Taos Convention Center (meeting only) Floorplan

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This meeting took place in 2003



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Membrane Proteins: Structure and Mechanism (J5)


Organizer(s) Joseph J. Falke and Douglas C. Rees
February 4—10, 2003
Taos Convention Center (meeting only) • Taos, New Mexico USA
Abstract Deadline: Oct 3, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 4, 2002

Sponsored in part by The Director's Sponsor Fund


Summary of Meeting:
The conference will feature presentations by established investigators and rising young stars in the rapidly expanding field of membrane proteins. Up to 30% of the human genome may encode transmembrane proteins and these proteins are the targets of most pharmaceuticals, yet progress toward a molecular understanding of membrane proteins has been slow until recent years. Now, however, sophisticated physical, chemical and biochemical methods are beginning to yield a structural and mechanistic view of the major functional subclasses, including transmembrane channels, receptors, transporters, and peripheral membrane proteins. The meeting is unique, since no other conference of this size brings together leading researchers focusing on all the major classes of membrane proteins to compare their latest findings and disseminate their newest experimental approaches.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 4

15:00—19:00
Registration

Rio Grande Hall D
18:15—19:15
Welcome

Rio Grande Hall A-C
19:15—19:30
Orientation

Bataan
19:30—20:30
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.

Bataan
Kurt Wüthrich, ETH Zürich, Switzerland
NMR Techniques for Large Structures in Solution Applied to Membrane Proteins


WEDNESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Rio Grande Hall A-C
08:00—11:15
NMR Studies of Membrane Proteins (Joint)
Meeting has ended...abstracts no longer viewable online.

Bataan
Lynmarie K. Thompson, University of Massachusetts, USA
Site-Directed Solid-State NMR Studies of Transmembrane Signaling

Timothy A. Cross, Florida State University, USA
Structural Features and Function of the M2 Proton Channel from Influenza A

* Charles R. Sanders, Vanderbilt University School of Medicine, USA
A Structural Biophysics Approach to Membrane Protein Misfolding

John H. Bushweller, University of Virginia, USA
Solution NMR Approaches to the Structure and Dynamics of Integral Membrane Proteins

Jun Qin, Lerner Research Institute, USA
Short Talk: Structural Basis of Integrin-Mediated Signaling in Cell Adhesion

Josep Rizo, University of Texas Southwestern Medical Center, USA
Short Talk: Differential Mechanisms of Action of Presynaptic C2-Domains

09:20—09:40
Coffee Break

Rio Grande Hall A-C
14:00—15:00
Poster Setup

Bataan
15:00—22:00
Poster Viewing

Bataan
16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:15
Membrane Protein Translocation, Folding and Assembly
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall D
* Donald M. Engelman, Yale University, USA
Stability and Specificity in Membrane Protein Folding

Linda L. Randall, University of Missouri, USA
Interaction between Protein Chaperones during Export in E. coli

Avram M. Slovic, Columbia University, USA
Short Talk: Computational Methods for the Design of Water-Soluble Membrane Proteins

Diane M. Papazian, University of California, Los Angeles, USA
Conformational States of Voltage Gated Channels

Christine A. Hrycyna, Purdue University, USA
Short Talk: Molecular Mechanisms of Ras Isoprenylcysteine Carboxyl Methyltransferase (ICMT)

17:00—19:00
Computational/NMR Interface in Protein Structure Determination
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall A-B
* Carol B. Post, Purdue University, USA

David A. Case, Rutgers University, USA
What Can We Learn About Hydrogen Bonding from Biomolecular NMR?

Jeffrey Skolnick, Georgia Institute of Technology, USA
Prediction of Protein Structure and Function on a Genomic Scale

Michael Nilges, Institut Pasteur, France
Inferential Structure Determination

Alexandre M.J.J. Bonvin, Utrecht University, Netherlands
Short Talk: HADDOCK: A Protein-Protein Docking Approach Based on Biochemical or Biophysical Information

19:00—20:00
Social Hour

Bataan
20:00—22:00
Poster Session 1: Channels

Bataan

THURSDAY, FEBRUARY 6

07:00—08:00
Breakfast

Bataan
08:00—11:00
Ion Channels I
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall D
* Douglas C. Rees, California Institute of Technology, USA

Randal B. Bass, California Institute of Technology, USA
Crystal Structure of MscS, a Voltage- and Mechano-Gated Channel

Sergei I. Sukharev, University of Maryland, USA
Mechanistic Studies of the MscL Mechanosensitive Channel

Eduardo A. Perozo, University of Chicago, USA
Large-Scale Rearrangements in Mechanosensitive Channel Gating

Merritt Maduke, Stanford University, USA
Probing the Mechanisms of "ClC" Chloride Channels

Kenneth H. Lundstrom, BioXtal, Inc., Switzerland
Short Talk: MePNet: Structural Genomics Initiative on Membrane Proteins

08:00—11:15
Large Proteins and Large Protein Assemblies
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall A-B
* Angela M. Gronenborn, University of Pittsburgh, USA

Gerhard Wagner, Harvard Medical School, USA
Structures and Interactions of Proteins in Eukaryotic Translation Initiation

Jacob Schaefer, Washington University, USA
Cell-Wall Complexes of Vancomycins in Whole Cells of S. aureus

Brian D. Sykes, University of Alberta, Canada
Calcium Regulatory Proteins: From Solution to Intact Muscle Fibers

Lewis E. Kay, University of Toronto, Canada
Domain Orientations in Large Proteins

Richard W. Kriwacki, St. Jude Children's Research Hospital, USA
Solution NMR Studies of Cell Cycle Regulatory Complexes

Tomas Åkerud, AstraZeneca, Sweden
Short Talk: Oligomerisation and Intramolecular Dynamics of Low Molecular Weight Protein Tyrosine Phosphatase Studied by NMR and Hydrodynamic Calculations

Paul B. Card, University of Texas Southwestern Medical Center, USA
Short Talk: PAS Domain Mediated Signaling in the Hypoxia Response

09:20—09:40
Coffee Break

Bataan
11:00—13:00
Poster Setup

Bataan
13:00—22:00
Poster Viewing

Bataan
14:30—16:30
Workshop in Honor of Sunney Chan (Joint)

Rio Grande Hall A-C
* Joseph J. Falke, University of Colorado, USA

* James H. Prestegard, University of Georgia, USA

Lynmarie K. Thompson, University of Massachusetts, USA
Introduction

Gary Brudvig, Yale University, USA
Magnetic Resonance Studies of Transmembrane Electron Transfer

David F. Blair, University of Utah, USA
Membrane Protein Structures in the Bacterial Rotary Motor

Hiep-Hoa T. Nguyen, TransMembrane Biosciences, USA
Methods for Overexpression of Membrane Proteins

16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:15
Receptors I
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall D
Joseph J. Falke, University of Colorado, USA
Receptor Transmembrane Signaling and Kinase Regulation

* James A. Wells, University of California, San Francisco, USA
Site-Directed Drug Discovery at Signaling Interfaces

K. Christopher Garcia, Stanford University School of Medicine, USA
New Structural Paradigms in Receptor/Ligand Interactions

Nagarajan Vaidehi, City of Hope National Medical Center, USA
Short Talk: Structure and Function for G Protein-Coupled Receptors

Reinhard Grisshammer, NIH/NINDS, Algeria
Short Talk: Expression and Purification of G-Protein-Coupled Receptors for Structure Determination

17:00—19:00
Structural Genomics - New Experimental Approaches. Session Sponsored in part by Bruker BioSpin Corporation.
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall A-B
* Gerhard Wagner, Harvard Medical School, USA

Gaetano Thomas Montelione, Rutgers University, USA
Protein Sample Production Technologies for Large-Scale Structural Genomics

Cheryl Arrowsmith, University of Toronto, Canada
Structural Proteomics: A Tool for Annotation of the Genome

James H. Prestegard, University of Georgia, USA
Residual Dipolar Couplings: A Basis for Structure Determination and Classification

Wolfgang Peti, University of Arizona, USA
Short Talk: NMR for Structural Genomics: The Thermotoga maritima Proteome

19:00—20:00
Social Hour

Bataan
20:00—22:00
Poster Session 2: Receptors

Bataan

FRIDAY, FEBRUARY 7

07:00—08:00
Breakfast

Bataan
08:00—11:00
Transporters I
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall D
* H. Ronald Kaback, University of California, Los Angeles, USA
Structure and Mechanism of Lac Permease

Geoffrey Chang, The Scripps Research Institute, USA
Structural Analysis of MDR-ABC Transporter

Nancy Carrasco, Albert Einstein College of Medicine, USA
The Sodium/Iodide Symporter (NIS): Characterization, Regulation and Medical Significance

Sunney Ignatius Chan, California Institute of Technology, USA
Structure and Mechanism of Membrane-Bound Electron Transport and Energy Transducing Enzymes: Old Tricks and New Strategies

Kaspar P. Locher, ETH - Zürich, Switzerland
Short Talk: Crystal Structure of a Bacterial ABC Transporter

08:00—11:15
New Methods in NMR
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall A-B
* Brian D. Sykes, University of Alberta, Canada

Stanley J. Opella, University of California, San Diego, USA
New NMR Methods for Membrane Proteins

Robert G. Griffin, Massachusetts Institute of Technology, USA
Amyloid and Membrane Protein Structure Determination with Dynamic Nuclear Polarization and MAS Dipolar Recoupling

Teresa Carlomagno, Universität Hannover, Germany
Cross-Correlated Relaxation Rates: Measuring Torsion Angles in Carbon Chains of Proteins and Protein-Ligand Complexes

Ad Bax, NIDDK, National Institutes of Health, USA
Shortcuts in NMR Structure Determination

Alfred Redfield, Brandeis University, USA
Short Talk: Field-Cycling Studies of Diverse Biopolymers by Field Cycling in a Shared Instrument: Screening of Binding?

John L. Markley, University of Wisconsin-Madison, USA
Short Talk: Cell-Free Preparation of Proteins for NMR Spectroscopy

09:20—09:40
Coffee Break

Bataan
11:00—13:00
Poster Setup

Bataan
13:00—22:00
Poster Viewing

Bataan
14:30—16:30
Workshop on Partially Aligned Molecules

Rio Grande Hall A-B
* Ad Bax, NIDDK, National Institutes of Health, USA

Gianluigi Veglia, University of Minnesota, USA
Residual Dipolar Couplings for Use in NMR Structure Determination of Membrane Proteins

Ronaldo M. Mohana-Borges, Federal University of Rio de Janeiro (UFRJ), Brazil
Mapping the Topology of Unfolded and Partially Folded Proteins by Residual Dipolar Couplings

Markus Zweckstetter, Max-Planck Institute for Biophysical Chemistry / DZNE, Germany
Rapid Characterization of Protein Assemblies using NMR Derived Molecular Alignment

Yufeng Wei, Seton Hall University, USA
Structure of the Anti-Apoptotic Protein PEA-15 Using Residual Dipolar Coupling Measurements

Frédéric H.T. Allain, ETH Zurich, Switzerland
Solution Structures of Two RNA Substrates for Editing

Justin Wu, Ohio State University, USA
Solution Structure of gS-crystallin from Residual Dipolar Couplings

Tobias Sebastian Ulmer, NIDDK, National Institutes of Health, USA
Refinement of the Backbone Geometry of GB3 Using Dipolar Couplings. Insight into the Proton Positions

Mirko Hennig, The Scripps Research Institute, USA
Labeling Methodology and 19F NMR of Fluoropyrimidine Substituted RNA

16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:15
Ion Channels II
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall D
* Richard W. Aldrich, Stanford University, USA
Conformational Changes and Allosteric Interactions in Potassium Channels Gated by Voltage and Calcium

Youxing Jiang, University of Texas Southwestern Medical Center, USA
Structure and Mechanism of a Calcium-Gated Potassium Channel

Francisco Bezanilla, University of Chicago, USA
Stuctural Rearrangement during Voltage Gating

Michael C. Wiener, University of Virginia, USA
Short Talk: Substrate-Induced Transmembrane Signaling in the Outer-Membrane Cobalamin Transporter BtuB

17:00—19:00
Protein Modifications and Interactions
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall A-B
* Erik R. P. Zuiderweg, University of Michigan, USA

David E. Wemmer, University of California, Berkeley, USA
Phosphoaspartate Signaling and Enzymology

Angela M. Gronenborn, University of Pittsburgh, USA
A Protein Contortionist: Core Mutations Switch Monomeric Protein GB1 into Different Multimers

David H. Live, University of Georgia, USA
Short Talk: Structure and Dynamics of Mucin Motifs

19:00—20:00
Social Hour

Bataan
20:00—22:00
Poster Session 3: Interfacial Membrane Proteins and Transporters

Bataan

SATURDAY, FEBRUARY 8

07:00—08:00
Breakfast

Bataan
08:00—11:00
Receptors II
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall D
* Wayne L. Hubbell, University of California, Los Angeles, USA
Mechanism of Rhodopsin Signaling

Brian K. Kobilka, Stanford University School of Medicine, USA
Ligand-Induced Conformational Changes in the Beta2 Adrenoceptor

Jonathan A. Javitch, Columbia University, USA
Mapping the Surface of the Binding-Site Crevice of the Dopamine D2 Receptor: Clues to the Structural Bases of Pharmacological Specificity and to the Identification of a Symmetrical Homodimer Interface

Mark Yeager, University of Virginia School of Medicine, USA
3D Structure of Membrane Proteins

Eric J. Hustedt, Vanderbilt University, USA
Short Talk: New Models and Methods for the Analysis of Dipolar Coupling Between Spin Labels

08:00—11:15
Small Molecule-Macromolecule Interactions and Drug Design
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall A-B
* David E. Wemmer, University of California, Berkeley, USA

Jonathan M. Moore, Vertex Pharmaceuticals Incorporated, USA
NMR-Based Strategies in Drug Discovery

Bernd Meyer, University of Hamburg, Germany
STD-NMR to Screen Libraries and to Characterize Ligand Binding to Receptors

Wolfgang Jahnke, Novartis Institutes for BioMedical Research, Switzerland
New Methods and Applications of NMR in Drug Discovery

Philip J. Hajduk, Abbott Laboratories, USA
NMR in Drug Discovery and Design

Andrew J. Benie, Novo Nordisk A/S, Denmark
Short Talk: NMR Studies of the Binding of Ligands to a Native Rhinovirus

John P. Marino, National Institute of Standards and Technology, USA
Short Talk: Using 19F NMR to Screen Small Molecules that Target a Soluble Mimic of the Light-Activated GPCR Rhodopsin

09:20—09:40
Coffee Break

Bataan
11:00—13:00
Poster Setup

Bataan
13:00—22:00
Poster Viewing

Bataan
14:30—16:30
Workshop on Automation of Data Analysis

Rio Grande Hall A-B
* Michael Nilges, Institut Pasteur, France

Xiaolian Gao, University of Houston, USA
Chemical Shift Correlated Protein Data Base (CSC-PDB) for Automated Protein Structure Determination

Thomas Szyperski, SUNY at Buffalo, USA
GFT NMR: New Methodology to Rapidly Obtain Precise High-Dimensional Spectral Information

Pei Zhou, Duke University Medical Center, USA
A Novel Exhaustive Search Algorithm for the Computer-Assisted Backbone Resonance Assignment from NMR Data

Sven G. Hyberts, Harvard Medical School, USA
IBIS, a User-Interactive Tool for Automated Sequential Assignment of Protein Spectra from Triple-Resonance Experiments

Torsten Herrmann, ETH - Zurich, Switzerland
Automated NOESY Peak Picking and NOE Assignment with the New Software RADAR

Jeffrey C. Hoch, Rowland Institute, USA
Bayesian Restraint Potentials for Consistent Inference of Biomolecular Structure from NMR Data

Eldon L. Ulrich, University of Wisconsin-Madison, USA
BioMagResBank (BMRB)

16:30—17:00
Coffee & Snacks Available

Bataan
17:00—19:00
Transporters II and Interfacial Proteins I
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall D
David S. Cafiso, University of Virginia, USA
Molecular Mechanism of Outer-Membrane Transport Studied using Site-Directed Spin Labeling

* Barry Honig, Columbia University / HHMI, USA
Computational Studies of the Interaction of Proteins and Peptides with Membrane Interfaces

William A. Cramer, Purdue University, USA
Import of Colicin E3 across the Outer Membrane: On the Role of the Coiled-Coil and a Two Receptor Mechanism

Nathan J. Malmberg, University of Colorado Boulder, USA
and

Susy C. Kohout, University of Colorado, Boulder, USA
Short Talk: EPR Analysis of Calcium-Activated C2 Domains Defines Membrane Docking and Penetration

17:00—19:00
Nucleic Acids and Protein-Nucleic Acid Complexes
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall A-B
* Harald Schwalbe, University of Frankfurt, Germany

Joseph D. Puglisi, Stanford University, USA
NMR Investigations of Large RNAs

Arthur Pardi, University of Colorado, Boulder, USA
Structure, Dynamics and Stability of tRNAs in Solution

Juli Feigon, University of California, Los Angeles, USA
Biophysical Studies of Telomerase RNA Structure and Mutations Linked to Disease

Robert T. Clubb, University of California, Los Angeles, USA
Short Talk: Reading the Major Groove Through Loop Immobilization: Structure and Dynamics of the ARID-DNA Complex

19:00—20:00
Social Hour

Bataan
20:00—22:00
Poster Session 4: Transporters

Bataan

SUNDAY, FEBRUARY 9

07:00—08:00
Breakfast

Bataan
08:00—11:00
Interfacial Proteins II
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall D
Lawrence S. Shapiro, Columbia University, USA
Cadherins and Cell-Cell Adhesion: Structure-Function Analysis

* Deborah E. Leckband, University of Illinois at Urbana-Champaign, USA
Novel Mechanisms of Cell Adhesion

Michael S. Wolfe, Brigham and Women's Hospital, Harvard Medical School, USA
Gamma-Secretase: Portrait of an Intramembrane Protease Complex

Michael J. Overdui, University of Birmingham, UK
Depth of FYVE Domain Membrane Insertione and DIX Domain's Actin and Vesicular Locallization

Christian F.W. Becker, Gryphon Therapeutics, USA
Short Talk: Solubilization of Tb_MscL by Covalent Detergent Modification

08:00—11:15
Motions in Proteins and Nucleic Acids
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall A-B
* James H. Prestegard, University of Georgia, USA

Erik R. P. Zuiderweg, University of Michigan, USA
A Role of Dynamics in Allosteric Proteins

A. Joshua Wand, University of Pennsylvania, USA
Protein Dynamics and Thermodynamics: A View Emerging from NMR Relaxation

David P. Cistola, Washington University School of Medicine, USA
Functionally Relevant Slow Motions in Proteins

Harald Schwalbe, University of Frankfurt, Germany
Nucleic Acids in Motion

Dorothee Kern, Brandeis University, HHMI, USA
Short Talk: Enzymes in Action in the NMR Tube- Protein Dynamics and Reaction Trajectories in Enzyme Catalysis

Ernesto J. Fuentes, University of Iowa, USA
Short Talk: Dynamic Response of a PDZ Domain Protein to Peptide Binding

09:00—09:20
Coffee Break

Bataan
17:00—19:00
Computational Analysis of Motions in Proteins
Meeting has ended...abstracts no longer viewable online.

Rio Grande Hall A-B
* A. Joshua Wand, University of Pennsylvania, USA

Carol B. Post, Purdue University, USA
Dengne Virus Capsid Protein

Ronald Levy, Stanford University, USA
Recent Studies of Protein Structure and Motions

Lennart Nilsson, Karolinska Institute, Sweden
Short Talk: Protein Dynamics, Correlations and Stability

19:00—20:00
Social Hour

Bataan
20:00—23:00
Entertainment

Bataan

MONDAY, FEBRUARY 10

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 GM67188-01




We gratefully acknowledge additional support for this conference from:


Cambridge Isotope Laboratories

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