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This meeting took place in 2002



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Stroke - Molecular, Cellular, Pharmacological and Development of New Therapeutics (C1)


Organizer(s) Giora Z. Feuerstein, John M. Hallenbeck and Chung Hsu
March 9—14, 2002
Sagebrush Inn & Suites • Taos, New Mexico USA
Abstract Deadline: Jan 14, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 31, 2002

Summary of Meeting:
Stroke research has emerged as a discrete discipline that exploits molecular, genetic, cell biology and integrated systems to discover new mechanisms and therapeutics for stroke. In the past few years, novel discoveries in neurogenesis, including neuronal stem cells, provide new insights towards brain plasticity, remodeling and reconstruction. These discoveries provide novel opportunities for brain cell replacement and reconstruction of viable and functional brain tissue. In addition, exciting new research established the presence of inflammatory reaction in brain ischemia. Inflammation bears on diverse aspects of brain response to ischemia including vulnerability, pre-conditioning (tolerance to ischemia) as well as repair, and repair and reconstruction. Such data has already yielded new strategies in design and development of neuroprotective agents, which so far have been based on ion channel modulators and excitotoxic neurotransmitters (e.g., glutamate). Substantial progress has also been made in understanding signaling pathways that govern neuronal survival and death. In particular, understanding the signal transduction pathways of redox molecules, protein kinases (MAPK, src) and caspases (apoptosis) provide fertile grounds for new interventions that enhance survival pathways and/or inhibit death pathways. Finally, the emerging Human (and other animals) genome provides bright prospectives for identification of new molecular targets that could be better exploited for prevention, treatment, diagnosis and prognosis of stroke. The key objective of this meeting is to deliberate on new strategies for stroke therapies based on the innovative research conducted in recent years.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, MARCH 9

16:00—19:00
Registration

Chamisa Lobby
18:15—19:15
Welcome

Chamisa Lobby
19:15—19:30
Orientation

Chamisa Ballroom 2
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Giora Z. Feuerstein, Bristol-Myers Squibb Company, USA
Introduction

Dennis W. Choi, Washington University School of Medicine, USA
Ischemia-Induced Perturbations in Neuronal Ionic Homeostasis


SUNDAY, MARCH 10

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Brain Plasticity - New Opportunities for Novel Therapeutics. Session Sponsored by GlaxoSmithKline.
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Michael M. Merzenich, University of California, San Francisco, USA
Pharmacology of Brain Plasticity

Seth P. Finklestein, ViaCell Inc., USA
Growth Factors - Potential New Strategies for Functional Recovery from Stroke

Timothy J. Schallert, University of Texas, USA
Behaviorally Driven Plasticity and Neuroprotection in Stroke and Neurdegeneration Models

Frank S. Walsh, GlaxoSmithKline Pharmaceuticals, UK
Growth Cone Remodelling Factors- Nogo: A Potent Neurite-Outgrowth Inhibitor and Regulator of Plasticity

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 1
13:00—22:30
Poster Viewing

Chamisa Ballroom 1
16:00—16:30
Coffee & Snacks Available

Chamisa Ballroom 2
16:00—18:00
Afternoon Session: Stem Cells

Chamisa Ballroom 2
Frank R. Sharp, University of Cincinnati, USA
Neurogenesis and Gliogenesis Following Cerebral Ischemia

James M. Weimann, Stanford University, USA
Adult Stem Cells: From Bone Marrow to Brain and Brawn

Michael Chopp, Henry Ford Hospital, USA
Cellular Therapies for the Treatment of Neural Injury

18:00—19:00
Welcome Mixer

Chamisa Ballroom 1
19:00—21:00
Molecular Mechanisms of Microvascular and BBB Dysfunction
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Gregory J. del Zoppo, University of Washington, USA

* Myron D. Ginsberg, University of Miami School of Medicine, USA

Gregory J. del Zoppo, University of Washington, USA
Integrin Receptor Responses to Focal Cerebral Ischemia

Gary A. Rosenberg, University of New Mexico, USA
Matrix Metalloproteinases in Stroke

Brian P. Eliceiri, The Scripps Research Institute, USA
Src Deficiency or Blockade of Src Activity in Mice Provides Cerebral Protection Following Stroke

21:00—22:00
Social Hour

Chamisa Ballroom 1
21:00—22:30
Poster Session 1

Chamisa Ballroom 1

MONDAY, MARCH 11

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Mitochondrial Mechanism and Signaling Pathways of Neuronal Cell Death (Apoptosis)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Michael A. Moskowitz, Massachusetts General Hospital, Harvard University, USA
Apoptosis and Acute Injury to the Nervous System

Gary Fiskum, University of Maryland, USA
Age- and Cell Type-Dependent Responses of Mitochondria to Death Signals

Jun Chen, University of Pittsburgh School of Medicine, USA
Caspase-Dependent and Caspase-Independent Pathways in Ischemic Neuronal Cell Death

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 1
13:00—22:30
Poster Viewing

Chamisa Ballroom 1
16:00—16:30
Coffee & Snacks Available

Chamisa Ballroom 2
16:00—18:00
Afternoon Session: New Perspective in Anti-Thrombotic Strategies for Ischemic Stroke

Chamisa Ballroom 2
* Bruce Coull, University of Arizona Health Sciences Center, USA

Justin A. Zivin, University of California, San Diego, USA
Thrombolysis in Stroke - Is There a Path Forward?

J. Donald Easton, Brown University, USA
Anticoagulants in Stroke - Perspectives from Recent Trials

18:00—19:00
Welcome Mixer

Chamisa Ballroom 1
18:30—21:00
DNA Damage and Repair Mechanism in Ischemic Brain Injury
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Thomas P. Jacobs, National Institutes of Health, USA

* Jun Chen, University of Pittsburgh School of Medicine, USA

Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Processing of Oxidative DNA Damage and Connections to Neurological Disease

Chung Y. Hsu, Washington University School of Medicine, USA
DNA Methylation/Demethylation in the Regulation of Angiogenesis Gene Expression

Ella W. Englander, University of Texas Medical Branch, USA
Activation of Base Excision Repair Pathway in Cerebral Hypoxia

20:30—21:30
Social Hour

Chamisa Ballroom 1
21:00—22:30
Poster Session 2

Chamisa Ballroom 1

TUESDAY, MARCH 12

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Inflammatory and Immune Cells and Mediators in Stroke
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* John M. Hallenbeck, National Institutes of Health, USA
In Spontaneously Hypertensive, Genetically Stroke-Prone Rats (SHR-SP), Induction of Mucosal Tolerance to E-Selectin Prevents Ischemic and Hemorrhagic Stroke

John M. Harlan, Harbor View Medical Center, USA
Signaling Pathways Regulating Endothelial Activation and Apoptosis

E. Sander Connolly, Columbia University, USA
The Receptor for Advanced Glycation End-Products in Cerebral Ischemia

David J. Pinsky, University of Michigan, USA
Complement and Adhesion Receptors in Ischemic Neuronal Injury

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 1
13:00—22:30
Poster Viewing

Chamisa Ballroom 1
16:00—16:30
Coffee & Snacks Available

Chamisa Ballroom 2
16:00—18:00
Afternoon Session

Chamisa Ballroom 2
* James Grotta, University of Texas Medical School, USA

* Frank W. Marcoux, Pfizer Global Research & Development, USA

Richard J. Traystman, Johns Hopkins School of Medicine, USA
Pharmacologic Neuroprotection: Animal Models - What Works, or Why it Doesn't

Vladimir Hachinski, London Health Sciences Centre, Canada
Why do Stroke Trails Fail?

18:00—18:30
Welcome Mixer

Chamisa Ballroom 1
18:30—20:30
Brain Cell-Cell Signaling
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Etty (Tika) Benveniste, University of Alabama at Birmingham, USA

Maiken Nedergaard, University of Copenhagen, Denmark
Astrocytes and Local Signaling

Etty (Tika) Benveniste, University of Alabama at Birmingham, USA
Astrocyte Signaling in Brain Inflammation

J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Regulation of Neuronal Survival/Death by BCL-2 Family Proteins and SMN

21:00—22:00
Social Hour

Chamisa Ballroom 1
20:30—22:30
Poster Session 3

Chamisa Ballroom 1

WEDNESDAY, MARCH 13

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Signaling Pathways in Neuronal Survival and Death
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Pak H. Chan, Stanford University, USA

* Roger P. Simon, Robert S. Dow Neurobiology Laboratories, USA

Joseph S. Beckman, Oregon State University, USA
Nitric Oxide and Peroxynitrite in Neuronal Apoptosis

Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Unraveling the Molecular Mechanisms of Excitotoxic and Ischemic Neuronal Death Cascades

Peter M. Kang, Beth Israel Deaconess Medical Center, USA
Survival and Death Signaling Pathways in Heart: Potential Implications in Stroke

09:20—09:40
Coffee Break

Chamisa Lobby
16:00—18:00
Afternoon Session: Molecular Mechanisms of Ischemic White Matter Injury

Chamisa Ballroom 2
* Bruce R. Ransom, University of Washington, USA

Peter K. Stys, University of Calgary, Canada
Ion Channels Contributing to Hypoxic-Ischemic Axonal Damage

* Mark P. Goldberg, Washington University School of Medicine, USA
Glutamate Excitotoxicity in Glial and Axonal Injury

Bruce R. Ransom, University of Washington, USA

16:00—16:30
Coffee & Snacks Available

Chamisa Ballroom 2
18:00—19:00
Welcome Mixer

Chamisa Ballroom 1
19:00—21:00
Genomics
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* Christine M. Debouck, Ardennes Biosciences LLC, USA

* XinKang Wang, Bristol-Myers Squibb Company, USA

Pankaj Agarwal, GlaxoSmithKline Pharmaceuticals, USA
Mining the Human Genome Treasures – The Challenges for Academic and Pharmaceutical Research

Philippe Sanseau, GlaxoSmithKline, UK
Therapeutic Opportunities from the Human Genome

XinKang Wang, Bristol-Myers Squibb Company, USA
SSH-DD RT-PCR for Novel Target Discovery-Application for Stroke Research

Derk J. Bergsma, GlaxoSmithKline, USA
Gene Microarray Technology for Disease Target Discovery and Validation

21:00—21:30
Final Session: Perspectives on Progress in Stroke Research (Open Discussion for All Attendees)
Meeting has ended...abstracts no longer viewable online.

Chamisa Ballroom 2
* John M. Hallenbeck, National Institutes of Health, USA

* Chung Y. Hsu, Washington University School of Medicine, USA

* Giora Z. Feuerstein, Bristol-Myers Squibb Company, USA

21:30—22:30
Social Hour

21:30—00:00
Entertainment

Chamisa Ballroom 1

THURSDAY, MARCH 14

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 NS44767-01




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