Granlibakken Tahoe Floorplan

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This meeting took place in 2003



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Drug Target Validation: Gene Suppression (B1)


Organizer(s) Peter B. Dervan, Stephen W. Fesik and Michael Briggs
January 17—22, 2003
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Sep 17, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 18, 2002

Sponsored by Abbott Laboratories

Summary of Meeting:
There is an enormous interest in the application of diverse chemical and biological tools to control the expression of specific genes or compromise the activities of specific mRNAs and proteins. The biotechnology industry develops these tools for plant and animal engineering, the pharmaceutical industry makes use of these tools to validate drug targets, and the medical community investigates a subset of these reagents as therapeutics in their own right. The purpose of this Keystone Symposium is to review the utility of chemical and biological approaches to selectively turning gene activity off at the transcriptional, post-transcriptional and protein level- especially with reference to functional genomics. The aim is to provide a broad overview of established and emerging methodologies, the basic science behind these approaches and their utility from an industrial and medical perspective. The availability of the human genome and widespread use of micro array strategies for assessing specificity should make the meeting especially timely and provide a unifying focus by 2003. The latest advances on RNA interference, protein engineering to repress transcription, chemical approaches to gene control, antisense, ribozymes and knockout strategies will be discussed.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


FRIDAY, JANUARY 17

15:00—19:00
Registration

Pre-Function
19:15—19:30
Orientation

Mountain/Lake Rooms
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
Robert G. Roeder, Rockefeller University, USA
Regulation of Eukaryotic Transcription through Diverse and Complex Transcription Machineries


SATURDAY, JANUARY 18

07:00—08:00
Breakfast

Granhall
08:00—11:00
RNA Interference
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Thomas Tuschl, HHMI/Rockefeller University, USA
Analysis of Mammalian Gene Function Using Small Interfering RNAs

Christophe J. Echeverri, Cenix BioScience GmbH, Germany
Exploring the Full Potential of RNAi: From Integrated Target Discovery and Validation to a New Class of Therapeutics

Helmuth H. van Es, ModiQuest B.V., Netherlands
Target Discovery and Validation Using Arrayed Knock-in and Knock-down Adenoviral Libraries

René Bernards, Netherlands Cancer Institute, Netherlands
Genome-Wide Loss-of-Function Phenotypic Screens in Mammalian Cells

09:20—09:40
Coffee Break

Pre-Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:00
Protein Engineering to Repress Transcription
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Carl O. Pabo, Sangamo Therapeutics, Inc., USA
Regulation of Endogenous Gene Expression with Engineered C2H2 Zinc Finger Transcription Factors

J. Keith Joung, Massachusetts General Hospital, USA
Engineered Zinc Finger Proteins for Transcription Regulation

Carlos F. Barbas III, The Scripps Research Institute, USA
Endogenous Gene Regulation with Polydactyl Zinc Finger Transcription Factors

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 1

Bay Room
20:00—21:00
Social Hour

Bay Room

SUNDAY, JANUARY 19

07:00—08:00
Breakfast

Granhall
08:00—11:00
Chemical Approaches to Transcriptional Control
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Joel M. Gottesfeld, The Scripps Research Institute, USA
Regulation of Gene Expression by Polyamides

Karolin Luger, Colorado State University, USA
Small DNA Binding Ligands to Study Structure and Dynamics of Chromatin

Aseem Z. Ansari, University of Wisconsin-Madison, USA
Modular Design of Artificial Transcription Factors

David M. Margolis, University of North Carolina at Chapel Hill, USA
Polyamides induce Derepression of HIV within Primary Resting T Cells

09:20—09:40
Coffee Break

Pre-Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:00
Antigene
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Carine Giovannangeli, Muséum National d'Histoire Naturelle, France
Sequence-Specific Control of Gene Transcription by Antigene Oligonucleotides

Peter E. Nielsen, University of Copenhagen, Denmark
Targeting Duplex DNA by Peptide Nucleic Acids

David R. Corey, University of Texas Southwestern Medical Center, USA
Strand Invasion by Peptide Nucleic Acids

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 2

Bay Room
20:00—21:00
Social Hour

Bay Room

MONDAY, JANUARY 20

07:00—08:00
Breakfast

Granhall
08:00—11:00
siRNA/Antisense
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
Michael R. Briggs, Vertex Pharmaceuticals Incorporated, USA

Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Target Identification/Validation using siRNA

Jonathan W. Nyce, Epigenesis Pharmaceuticals, Inc., USA
Respirable Antisense Oligonucleotides (RANs) as Therapeutics and Tools for Respiratory Target Evaluation

Nicholas M. Dean, Providence Therapeutics, Canada
Functional Genomics Applications of Antisense

David L. Lewis, Arrowhead Research Corporation, USA
Short Talk

09:20—09:40
Coffee Break

Pre-Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:00
Chemical Approaches to Gene Control
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Laurence H. Hurley, Arizona Cancer Center, USA
Transcription Control by Ligand-Mediated G-Quadruplex Stabilization

James E. Summerton, Gene Tools, LLC, USA
Morpholino Antisense Oligos: Efficient and Reliable Tools for Validating Drug Targets

Vikram Arora, AVI BioPharma, Inc., USA
Inhibition of Gene Expression in the Liver Following Oral Administration of Morpholino Oligomers

19:00—20:00
Dinner

Granhall
20:00—22:00
Poster Session 3

Bay Room
20:00—21:00
Social Hour

Bay Room

TUESDAY, JANUARY 21

07:00—08:00
Breakfast

Granhall
08:00—11:00
Knockout
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Bill Matthews, Deltagen, USA
Creating a Research Infrastructure for Systems Biology Using High Throughput Gene Knockouts

Pengbo Zhou, Weill Cornell Medical College, USA
Targeted Protein Degradation

Brian Zambrowicz, Regeneron, USA
The Value of Mouse Genetics for Drug Discovery

Andras Nagy, Mount Sinai Hospital, University of Toronto, Canada
Mutagenesis in ES Cells and Mice

09:20—09:40
Coffee Break

Pre-Function
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:00
Ribozymes
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Flossie Wong-Staal, ItherX Pharmaceuticals Inc., USA
Ribozymes and Inverse Genomics for Functional Gene Dicovery

David V. Morrissey, Intellia Therapeutics, Inc., USA
Ribozyme and siRNA Therapies for Viral Hepatitis

John J. Rossi, Beckman Research Institute of the City of Hope, USA
Combinatorial Ribozyme, Decoy and siRNA Therapies for HIV-1

19:00—20:00
Social Hour

Granhall
20:00—21:00
Dinner

Mountain/Lake Rooms
21:00—00:00
Entertainment

Mountain/Lake Rooms

WEDNESDAY, JANUARY 22

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 GM067309-01




We gratefully acknowledge additional support for this conference from:


Abbott Laboratories

Abbott Laboratories

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676