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This meeting took place in 2002



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HIV Pathogenesis: Recent Advances in the Biology and Pathogenesis of Primate Lentiviruses (X7)


Organizer(s) Mario Stevenson, Bryan R. Cullen, Beatrice H. Hahn and Ronald C. Desrosiers
April 5—11, 2002
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Dec 13, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 5, 2002


Summary of Meeting:
Steady advances are being made in understanding the functions of viral regulatory genes in virus replication and pathogenecity. However, there has been relatively little advance in attempting to exploit such regulatory proteins as antiviral targets. One goal of the meting would be to stimulate discussion on what regulatory protein functions could be exploited for antiviral strategies. Several emerging studies suggest that HIV-1 replication may persist in the host despite suppression of virus replication to below detectable limits by current plasma-based viral RNA assays. Thus, highly active antiretroviral therapy in its current form appears to be incapable of eradicating these reservoirs. The task ahead is to identify the nature of the persistent reservoir and to develop alternate strategies to more effectively control virus replication. In an attempt to establish the underlying basis for lymphocyte depletion in HIV-1 infection, investigators are taking various approaches to evaluate various aspects of the hematopoietic function, lymphocyte maturation, lymphocyte turnover and compartmentalization. These approaches are providing a more complete understanding of how primate lentiviruses affect lymphocyte depletion. In addition, these studies are providing important information on the processes that regulate hematopoiesis and lymphocyte function in humans. This information is critical to immune-based strategies to restore immune function in immunocompromised HIV-1 infected individuals. We believe that the meeting format will provide a unique opportunity for scientists with interests in AIDS immunology, virology and pathogenesis to be appraised of and to discuss the most exciting research developments and major problems in AIDS research. Such a forum does not exist outside of the National AIDS and Human Retrovirus meeting, however, the small size of the Keystone Symposium allows the intimacy in which scientific ideas can be exchanged and such an intimacy is not provided by the National AIDS meeting.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, APRIL 5

16:00—19:00
Registration

Shavano Foyer
18:15—19:15
Welcome

Shavano Foyer
19:15—19:30
Orientation

Shavano/Torreys
19:30—21:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Rafi Ahmed, Emory University School of Medicine, USA
Vaccines and Immune Memory

Joseph G. Sodroski, Dana-Farber Cancer Institute, USA
Structure and Function of the HIV-1 Envelope Glycoproteins and Receptors


SATURDAY, APRIL 6

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
HIV Life Cycle
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Bryan R. Cullen, Duke University Medical Center, USA
Role and Mechanism of Action of Tat and Rev

* David Kabat, Oregon Health & Science University, USA
Innate Resistance of Human Lymphocytes to HIV-1 is Overcome by Vif

Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland
HIV and Chromatin Remodeling Factors

Mark A. Goldsmith, REVOLUTION Medicines, USA
Determinants of Cellular Infection and Depletion by HIV-1

Roger J. Pomerantz, Seres Therapeutics, Inc., USA
Short Talk: Residual HIV-1 Disease Eradication (RHIDE) Using Stimulatory and Novel Intensification Therapy: Dissecting Residual Disease Pathogenesis

08:00—11:00
Current Strategies in Clinical Vaccine Trials
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
Induction of HIV-Specific Immunity in HIV-1 Vaccine Trials (HVTN)

Emilio A. Emini, Bill and Melinda Gates Foundation, USA
A Potential HIV Vaccine that Elicits Specific and Effective Cellular Immune Responses

Andrew J. McMichael, Oxford University, UK
DNA and MVA Phase I Trials

Barney S. Graham, NIAID, National Institutes of Health, USA
Phase I Clinical Trials

09:20—09:40
Coffee Break

Shavano Foyer/Lobby
11:00—13:00
Poster Setup

Grays Peak
13:00—22:00
Poster Viewing

Grays Peak
16:30—17:00
Coffee & Snacks Available

Shavano Foyer/Lobby
17:00—19:00
Preclinical Vaccine Trials: Promising Leads
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* David I. Watkins, University of Miami, USA
T Cell Responses Against SIV

Norman L. Letvin, Beth Israel Deaconess Medical Center, USA
Correlates of Immunity in the Macaque Model

Jay A. Berzofsky, NCI, NIH, USA
The Importance of Mucosal Immunity in Controlling SHIV Infection and Strategies to Enhance Vaccines

Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Early Transient Antiretroviral Treatment of SIV Infection

17:00—19:00
Enzymes
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Daria J. Hazuda, Merck Research Laboratories, USA
Inhibitors of HIV-1 Integrase

Stuart F.J. Le Grice, NCI, National Institutes of Health, USA
Programmed Initiation of DNA Synthesis in Lentiviruses

Frederic D. Bushman, University of Pennsylvania, USA
Host Factors Affecting the Early Steps of HIV Replication

19:00—20:00
Welcome Mixer

Grays Peak
20:00—22:00
Poster Session 1

Grays Peak

SUNDAY, APRIL 7

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
Virus - Host Interactions (Joint)
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Dan R. Littman, HHMI/New York University School of Medicine, USA
HIV Entry: Animal Models and Strategies for Vaccine Development

* John P. Moore, Weill Medical College of Cornell University, USA
Studies on Disulfide-Stabilized HIV-1 Envelope Glycoproteins

Robert W. Doms, University of Pennsylvania School of Medicine, USA
Virus Attachment, Receptor Engagement and Membrane Fusion

James A. Hoxie, University of Pennsylvania, USA
New Insights into gp120-Chemokine Receptor Interactions from CD4-Independent Isolates of HIV-1 and HIV-2

09:20—09:40
Coffee Break

Shavano Foyer/Lobby
11:00—13:00
Poster Setup

Grays Peak
13:00—22:00
Poster Viewing

Grays Peak
16:30—17:00
Coffee & Snacks Available

Shavano Foyer/Lobby
17:00—19:00
HIV Structure (Joint)
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
B. Matija Peterlin, University of California, San Francisco, USA
From Tat to Nef: Fine Tuning HIV Replication and Infectivity

* Wesley I. Sundquist, University of Utah School of Medicine, USA
Biochemical and Structural Studies of HIV Budding

Richard T. Wyatt, IAVI Neutralizing Antibody Center at The Scripps Research Institute, USA
Analysis of HIV-1 Envelope Glycoproteins for Immunogen Design to Elicit Broadly Neutralizing Antibodies

19:00—20:00
Welcome Mixer

Grays Peak
20:00—22:00
Poster Session 2

Grays Peak

MONDAY, APRIL 8

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
Viral Pathogenesis (Joint)
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
Latency and Viral Evolution in HIV-1 Infection

* Ashley T. Haase, University of Minnesota, USA
Mechanisms, Sites and Sources of Persistent Infection

James I. Mullins, University of Washington, USA
Genetic Evolution in Forward and Reverse

Douglas D. Richman, University of California, San Diego, USA
Rapid Evolution of Neutralizing Antibody Response following Primary HIV Infection

09:20—09:40
Coffee Break

Shavano Foyer/Lobby
11:00—13:00
Poster Setup

Grays Peak
13:00—22:00
Poster Viewing

Grays Peak
16:30—17:00
Coffee & Snacks Available

Shavano Foyer/Lobby
17:00—19:00
Immune Reconstitution and Therapeutic Vaccination (Joint)
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Harnessing the Immune System in the Fight Against AIDS

Joseph Michael McCune, University of California, San Francisco, USA
Regulation of T Lymphopoiesis in HIV Disease

Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC, France
Restoration of HIV-Specific Immunity with Immune-Based Therapeutic Strategies

19:00—20:00
Welcome Mixer

Grays Peak
20:00—22:00
Poster Session 3

Grays Peak

TUESDAY, APRIL 9

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
Accessory Functions
Meeting has ended...abstracts no longer viewable online.

Red Cloud
* Warner Craig Greene, Gladstone Institute of Virology and Immunology, USA
HIV Infection Results in G2 Cell Cycle Arrest in vivo

Mario Stevenson, University of Miami, Leonard M. Miller School of Medicine, USA
Mimicry of CD40 by HIV-1 Nef

Nathaniel R. Landau, New York University School of Medicine, USA
Blocks to HIV Replication in Non-Human Cells

Jon W. Marsh, National Institutes of Health, USA
Nef Actvity in T Cells

Andreas Stephan Baur, , Germany
Short Talk: The HIV NEF N-Terminus Activates LCK Involving A PcG-Complex Protein

Jacek Skowronski, Case Western University, USA
Short Talk: Host Factors that Mediate Nef Function.

08:00—11:00
Optimizing Antigenic Presentation and Effector Responses
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Nina Bhardwaj, Icahn School of Medicine at Mt Sinai, USA
Dendritic Cells: Antigen Presenting Functions and Applications to Vaccines

James P. Allison, University of Texas MD Anderson Cancer Center, USA
More is Less: New Insights into the Mechanisms of Negative Costimulation by CTLA-4 and its Manipulation in the Enhancement of T Cell Responses

Thomas Spies, Fred Hutchinson Cancer Research Center, USA
T Cell Costimulation by NKG2D

09:20—09:40
Coffee Break

Shavano Foyer/Lobby
11:00—13:00
Poster Setup

Grays Peak
13:00—22:00
Poster Viewing

Grays Peak
14:30—16:30
Workshop 1: Vaccine Innovation and New Investigators

Shavano/Torreys
* Mark B. Feinberg, IAVI International AIDS Vaccine Initiative, USA

* Deborah L. Birx, Centers for Disease Control and Prevention, USA

Jason E. Hammonds, Emory University, USA
Enhanced Stability of Primary Isolate gp120 on Pseudovirions

Erica Ollmann Saphire, The Scripps Research Institute, USA
Crystal Structures of a Broadly Neutralizing Antibody: Two Templates for HIV-1 Vaccine Design

John R. Mascola, NIAID, National Institutes of Health, USA
Evaluating the Neutralizing Antibody Response Elicited by DNA and Recombinant Adenoviral Vaccines

Francisco Veas, Institut de Recherche pour le Development, France
Serial Analysis Genome Expression Method to Study Transcriptomes from Primary Human T Cells Activated by HIV Envelope or Chemokines

Michael E. Horn, ProdiGene, USA
Expression of an SIV Protein in Transgenic Maize for Use as an Edible Vaccine and Reagent Supply

Luzheng Liu, Brigham and Women's Hospital, USA
Antigen Presentation by Dendritic Cells Following MVA Vaccination

Phillip W. Berman, University of California, Santa Cruz, USA
Update on Phase III Vaccine Trials in the US and Thailand

16:30—17:00
Coffee & Snacks Available

Shavano Foyer/Lobby
17:00—19:00
New Vaccine Strategies
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Gary J. Nabel, Sanofi, USA
Progress in the Development of Improved AIDS Vaccines

David D. Ho, Aaron Diamond AIDS Research Center, USA
Clade C Vaccine Approaches

Philip R. Johnson, Children's Hospital of Philadelphia, USA
AAV Vectors as HIV Vaccines

Marta L. Marthas, California National Primate Research Center, USA
Vaccination of Infant Macaques Against Oral Challenge with Pathogenic SIVmac251

17:00—19:00
HIV Life Cycle
Meeting has ended...abstracts no longer viewable online.

Red Cloud
Michael H. Malim, King's College London, UK
Modulation of HIV-1 Infection Through VIF-Host Cell Interactions

C. Martin Stoltzfus, University of Iowa, USA
Repression of HIV-1 RNA Splicing by Exonic Splicing Silencers

Heinrich Göttlinger, Dana Farber Cancer Institute, USA
Host Factors in HIV-1 Particle Release

Paul D. Bieniasz, Aaron Diamond AIDS Research Center, USA
Short Talk: Recruitment of Tsg101 to Sites of Particle Assembly, Mediated by Short Peptide Motifs, is Required for Efficient HIV-1 and Ebola Virus Particle Budding

19:00—20:00
Welcome Mixer

Grays Peak
20:00—22:00
Poster Session 4

Grays Peak

WEDNESDAY, APRIL 10

07:00—08:00
Breakfast

Longs/Quandary
08:00—11:00
Special Topics/Late Breaker
Meeting has ended...abstracts no longer viewable online.

Red Cloud
David Camerini, University of California, Irvine, USA
HIV-1 Mediated Signal Transduction via CCR5 Allows Infection of Resting Memory T Cells

Jean-Marc Jacque, University of Massachusetts Medical School, USA
Modulating the HIV-1 Replication Cycle through RNAi

Melissa J. Robbiani (Pope), Population Council, USA
Nef-Expressing Immature Dendritic Cells Secrete Inflammatory Cytokines and Chemokines, Activate Autologous CD4+ T Cells, and Rescue SIV Delta Nef Replication

Michael P. Sherman, J. David Gladstone Institutes, USA
HIV-1 Vpr Nuclear Export is Required for Efficient Macrophage Infection in Lymphoid Tissue

Christopher Aiken, Vanderbilt University School of Medicine, USA
Role of Virion Capsid Stability in HIV-1 Infection

Olivier Schwartz, Institut Pasteur, France
HIV-1 Nef-Induced Up-Regulation of DC-SIGN in Dendritic Cells Promotes Lymphocyte Clustering and Viral Spread

Laura A. Napolitano, Gladstone Institute of Virology and Immunology, USA
Increased Thymic Mass and Circulating Naive CD4+ T Cell Counts in HIV-1-Infected Adults Treated with Growth Hormone

Juan Lama, RetroVirox Inc., USA
Cell-Surface CD4 Modulates HIV Infectivity in T-Cells

Ann-Marie M. Roy, University of California, San Francisco, USA
Impact of Co-Receptor Use on HIV-1 "Burst Size" in Dispersed Human Lymphoid Tissue

David McDonald, National Institute of Allergy and Infectious Disease, USA
HIV Trafficking in Dendritic Cells

08:00—11:00
Late Breaking Topics
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
* Richard A. Koup, NIAID, National Institutes of Health, USA
HIV and T Cell Help

Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
Short Talk: Indetification of Different Binding Sites in DC-SIGN for ICAM-3 AND HIV-1

Marcus Altfeld, Heinrich-Pette-Institute, Germany
Short Talk: Enhancement of HIV-1-Specific CD8+ T Cell Responses During STI is Largely Due to the Expansion of CD8+ T Cell Responses Pre-Existing in Lymphoid Tissue

Daniel C. Douek, NIAID, National Institutes of Health, USA
Short Talk: A Novel Approach to the Analysis of Specificity, Clonality and Frequency of HIV-Specific T Cell Responses Reveals a Mechanism for Control of Viral Escape

Jianhong Cao, Fred Hutchinson Cancer Research Center, USA
Short Talk: Escape of HIV-1 Tat Specific CTL Response During Acute Infection

Michael Egan, Profectus Biosciences, USA
Short Talk: Immunogenicity and Protective Capacity of VSV-Based Vaccine Vectors Expressing Hiv-1 env and Siv gag in Rhesus Macaques

Rama Rao Amara, Emory University, USA
Short Talk: MVA Compared to a DNA/MVA-Vaccine; Slower but Similar Long-Term Control of a SHIV 89.6P Challenge

Todd M. Allen, Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Acute Phase CTL Escape in SIV and HIV

Bartek T. Zuber, Swedish Orphan Biovitrum, SOBI, Sweden
Short Talk: CCR5 Gene Immunization Lowers Viral Setpoint and May Select for SIV that Uses CCR5 More Efficiently

Douglas F. Nixon, George Washington University, USA
Short Talk: Competitive Selection Pressures From Drug and Immune Responses on HIV RT and Protease Genes

09:20—09:40
Coffee Break

Shavano Foyer/Lobby
16:30—17:00
Coffee & Snacks Available

Shavano Foyer/Lobby
17:00—19:00
Viral Evolution (Joint)
Meeting has ended...abstracts no longer viewable online.

Shavano/Torreys
Martine Peeters, University of Montpellier, France
Ongoing Exposure of Humans to an Extraordinary Variety of Simian Immunodeficiency Viruses in West Central Africa: Identification of New SIV Lineages

* Beatrice H. Hahn, University of Pennsylvania, USA
SIVcpz Infection in Wild Chimpanzees

Bette Tina Marie Korber, Los Alamos National Laboratory, USA
Factors that Drive the Diversity of the HIV-1 Epidemic.

19:00—20:00
Welcome Mixer

Longs/Quandary
20:00—23:00
Entertainment

Longs/Quandary

THURSDAY, APRIL 11

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI50957-01




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