ayer, University of Utah, USA
Sin3, Transcriptional Repression and Senescence

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
The Role of PML in Tumor Suppression

Oliver Bischof, Institut Pasteur, France
Short Talk: PML Nuclear Bodies and Senescence

19:00—20:00
Welcome Mixer

Torreys Peak 1-4
20:00—22:00
Poster Session 2

Torreys Peak 1-4

FRIDAY, JANUARY 25

07:00—08:00
Breakfast

Red Cloud
08:00—11:00
Mouse Models
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Lothar Hennighausen, National Institutes of Health, USA
Genetic Pathways Controlling Epithelial Cell Specification, Proliferation and Differentiation

Suzanne Cory-Adams, Walter & Eliza Hall Institute of Medical Research, Australia
Apoptosis and Leukemogenesis: Insights from Mouse Models

* Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Conditional Mouse Models for Sporadic Cancer

Winfried Edelmann, Albert Einstein College of Medicine, USA
Mismatch Repair in Intestinal Neoplasia and in Meoisis

Bruce E. Clurman, Fred Hutchinson Cancer Research Center, USA
Short Talk: Identification of p27-Complementing Oncogenes by Insertional Mutagenesis and High-Throughput Insertion Site Cloning

09:20—09:40
Coffee Break

Shavano Peak Foyer
11:00—13:00
Poster Setup

Torreys Peak 1-4
13:00—22:00
Poster Viewing

Torreys Peak 1-4
16:30—17:00
Coffee & Snacks Available

Torreys Peak 1-4
17:00—17:30
Subsession: Special Lecture
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
17:00—18:30
Cancer Gene Discovery and New Model Systems I
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Neal G. Copeland, Institute of Molecular and Cell Biology, Singapore
Retroviral Insertional Mutagenesis Provides a Potent Cancer Gene Discovery Tool in the Modern Genome Era

Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
Loss of p16INK4a with Retention of p19ARF Predisposes to Tumourigenesis in Mice

Anders H. Lund, University of Copenhagen, Denmark
Short Talk: Genome-Wide Retrovirus-Insertional Mutagenesis in Tumors Induced in Ink4a/Arf (-/-) Mice

18:30—19:30
Welcome Mixer

Shavano Peak Foyer
19:30—21:30
Poster Session 3

Torreys Peak 1-4

SATURDAY, JANUARY 26

07:00—08:00
Breakfast

Red Cloud
08:00—11:00
Genomes and Transcriptomes
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
Bradley R. Cairns, HHMI/University of Utah, USA
Mechanism and Targeting of the Chromatin Remodeling Complex RSC

* Elizabeth H. Blackburn, The Salk Institute, USA
Cellular and Genomic Responses to Interference with Telomeres

Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Breast Cancer Gene Discovery Using SAGE (Serial Analysis of Gene Expression)

Todd R. Golub, Broad Institute, USA
Genome-Wide Views of Transcriptional Regulation in Cancer

Thomas G. Graeber, University of California, Los Angeles, USA
Short Talk: Bioinformatic Identification of Potential Autocrine Signaling Loops in Cancers from Gene Expression Profiles

09:20—09:40
Coffee Break

Shavano Peak Foyer
16:30—17:00
Coffee & Snacks Available

Shavano Peak Foyer
17:00—18:20
Cancer Gene Discovery and New Model Systems II
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
* Peter K. Vogt, The Scripps Research Institute, USA
Oncogenic Transformation of PI 3-Kinase: The Role of Protein Synthesis

Ramon Parsons, Icahn School of Medicine at Mount Sinai, USA
PTEN and Cancer

18:20—19:00
Intersection of Biology and Physical Sciences
Meeting has ended...abstracts no longer viewable online.

Shavano Peak
John R. Yates III, The Scripps Research Institute, USA
Towards Comprehensive Proteomics of Cells

19:00—20:00
Welcome Mixer

Torreys Peak 1-4
20:00—23:00
Entertainment

Torreys Peak 1-4

SUNDAY, JANUARY 27

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA94238-01




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