Fairmont Banff Springs Floorplan

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This meeting took place in 2003



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Twenty Years of HIV Research: From Discovery to Understanding (X2)


Organizer(s) Jay A. Levy, Alan L. Landay and Richard B. Gaynor
March 29—April 4, 2003
Fairmont Banff Springs • Banff, Alberta Canada
Abstract Deadline: Dec 31, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 29, 2003

Sponsored by Abbott Laboratories


Summary of Meeting:
Research on HIV/AIDS has defined new biologic processes involving HIV accessory genes and novel host immune responses including innate and adaptive immune activities. Moreover, the recognition of recombinant viruses may prove a challenge to antiviral strategies. Current antiviral drugs have prolonged the life of infected people but the emergence of drug resistance and drug toxicities calls for new avenues, particularly immune-based therapies. Approaches for inducing protective immune responses against HIV can be helpful for therapy and vaccine development. The 2003 Keystone Symposium will be dedicated to the knowledge gained in the 20 years since the discovery of HIV. The conference will deal with major issues in viral pathogenesis and the host immune responses to the virus by bringing together pioneers, well-known scientists and young investigators dedicated to reviewing the progress made. The sessions will assess new findings and address novel approaches for arresting viral replication within the infected host and define new directions in therapy and prevention.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


SATURDAY, MARCH 29

15:00—19:00
Registration

Van Horne Foyer
18:15—19:15
Welcome

Van Horne Foyer
19:15—19:30
Orientation

Van Horne Ballroom
19:30—21:30
Keynote Addresses (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Jay A. Levy, University of California, San Francisco, USA

* Richard A. Koup, NIAID, National Institutes of Health, USA

Daniel Tarantola, University of New South Wales, Australia
HIV/AIDS: Status of the Worldwide Epidemic

Richard B. Gaynor, Neon Therapeutics, USA
Intracellular Events Involved in HIV-1 Replication


SUNDAY, MARCH 30

06:30—08:00
Breakfast

New Brunswick/Riverview/Cascade/Conservatory
08:00—11:00
Pioneer Lecture - Virology (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Mario Stevenson, University of Miami, Leonard M. Miller School of Medicine, USA

08:00—11:00
Viral Diversity I (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
Robert W. Doms, University of Pennsylvania School of Medicine, USA
Virus Interaction at the Cell Surface

James E.K. Hildreth, UC Davis College of Biological Sciences, USA
HIV-1, Lipid Rafts, and Primary Macrophages: Modeling HIV-1 as a Trojan Exosome

* David I. Watkins, University of Miami, USA
SIV Diversity and Cellular Immune Responses

Cecilia Cheng-Mayer, Aaron Diamond AIDS Research Center, USA
Impact of HIV-1 Coreceptor Usage/Tropism on Viral Transmission, Persistence and Pathogenesis

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/NB/Riverview/Cascade/Conservatory
13:00—22:00
Poster Viewing

Alberta/NB/Riverview/Cascade/Conservatory
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Viral Diversity II (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Preston A. Marx, Tulane National Primate Research Center, USA

* Robert W. Coombs, University of Washington, USA

Bette Tina Marie Korber, Los Alamos National Laboratory, USA
Recombination: Now You See It, Now You Don't

Julie M. Overbaugh, Fred Hutchinson Cancer Research Center, USA
The Role of Hormones and Viral Diversity in HIV-1 Pathogenesis.

Phyllis J. Kanki, Harvard School of Public Health, USA
Pathogenesis of HIV Infections of Africa

Vanessa M. Hirsch, NIAID, National Institutes of Health, USA
Diversity of SIV: Relationship to Pathogenesis and Vaccine Development

19:30—20:30
Social Hour

Alberta/NB/Riverview/Cascade/Conservatory
20:00—22:00
Poster Session 1

Alberta/NB/Riverview/Cascade/Conservatory

MONDAY, MARCH 31

06:30—08:00
Breakfast

New Brunswick/Riverview/Cascade/Conservatory
08:00—11:00
Pioneer Lecture - Epidemiology
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Jan Andersson, Karolinska Institutet, Sweden

* Richard W. Price, University of California, San Francisco, USA

Harold W. Jaffe, Centers for Disease Control and Prevention, USA
HIV Epidemiology: Then and Now

08:00—11:00
HIV Pathogenesis I
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
Gene M. Shearer, National Cancer Institute, National Institutes of Health, USA
HIV-1 Pathogenesis: Revisiting Discarded and Ignored Models

Clayton A. Wiley, University of Pittsburgh, USA
HIV and the Brain: What Have We Learned and Where Are We Going?

Donald P. Kotler, St. Luke's Roosevelt Hospital Center, USA
HIV Pathogenesis in the Gastrointestinal Tract

Paul Klotman, Mount Sinai Medical Center, USA
Renal Epithelium is a Reservoir for HIV-1 Replication

08:00—11:00
New Findings From Human Clinical Trials
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
Emilio A. Emini, Bill and Melinda Gates Foundation, USA
Ongoing Development and Evaluation of a Potential HIV-1 Vaccine Using a Replication-Defective Adenoviral Vector

* Andrew J. McMichael, Oxford University, UK
On the AIDS Vaccine Trail

Barney S. Graham, NIAID, National Institutes of Health, USA
Update on Vaccine Research Center Clinical Trials of Candidate HIV Vaccines

M. Juliana McElrath, Fred Hutchinson Cancer Research Center, USA
Induction of Vaccine-Induced T Cell Responses and Their Role in HIV-1 Protection

Phillip W. Berman, University of California, Santa Cruz, USA
Preliminary Results of the Phase III Efficacy Trial of AIDSVAX B/B

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/NB/Riverview/Cascade/Conservatory
13:00—22:00
Poster Viewing

Alberta/NB/Riverview/Cascade/Conservatory
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
HIV Pathogenesis II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Anthony L. Cunningham, Westmead Institute for Medical Research, Australia

* Susan F. Plaeger, NIAID, National Institutes of Health, HHS, USA

Henry Masur, National Institutes of Health, USA
Opportunistic Infections in the Era of HAART

Patrick S. Moore, University of Pittsburgh Cancer Institute, USA
KSHV and Its Designer Genes

Joel M. Palefsky, University of California, San Francisco, USA
Cofactors: HPV infection

W. Henry Boom, Case Western Reserve University, USA
M. tuberculosis: Hiding from the Host Implications for HIV-TB

17:00—19:00
Pre-Clinical Leads in Non-Human Primates
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
Norman L. Letvin, Beth Israel Deaconess Medical Center, USA
Defining Protective Immunity to SHIV in Non-Human Primates

Ronald C. Desrosiers, University of Miami Miller School of Medicine, USA
Single Cycle SIV as a Vaccine Approach for AIDS Factors that Influence Resistance to Antibody-Mediated Neutralization

* Harriet L. Robinson, GeoVax Inc., USA
A Multiprotein DNA/MVA Vaccine for AIDS

John K. Rose, Yale University School of Medicine, USA
A Single VSV/SHIV Immunization Followed by One Heterologous MVA/SHIV Boost Results in Effective Control of Peak Virus Load After SHIV Challenge

19:30—20:30
Social Hour

Alberta/NB/Riverview/Cascade/Conservatory
20:00—22:00
Poster Session 2

Alberta/NB/Riverview/Cascade/Conservatory

TUESDAY, APRIL 1

06:30—08:00
Breakfast

New Brunswick/Riverview/Cascade/Conservatory
08:00—11:00
Pioneer Lecture - Immunology (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* Jack H. Nunberg†, University of Montana, USA

Susan Zolla-Pazner, Icahn School of Medicine at Mount Sinai, USA
Two Decades of Debate: The Role of Antibodies in HIV Immunity

08:00—11:00
Immune Responses in HIV Infection (Joint)
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom
* David C. Montefiori, Duke University Medical Center, USA
Understanding the New Generation of Neutralizing Antibody Assays

John R. Mascola, NIAID, National Institutes of Health, USA
Neutralizing Antibodies and Protective Immunity

Douglas F. Nixon, Weill Cornell Medicine, USA
CD8 T cell Effector Subsets and HIV infection

Mary Carrington, NCI, National Institutes of Health, USA
The Multifaceted Effects of the HLA class I Loci on HIV-1 Disease

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/NB/Riverview/Cascade/Conservatory
13:00—22:00
Poster Viewing

Alberta/NB/Riverview/Cascade/Conservatory
14:30—16:30
Workshop: Notable Observations in HIV Pathogenesis

Van Horne Ballroom C
* George N. Pavlakis, NCI, National Institutes of Health, USA
Role of Natural Killer Cells as Long-Term Viral Reservoir and Pharmacological Cellular Sanctuaries for HIV-1 in Patients

Roger J. Pomerantz, Seres Therapeutics, Inc., USA
Purging HIV-1 Reservoirs

Thomas Lehner, Guy's, King's & St. Thomas' Hospital Medical and Dental School, UK
Innate Mucosal and Systemic Immunity to HIV Infection

Ben Berkhout, University of Amsterdam, Academic Medical Center, Netherlands
Switching HIV Replication On and Off

* Hana Golding, US Food and Drug Administration, USA
A Novel Protozoan Derived CCR5 Antagonist, which Blocks HIV Infectivity

James A. Hoxie, University of Pennsylvania, USA
Enhanced Immune Control of SIVmac239 Infection by Mutations in a Conserved YxxØ Sorting Signal in the Transmembrane Cytoplasmic Tail

Donald L. Sodora, Center for Infectious Disease Research, USA
T-Cell Depletion in SIV Infected Macaques is followed by Elevated IL-7 Levels at Times prior to Simian AIDS and Death

Rafael V. Nájera, Instituto de Salud Carlos III, Spain
HIV-1 Unique Recombinant Forms and Superinfection in AIDS Pathogenesis

16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
The Envelope and Entry
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* Dan R. Littman, HHMI/New York University School of Medicine, USA
Role of Dendritic Cells in HIV Entry and Host Immune Responses

Dennis R. Burton, The Scripps Research Institute, USA
The Recognition of HIV-1 by Broadly Neutralizing Antibodies: Clues for Vaccine Design

Peter D. Kwong, NIAID, National Institutes of Health, USA
Application of Structural Biology to the Development of an HIV Vaccine

Cynthia A. Derdeyn, Emory University, USA
Short Talk: Selective Heterosexual Transmission of Envelope-constrained, Neutralization-sensitive HIV-1

17:00—19:00
Immune Responses (Innate) in HIV Infection II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Mario Clerici, Dipartimento di Fisiologia Medico-Chirurgica e dei Trapianti, Italy

* Carl W. Dieffenbach, NIAID, National Institutes of Health, USA

Bruce A. Beutler, University of Texas Southwestern Medical Center, USA
Forward Genetic Analysis of Innate Immunity

Christine A. Biron, Brown University, USA
Interferon and NK Cell Responses to Viral Infections

Jay A. Levy, University of California, San Francisco, USA
Innate Immunity: Plasmacytoid Dendritic Cells and the CD8+ Cell Noncytotoxic Anti-HIV Response

Deborah J. Anderson, Brigham and Women's Hospital, USA
Genital Tract Mucosal Immunity and HIV Infection

19:30—20:30
Social Hour

Alberta/NB/Riverview/Cascade/Conservatory
20:00—22:00
Poster Session 3

Alberta/NB/Riverview/Cascade/Conservatory

WEDNESDAY, APRIL 2

06:30—08:00
Breakfast

New Brunswick/Riverview/Cascade/Conservatory
08:00—11:00
Pioneer Lecture - Clinical Approaches
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Salvatore T. Butera, Centers for Disease Control and Prevention, USA

* Barbara Weiser, New York State Department of Health, USA

Paul A. Volberding, University of California, San Francisco, USA
Clinical Care

08:00—11:00
Antiviral Strategies I
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
Carl Grunfeld, Veterans Affairs Medical Center, USA
The Role of Antiretroviral Drugs in Metabolic and Fat Distribution Changes of HIV Infection

Edward A. Berger, NIAID, National Institutes of Health, USA
Immunotoxins to Target HIV Infected Cell Reservoirs

Flossie Wong-Staal, ItherX Pharmaceuticals Inc., USA
Identification of Essential HIV Cellular Co-Factors through Genomic Approaches

Michael M. Lederman, Case Western Reserve University, USA
Interleukin-2: A Determinant of Immune Competence in HIV disease? Will Administration Confer Clinical Benefit?

08:00—11:00
Immunopathogenesis I
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* Rafi Ahmed, Emory University School of Medicine, USA
Understanding Immunological Memory to Improve Vaccination Strategies"

Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Immune Control and Immune Failure in HIV Infection

Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois, Switzerland
Protective CD4 and CD8 T Cell Responses in HIV-1 Infection

Genoveffa Franchini, NCI, National Institutes of Health, USA
Modeling Immune Intervention Strategies for HIV-1 Infection of Humans in the Macaque Model

Olivier Schwartz, Institut Pasteur, France
HIV and Dendritic Cells: Virus Spread and Antigen Presentation

09:20—09:40
Coffee Break

Van Horne Foyer
11:00—13:00
Poster Setup

Alberta/NB/Riverview/Cascade/Conservatory
13:00—22:00
Poster Viewing

Alberta/NB/Riverview/Cascade/Conservatory
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
HIV Pathogenesis III
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Ronald G. Collman, University of Pennsylvania, USA

* Loyda M. Meléndez, University of Puerto Rico School of Medicine, USA

Crystal L. Mackall, Stanford University, USA
Therapeutic Modulation of T Cell Homeostasis

Maria Prins, Municipal Health Service, Netherlands
Gender Differences in HIV Infection

Keith R. Fowke, University of Manitoba, Canada
Natural Immunity to HIV Infection

17:00—19:00
Immunopathogenesis II
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
Halting HIV Evolution

* Douglas D. Richman, University of California, San Diego, USA
The Evolution and Neutralization Escape of HIV

Daniel C. Douek, NIAID, National Institutes of Health, USA
In Vivo distribution of HIV among T cell subsets

Louis J. Picker, Oregon Health & Science University, USA
T Cell Dynamics in SIV Infection

19:30—20:30
Social Hour

Alberta/NB/Riverview/Cascade/Conservatory
20:00—22:00
Poster Session 4

Alberta/NB/Riverview/Cascade/Conservatory

THURSDAY, APRIL 3

06:30—08:00
Breakfast

New Brunswick/Riverview/Cascade/Conservatory
08:00—11:00
HIV Pathogenesis IV
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Peter Simmonds, University of Edinburgh, UK

Klaus Strebel, NIAID, National Institutes of Health, USA
HIV-1 Vif: A Multifunctional Adaptor Molecule

Frederic D. Bushman, University of Pennsylvania, USA
Twenty Years of Research on Retroviral Integration

Tristram G. Parslow, Emory University, USA
RNA Dimers as Templates for Viral and Cellular Reverse Transcription

* David Camerini, University of California, Irvine, USA

James J. Goedert, National Institutes of Health, USA
Roles of Hepatitis C virus (HCV) and GB virus C (GBV-C) in HIV Pathogenesis

08:00—11:00
Novel Approaches in Pre-Clinical and Clinical Development
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
Robert E. Johnston, Global Vaccines, Inc., USA
Use of VEE to Stimulate Protective Immunity to HIV

* Philip R. Johnson, Children's Hospital of Philadelphia, USA
Pre-clinical Evaluation of a Novel HIV Vaccine Based on an Adeno-associated Virus Vector.

Jeffrey D. Lifson, Leidos Biomedical Research, Inc., USA
Control of Pathogenic SIV Infection: Different Routes to the Same Goal

Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC, France
Effect of Therapeutic Vaccination and STI on Immune Control of HIV

09:20—09:40
Coffee Break

Van Horne Foyer
16:30—17:00
Coffee & Snacks Available

Van Horne Foyer
17:00—19:00
Late Breaking Observations and Conclusions
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom C
* Alan L. Landay, Rush Medical University, USA

Jerome A. Zack, University of California, Los Angeles, USA
Strategies to Eliminate Latent HIV

David M. Margolis, University of North Carolina at Chapel Hill HIV Cure Center, USA
Derepression by DNA-binding Polyamides Allows Outgrowth of Human Immunodeficiency Type 1 from Resting CD4+ T Cells: Regulators of HIV Latency

Thomas J. Hope, Northwestern University, USA
Enhancement of HIV Infection by Dendritic Cells: Transfer of HIV to Target Cells Through an Infectious Synapse

Leonid Margolis, NICHD, National Institutes of Health, USA
Viral Interactions in HIV-Infected Human Lymphoid Tissue

Joshua J. Anzinger, NHLBI, National Institutes of Health, USA
Attachment Levels of HIV Differ between PBMC Donors In A CD4 Independent Manner

Edward Barker, Rush University Medical Center, USA
Inability of Natural Killer Cells to Destroy Autologous HIV-Infected Primary CD4+ T Cells

David J. Volsky, Columbia University, St. Luke's Roosevelt Hospital Center, USA
Interaction of HIV with Astrocytes: A Case for a Direct Role of HIV in Neuropathogenesis

Lishan Su, University of North Carolina at Chapel Hill, USA
A Novel Genetic Approach to Inactivating Chemokine Receptors by a Modified HIV Protein

17:00—19:00
Late Breakers
Meeting has ended...abstracts no longer viewable online.

Van Horne Ballroom A-B
* Richard A. Koup, NIAID, National Institutes of Health, USA

Daniel E. Kaufmann, University of Montreal, Canada
Short Talk: Comprehensive Analysis of HIV-Specific CD4 Responses by IFN-Gamma Elispot in Early Chronic HIV-1 Infection Shows Marked Immunodominance of gag and nef and the Presence of Broadly Recognized Peptides

Victor Appay, INSERM U1135 - CIMI, France
Short Talk: Activation and Differentiation of HIV Non-Specific CD8+ T Cells During HIV-1 Infection

Matthew R. Reynolds, University of Wisconsin-Madison, USA
Short Talk: Viral Dissemination and Kinetics of Cytotoxic T-Lymphocyte Development in Mamu-A*01 Positive Macaques Infected with SIVmac239

Ann Chahroudi, Emory University School of Medicine, USA
Short Talk: Towards Better Strategies for Poxvirus-Based HIV Vaccines: Studies of the Cellular Tropism of Modified Vaccinia Ankara (MVA) and Vaccinia Virus (VV) in Primary Human Cells

Teunis B.H. Geijtenbeek, University of Amsterdam, Netherlands
Short Talk: Mycobacteria Suppress Dendritic Cell Function: Effects on HIV-1 Infection

John P. Moore, Weill Medical College of Cornell University, USA
Short Talk: Prevention of Virus Transmission to Macaque Monkeys by Vaginally Applied Entry Inhibitors

Leonidas Stamatatos, Fred Hutchinson Cancer Research Center, USA
Short Talk: Priming by Vaccination of HIV Envelope-Specific B-Cell Responses Allows for the Long-Term Control of SHIVSF162P4-Replication in Macaques

Pascal Poignard, IAVI Neutralizing Antibody Center at The Scripps Research Institute, USA
Short Talk: Stoichiometry of Neutralization of the Primary HIV-1 Isolate JR-CSF by the Anti-CD4 Binding Site Antibody b12

19:30—20:30
Social Hour

Alberta/NB/Riverview/Cascade/Conservatory
20:30—23:30
Entertainment

Alberta/NB/Riverview/Cascade/Conservatory

FRIDAY, APRIL 4

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI054154-01




We gratefully acknowledge additional support for this conference from:


Abbott Laboratories
Office of AIDS Research, NIH

Abbott Laboratories

Boehringer Ingelheim (Canada) Ltd.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

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Phone:+1 970-262-2676