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This meeting took place in 2003



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PPARs: Transcriptional Regulators of Metabolism and Metabolic Disease (B5)


Organizer(s) Ronald M. Evans, Bruce M. Spiegelman and Christopher K. Glass
February 4—9, 2003
Keystone Resort • Keystone, Colorado USA
Abstract Deadline: Oct 3, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 4, 2002

Sponsored by Pfizer Global Research and Development

Summary of Meeting:
· To review recent findings that focus attention on PPARs as key targets in the pathogenicity of obesity, diabetes, atherosclerosis and cancer. Also, genetic alterations in PPARs in humans with diabetes/lipodystrophy syndrome and cancer. · To describe insights from new animal models and clinical studies that relate to an emerging biology of lipid metabolism and inflammation and disease. · To identify the transcriptional basis of these phenomena by the identification of PPAR target genes. · To dissect the mechanism(s) by which PPAR active drugs modulate cancer, affect heart disease, and function as anti-diabetic compounds. · To explore the recent links between the action of the PPARs with other nuclear receptors such as LXR and implications for cholesterol metabolism. · To foster new insights that will lead to novel and effective insights to the origin and treatment of PPAR related disease. · To develop new collaborations among the scientists in attendance.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 4

15:00—19:00
Registration

Longs Peak Foyer
18:15—19:15
Welcome

Longs Peak Foyer
19:15—19:30
Orientation

Grays Peak 1-2
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Grays Peak 1-2
Jeffrey M. Friedman, Rockefeller University, USA


WEDNESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Molecular Mechanisms
Meeting has ended...abstracts no longer viewable online.

Grays Peak 1-2
Christopher K. Glass, University of California, San Diego, USA
Roles of PPARgamma in Macrophage Biology and Atherosclerosis

Johan Auwerx, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
PPARgamma and its Coregulators in the Control of Metabolism

Stephen R. Farmer, Boston University School of Medicine, USA
Regulation of PPARgamma Expression and Function in the Adipocyte

Robert G. Roeder, Rockefeller University, USA
Function of Distinct Transcriptional Coactivators in PPARgamma-Stimulated Adipogenesis

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
15:00—16:30
Workshop 1: Hot Topics

Grays Peak 1-2
* V. Krishna K. Chatterjee, University of Cambridge, UK

* Alan R. Tall, Columbia University, USA
A PEST Sequence in ABCA1 Regulates Degradation by Calpain Protease and Stabilization of ABCA1 by apoA-I

Jae In Lee, Amgen Inc., USA
A Novel Transcriptional Coactivator Complex ASCOM and its Role in Lipid Metabolism

Bethany D. Freedman, Northwestern University Medical School, USA
Creation and Analysis of a Dominant Negative PPARgamma Knock-In Mouse

Short Talk(s) Chosen from Abstracts

16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Adipogenesis and Obesity
Meeting has ended...abstracts no longer viewable online.

Grays Peak 1-2
Bruce M. Spiegelman, Harvard Medical School, USA
Control of Energy Metabolism and Cell Lineage Determination by PPARgamma and its Coactivators

Barbara C. Hansen, University of South Florida, Tampa, USA
Differentiating the Functions of the PPARs

V. Krishna K. Chatterjee, University of Cambridge, UK
PPARgamma: Lessons from Human Genetics

19:00—20:00
Social Hour

Longs Peak
20:00—22:00
Poster Session 1: Molecular Mechanisms

Longs Peak

THURSDAY, FEBRUARY 6

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Fatty Acid Metabolism
Meeting has ended...abstracts no longer viewable online.

Grays Peak 1-2
Ronald M. Evans, Howard Hughes Medical Institute, Salk Institute, USA
PPARgamma and delta in Obesity, Diabetes and Heart Disease

Daniel P. Kelly, University of Pennsylvania, USA
Control of Mitochondrial Function by the PPARalpha/PGC-1 Axis in the Developing and Diseased Heart

Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
PPARgamma, Adipogenesis and Insulin Sensitivity

George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA
Axokine in Ongoing Obesity Trials, and Velocigene for What’s Next

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
15:00—16:30
Workshop 2: Hot Topics

Grays Peak 1-2
* Barry Marc Forman, City of Hope, USA
Orphan Nuclear Receptors in Lipid Metabolism

* Geoffrey D. Girnun, Stony Brook University, USA
APC-Dependent Suppression of Colon Carcinongenesis by PPARgamma

George E.O. Muscat, University of Queensland, Australia
Regulation of Metabolism in Skeletal Muscle by PPARs

Yau-Sheng Tsai, National Cheng Kung University, Taiwan
Hypertension but Not Overt Insulin Resistance in Mice with the P467L Mutation in PPARgamma

Short Talk(s) Chosen from Abstracts

16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Glucose Homeostasis and Diabetes
Meeting has ended...abstracts no longer viewable online.

Grays Peak 1-2
Willa A. Hsueh, Methodist Hospital Research Institute, USA
PPARgamma and Angiotensin II in the Vascular Disease in Diabetes

Jerrold M. Olefsky, University of California, San Diego, USA
Role of the PPARgamma Receptor in Muscle and Adipose Tissue Metabolism: Studies of Tissue Specific KO Mice

Takashi Kadowaki, University of Tokyo, Japan
The Role of PPARs in the Regulation of Insulin Sensitivity and Atherosclerosis

Ronald N. Margolis, NIDDK, National Institutes of Health, USA
Short Talk: An Orphan Nuclear Receptor Atlas

19:00—20:00
Social Hour

Longs Peak
20:00—22:00
Poster Session 2: Metabolism

Longs Peak

FRIDAY, FEBRUARY 7

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Cholesterol Homeostasis and Atherosclerosis
Meeting has ended...abstracts no longer viewable online.

Grays Peak 1-2
Richard A. Heyman, ORIC Pharmaceuticals, USA
Orphan Nuclear Receptors as Drug Discovery Target for Metabolic Disease

Linda K. Curtiss, The Scripps Research Institute, USA
Plasma Phospholipid Transfer Protein (PLTP) is Expressed in Macrophages and Present in Atherosclerotic Lesions

David D. Moore, Baylor College of Medicine, USA
Orphan Receptors in the Enterohepatic Axis

Michael P. Czubryt, University of Manitoba, Canada
Short Talk: MEF2/HDAC5 Regulation of PGC-1alpha Expression and Mitochondrial Maintenance

Thomas P. Burris, St. Louis University School of Medicine, USA
Short Talk: Ligand and Coactivator Identity Determines the Requirement of the “Charge Clamp” of PPARgamma for Coactivation

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs Peak
13:00—22:00
Poster Viewing

Longs Peak
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Glucose Homeostasis and Diabetes II
Meeting has ended...abstracts no longer viewable online.

Grays Peak 1-2
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Role of PPARgamma in Insulin Action and Gene Regulation in Skeletal Muscle

Peter Tontonoz, University of California, Los Angeles, USA
Role of PPARs and LXRs in Macrophage Lipid Metabolism

Timothy M. Willson, GlaxoSmithKline, USA
Structural Insights into the Regulation of Orphan Nuclear Receptors

19:00—20:00
Social Hour

Longs Peak
20:00—22:00
Poster Session 3: Inflammation

Longs Peak

SATURDAY, FEBRUARY 8

07:00—08:00
Breakfast

Longs Peak
08:00—11:00
Inflammation
Meeting has ended...abstracts no longer viewable online.

Grays Peak 1-2
Bart Staels, Institut Pasteur de Lille, Université Lille, France
PPARs at the Crossroads of Lipid Metabolism and Inflammation Control

Jorge Plutzky, Brigham and Women's Hospital, USA
PPARs as Modulators of the Inflammatory Response in the Vasculature

Peter A. Edwards, UCLA, USA
Nuclear Receptors and Lipid Transport

Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
Short Talk: Activation of PPARgamma in Dendritic Cells Alters Their Differentiation and T-Cell Activating Specificity

09:20—09:40
Coffee Break

Longs Peak Foyer
16:30—17:00
Coffee & Snacks Available

Longs Peak Foyer
17:00—19:00
Differentiation and Cancer
Meeting has ended...abstracts no longer viewable online.

Grays Peak 1-2
Walter Wahli, Nanyang Technological University, Singapore
Role of PPARs in Epidermal Differentiation

Philip W. Kantoff, Dana Farber Cancer Institute, USA
Is PPARgamma a Therapeutic Target in Prostate Cancer?

Frank J. Gonzalez, National Institutes of Health, USA
PPAR Null Mouse Update

19:00—20:00
Social Hour

Longs Peak
20:00—23:00
Entertainment

Longs Peak

SUNDAY, FEBRUARY 9

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 DK063898-01




We gratefully acknowledge additional support for this conference from:


Affinity BioReagents, Inc.

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