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This meeting took place in 2002



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Mitochondria and Pathogenesis (D2)


Organizer(s) John J. Lemasters and Anna-Liisa Nieminen
April 6—11, 2002
Copper Mountain Resort • Copper Mountain, Colorado USA
Abstract Deadline: Dec 6, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 6, 2002

Sponsored by MitoKor

Summary of Meeting:
Current research is showing involvement of mitochondria in a variety of pathological situations. Inherited mitochondrial diseases show a unique maternal inheritance characterized by partial penetrance and heteroplasmy among the tissues. Mitochondrial DNA mutations may accumulate with age due to inadequate repair and turnover. In several instances of necrotic cell death caused by hypoxia/ischemia or chemical toxicity, opening of high conductance permeability transition pores in the mitochondrial inner membrane has been shown to lead to mitochondrial depolarization, release of ions, uncoupling of oxidative phosphorylation, permeation of solutes and, ultimately, cell killing. Onset of this mitochondrial permeability transition also activates the machinery for apoptosis. Release of cytochrome c after onset of the mitochondrial permeability transition activates proteases and endonucleases of the apoptotic program. The anti-apoptotic gene, Bcl-2, encodes a protein that localizes to mitochondria and prevents onset of the mitochondrial permeability transition. Inherited and acquired defects of the mitochondrial genome are linked to impaired mitochondrial energy production, increased mitochondrial free radical generation and cell death in aging, neurodegenerative diseases and maternally inherited mitochondrial disorders. These examples illustrate how mitochondrial dysfunction underlies a wide spectrum of disease. Understanding of the basic mechanisms underlying mitochondrial dysfunction can lead to a better understanding of pathophysiologic processes and new strategies for prevention and treatment. The purpose of this conference is to bring together leading researchers studying mitochondrial dysfunction in many different disease settings to share ideas and recent research findings.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, APRIL 6

16:00—19:00
Registration

Kokopelli's
18:15—19:15
Welcome

Kokopelli's
19:15—19:30
Orientation

Bighorn B
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Bighorn B
Paolo Bernardi, University of Padova Medical School, Italy
Mitochondria and Cell Death: A Pore Man's View


SUNDAY, APRIL 7

07:00—08:00
Breakfast

Jack's
08:00—11:00
Mitochondrial DNA Turnover, Repair and Biogenesis
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Phillip Nagley, Monash University, Australia

Eric A. Shoubridge, McGill University, Canada
Nuclear Control of mtDNA Segregation

Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Mitochondrial DNA Repair

Walter Neupert, Universität Muenchen, Germany
Protein Import into Mitochondria

William Lewis, Emory University, USA
Mitochondrial Toxicity of Antiviral Agents

Carl A. Pinkert, Auburn University, USA
Short Talk: Development of Transmitochondrial Mice Using Mitochondrial Injection and ES Cell Cybrid Technologies

Keshav K. Singh, Johns Hopkins School of Medicine, USA
Short Talk: Genetics of DNA Repair in Yeast Mitochondria

09:20—09:40
Coffee Break

Kokopelli's
11:00—13:00
Poster Setup

Bighorn C
13:00—22:00
Poster Viewing

Bighorn C
16:30—17:00
Coffee & Snacks Available

Kokopelli's
17:00—19:00
Inherited and Acquired Mitochondrial Mutations
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Eric A. Shoubridge, McGill University, Canada

Neil Howell, Migenix, USA
Evolution and Divergence of the Human Mitochondrial Genome

Phillip Nagley, Monash University, Australia
Mitochondria in Aging, Cancer and Cell Death

William C. Copeland, NIEHS, National Institutes of Health, USA
Short Talk: DNA Mutations Produced by Mitochondrial DNA Replication

Siu Sylvia Lee, Cornell University, USA
Short Talk: A Critical Role for Mitochondria in C. elegans Lifespan Regulation

Justin Lee Mott, Mayo Clinic College of Medicine, USA
Short Talk: The Mitochondrial Permeability Transition Pore may Initiate Disease Caused by MtDNA Mutations

19:00—20:00
Welcome Mixer

Bighorn C/Kokopelli's
20:00—22:00
Poster Session 1: Mitochondrial DNA Turnover, Repair, Biogenesis and Mutations

Bighorn C

MONDAY, APRIL 8

07:00—08:00
Breakfast

Jack's
08:00—11:00
Oxidative Stress
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Donald A. Fox, University of Houston, USA

Enrique Cadenas, University of Southern California, USA
Oxyradical Production by Mitochondria: Regulation by Nitric Oxide

Simon Melov, Buck Institute for Research on Aging, USA
Mitochondrial Oxidative Stress and Neurodegeneration

Jose C. Fernandez-Checa, Instituto Investigaciones Biomedicas Barcelona, CSIC, Spain
Mitochondria, Glutathione and Cell Death

Sten Orrenius, Karolinska Institutet, Sweden
Role of Calcium and Oxidative Stress in Mitochondrial Regulation of Cell Death

Guy C. Brown, University of Cambridge, UK
Short Talk: The Role of Mitochondria in Nitric Oxide-Induced Cell Death

Giorgio Lenaz, University of Bologna, Italy
Short Talk: Factors Affecting Superoxide Radical Production by Complex 1 of the Mitochondrial Respiratory Chain

09:20—09:40
Coffee Break

Kokopelli's
11:00—13:00
Poster Setup

Bighorn C
13:00—22:00
Poster Viewing

Bighorn C
14:30—16:30
Workshop 1: Mechanisms of Mitochondria Membrane Permeabilization

Bighorn B
* Paolo Bernardi, University of Padova Medical School, Italy

Andrew P. Halestrap, University of Bristol, UK
Molecular Mechanisms and Pathophysiological Implications of the Permeability Transition Pore

Kathleen W. Kinnally, New York University College of Dentistry, USA
Characterization of the Mitochondrial Apoptosis-induced Channel, MAC.

Marco Colombini, University of Maryland, USA
Ceramide Channels in the Mitochondrial Outer Membrane are Conduits for Protein Flux

Paul H. Schlesinger, Washington University School of Medicine, USA
Mechanism of Pore Formation by Bcl-2 Family Proteins in Phospholipid Bilayer Membranes

Donald A. Fox, University of Houston, USA
Bcl-XL Overexpression Blocks Apoptosis and Contact Site Formation in Retinas of Lead-Exposed Mice

16:30—17:00
Coffee & Snacks Available

Kokopelli's
17:00—19:00
Imaging Mitochondrial Physiology and Pathophysiology in Living Cells
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* György Hajnóczky, Thomas Jefferson University, USA

Rosario Rizzuto, University of Padua, Italy
Mitochondrial Ca2+ Signalling: Molecular Determinants and Physiological Role

Francois Ichas, INSERM, European Institute of Chemistry and Biology, France
Regulation of the Permeability Transition Pore in situ

John J. Lemasters, Medical University of South Carolina, USA
Mitochondrial Inner Membrane Permeabilization in Cell Life and Death

Shana Katzman, Marine Biological Laboratory, USA
Short Talk: Monitoring Mitochondrial Membrane Potential Reveals a Distinguished Functional Architecture in Intact Langerhans Islets of Psammomys obesus: A Rodent Model for Type II Diabetes

19:00—20:00
Welcome Mixer

Bighorn C/Kokopelli's
20:00—22:00
Poster Session 2: Oxidative Stress and Pathophysiology

Bighorn C

TUESDAY, APRIL 9

07:00—08:00
Breakfast

Jack's
08:00—11:00
Mitochondrial Permeabilization in Apoptosis
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* John J. Lemasters, Medical University of South Carolina, USA

Stanley J. Korsmeyer, Harvard University, USA
The Mitochondrial Gateway to Apoptosis

Douglas R. Green, St. Jude Children's Research Hospital, USA
Cytochrome c Release during Apoptosis

Richard J. Youle, NINDS, National Institutes of Health, USA
Consequences of Bax Translocation to Mitochondria

Guido Kroemer, Cordeliers Research Center, France
Mechanisms of Mitochondrial Membrane Permeabilization during Apoptosis

Anne Chomyn, California Institute of Technology, USA
Short Talk: Early Decrease in Respiration, Independent of Cytochrome c Release, in Apoptotic 143B Osteosarcoma Cells

Anatoly A. Starkov, University of Maryland, USA
Short Talk: Bax-Mediated Cytochrome C Release From Brain Mitochondria Stimulates Production of Reactive Oxygen Species

09:20—09:40
Coffee Break

Kokopelli's
11:00—13:00
Poster Setup

Bighorn C
13:00—22:00
Poster Viewing

Bighorn C
16:30—17:00
Coffee & Snacks Available

Kokopelli's
17:00—19:00
Mitochondrial Regulation of Cell Signaling and Cytotoxicity
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* David G. Nicholls, Buck Institute for Research on Aging, USA

Pierre Maechler, University of Geneva Medical Center, Switzerland
Mitochondrial Signals in Metabolism Secretion Coupling in the Pancreatic Beta Cell

Anna-Liisa Nieminen, Case Western Reserve University, USA
Mitochondria in Apoptosis Induced by Photodynamic and Hypoxic Stress

Jan B. Hoek, Thomas Jefferson University, USA
Mitochondrial Dysfunction and Alcoholic Liver Damage

Frederic Bouillaud, Centre National de la Recherche Scientifique, France
Short Talk: Uncoupling Protein 2(UCP2): Translational Control of Expression, and Studies with Mitochondria of Ucp2 Knock-Out Mice

19:00—20:00
Welcome Mixer

Bighorn C/Kokopelli's
20:00—22:00
Poster Session 3: Mitochondria in Apoptosis, Neurodegeneration and Ischemia/Reperfusion

Bighorn C

WEDNESDAY, APRIL 10

07:00—08:00
Breakfast

Jack's
08:00—11:00
Mitochondria in Acute and Chronic Neurodegeneration
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Simon Melov, Buck Institute for Research on Aging, USA

David G. Nicholls, Buck Institute for Research on Aging, USA
Mitochondrial Control of Glutamate Excitotoxicity

M. Flint Beal, Weill Medical College of Cornell University, USA
Bioenergetics in Neurodegenerative Diseases

Eric A. Schon, Columbia University, USA
Mitochondrial Deficiencies and Mutations in Human Disease

Mohanish Deshmukh, University of North Carolina at Chapel Hill, USA
Development of Competence for Cytochrome c Mediated Apoptosis in Sympathetic Neurons

Alexander V. Panov, Emory University School of Medicine, USA
Short Talk: Early Mitochondrial Calcium Defects in Huntington's Disease Transgenic Mice

Zhenhai Yao, University of North Carolina at Chapel Hill, USA
Short Talk: Role of Mitochondria and Nitric Oxide in Signaling Opioid Preconditioning

09:20—09:40
Coffee Break

Kokopelli's
16:30—17:00
Coffee & Snacks Available

Kokopelli's
17:00—18:45
Ischemia/Reperfusion and Preconditioning
Meeting has ended...abstracts no longer viewable online.

Bighorn B
* Andrew P. Halestrap, University of Bristol, UK

Tadeusz W. Wieloch, Lund University, Sweden
Mitochondrial Involvement in Acute Neurodegeneration and Preconditioning

Eduardo Marban, Cedars-Sinai Medical Center, USA
Role of Mitochondria in Ischemic Preconditioning

György Hajnóczky, Thomas Jefferson University, USA
Mitochondrial Calcium Signaling and Cardiac Apoptosis

18:45—19:00
Closing Remarks
Meeting has ended...abstracts no longer viewable online.

Bighorn B
19:00—20:00
Welcome Mixer

Bighorn C/Kokopelli's
20:00—23:00
Entertainment

Bighorn C

THURSDAY, APRIL 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AA13453-01




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