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This meeting took place in 2002



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Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies (J4)


Organizer(s) Alan R. Saltiel and C. Ronald Kahn
January 10—16, 2002
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 1, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 12, 2001

Sponsored by Abbott Laboratories


Summary of Meeting:
Our understanding of the pathogenesis of diabetes mellitus is advancing at a rapid pace. New insights are emerging in the areas of insulin signaling, genetics, metabolic regulation, beta cell function and development, and interplay between organ systems. These developments are leading to new advances in the diagnosis of individuals at risk for diabetes, as well as in the treatment of the disease and its complications. The goal of this conference (in conjunction with the Molecular Control of Adipogenesis and Obesity symposium organized by Speigelman and Friedman) will be to identify the most exciting areas of research, look for common themes among scientists exploring basic approaches to hormone action and secretion, genetics and therapeutics. Areas of particular interest will include the identification and analyses of new phosphorylation cascades, negative regulation of signaling, genes and processes involved in beta cell development, complex interactions between tissues in the metabolic staging of diabetes, regulation of gene expression, especially using new technologies in functional genomics, and issues concerning the central regulation of energy expenditure and glucose metabolism. Most of these topics will interface with the proposed concurrent meeting on adipogenesis, so that we can share sessions, and explore the complex interactions between obesity and diabetes.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


THURSDAY, JANUARY 10

16:00—19:00
Registration

Shavano Peak Foyer
18:15—19:15
Welcome

Shavano Peak Foyer
19:15—19:30
Orientation

Crestone/Red Cloud
19:30—20:30
Keynote Address (Joint). Sponsored in part by OSI Pharmaceuticals, Inc.
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Jeffrey M. Friedman, Rockefeller University, USA

Robert G. Roeder, Rockefeller University, USA
Regulation of Transcription in Mammalian Cells: Complexities and Challenges

19:30—20:30
Keynote Address (Joint). Sponsored in part by OSI Pharmaceuticals, Inc.
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Jeffrey M. Friedman, Rockefeller University, USA

Robert G. Roeder, Rockefeller University, USA
Regulation of Transcription in Mammalian Cells: Complexities and Challenges


FRIDAY, JANUARY 11

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
Central vs. Peripheral Signals Regulating Appetite and Glucose Metabolism (Joint)
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Jeffrey M. Friedman, Rockefeller University, USA
Leptin

Hiroaki Masuzaki, Beth Israel Deaconess Medical Center, USA
Glucocorticoid Reactivation in Adipose Tissue and the Pathogenesis of Visceral Fat Obesity and Metabolic Syndrome

Roger D. Cone, University of Michigan, USA
Role of the Melanocortin System in Regulation of Acute Aspects of Energy Homeostasis

* Luciano Rossetti, Merck Research Laboratories, USA
A Tale of Fat and Sugar

09:20—09:40
Coffee Break

Shavano Peak Foyer/Lobby
11:00—13:00
Poster Setup

Grays Peak 1-3
13:00—22:30
Poster Viewing

Grays Peak 1-3
16:00—16:30
Coffee & Snacks Available

Shavano Peak Foyer/Lobby
16:30—18:30
Lipid Mediators and Protein Kinases in Hormone Action
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* David E. Moller†, Eli Lilly and Company, USA

Morris J. Birnbaum, Pfizer Inc., USA
Akt/PKB as a Critical Determinant of Cell Growth and Metabolism

Masato Kasuga, National Center for Global Health and Medicine, Japan
Downstream Effectors of PI3- Kinase

Michael P. Czech, University of Massachusetts Medical School, USA
Insulin Signaling to Molecular Motors

Emmanuel Van Obberghen, INSERM U145, France
Modulators of Insulin Action

16:30—18:30
Central Signaling II
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Jeffrey Flier, Harvard University, USA

Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA
The multiple roles of melanin-concentrating hormone in regulating energy balance.

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
CNS Pathways Underlying the Coordinated Responses to Metabolic Perturbations

George Kunos, NIAAA, National Institutes of Health, USA
Short Talk: Endocannabinoids and the Control of Food and Ethanol Intake

Jürgen Wess, National Institutes of Health, USA
Short Talk: Muscarinic Acetylcholine Receptors in Body Weight Control

Kendra K. Bence, Pfizer Inc., USA
Short Talk: Regulation of Leptin Signaling by PTP1B

20:30—22:30
Poster Session 1: Signal Transduction

Grays Peak 1-3
20:30—21:30
Social Hour

Grays Peak 1-3

SATURDAY, JANUARY 12

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
Early Signaling Events in Insulin Action. Sponsored in part by Novo Nordisk A/S.
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Pierre De Meyts, Hagedorn Research Institute, Novo Nordisk A/S, Denmark

Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
IRS-Proteins and the Common Path to Diabetes

Alan R. Saltiel, University of California, San Diego, USA
Spatial Compartments in Insulin Action

Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center, USA
Relationships Between Inflammation, IKKbeta, and Insulin Resistance in Type 2 Diabetes

Michael R. Jirousek, Catabasis Pharmaceuticals, Inc., USA
Recent Advances in PTP1B Inhibitor Design and as a Therapeutic Approach to Treat Type 2 Diabetes

08:00—11:00
Adipogenesis
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
M. Daniel Lane, Johns Hopkins University, USA
Role of the Cell Cycle in the Adipocyte Differentiation Program

Stephen R. Farmer, Boston University School of Medicine, USA
Transcriptional Control of Adipogenesis

Karsten Kristiansen, University of Copenhagen, Denmark
The Retinoblastoma Protein and Adipocyte Differentiation

Ormond A. MacDougald, University of Michigan, USA
Role of Wnt signaling in Adipocyte Biology

Jean Sébastien Saulnier-Blache, INSERM U317, France
Short Talk: Secretion of Lysophosphatidic Acid by Adipocytes: Metabolic Origin and Biological Consequences

09:20—09:40
Coffee Break

Shavano Peak Foyer/Lobby
11:00—13:00
Poster Setup

Grays Peak 1-3
13:00—22:30
Poster Viewing

Grays Peak 1-3
16:00—16:30
Coffee & Snacks Available

Shavano Peak Foyer/Lobby
16:30—18:30
Crosstalk Between Tissues in Metabolic Regulation (Joint). Sponsored in part by Affinity BioReagents, Inc.
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* E. Dale Abel, University of Iowa, Carver College of Medicine, USA

C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Dissecting Insulin Action and Gene Expression Using Knockout Mouse Models

Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Mitochondrial Dysfunction and Type 2 Diabetes

Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Acrp30 and Insulin Action

Se-Jin Lee, Johns Hopkins School of Medicine, USA
Regulation of Muscle Mass by Myostatin

20:30—22:30
Poster Session 2: Metabolism

Grays Peak 1-3
20:30—22:30
Social Hour

Grays Peak 1-3

SUNDAY, JANUARY 13

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
Adipose-Derived Regulators of Metabolism and Energy Expenditure (Joint)
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
Gökhan S. Hotamisligil, Harvard University, USA
Molecular Mechanisms of Insulin Resistance in Adipocytes

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Update on Resistin

* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Leptin Activates AMP-Activated Protein Kinase in Muscle Through Central and Peripheral Mechanisms: Implications for Fatty Acid Metabolism

Sven Enerbäck, University of Gothenburg, Sweden
FOXC2 is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia and Diet Induced Insulin Resistance

09:20—09:40
Coffee Break

Shavano Peak Foyer/Lobby
11:00—13:00
Poster Setup

Grays Peak 1-3
13:00—22:30
Poster Viewing

Grays Peak 1-3
16:00—16:30
Coffee & Snacks Available

Shavano Peak Foyer/Lobby
16:30—18:30
Vesicle Trafficking and Glucose Transport
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Paul F. Pilch, Boston University School of Medicine, USA

Jeffrey E. Pessin, Albert Einstein College of Medicine, USA
The Role of TC10 and Actin in the Insulin Regulation of GLUT4 Translocation

Silvia Corvera, University of Massachusetts Medical School, USA
Analysis of GLUT4 Trafficking by Ultrafast Microscopy

Amira Klip, Hospital for Sick Children, Canada
Regulation of GLUT4 Activity by Insulin in Muscle and Adipose Cells

Yannick Le Marchand-Brustel, INSERM, France
Role of Rab4 and its Effectors in Glut4 Traffic

16:30—18:30
Energy Expenditure and Thermogenesis
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Bradford B. Lowell, Beth Israel Deaconess Medical Center, USA

Daniel Ricquier, Centre National de la Recherche Scientifique, France
Uncoupling Proteins: Functional Roles

Jan Nedergaard, Stockholm University, Sweden
Adrenergic Thermogenesis

Leslie P. Kozak, Polish Academy of Sciences, Poland
UCP1-Independent Mechanisms of Thermogenesis and Body Weight Regulation

Sheila Collins, Vanderbilt University Medical Center, USA
Short Talk: Control of UCP1 Expression by PKA/p38 MAPK and PGC1

20:30—22:30
Poster Session 3: Gene Expression/Genetics

Grays Peak 1-3
20:30—22:30
Social Hour

Grays Peak 1-3

MONDAY, JANUARY 14

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
Regulation of Glycogen, Protein and Lipid Metabolism
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* André Marette†, Laval University Hospital Research Center, Canada

John C. Lawrence, University of Virginia Health System, USA
mTOR Signaling in Insulin Action

Christopher B. Newgard, Duke University Medical Center, USA
Spatial Organization and Regulation of Hepatic Glucose Metabolism

Takashi Kadowaki, University of Tokyo, Japan
The Role of Adiponectin in Insulin Action and Inaction

08:00—11:00
Lipodystrophy and Adipocyte Function
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Phillip Gorden, National Institutes of Health, USA

Constantine Londos, National Institutes of Health, USA
Perilipin: A Key Component of the Adipocyte Lipolytic Reaction

Jocelyne Magré, INSERM, France
Molecular Basis of Generalized and Partial Lipodystrophy

Marc L. Reitman, NIDDK, National Institutes of Health, USA
The Physiology of Lipoatrophic Mice: Role of Leptin, Liver PPARgamma, and Genetic Background

Karen Reue, University of California, Los Angeles, USA
Short Talk: The Role of Lipin in Adipogenesis and Lipodystrophy

Rudolf Zechner, University of Graz, Austria
Resistance to Diet Induced Obesity in Mice that Lack Lipoprotein Lipase in Adipose Tissue

09:20—09:40
Coffee Break

Shavano Peak Foyer/Lobby
11:00—13:00
Poster Setup

Grays Peak 1-3
13:00—22:30
Poster Viewing

Grays Peak 1-3
16:00—16:30
Coffee & Snacks Available

Shavano Peak Foyer/Lobby
16:30—18:30
Regulation of Gene Expression by Hormones and Nutrients (Joint)
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Barry Marc Forman, City of Hope, USA

Domenico Accili, Columbia University, USA
Metabolic Regulation by Forkhead Proteins

Bruce M. Spiegelman, Harvard Medical School, USA
Control of Energy Homeostasis and Glucose Metabolism Through a PGC-1, Regulated Transcriptional Coactivater

Bradford B. Lowell, Beth Israel Deaconess Medical Center, USA
UCP2 and UCP3: Regulators of Intracellular Energy Metabolism

20:30—22:30
Poster Session 4: B Cells/Glucose Transport

Grays Peak 1-3
20:30—22:30
Social Hour

Grays Peak 1-3

TUESDAY, JANUARY 15

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
Genetics of Diabetes and Obesity (Joint)
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Simeon Taylor, University of Maryland School of Medicine, USA

Philippe Froguel, Imperial College of London, UK
Genetics of Type 2 Diabetes and Obesity: Is There a Molecular Link?

Stephen O'Rahilly, University of Cambridge, UK
Monogenic Human Syndromes of Obesity and Diabetes

Alan D. Attie, University of Wisconsin-Madison, USA
Genetics and Genomics of Obesity and Diabetes in Mice

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
Insulin Regulation of C. elegans Metabolism and Lifespan

09:20—09:40
Coffee Break

Shavano Peak Foyer/Lobby
15:00—15:30
Coffee & Snacks Available

Shavano Peak Foyer/Lobby
15:30—17:30
Beta Cell Signaling and Development. Session Sponsored by the Juvenile Diabetes Research Foundation.
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Rohit N. Kulkarni†, Joslin Diabetes Center, Harvard Medical School, USA

Per-Olof Berggren, Karolinska Institutet, Sweden
Voltage-gated L-type Ca2+ Channels in Beta Cell Physiology and Pathophysiology

Frans C. Schuit, Katholieke Universiteit Leuven, Belgium
Glucose-Induced Gene Expression in Pancreatic Beta-Cells

Markus Stoffel, ETH Zürich, Switzerland
Gene Expression in Beta-Cell Development

15:30—17:30
Therapy of Obesity
Meeting has ended...abstracts no longer viewable online.

Crestone/Red Cloud
* Phillip Gorden, National Institutes of Health, USA

Steven B. Heymsfield, Merck and Co., Inc., USA
Therapies for Obesity

Salih J. Wakil, Baylor College of Medicine, USA
ACC as a Target for Anti-Obesity Therapy

George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA
CNTF/Axokine Causes Weight Loss via Leptin-Like Pathway in Mice and Man

Elif Arioglu, National Institutes of Health, USA
Short Talk: Leptin Replacement in Treatment of Lipodystrophy

Jian Luo, Amgen Inc., USA
Short Talk: Oral Melanocortin 4 Receptor Agonist for the Treatment of Obesity and Type 2 Diabetes

19:00—20:00
Social Hour

Longs Peak Foyer
20:00—22:00
Banquet

Longs/Quandary
21:00—00:00
Entertainment

Longs/Quandary

WEDNESDAY, JANUARY 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK61572-01




We gratefully acknowledge additional support for this conference from:

Abbott Laboratories

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