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This meeting took place in 2002



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Mechanisms and Applications of Immune Tolerance (D1)


Organizer(s) Jeffrey A. Bluestone, Abul K. Abbas and Christopher C. Goodnow
April 3—9, 2002
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Dec 3, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 4, 2002

Sponsored by The Director's Sponsor Fund

Summary of Meeting:
The idea of reprogramming immune cells in a way that would eliminate pathogenic responses while preserving normal immune function is a concept that has tantalized immunologists for decades. Current immunotherapeutic drugs have met with a degree of clinical success, however, such therapies require lifelong usage and non-specifically suppress the entire immune system. Recent conceptual advances in our understanding of the mechanisms operative in the induction of tolerance and restoration of self-tolerance provide unprecedented insights into the development of new tolerogenic strategies. However, major challenges remain. What are the biochemical and molecular events that lead to tolerance? How do the central and peripheral mechanisms of tolerance interact? This meeting will bring together researchers to present recent breakthroughs in the study of the processes that regulate tolerance: clonal deletion; clonal inactivation; immune deviation and suppression. The topics will include: T and B cell receptor signaling; co-stimulation; accessory cell function; cell survival; and the intracellular signaling events that control immune tolerance. Finally, specific talks in immunotherapy of autoimmunity, transplantation, cancer and infectious disease will be included.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


WEDNESDAY, APRIL 3

16:00—19:00
Registration

Foyer
18:15—19:15
Welcome

Foyer
19:15—19:30
Orientation

Sunshine/Mt. Werner
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
Hugh O. McDevitt, Stanford University, USA
Tolerance and Autoimmunity


THURSDAY, APRIL 4

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Central T Cell Tolerance
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
Jonathan Sprent, Garvan Institute, Australia
Requirements for Negative Selection of Thymocytes

Bruno A. Kyewski, German Cancer Research Center, Germany
'Promiscuous' Gene Expression and Immunological Self Tolerance: An Intricate Interface

Kristin A. Hogquist, University of Minnesota, USA
The Thymocyte Response to Self Peptide Ligands

* Ronald N. Germain, NIAID, National Institutes of Health, USA
Molecular Mechanisms Underlying Ligand-Selective Signaling in Immature and Mature T Cells

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Storm Pk/Twilight/Rainbow
13:00—22:00
Poster Viewing

Storm Pk/Twilight/Rainbow
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
B Cell Tolerance - 1
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Loss of B Cell Tolerance in Systemic Autoimmunity

* Anthony L. DeFranco, University of California, San Francisco, USA
Autoimmunity and B Cell Tolerance Defects in Lyn-Deficient Mice

Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Genetic Manipulation of Tolerance

19:00—20:00
Welcome Mixer

Foyer
20:00—22:00
Poster Session 1: Central T Cell Tolerance/B Cell Tolerance - 1

Storm Pk/Twilight/Rainbow

FRIDAY, APRIL 5

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
B Cell Tolerance - 2
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
Jan S. Erikson, Wistar Institute, USA
Regulation of Autoreactive B Cells in Healthy and Autoimmune Mice

Timothy W. Behrens, Genentech, Inc., USA
Regulation of Receptor Editing and Allelic Exclusion in Immature B Cells

* Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

Ann Marshak-Rothstein, University of Massachusetts Medical School, USA
Short Talk: Activation of Autoreactive B Cells by BCR/TLR Dual Engagement

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Storm Pk/Twilight/Rainbow
13:00—22:00
Poster Viewing

Storm Pk/Twilight/Rainbow
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Anergy and Apoptosis in Peripheral T Cell Tolerance
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
* Abul K. Abbas, University of California, San Francisco, USA
Anergy and Apoptosis in Peripheral T Cell Tolerance

Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
BH3-Only Members of the Bcl-2 Family Are Critical Inducers of Apoptosis and Preclude Autoimmunity

Luk Van Parijs, Massachusetts Institute of Technology, USA
Short Talk: Regulation of Regulatory T Cell Development and Function by IL-2

19:00—20:00
Welcome Mixer

Foyer
20:00—22:00
Poster Session 2: B Cell Tolerance - 2/Anergy and Apoptosis in Peripheral T Cell Tolerance

Storm Pk/Twilight/Rainbow

SATURDAY, APRIL 6

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Immune Suppression
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
Jean François Bach, American Autoimmune Related Diseases Association, Inc., USA
CD4+ Regulatory Cells

* Jeffrey A. Bluestone, University of California, San Francisco, USA
Regulation of Autoimmunity in Ongoing Responses

Ethan M. Shevach, NIAID, National Institutes of Health, USA
Control of Autoimmunity by Regulatory T Cells88

Fred J. Ramsdell, Parker Institute for Cancer Immunotherapy, USA
Short Talk: A Novel Transcription Factor Involved in CD4+25+ T Cell Function

Yang-Xin Fu, utsouthwestern medical center, USA
Short Talk: The Regulation of T Cell Homeostasis and Autoimmunity by T Cell Derived LIGHT

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Storm Pk/Twilight/Rainbow
13:00—22:00
Poster Viewing

Storm Pk/Twilight/Rainbow
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
APCs and Peripheral Activation vs. Tolerance
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
Marc K. Jenkins, University of Minnesota Medical School, USA
Mechanisms of CD4 T Cell Tolerance Induced by Peptide Antigen in the Absence of Inflammation

Ralph M. Steinman, Rockefeller University, USA
Dendritic Cells and the Induction of Peripheral T Cell Tolerance

* Linda A. Sherman, The Scripps Research Institute, USA
Life, Death, and the Pursuit of Immortality by CD8 T Lymphocytes.

Gordon Freeman, Dana Farber Cancer Institute, USA
Short Talk: Blockade of PD-1 Ligands on Dendritic Cells and Tumors Enhances T Cell Activation and Cytokine Production

19:00—20:00
Welcome Mixer

Foyer
20:00—22:00
Poster Session 3: Immune Suppression/APCs and Peripheral Activation vs. Tolerance

Storm Pk/Twilight/Rainbow

SUNDAY, APRIL 7

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Signaling in Activation vs. Tolerance. Session Sponsored in part by SangStat
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
Arthur Weiss, University of California, San Francisco, USA
CD45 Turns T Cells On and Off

* Ed Palmer, University of Basel Hospital, Switzerland
T Cell Receptor Regulation of T Cell Biology

Daniel L. Mueller, University of Minnesota Medical School, USA
Transcriptional Regulation by B7 and CD28 Costimulatory Signals

Michael L. Dustin, University of Oxford, UK
The Immunological Synapse

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Storm Pk/Twilight/Rainbow
13:00—22:00
Poster Viewing

Storm Pk/Twilight/Rainbow
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Tolerance in Cancer and Transplantation
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
James P. Allison, University of Texas MD Anderson Cancer Center, USA
More is Less: New Insights into The Mechanisms of Negative Costimulation by CTLA-4 and its Manipulation in Tumor Immunotherapy

Hyam I. Levitsky, , USA
Tumor Specific CD4+ T Cell Tolerance- Concomitant Immunity Revisited.

* Laurence A. Turka, Massachusetts General Hospital, USA
Clonal Size Restriction and Tolerance

Kathryn J. Wood, University of Oxford, UK
Tolerance in Transplantation: Epitope Spreading and Immune Tolerance

19:00—20:00
Welcome Mixer

Foyer
20:00—22:00
Poster Session 4: Signaling in Activation vs. Tolerance/Tolerance in Cancer and Transplantation/Tolerance in Infectious Disease and Autoimmunity/Therapeutic Approaches

Storm Pk/Twilight/Rainbow

MONDAY, APRIL 8

07:00—08:00
Breakfast

3 Saddles/Sevens
08:00—11:00
Tolerance in Infectious Disease and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
* Stephen D. Miller, Northwestern University Medical School, USA
Mechanisms of Intrinsic and Induced Regulation of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis

Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Autoreactive CD4+ Cells, Bystander Suppression and Virus Infections

Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Critical Cytokines in the Generation and Function of T Regulatory Cells

Nora E. Sarvetnick, University of Nebraska Medical Center, USA
Regulation of Autoimmunity

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Therapeutic Approaches
Meeting has ended...abstracts no longer viewable online.

Sunshine/Mt. Werner
* C. Garrison Fathman, Stanford University, USA
Adoptive Cellular Gene Therapy

Kevan C. Herold, Yale University, USA
Preservation of Insulin Production in Type 1 Diabetes with a FcR Non-Binding Anti-CD3 mAb (hOKT3gamma1(Ala-Ala))

Terry B. Strom, Beth Israel Deaconess Medical Center, USA
Harnessing Apoptosis to Promote Transplantation Tolerance

19:00—20:00
Welcome Mixer

Foyer
20:00—23:00
Entertainment

Sunshine/Mt. Werner

TUESDAY, APRIL 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI51294-01




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