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This meeting took place in 2003



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Mechanisms of Immunologic Tolerance and its Breakdown (A2)


Organizer(s) David W. Scott, Rachel R. Caspi, Anne Cooke and Terry L. Delovitch
January 7—13, 2003
Snowbird Resort • Snowbird, Utah USA
Abstract Deadline: Sep 16, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 7, 2002

Sponsored in part by The Director's Sponsor Fund

Summary of Meeting:
An understanding of the pathways of immunologic tolerance and the mechanisms of its breakdown in autoimmunity are critical to developing future therapies for a variety of autoimmune disorders, such as diabetes and multiple sclerosis. Novel approaches need to be developed for the treatment of the autoimmune disorders that lead to immune target cell destruction. This Keystone meeting is centered at understanding tolerance and its breakdown and bridging the gap between basic, pre-clinical and clinical studies (the co-chairs have devoted their entire careers to understanding immune tolerance and autoimmunity, including novel therapies). Thus, several speakers (and workshop chairs) will be strongly oriented towards basic studies, while others will focus on diabetes, multiple sclerosis, inflammatory bowel disease, uveitis, and lupus. A major theme will be the underlying tolerance pathways, as well as how they are subverted. Finally, sessions will be devoted to new models and therapies, and a special clinical trials session will be added. A novel feature is the presentation of Lifetime Achievement Awards at the banquet. Sessions to be covered include development of the tolerance and lymphoid homeostasis, genetics of autoimmunity, immune suppression, model systems and new therapies for autoimmune diseases, with an emphasis on proof of principle and biotechnology, and clinical trial results. The goals of the meeting are: ¨ To provide an understanding of the mechanisms of immune tolerance and its breakdown ¨ To update the audience on autoimmune models and clinical trials. ¨ To stimulate interactions between basic and clinical scientists, as well as R & D scientists in industry, from around the globe to collaborate to respond to the challenges in this area.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 7

15:00—19:00
Registration

Ballroom Lobby
18:15—19:15
Welcome

Ballroom Mezzanine
19:15—19:30
Orientation

Ballroom 2-3
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
James P. Allison, University of Texas MD Anderson Cancer Center, USA
Regulation of Immune Responses by CTLA-4


WEDNESDAY, JANUARY 8

07:00—08:00
Breakfast

Golden Cliff, Superior, Superior Lobby
08:00—12:00
Development of the Repertoire, Homeostasis and Tolerance
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Regulation and Activation of Autoreactive B Cells in Autoimmunity

Pamela J. Fink, University of Washington, USA
Induction of Peripheral T Cell Tolerance Through Antigen Receptor Revision

Josef M. Penninger, Institute of Molecular Biotechnology GmbH, Austria
Cbl and Friends: Controlling Autoimmunity and T Cell Activation

C. Garrison Fathman, Stanford University, USA
GRAIL: A Novel E3 Ligase Related to Anergy in CD4+ Lymphocytes

Joan Goverman, University of Washington, USA
Immune Tolerance to Myelin Basic Protein

Mark S. Anderson, University of California, San Francisco, USA
Short Talk: Immune Tolerance Defects in Aire-Deficient Mice

09:20—09:40
Coffee Break

Ballroom Mezzanine
12:00—13:00
Poster Setup

Wasatch, Maybird, Superior, Superior Lobby
13:00—22:30
Poster Viewing

Wasatch, Maybird, Superior, Superior Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine
17:00—18:00
Plenary Speaker Day 1
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Marc K. Jenkins, University of Minnesota Medical School, USA
Mechanisms of CD4 T Cell Tolerance Induced by Antigen-Presentation without Inflammation

18:00—19:00
Social Hour

Maybird, Superior, Superior Lobby
19:00—20:30
Poster Session 1

Wasatch, Maybird, Superior, Superior Lobby
20:30—22:30
Workshop 1: Repertoire Development and Central Tolerance

Ballroom 2
Melanie S. Vacchio, National Institutes of Health, USA

M. Carrie Miceli, University of California, Los Angeles, USA

Brian W. Busser, University of Pennsylvania, USA

Janson Leung, University of Oxford, UK

Jerold G. Woodward, University of Kentucky Medical Center, USA

Eli E. Sercarz, Torrey Pines Institute for Molecular Studies, USA

* Joan Goverman, University of Washington, USA

20:30—22:30
Workshop 2: Apoptosis and Homeostasis in the Immune System

Ballroom 3
* Charles D. Surh, La Jolla Institute for Allergy and Immunology, USA

Booki Min, Lerner Research Institute, Cleveland Clinic Foundation, USA

Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA

Michelle L. Hermiston, University of California, San Francisco, USA

Yonglian Sun, University of Chicago, USA

Christopher M. Snyder, Thomas Jefferson University, USA

Elliot T. Stevens, University of Nebraska Medical Center, USA

Kiley R. Prilliman, La Jolla Institute for Allergy and Immunology, USA

Sarah Cabbage, University of Washington, USA


THURSDAY, JANUARY 9

07:00—08:00
Breakfast

Golden Cliff, Superior, Superior Lobby
08:00—00:00
Genetics, Genomics and Autoimmune Disease
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* Edward K. Wakeland, University of Texas Southwestern Medical Center, USA
Genetics of Lupus

Chella S. David, Mayo Clinic, USA
Role of HLA-DQ and -DR Genes in Human Autoimmune Diseases. Studies with Transgenic/Knock-Out Mice

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Role of Th1 Specific Cell Surface Molecule TIM-3 in Regulating Autoimmunity, Asthma and Allergies

Pere Santamaria, University of Calgary, Canada
Recruitment of Dominant Autoreactive CD8+ T Cells in Type 1 Diabetes: A Love-Hate Affair with Dendritic Cells, Regulatory T Cells and T Helper

* Linda S. Wicker, University of Cambridge, UK
Defining Idd Genes in the NOD Model of Type 1 Diabetes

Andrew L. Mellor, Georgia Regents University, USA
Short Talk: Potential Regulatory Dendritic Cells Expressing IDO

09:20—09:40
Coffee Break

Ballroom Mezzanine
12:00—13:00
Poster Setup

Wasatch, Maybird, Superior, Superior Lobby
13:00—22:30
Poster Viewing

Wasatch, Maybird, Superior, Superior Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine
17:00—18:00
Plenary Speaker Day 2
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Christopher C. Goodnow, Garvan Institute of Medical Research, Australia
Tolerogenic versus Immunogenic Signaling

18:00—19:00
Social Hour

Maybird, Superior, Superior Lobby
19:00—20:30
Poster Session 2

Wasatch, Maybird, Superior, Superior Lobby
20:30—22:30
Workshop 3: Genomics and Autoimmunity

Ballroom 2
* Linda S. Wicker, University of Cambridge, UK

Maria Halonen, National Public Health Institute, Finland

Raffaele Badolato, Universita di Brescia, Italy

Tanja Ilmarinen, National Public Health Institute, Finland

Paula Y. Arnold, St. Jude Children's Research Hospital, USA

Lynda Bennett, Baylor Institute for Immunology Research, USA

Jennifer H. Anolik, University of Rochester, USA

Philip L. Kong, Kennedy Institute of Rheumatology, UK

20:30—22:30
Workshop 4: Immunotherapy: Animal Models to Clinical Trials

Ballroom 3
* David M. Harlan, National Institutes of Health, NIDDK, USA

* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA

 
Therapeutic Agents for Limiting Autoimmune Responses

Martin Drage, University of Cambridge, UK

Jeffrey L. Browning, Boston University School of Medicine, USA

Ann Herman, Genentech, USA

 
Cell Bases Approaches to Blunt Autoimmune Responses

Mandy L. Ford, Emory University, USA

Amy E. Juedes, La Jolla Institute for Allergy & Immunology, USA

Tracey A. Stephens, University of Western Ontario, Canada

 
Mechanistic Studies: Are We Doing What We Think We Are Doing?

Clara M. Pelfrey, Cleveland Clinic Foundation, Lerner Research Institute, USA

Liliana Graciela Petrich de Marquesini, University of Bristol, UK

Jack A. Ragheb, FDA, USA


FRIDAY, JANUARY 10

07:00—08:00
Breakfast

Golden Cliff, Superior, Superior Lobby
08:00—12:00
Suppression and Regulation of the Immune System
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Jean François Bach, American Autoimmune Related Diseases Association, Inc., USA
Immunotherapy of Diabetes by Stimulation of Regulatory T Cells

* Terry L. Delovitch, John P. Robarts Research Institute and University of Western Ontario, Canada
Protection Against Type 1 Diabetes by Regulation of NKT Cell, IL-16 and CCL4 Activity

Ethan M. Shevach, NIAID, National Institutes of Health, USA
The Pleiotropic Effects of CD4+CD25+ Suppressor T Cells on Immune Responses

Joost J. Oppenheim, National Institutes of Health, USA
Intolerance to Autoantigens Based on Interactions with Dendritic Cell Receptors

Fiona M. Powrie, University of Oxford, UK
Control of Immune Pathology by CD4+CD25+ TR Cells

* Douglas R. Green, St. Jude Children's Research Hospital, USA
Regulation of Tolerance by Suppression and Apoptosis

09:20—09:40
Coffee Break

Ballroom Mezzanine
12:00—13:00
Poster Setup

Wasatch, Maybird, Superior, Superior Lobby
13:00—22:30
Poster Viewing

Wasatch, Maybird, Superior, Superior Lobby
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine
17:00—18:00
Plenary Speaker Day 3
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Anne O'Garra, Francis Crick Institute, UK
Development and Function of IL-10-Producing Regulatory CD4+ T Cells

18:00—19:00
Social Hour

Maybird, Superior, Superior Lobby
19:00—20:30
Poster Session 3

Wasatch, Maybird, Superior, Superior Lobby
20:30—22:30
Workshop 5: Role of the APC in Tolerance

Ballroom 2
* Stephen D. Miller, Northwestern University Medical School, USA

Lucy S. K. Walker, University College London, UK

Kenneth S. Tung, University of Virginia, USA

Susmit Suvas, Oakland University, USA

Michele M. Kosiewicz, University of Louisville, USA

Janet Liversidge, University of Aberdeen, UK

Birgit Knoechel, Dana-Farber Cancer Institute, USA

Leon L. Su, Stanford University, USA

20:30—22:30
Workshop 6: Critical Factors in the Activation of Autoreactive T and B Cells

Ballroom 3
* Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA

Todd N. Eagar, University of California, San Francisco, USA

Lesley Young, , UK

Stephen M. Anderton, University of Edinburgh, UK

Haoli Jin, University of Miami School of Medicine, USA

Francoise Lepault, INSERM, France

Thomas A. Ferguson, Washington University School of Medicine, USA

Jinyoung Choi, Yale University, USA


SATURDAY, JANUARY 11

07:00—08:00
Breakfast

Golden Cliff, Superior, Superior Lobby
08:00—00:00
Immune Modulation of Inflammation and Autoimmunity
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* David W. Scott, Uniformed Services University of Health Sciences, USA
Gene Therapy for Tolerance and Vice Versa

Anne Cooke, University of Cambridge, UK
The Relationship between Infection and Type 1 Diabetes

* Rachel R. Caspi, NEI, National Institutes of Health, USA
Central and Peripheral Mechanisms in Tolerance to Immunologically Privileged Retinal Antigens

David C. Wraith, University of Bristol, UK
Designing Peptides for Therapy of Autoimmune Diseases

George C. Tsokos, Beth Israel Deaconess Medical Center, USA
Short Talk: T Cell Receptor Rewiring in Autoimmmune Disease: The Story of Two Chains

Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
Short Talk: Immunizing with APCs against Autoimmunity

09:20—09:40
Coffee Break

Ballroom Mezzanine
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine
17:00—18:00
Plenary Speaker Day 4
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Michael J. Lenardo, NIAID, National Institutes of Health, USA
The Dual Role of Caspases in Cell Death and Proliferation

18:00—19:00
Social Hour

Maybird, Superior, Superior Lobby

SUNDAY, JANUARY 12

07:00—08:00
Breakfast

Golden Cliff, Superior, Superior Lobby
08:00—12:00
Clinical Trials for Autoimmune Diseases. Session Sponsored by the Juvenile Diabetes Research Foundation International.
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
* David M. Harlan, National Institutes of Health, NIDDK, USA
Immunotherapeutic Diabetes Trials at the NIH

Breay W. Paty, University of Alberta, Canada
Islet Transplantation: The Edmonton Experience

Gerald T. Nepom, Benaroya Research Institute, USA
Tracking Autoantigen-Specific Responses

Richard K. Burt, Northwestern University, USA
Clinical Trials Using Stem Cells to Induce Tolerance

David A. Hafler, Yale University School of Medicine, USA
Higher Strength of Signals Delivered to Responder T Cells Prevents Suppression by Regulatory CD4+CD25+ T Cells

* Jeffrey A. Bluestone, University of California, San Francisco, USA
Clinical Trials with Anti-CD3 in Type 1 Diabetes

09:20—09:40
Coffee Break

Ballroom Mezzanine
16:30—17:00
Coffee & Snacks Available

Ballroom Mezzanine
17:00—18:00
Special Lifetime Achievement Awards
Meeting has ended...abstracts no longer viewable online.

Ballroom 2-3
Ray D. Owen, California Institute of Technology, USA
Twin Calves, Tolerance and Beyond

19:00—20:00
Social Hour

Ballroom Mezzanine
20:00—22:00
Banquet

Ballroom 2-3
21:00—00:00
Entertainment

Ballroom 2-3

MONDAY, JANUARY 13

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI0853209-01




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