Hilton Santa Fe Historic Plaza Hotel Floorplan

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This meeting took place in 2003



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Molecular Pathology of Cardiac Arrhythmias (A6)


Organizer(s) Dan M. Roden and Andrew R. Marks
January 14—19, 2003
Hilton Santa Fe Historic Plaza Hotel • Santa Fe, New Mexico USA
Abstract Deadline: Oct 30, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 14, 2002

Sponsored in part by The Director's Sponsor Fund

Summary of Meeting:
Cardiac arrhythmias kill approximately 300,000 Americans each year, and a much greater number suffer disability ranging from minor symptoms to stroke. Implanted defibrillators and ablative techniques have provided benefit in some patients, but available antiarrhythmic drugs are incompletely effective and impose serious toxicity. Advances in clinical medicine and animal models that define specific arrhythmia syndromes and an increasingly sophisticated view of the molecular and genetic mechanisms that underlie them generate a realistic expectation of developing new drug strategies to impact this problem. Current drugs impair normal ion channel function; new advances identify new targets, such as channels activated in disease or signaling pathways whose activation is arrhythmogenic. The goal of this meeting will be to bring together scientists with diverse expertise in the perturbed biology that underlies arrhythmias, to develop new interdisciplinary dialogue and collaborations that will be necessary to exploit the opportunities offered by new information on arrhythmia mechanisms.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, JANUARY 14

15:00—19:00
Registration

Promenade
18:15—19:15
Welcome

Promenade
19:15—19:30
Orientation

Mesa A
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mesa A
* Dan M. Roden, Vanderbilt University School of Medicine, USA

David E. Clapham, Children's Hospital Boston, USA
New Classes of Calcium-Permeant Ion Channels


WEDNESDAY, JANUARY 15

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Ion Channel Structure-Function and Regulation I
Meeting has ended...abstracts no longer viewable online.

Mesa A
* Paul B. Bennett, Merck & Co., Inc., USA

Lily Yeh Jan, University of California, San Francisco, USA
Potassium Channels

William A. Catterall, University of Washington, USA
Regulation of L-Type Voltage-Gated Calcium Channels by a Signaling Complex

Eduardo Marban, Cedars-Sinai Medical Center, USA
Gene Therapy for Cardiac Arrhythmias

Sebastian K.G. Maier, University of Wuerzburg, Germany
Short Talk: Unexpected Roles of Brain-Type Sodium Channels in Ventricular Contraction and Sino-Atrial Pacemaking

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa B
13:00—22:00
Poster Viewing

Mesa B
14:30—16:30
Workshop: Animal Models of Cardiac Arrhythmias

Mesa A
Jeanne M. Nerbonne, Washington University School of Medicine, USA
Animal Models of Cardiac Arrhythmias - Is Bigger Better or Do Good Things Really Come in Small Packages?

Penelope A. Boyden, Columbia University, USA
Models of Arrhythmias: A Discussion

Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Electrophysiological Remodeling in Cardiac Hypertrophy: Differential Mechanisms in Compensated versus Decompensated Phenotypes

16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
Ion Channel Structure-Function and Regulation II
Meeting has ended...abstracts no longer viewable online.

Mesa A
* Penelope A. Boyden, Columbia University, USA

Robert S. Kass, Columbia University, USA
Ion Channel Mutations and Inherited Arrhythmias: Inherited Mutations Uncouple IKs Channels from Regulation by the Sympathetic Nervous System (SNS)

Barbara E. Ehrlich, Yale University, USA
Modulation of the Inositol-1,4,5-Triphosphate Receptor (InsP3R)

Christian Ramakers, Cardiovascular Research Institute Maastricht, Netherlands
Short Talk: Downregulation of KCNQ1 and KCNE1 Contributes to Reduction of IKs in Canine Hypertrophied Hearts

19:00—20:00
Social Hour

Mesa B
20:00—22:00
Poster Session 1: Arrhythmia Models

Mesa B

THURSDAY, JANUARY 16

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Genetics of Cardiac Arrhythmias I
Meeting has ended...abstracts no longer viewable online.

Mesa A
* Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA

Christine E. Seidman, Harvard Medical School, USA
PRKAG2 Mutations: Molecular Insights into Cardiac Hypertrophy, Ventricular Preexcitation and Conduction System Disease

Mark T. Keating, Novartis Institutes for BioMedical Research, USA
Variant of SCN5A Sodium Channel Implicated in Risk of Cardiac Arrhythmia

Jeffrey R. Balser, Vanderbilt University School of Medicine, USA
Inherited Disease of the Sodium Channel: Insights into Calcium Signaling and Function

Denis Escande, University of Nantes, France
Short Talk: Ankyrin-B Mutation Causes Type 4 Long QT Syndrome

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa B
13:00—22:00
Poster Viewing

Mesa B
16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
From Molecule to Whole Heart
Meeting has ended...abstracts no longer viewable online.

Mesa A
Dan M. Roden, Vanderbilt University School of Medicine, USA
Human Genomics and its Impact on Arrhythmia Presentation and Therapy

Michael C. Sanguinetti, University of Utah, USA
Molecular Mechanisms of Drug-Induced Long QT Syndrome

James N. Weiss, University of California, Los Angeles, USA
A Novel Approach to Identifying Antiarrhythmic Drug Targets

Dou Zhang, Baylor College of Medicine, USA
Short Talk: Conditional Inhibition of TAK1 (MAP3K7) Provokes Wolff Parkinson-White Syndrome and Early-Onset Heart Failure in Mice

19:00—20:00
Social Hour

Mesa B
20:00—22:00
Poster Session 2: Molecular Genetics of Arrhythmias

Mesa B

FRIDAY, JANUARY 17

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Calcium and Cardiac Arrhythmogenesis
Meeting has ended...abstracts no longer viewable online.

Mesa A
* Mark E. Anderson, Johns Hopkins University School of Medicine, USA

Martin D. Bootman, Babraham Institute, UK
Inositol 1,4,5-Trisphosphate Receptors in Cardiac Myocytes - Where are They and What Do They Do?

Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Macromolecular Complexes: Regulation of Ryanodine Receptors by Phosphorylation

W. Jonathan Lederer, University of Maryland Baltimore, USA
Local Calcium Signaling in Heart

Susan L. Hamilton, Baylor College of Medicine, USA
Regulation of RyR1 and RyR2 by Calmodulin and FKBP12

Samuel C. Dudley, Jr.†, Brown University, USA
Short Talk: Disordered Sarcoplasmic Reticulum Ca2+ Release May Contribute to Arrhythmic Risk in Heart Failure

09:20—09:40
Coffee Break

Promenade
11:00—13:00
Poster Setup

Mesa B
13:00—22:00
Poster Viewing

Mesa B
16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
Physiological Triggers for Cardiac Arrhythmias
Meeting has ended...abstracts no longer viewable online.

Mesa A
* Susan L. Hamilton, Baylor College of Medicine, USA

Jeffrey E. Saffitz, Beth Israel Deaconess Medical Center, USA
Molecular Defects in Intercellular Junctions in Cardiac Arrhythmogenesis

Donald M. Bers, University of California, Davis, USA
Cellular Basis of Triggered Arrhythmias in Heart Failure

Heather S. Duffy, Beth Israel Deaconess Medical Center, USA
Short Talk: Biochemical and Structural Analysis of the pH-Dependent Closure of Connexin43

19:00—20:00
Social Hour

Mesa B
20:00—22:00
Poster Session 3: Ion Channel Function

Mesa B

SATURDAY, JANUARY 18

07:00—08:00
Breakfast

Chamisa
08:00—11:00
Ion Channel Assembly and Modulation
Meeting has ended...abstracts no longer viewable online.

Mesa A
* William A. Catterall, University of Washington, USA

Franz Hofmann, Technische Universit√§t M√ľnchen, Germany
Pacemaker Channels and Sinus Node Arrhythmia

Michael M. Tamkun, Colorado State University, USA
Ion Channel Targeting to Lipid Raft Domains

Mark E. Anderson, Johns Hopkins University School of Medicine, USA
CaM Kinase and L-Type Ca2+ Channels: A Recipe for Arrhythmias?

Diomedes E. Logothetis, Mount Sinai School of Medicine, USA
Gating of a Potassium Channel by the betagamma Subunits of G Proteins

David R. Van Wagoner, Cleveland Clinic Foundation, USA
Short Talk: Inflammation and Pacing Promote Atrial Fibrillation via Distinct Mechanisms

09:20—09:40
Coffee Break

Promenade
16:30—17:00
Coffee & Snacks Available

Promenade
17:00—19:00
High Throughput Screening and Identification of Novel Therapeutic Targets
Meeting has ended...abstracts no longer viewable online.

Mesa A
* Robert S. Kass, Columbia University, USA

Paul B. Bennett, Merck & Co., Inc., USA
Critical Issues in the Development of Ion Channels as Drug Targets

Morten Grunnet, University of Copenhagen, Denmark
Short Talk: KCNQ1 Channels: Sensors of Cell Volume Changes

19:00—20:00
Social Hour

Mesa B
20:00—23:00
Entertainment

Mesa B

SUNDAY, JANUARY 19

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 HL071668-01




We gratefully acknowledge additional support for this conference from:


American Heart Association's Council on Basic Cardiovascular Sciences


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