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This meeting took place in 2002



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Biological Response to the Extracellular Matrix (Z1)


Organizer(s) David A. Cheresh and Donald E. Ingber
February 8—13, 2002
Banff Centre • Banff, Alberta Canada
Abstract Deadline: Oct 8, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 7, 2001


Summary of Meeting:
The extracellular matrix (ECM) consists of structural and adhesive proteins that, together with growth factors, convey biochemical and mechanical information to cells. This meeting will bring together many of the leading cell biologists and biochemists to discuss the role of the ECM in regulating the fate and biological response of cells to their environment. This meeting will be held jointly with the Angiogenesis meeting chaired by Rakesh Jain, Peter Carmeliet and James Pluda. Therefore, the conference on ‘Biological Response to the Extracellular Matrix’ will focus on the response of vascular cells to the ECM. While the focus may involve vascular cells, it is clear that many of the ‘take home’ messages will apply to cells and tissues in a general way. The opening session includes three keynote speakers of world renown status who will discuss how intracellular pathways and extracellular events regulate complex mechanisms of cellular and tissue behavior. The general sessions will focus on the many roles the ECM plays in tissue remodeling associated with development, and cell invasion during tissue repair. There have been very exciting new developments in the area of cell signaling responsiveness to the ECM. This meeting will feature leaders in this emerging field and will represent one of four joint sessions. Other joint session topics include the role of the endothelial cell microenvironment in angiogenesis and the structural factors in cell and vessel regulation. Finally, the meeting will conclude with a session on therapeutic implications. This is important as several new drugs that target cell matrix interactions have been approved or are being clinically tested for specific disease indications. This program should attract a broad audience including basic and clinical scientists from academia to scientists within the commercial sector. It is clear that the fields of Angiogenesis and ECM biology have been naturally moving toward one another over the past several years. This joint meeting represents the first opportunity to enable vascular biologists and experts in the ECM to have a formal interchange of ideas. It is anticipated that both groups will greatly benefit from this interaction which may well lead to new insights in the mechanisms of angiogenesis and conceptual approaches to new therapeutic strategies for disease.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, FEBRUARY 8

16:00—19:00
Registration

Eric Harvey Foyer
18:15—19:15
Welcome

Eric Harvey Foyer
19:15—19:30
Orientation

Eric Harvey Theatre
19:30—22:00
Keynote Session (Joint). Sponsored in part by OSI Pharmaceuticals, Inc.
Meeting has ended...abstracts no longer viewable online.

Eric Harvey Theatre
* David A. Cheresh, University of California, San Diego, USA

* Rakesh K. Jain, Massachusetts General Hospital and Harvard Medical School, USA

Bjorn Reino Olsen, Harvard Medical School, USA
Molecular Mechanisms of Endostatin: Lessons from Collagen XVIII Knock-Out Mice

M. Amin Arnaout, Massachusetts General Hospital, USA
Crystal Structure of Heterodimeric Integrin aVb3.

M. Judah Folkman, Children's Hospital Boston, USA
Anti-Angiogenic Therapy of Cancer: Lessons from the Clinical Trials


SATURDAY, FEBRUARY 9

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
The Matrix in Development
Meeting has ended...abstracts no longer viewable online.

Margaret Greenham Hall
* Elaine V. Fuchs, HHMI/Rockefeller University, USA
Beauty is Skin Deep: Differentiation and Development in the Skin

Robert Benezra, Memorial Sloan-Kettering Cancer Center, USA
The Id Proteins are Required for Tumor Angiogenesis

Mina J. Bissell, Lawrence Berkeley National Laboratory, USA
The Structural Basis of Tissue-Specific Signaling in Normal and Malignant Breast

08:00—11:00
Endothelial Stem Cells and Vascular Development
Meeting has ended...abstracts no longer viewable online.

Eric Harvey Theatre
* Shahin Rafii, Weill Cornell Medical College, USA
Co-Recruitment of Marrow-Derived VEGFR1 (+)Hematopoietic and VEGFR2+ Vasculogenic Progenitors Cells by Angiogenic Factors is Essential for Angiogenesis.

Jun Yamashita, Kyoto University Graduate School of Medicine, Japan
Vascular Progenitor Cells Common to Endothelial and Mural Cells

Patrick H. Maxwell, Rayne Institute, UK
Cellular Oxygen Sensing - A Key Regulator of Angiogenesis

Sarah J. Childs, University of Calgary, Canada
Short Talk: Patterning Angiogenesis in the Zebrafish Embryo

09:20—09:40
Coffee Break

Eric Harvey Foyer
11:00—13:00
Poster Setup

Laslow Funtek 222-224
13:00—22:00
Poster Viewing

Laslow Funtek 222-224
16:30—17:00
Coffee & Snacks Available

Eric Harvey Foyer
17:00—19:00
Matrix Structure and Assembly
Meeting has ended...abstracts no longer viewable online.

Margaret Greenham Hall
* Peter D. Yurchenco, UMDNJ RW Johnson Medical School, USA
Matrix Assembly, Regulatory and Survival Functions of Laminin and its Receptors in Embryonic Stem Cell Differentiation

Harold P. Erickson, Duke University Medical Center, USA
Stretching Fibronectin Matrix Fibrils and Single Molecules

Bianca Tomasini-Johansson, University of Wisconsin-Madison, USA
Cellular Control of Fibronectin Assembly

17:00—19:00
Endothelial Specification: Arteries, Veins, Lymphatics
Meeting has ended...abstracts no longer viewable online.

Eric Harvey Theatre
Jan K. Kitajewski, Columbia University, USA
Notch Function in Vascular Specification

* Harold F. Dvorak, Beth Israel Deaconess Medical Center, USA
Structure and Function of Cytokine Induced Vessels: Tumor Vessel Surrogates?

Rüdiger Klein, Max Planck Institute of Neurobiology, Germany
Requirements for Bi-Directional Eph/Ephrin Signaling in vivo

19:00—20:00
Welcome Mixer

Laslow Funtek 222-224
20:00—22:00
Poster Session 1: The Matrix in Development, Tissue Remodeling and Disease

Laslow Funtek 222-224

SUNDAY, FEBRUARY 10

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
Biological Consequences of Matrix Turnover
Meeting has ended...abstracts no longer viewable online.

Margaret Greenham Hall
Vito Quaranta, Vanderbilt University School of Medicine, USA
Laminin Processing by MMPs in Tumor Invasion Across Basement Membranes

Marsha A. Moses, Children's Hospital, USA
Matrix Metalloproteinases: Positive and Negative Regulators of Angiogenesis and Tumor Progression

Nathalie Ortega, University of California, San Francisco, USA
Biological Response to ECM Degradation: Insights from Endochondral Ossification and MMPs

* Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Regulation of Angiogenesis by Vascular Basement Membrane

08:00—11:00
Angiogenesis and Neurogenesis
Meeting has ended...abstracts no longer viewable online.

Eric Harvey Theatre
Elizabeth Lindsay Illingsworth Baldini, Texas A&M Health Science Center, USA
Genetic Dissection of the Vascular Defects in DiGeorge Syndrome

* Peter F. Carmeliet, University of Leuven, VIB, Belgium
The VEGF Family: Angiogenesis and Beyond

Kari K. Alitalo, University of Helsinki, Finland
Lymphangiogenesis in Development and Diseases

Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Function of VEGF-C in Angiogenesis, Organogenesis and Neurogenesis

09:20—09:40
Coffee Break

Eric Harvey Foyer
11:00—13:00
Poster Setup

Laslow Funtek 222-224
13:00—22:00
Poster Viewing

Laslow Funtek 222-224
16:30—17:00
Coffee & Snacks Available

Eric Harvey Foyer
17:00—19:00
Angiogenesis and Endothelial Microenvironment (Joint). Session Sponsored by Cell Genesys, Inc.
Meeting has ended...abstracts no longer viewable online.

Eric Harvey Theatre
* David A. Cheresh, University of California, San Diego, USA
Differential Raf-ERK Activation by Distinct Integrin/Growth Factor Receptor Pairs During Two Pathways of Angiogenesis: Therapeutic Implications

Rakesh K. Jain, Massachusetts General Hospital and Harvard Medical School, USA
Functional Heterogeneity in Blood and Lymphatic Vessels in Tumors: Insight from Intravital Microscopy

Erkki Ruoslahti, Sanford-Burnham Medical Research Institute, USA
Targeting the Endothelium

19:00—20:00
Welcome Mixer

Laslow Funtek 222-224
20:00—22:00
Poster Session 2: Matrix Structure, Turnover, and Function

Laslow Funtek 222-224

MONDAY, FEBRUARY 11

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
Matrix/Growth Factor Dependent Signaling (Joint)
Meeting has ended...abstracts no longer viewable online.

Eric Harvey Theatre
* Martin Schwartz, Yale School of Medicine, USA
Integrins and Rho Family GTPases in Mechanotransduction

Anne J. Ridley, King's College London, UK
Rho GTPase Signaling in Endothelial Cells

Richard K. Assoian, University of Pennsylvania School of Medicine, USA
Defining the Requirement for Stress Fibers During G1 Phase Cell Cycle Progression

Tony Hunter, The Salk Institute for Biological Studies, USA
Signaling by Tyrosine Phosphorylation

09:20—09:40
Coffee Break

Eric Harvey Foyer
11:00—13:00
Poster Setup

Laslow Funtek 222-224
13:00—22:00
Poster Viewing

Laslow Funtek 222-224
16:30—17:00
Coffee & Snacks Available

Eric Harvey Foyer
17:00—19:00
Mechanical and Cytoskeletal Responses
Meeting has ended...abstracts no longer viewable online.

Margaret Greenham Hall
* Keith W.T. Burridge, University of North Carolina at Chapel Hill, USA
Signaling from Adhesion to Rho Family GTPases

Paul A. Janmey, University of Pennsylvania, USA
The Cytoskeleton and Signal Transduction

Christopher S. Chen, Boston University, USA
Short Talk: New Microengineered Microenvironments to Study Cell Adhesion and Mechanics

Peter F. Davies, University of Pennsylvania, USA
Title to be Determined

17:00—19:00
Tumor and Pathological Angiogenesis. Session Sponsored by Enzon, Inc.
Meeting has ended...abstracts no longer viewable online.

Eric Harvey Theatre
Napoleone Ferrara, University of California, San Diego, USA
New Insights into the Regulation of Angiogenesis by VEGF

Richard O. Hynes, Massachusetts Institute of Technology, USA
Alpha-v Integrins as Negative Regulators of Angiogenesis

* Robert S. Kerbel, Sunnybrook Research Institute, Canada
Metronomic Antiangiogenic Chemotherapy: Genetic and Epigenetic Mechanisms Governing Longterm Response and Resistance

Dwayne G. Stupack, The Scripps Research Institute, USA
Short Talk: Intergrin-Mediated Death: Establishing a New Role for alphanu Intergrins in Angiogenesis

19:00—20:00
Welcome Mixer

Laslow Funtek 222-224
20:00—22:00
Poster Session 3: Matrix-Dependent Cell Signaling and Cell Function/Matrix-Dependent Cell Structure and Cell Function

Laslow Funtek 222-224

TUESDAY, FEBRUARY 12

07:00—08:00
Breakfast

Donald Cameron Hall
08:00—11:00
Structural Factors in Cell and Vessel Regulation (Joint)
Meeting has ended...abstracts no longer viewable online.

Eric Harvey Theatre
* Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Mechanochemical Signaling and Control of Angiogenesis

Donald M. McDonald, University of California, San Francisco, USA
Structural Heterogeneity of Angiogenic Blood Vessels

Michael P. Sheetz, Mechanobiology Institute, National University of Singapore, Singapore
Force-Dependent Signals in Cell Motility

Elisabetta Dejana, Uppsala University, Sweden
Role of Adherence Junctions in Endothelial Cell Proliferation and Angiogenesis

09:20—09:40
Coffee Break

Eric Harvey Foyer
16:30—17:00
Coffee & Snacks Available

Eric Harvey Foyer
17:00—19:00
Disruption of ECM Interactions: Therapeutic Implications
Meeting has ended...abstracts no longer viewable online.

Margaret Greenham Hall
* Judith A. Varner, University of California, San Diego, USA
Role of Fibronectin and its Receptors in Angiogenesis

Peter C. Brooks, New York University School of Medicine, USA
Cryptic ECM Elements and the Regulation of Angiogenesis and Tumor Invasion

Mark D. Bednarski, Targesome, Inc., USA
Integrin Targeted Nanoparticles for Imaging and Therapeutics

17:00—19:00
Therapeutic Angiogenesis/Inhibition. Session Sponsored by the Juvenile Diabetes Research Foundation.
Meeting has ended...abstracts no longer viewable online.

Eric Harvey Theatre
Katherine W. Ferrara, University of California, Davis, USA
Imaging of Angiogenesis

Michael Simons, Yale University, USA
FGF Therapeutic Angiogenesis

* James M. Pluda, MedImmune, Inc., USA
Lessons from Anti-Angiogenesis Clinical Trials

20:00—21:00
Welcome Mixer

Donald Cameron Hall
20:00—23:00
Entertainment

Donald Cameron Hall

WEDNESDAY, FEBRUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA94245-01




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