Beaver Run Resort Floorplan

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This meeting took place in 2002



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Microbial - Epithelial - Lymphocyte Interactions in Mucosal Immunity (F1)


Organizer(s) Martin F. Kagnoff and Richard S. Blumberg
April 5—10, 2002
Beaver Run Resort • Breckenridge, Colorado USA
Abstract Deadline: Dec 13, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 5, 2002

Summary of Meeting:
Significant advances have occurred recently in understanding innate and acquired mucosal immune responses and their regulation. This meeting will focus on the mucosal immune system and the regulation of intestinal mucosal immune responses. Exciting new information will be presented that highlights new findings relevant to the development of the intestinal mucosal immune system, important luminal defense mechanisms, antigen entry and presentation at intestinal mucosal surfaces, mechanisms and functional consequences of signaling innate and adaptive mucosal immune responses, new concepts and data on the regulation of mucosal CD4 and CD8 T cell responses, and mechanisms by which abnormal regulation of intestinal mucosal immune responses results in mucosal immune and inflammatory disease. Insights derived from those sessions will be examined in the context of novel new strategies for treating mucosal immune and inflammatory responses.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, APRIL 5

16:00—19:00
Registration

Third Floor Foyer
18:15—19:15
Welcome

Third Floor Foyer
19:15—19:30
Orientation

Peaks 4-5
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Laurie H. Glimcher, Dana-Farber Cancer Institute, USA
T-Bet: A Transcription Factor with Key Functions in Both T and B Cells


SATURDAY, APRIL 6

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Development of the Enteric Mucosal Immune System
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Jean-Pierre Kraehenbuhl, Institut Suisse de Recherche Experimentale sur le Cancer, Switzerland
Ontogeny of Peyer’s Patches and Mucosa-Associated Lymphoid Tissue

William W. Agace, Lund University, Sweden
Selective Chemokine Targeting in the Development of the Intestinal Mucosal Immune System

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Life in a Microbial World: Exploring How Normal Gut Bacteria Influence Host Physiology and Development

R. Balfour Sartor, University of North Carolina at Chapel Hill, USA
Commensal Enteric Bacteria: An Essential Role in Immune Mediated Chronic Intestinal Inflammation

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peak 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
14:30—16:30
Workshop 1: Development and Expression of Mucosal Immunity

Peaks 4-5
* Sean P. Colgan, University of Colorado Denver, USA

* Cathryn Nagler, University of Chicago, USA

Charlotte Slayton Kaetzel, University of Kentucky, USA
Regulation of the Polymeric Ig Receptor by Herpesviruses

Erika B. Stromberg, Göteborg University, Sweden
Increased Frequencies of CTLA-4 Positive Cells in the Duodenum of Helicobacter Pylori-Infected Duodenal Ulcer Patients

Harnisha N. Dalwadi, University of California, Los Angeles, USA
T2 and MZ B Cells: Role in Mucosal Immunologic Homeostasis, and Developmental Requirement for the Galphai2 Gene

Donald Smith, Massachusetts General Hospital, USA
Presentation of Model Immunogenic and Tolerogenic Antigens by the Gut Associated Lymphoid Tissue

Ifor Williams, Science Immunology, USA
CD8alphaalpha-Expressing Intraepithelial Lymphocytes (IEL) with an alphabeta TCR are Selectively Expanded in the Intestine of CCR6 Deficient Mice

Masafumi Yamamoto, Nihon University, Japan
Role of TNF/LT and LTalpha/beta for the Intestinal Mucosal Immunity

Ana Maria Terres, Trinity College Dublin, Ireland
Synergistic Effect of Lipopolysaccharide and Soluble Proteins from Helicobacter pylori Induce Endocytosis Dependent-Blistering of Polarized Epithelia. An Ulcerogenic Mechanism?

Donald P. Satchell, University of California, Irvine, USA
Processing and Activation of alpha-Defensins in Mouse Small Intestinal Paneth Cells

Vijay K. Shreedhar, Wyeth Inc., USA
Orally-Administered Cholera Toxin Induces Migration of Dendritic Cells from the Sub-Epithelial Dome Region to T and B Cell Areas of Peyer’s Patches

Edward Nieuwenhuis, Vrije Universiteit Medical Center,

16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Luminal Host Defense Mechanisms
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Andre J. Ouellette, University of California, Irvine, USA
Paneth Cells, alpha-Defensins, and Mucosal Immunity in the Small Intestine

Judith Appleton, Cornell University, USA
Glycan Specific Antibodies Perturb the Epithelial Habitat of Trichinella Spirals

Pascale Cossart, Institut Pasteur, France
Transgenic Mouse Models for Studying Intestinal Microbial Infection: The Listeria Paradigm

19:00—20:00
Welcome Mixer

Peaks 1-3
20:00—22:00
Poster Session 1

Peaks 1-3

SUNDAY, APRIL 7

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Antigen Entry and Presentation at Enteric Mucosal Surfaces
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Daniel Louvard, Institut Curie, France
Role of Intestinal Epithelial Cell Cytoskeletal Proteins in Regulating Motility of Intracellular Pathogens

G. Gordon MacPherson, University of Oxford, UK
Dendritic Cells and Antigen Transport from the Intestine

Paola Ricciardi-Castagnoli, Toscana Life Science Foundation, Italy
Mechanisms of Tight Junction Penetration and Antigen Uptake by Mucosal Dendritic Cells

Wayne Lencer, Children's Hospital Boston, USA
IgG Transport Across Mucosal Barriers: Functional Expression of FcRn in the Mouse Lung and Bronchial Epithelium of the Human and Non-Human Primate.

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
16:30—17:00
Coffee & Snacks Available

Foyer
17:00—19:00
Innate Mucosal Immunity and Luminal Host Defense Mechanisms
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Daniel K. Podolsky, Massachusetts General Hospital, USA
Toll-Like Receptors and the Mucosal Frontier

Gabriel Nuñez, University of Michigan, USA
Nods: Apaf-1-Like Molecules Regulating the Host Response to Pathogens

* Martin F. Kagnoff, University of California, San Diego, USA
Epithelial Cells as a Signal Integrator in the Host Response to Microbial Infection

19:00—20:00
Welcome Mixer

Peaks 1-3
20:00—22:00
Poster Session 2

Peaks 1-3

MONDAY, APRIL 8

07:00—08:00
Breakfast

Peak 6-12
08:00—11:00
Signaling the Onset of Adaptive Mucosal Immune Responses
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Ferric C. Fang, University of Washington School of Medicine, USA
Critical Role of Reactive Nitrogen and Oxygen Species in Innate Immunity to Salmonella typhimurium

Ludger Johannes, Institut Curie, France
Microbial Toxins as Probes for Antigen Uptake and Trafficking and as Vehicles for Initiating Host Adaptive Immunity: Lessons from Shiga Toxin

* Terrence A. Barrett, Northwestern University Medical School, USA
T Cell Activation Regulates Epithelial Cell Differentiation and Induces Innate Immune Responses in the Intestine

Lloyd F. Mayer, Mount Sinai Medical Center, USA
Unique Antigens and Cell Surface Interactions Define the Activation of Regulatory T Cells by Intestinal Epithelium

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 1-3
13:00—22:00
Poster Viewing

Peaks 1-3
14:30—16:50
Workshop 2: Epithelial Cell Interactions and Microbial Infections

Peaks 4-5
* Lars Eckmann, University of California, San Diego, USA

M. Cecilia Berin, Mount Sinai School of Medicine, USA
Activation of Epithelial Cell NF-kappaB and MAP Kinase Signaling Pathways by Enterohemorrhagic E. coli: Role of Bacterial Virulence Factors

Dirk Haller, Technical University of Munich, Germany
Immune-Mediated Inhibition of Bacteroides vulgatus Induced NF-kappaB Activation and Gene Expression in Intestinal Epithelial Cells by Blocking IkappaBalpha Degradation

* Maria T. Abreu, University of Miami, Miller School of Medicine, USA
TLR4 and MD-2 Expression are Regulated by Th1 Cytokines in Human Intestinal Epithelial Cells (IEC)

Maria T. Abreu, University of Miami, Miller School of Medicine, USA
Intestinal Epithelial Cells (IEC) are Broadly Unresponsive to TLR2-Dependent Bacterial Ligands

Karen L. Madsen, University of Alberta, Canada
DNA from Probiotic Bacteria Exerts Anti-Inflammatory Actions on Intestinal Epithelial Cells by Inhibition of NF-kappaB

Geraldine O. Canny, Central University Hospital of Vaud, Switzerland
Lipid Mediator-Induction of Bactericidal / Permeability-Increasing Protein (BPI) in Human Epithelia

David L. Boone, Indiana University School of Medicine, USA
Expression of A20 in Hematopoietic Cells is Critical for the Regulation of Intestinal Inflammation

Dominique Buzoni-Gatel, Institut Pasteur, France
Importance of Chemokine Receptors for the Leukocyte Trafficking and Protection Against Intestinal Inflammation during T.gondii Infection

Nicolas K. Rachinel, Dartmouth College, USA
Cellular Events in Pathogen Induced Acute Ileitis Driven by a Single Parasite Membrane Antigen (SAG1)

Sonia Lacroix-Lamande, Institut National de La Recherche Agronomique, France
Intestinal Chemokine Response during Cryptosporidium parvum Infection

Christian Maaser, University of Muenster, Germany
Clearance of Citrobacter rodentium Requires B Cells but not Secretory IgA or IgM Antibodies

Bana Jabri, University of Chicago, USA
Isotypes of the NKG2 Family of NK Receptors Tightly Regulate the Function of Normal and Celiac Intestinal alpha/beta T Lymphocytes

16:30—17:00
Coffee & Snacks Available

Foyer
17:15—19:00
Regulation of Mucosal CD4 and CD8 T Cell Responses
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Hiroshi Kiyono, University of Tokyo, Japan
Cross Communication of Mucosal and Systemic T Cells for Allergic Responses in Gastrointestinal Tract

* Richard S. Blumberg, Brigham and Women's Hospital, USA
Epstein-Barr Virus-Induced Gene 3 (EBI3) Deficiency Disrupts T Helper 2-Mediated Immune Responses

Hilde Cheroutre, La Jolla Institute for Allergy and Immunology, USA
Adapt and Survive! A Well Kept Sercret of CD8aa Expressing T Cells

19:00—20:00
Welcome Mixer

Peaks 1-3
20:00—22:00
Poster Session 3

Peaks 1-3

TUESDAY, APRIL 9

07:00—08:00
Breakfast

Peak 6-12
08:00—11:00
Abnormal Mucosal Regulation and Mucosal Disease
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
Dale T. Umetsu, Harvard Medical School, Children's Hospital Boston, USA
Asthma as a Mucosal Disease: Mucosal Antigen Induces T Cell Tolerance and Protects Against Asthma

* Warren Strober, National Institutes of Health, USA
Spontaneous and Induced Immunoregulation of Experimental Mucosal Inflammation

Sean P. Colgan, University of Colorado Denver, USA
Hypoxia-Inducible Factor (HIF) is Protective for Experimental Murine Colitis

Markus F. Neurath, University Hospital Erlangen, Germany
The Life and Death of Mucosal Lymphocytes

09:20—09:40
Coffee Break

Foyer
16:30—17:00
Coffee & Snacks Available

Foyer
14:30—16:30
Worskshop 3: Inflammatory and Immune Processes in IBD

Peaks 4-5
* Lloyd H. Kasper, Geisel School of Medicine at Dartmouth, USA

* Eyal Raz, University of California, San Diego, USA

Nicolaas A. Bos, University of Groningen, Netherlands
iNOS and FAS Expression in Colonic Enterocytes in SCID Mice after Induction of Inflammatory Bowel Disease by CD45RBhigh , CD4+ T Cells

Franck J.D. Mennechet, Universite Montpellier 2, France
Lamina propria CD4+ T Lymphocytes Synergize with Murine Intestinal Epithelial Cells to Enhance Pro-Inflammatory Response Against an Intracellular Pathogen

Britta Siegmund, University of Colorado Health Sciences Center, USA
Leptin: A Critical Proinflammatory Mediator in Different Models of Experimental Colitis

Kiyoshi Takeda, Osaka University, Japan
IL-12 is Essential for Development of Chronic Enterocolitis in Macrophage-Specific Stat3-Deficient Mice

John S. Whoriskey, Amgen Inc., USA
Transgenic Mice Over-Expressing B7.2 Develop an Intestinal Pathology Similar to Human Inflammatory Bowel Disease

Marika C. Kullberg, Centre for Immunology and Infection, University of York, UK
Bacterial-Induced IL-10-Producing CD4+ CD45RBlow CD25+ and CD25- Regulatory T Cells Suppress Helicobacter hepaticus-Triggered Colitis

Han-Qing Jiang, University of Pennsylvania, USA
Monoassociation of Germ Free SCID Mice with Helicobacter muridarum Provokes Inflammatory Bowel Disease upon Transfer of CD4+ CD45RBhigh T cells

Nadia Corazza, Brigham and Women's Hospital, USA
Impaired Function of NK-T Cells in EB13-Deficient Animals

Susetta Finotto, University of Mainz, Germany
Development of Spontaneous Airway Hyperresponsiveness and Remodeling Consistent with Human Asthma in Mice Lacking T-bet

Lothar Steidler, Alimentary Pharmabiotic Centre, Ireland
Ingestion of MouseTFF1, 2 or 3 Producing Recombinant Lactococcus lactis Prevents Acute Colitis in Mice

Theresa Torres Pizarro, University of Virginia, USA

17:00—19:00
Novel Therapeutic Approaches for Treating Mucosal Inflammation
Meeting has ended...abstracts no longer viewable online.

Peaks 4-5
* Eyal Raz, University of California, San Diego, USA
DNA-Based Immunotherapeutics for the Treatment of Enteric Inflammatory Diseases

Averil I. Ma, University of California, San Francisco, USA
A20—Pleiotropic Regulator of Intestinal Immune Homeostasis

Cathryn Nagler, University of Chicago, USA
Regulation of Tolerance and Immunity in the Intestinal Mucosa

19:00—20:00
Welcome Mixer

Peaks 1-3
20:00—23:00
Entertainment

Peaks 1-3

WEDNESDAY, APRIL 10

 
Departure


*Session Chair †Invited, not yet responded.



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