Granlibakken Tahoe Floorplan

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This meeting took place in 2002



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DNA Helicases, Cancer and Aging (C2)


Organizer(s) Ian D. Hickson and Judith Campisi
March 12—17, 2002
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Nov 12, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 11, 2002

Summary of Meeting:
Cancer and aging are frequently considered distinct disorders, although both are associated with genomic instability and are phenotypic consequences of the interplay between genes and the environment. The totally unexpected finding that defects in DNA helicases are responsible for several cancer-prone and/or premature aging syndromes in humans, indicates a need to integrate studies of the basic biology of helicases with studies of cancer and longevity. This conference will provide a unique opportunity to bring together world leaders in aging and cancer biology, with experts on the structure and function of DNA helicases. Sessions will cover structural and functional characterization of DNA helicases from humans and model organisms, and their roles in cancer predisposition or premature aging disorders. By bringing together scientists from the fields of structural biology, biochemistry, cell and molecular biology, cancer and aging research, the conference will facilitate the application of fundamental studies in biology to improvements in human health.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 12

16:00—19:00
Registration

Lobby
17:00—18:00
Cocktail Social

19:15—19:30
Orientation

Granhall
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Granhall
George M. Martin, University of Washington, USA
Classes of Gene Action that Escape the Force of Natural Selection and Thus Modulate Cancer and Senescence


WEDNESDAY, MARCH 13

07:00—08:00
Breakfast

Granhall
08:00—11:00
DNA Helicases: Structure and Function I
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
Dale B. Wigley, Institute of Cancer Research, UK
Relating Structure to Mechanism in Helicases

Timothy M. Lohman, Washington University School of Medicine, USA
DNA Unwinding by the E. coli SF-1 Helicases, Rep and UvrD

* Steven W. Matson, University of North Carolina at Chapel Hill, USA
Biochemical and Genetic Studies of DNA Helicases I and II from E. coli

Edward H. Egelman, University of Virginia, USA
Structural Analysis of Oligomeric Helicases Using Electron Microscopy

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Lake
13:00—22:00
Poster Viewing

Lake
14:30—16:30
Workshop 1

Mountain/Lake Room
* Dale B. Wigley, Institute of Cancer Research, UK

Jennifer A. Cobb, University of Calgary, Canada
Evidence for Interaction Between Sgs1 and Rad53 in the S- Phase Checkpoint Response to HU

Matthew R. Redinbo, University of North Carolina at Chapel Hill, USA
WRN Exonuclease Forms a Hexamer on DNA and Possesses Both 3'-5' Exonuclease and 5'-Protruding Strand Endonuclease Activities

Moreshwar Bhanudas Vaze, Cequent Pharmaceuticals, USA
The SRS2 Helicase is Required for Cells to Recover from Checkpoint-Mediated Arrest that Precedes Repair of a Double-Strand Break

Lars Eide, National Hospital of Norway, Norway
Characterization of a Novel DNA Glycosylase / AP Lyase Activity that Removes Premutagenic Lesions from Mouse Mitochondrial DNA

Maria Spies, University of California, Davis, USA
Definition of the RecA Loading Domain of the RecBCD Helicase/Nuclease

Zeynep Ayse Ozsoy, University of North Carolina at Chapel Hill, USA
Biochemical Characterization of Small and Large Isoforms of Drosophila RecQ5

16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
DNA Helicases: Structure and Function II
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
Stephen C. West, Francis Crick Institute, UK
Strand Transfer and DNA Helicase Activities in the Recombinational Repair of DNA Breaks

* Kenneth J. Marians, Memorial Sloan Kettering Cancer Center, USA
DNA Helicases and Replication Fork Restart

Fyodor D. Urnov, Altius Institute for Biomedical Sciences, USA
Mechanisms of Chromatin Remodeling

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 1: DNA Helicases: Structure and Function

Lake
20:00—21:00
Welcome Mixer

Lake

THURSDAY, MARCH 14

07:00—08:00
Breakfast

Granhall
08:00—11:00
Biochemistry and Genetics of DNA Helicases I
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
Philip C. Hanawalt, Stanford University, USA
Discovery of Rec Q: Role of the Rec Q Helicase in E. coli

Clare H. McGowan, The Scripps Research Institute, USA
Human Mus81 Associated Endonuclease Cleaves Holliday Junctions in vitro

Jean-Marc Egly, Institut de Genetique et de Biologie Moleculaire Cellulaire, France
Transcription Defects Associated with Xeroderma pigmentosum and Cockayne Syndromes

* Rodney J. Rothstein, Columbia University Medical Center, USA
Genetic Analysis of the Sgs1/Top3 Complex of Saccharomyces cerevisiae

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Lake
13:00—22:00
Poster Viewing

Lake
14:30—16:30
Workshop 2

Mountain/Lake Room
* Nathan A. Ellis, University of Illinois, Chicago, USA

Hong Yan, Fox Chase Cancer Center, USA
Distinct Roles of Werner Syndrome Protein and Bloom Syndrome Protein in DNA Replication and Double-strand Break Repair

Giordano Liberi, F.I.R.C. Institute of Molecular Oncology Foundation, Italy
DNA Replication Fork Progression and Processing in sgs1 snd srs2 Mutant Cells Experiencing Intra-S DNA Damage

Steven M. Yannone, Lawrence Berkeley National Laboratory, USA
Werner Syndrome Protein is Regulated and Phosphorylated by DNA-Dependent Protein Kinase

Sharon B. Cantor, University of Massachusetts Medical School, USA
BACH1, a DNA Helicase that Binds Directly to BRCA1

Feyruz V. Rassool, Rayne Institute, UK
Increased Constitutive Replication-Associated DNA Damage in Bloom's Syndrome (BS) is Associated with Increased Infidelity of Non Homologous End-Joining (NHEJ): Implication for Chromosomal Instability in BS?

Hyeon-Sook Koo, Yonsei University, South Korea
The Functions of RecQ Family DNA Helicases in Caenorhabditis elegans

16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
Biochemistry and Genetics of DNA Helicases II
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* Stephen C. Kowalczykowski, University of California, Davis, USA
Mechanism of RecQ Helicase and Topoisomerase III Function

Virginia A. Zakian, Princeton University, USA
The Pif1-Subfamily of DNA Helicases: Functional Consequences of Sequence Similarity?

James E. Haber, Brandeis University, USA
Role of S. cerevisiae Sgs1 and Srs2 in Recombination and Checkpoint Control

John Bradsher, National Cancer Institute, National Institutes of Health, USA
Short Talk: Novel Roles for 3 Helicases in RNA pol I Transcription

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 2: Biochemistry and Genetics of DNA Helicases

Lake
20:00—21:00
Welcome Mixer

Lake

FRIDAY, MARCH 15

07:00—08:00
Breakfast

Granhall
08:00—11:00
Helicases and Cancer I
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
Ian D. Hickson, University of Copenhagen, Denmark
Molecular Pathways to Genome Instability and Cancer: Analysis of the Bloom's Syndrome Helicase

* Errol C. Friedberg, University of Texas Southwestern Medical Center, USA
Error-Prone DNA Polymerases, Mutagenesis and Cancer

Wim Vermeulen, Erasmus University, Netherlands
DNA Repair and Transcription Defects in the Human Population

Nathan A. Ellis, University of Illinois, Chicago, USA
Bloom's Syndrome: Genomic Instability, Nuclear Bodies, and the BLM Helicase

09:20—09:40
Coffee Break

Prefunction
11:00—13:00
Poster Setup

Lake
13:00—22:00
Poster Viewing

Lake
14:30—16:30
Workshop 3

Mountain/Lake Room
* Edward J. Louis, University of Nottingham, UK

Narendra Tuteja, International Center Genetic Engineering & Biotechnology, India
A Pea Homologue of Human DNA Helicase I is Upregulated by Phosphorylation and is Localised Within the Nucleolus

Lucio Comai, University of Southern California, USA
The Werner Syndrome Protein and DNA Damage

F. Brad Johnson, University of Pennsylvania School of Medicine, USA
Testing the Function of the Werner and Bloom Syndrome Genes in Mice Lacking Telomerase

Lisa L. Wang, Baylor College of Medicine, USA
Deleterious Mutations in RecQL4 are Associated with Osteosarcoma Risk in Rothmund-Thomson Syndrome

Robert Michael Brosh Jr., NIA, National Institutes of Health, USA
Dual Functions of Werner Syndrome Protein as a DNA Helicase and Activator of Flap Endonuclease 1

16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
Helicases and Cancer II
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* Curtis C. Harris, NCI, National Institutes of Health, USA
p53-Mediated Apoptosis and Genomic Instability Syndromes

Joanna L. Groden, Ohio State University, USA
Mouse Models for Studying Cancer Predisposition

Hans Spelbrink, University of Tampere, Finland
Human Mitochondrial DNA Instability Caused By Mutations in Twinkle, a Helicase with Similarity to Phage T7 gp4

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 3: Helicases and Cancer/Helicases and Aging

Lake
20:00—21:00
Welcome Mixer

Lake

SATURDAY, MARCH 16

07:00—08:00
Breakfast

Granhall
08:00—11:00
Helicases and Aging I
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
Judith Campisi, Buck Institute for Research on Aging, USA
Mammalian RECQ-Like Helicases and Cellular Senescence

Edward J. Louis, University of Nottingham, UK
Helicases, Telomere Maintenance and Genome Stability

* Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Werner Protein Function, Interactions and Pathways

Junko Oshima, University of Washington, USA
Role of the WRN Gene in Maintenance of Genome Stability and Aging

09:20—09:40
Coffee Break

Prefunction
16:30—17:00
Coffee & Snacks Available

Prefunction
17:00—19:00
Helicases and Aging II
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Room
* Raymond J. Monnat Jr., University of Washington, USA
Genome Instability and Cancer Pathogenesis in the Human RecQ Helicase Deficiencies

Yasuhiro Furuichi, GeneCare Research Institute Co., Ltd., Japan
Upregulation of Human RecQ Helicases in Transformed and Cancer Cells

Jan Vijg, Albert Einstein College of Medicine, USA
Genomic Instability in Mouse Models of Aging and Cancer

19:00—20:00
Welcome Mixer

Granhall
20:00—21:00
Dinner

Granhall
21:00—00:00
Entertainment

Granhall

SUNDAY, MARCH 17

07:00—08:00
Breakfast

Granhall
 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA94351-01




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