Granlibakken Tahoe Floorplan

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This meeting took place in 2003



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Eicosanoid Lipid Mediators: From Molecular Discovery to Clinical Application (D5)


Organizer(s) Jilly F. Evans, Colin D. Funk and Takao Shimizu
March 11—16, 2003
Granlibakken Tahoe • Tahoe City, California USA
Abstract Deadline: Nov 11, 2002
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Jan 13, 2003

Sponsored by Aventis Pharmaceuticals, Inc.

Summary of Meeting:
Recent advances in the cloning and molecular characterization of eicosanoid pathway enzymes and receptors have provided both new structural, functional and genetic information and novel therapeutic targets. Eicosanoid pathway inhibitors (notably COX-2 inhibitors) and antagonists (notably CysLT1 receptor antagonists) have already found important places in the therapies of arthritis, pain and asthma. Novel applications for eicosanoid pathway modulators include other inflammatory and allergic diseases and cancer. The goal of the Keystone meeting in 2003 will be to combine state-of-the-art basic biology, including biochemistry, pharmacology and structural and genetic biology, with application of this knowledge to human therapeutics. This meeting will encourage scientific networking amongst different academic disciplines and industrial speakers in an informal and friendly atmosphere conducive to sharing latest data and building further collaborations. The key organizer is a woman and there will be a strong representation of women and minority speakers and interactive talks, eicosanoid trivia quizzes, poster prizes and special social events to encourage maximum scientific and social interactions. Specific topics will include cyclooxygenase structure and function and clinical benefit of cyclooxygenase-2 inhibitors, prostaglandin receptor expression, function and disease targets, lipoxygenases and leukotriene receptor cell biology and genetics, and clinical applications of eicosanoid pathway modulators.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, MARCH 11

15:00—19:00
Registration

Pre-Function
19:15—19:30
Orientation

Mountain/Lake Rooms
19:30—20:30
Keynote Address
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
Peter C. Isakson, Abbott Bioresearch Center, USA
Pharmacology and Clinical Utility of Cyclooxygenase-2 Inhibitors


WEDNESDAY, MARCH 12

07:00—08:00
Breakfast

Granhall
08:00—11:00
Cyclooxygenase Biochemistry and Cell Biology
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Lawrence J. Marnett, Vanderbilt University School of Medicine, USA

William L. Smith, University of Michigan, USA
Cyclooxygenase and Peroxidase Catalysis by Prostaglandin Endoperoxide H Synthases

Paola Patrignani, G. D'Annunzio University, Italy
Cyclooxygenase Inhibition and Cardiovascular Disease

Marc Pouliot, Université Laval, Canada
Cell Biology of COX-2 in Human Neutrophils: Impact of Adenosine

Raymond N. DuBois, Arizona State University, USA
COX-2 I and Cancer: Is There a Connection?

09:20—09:40
Coffee Break

Pre-Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:00
Prostaglandin Receptors
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Paola Patrignani, G. D'Annunzio University, Italy

Shuh Narumiya, Kyoto University, Japan
Prostanoid-Mediated Body Defense Mechanisms and Outcome of their Breakdown

Kathleen M. Metters, Merck Frosst Centre for Therapeutic Research, Canada
The Prostanoid DP Receptor as a Target for Respiratory Diseases

Hiroyuki Hirai, BioMedical Laboratories, Japan
CRTH2, a Novel Prostaglandin D2 Receptor

19:00—20:00
Dinner

Granhall
20:00—21:00
Social Hour

Bay Room
20:00—22:00
Poster Session 1

Bay Room

THURSDAY, MARCH 13

07:00—08:00
Breakfast

Granhall
08:00—11:00
Lipoxygenases and Leukotrienes
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Jilly F. Evans, PharmAkea Therapeutics, USA

Olof Radmark, Karolinska Institute, Sweden
5-Lipoxygenase: Ca2+, Phosphorylation and Interacting Proteins

Roy J. Soberman, Harvard Medical School, USA
Assembly of the Macromolecular Leukotriene Biosynthetic Complex

Wonhwa Cho, University of Illinois at Chicago, USA
Interactions of Secretory PLA2, Cytosolic PLA2 and 5-Lipoxygenase in Leukotriene Biosynthesis

Alan R. Brash, Vanderbilt University Medical Center, USA
Short Talk: Epithelial Lipoxygenases and their Functioning

09:20—09:40
Coffee Break

Pre-Function
11:00—13:00
Poster Setup

Bay Room
13:00—22:00
Poster Viewing

Bay Room
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:15
Prostaglandin and Leukotriene Synthases
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Robert C. Murphy, University of Colorado Denver, USA

Per-Johan Jakobsson, Karolinska Institutet, Sweden
Microsomal Prostaglandin E synthase 1

Laurent Audoly, Pieris AG, Germany
PGE Synthase

Yoshihiro Urade, Osaka Bioscience Institute, Japan
Prostaglandin D Synthase: From X-Ray Crystallography to Gene Manipulation

K. Frank Austen, Harvard Medical School, USA
Leukotriene C4 Synthase

19:15—20:15
Theme Dinner
The Thursday night dinner will have a dress theme for those that wish to come as someone/something starting with the letter M, e.g. Mickey Mouse, Madonna, Michael Jackson, etc. There will be prizes for most original, most easy to identify and most colorful. The organizers hope you will wear your M theme clothing for a fun dinner.

Granhall
20:00—21:00
Social Hour

Bay Room
20:00—22:00
Poster Session 2

Bay Room

FRIDAY, MARCH 14

07:00—08:00
Breakfast

Granhall
08:00—11:00
Phospholipases
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Colin D. Funk, Queen's University, Canada

Gérard Lambeau, Centre National de la Recherche Scientifique, France
Molecular Diversity and Functional Properties of Secreted Phospholipases A2

Christina C. Leslie, National Jewish Health, USA
The Cytosolic Phospholipase A2 Catalytic Domain Modulates Association and Residence Time at Golgi Membranes

Michael H. Gelb, University of Washington, USA
Structure, Function and Cellular Behavior of Mammalian Phospholipases A2

Takao Shimizu, University of Tokyo, Japan
Roles of Cytosolic Phospholipase A2 and Related Molecules in vivo

09:20—09:40
Coffee Break

Pre-Function
11:30—13:00
BBQ Lunch

Granhall
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:00
Novel Eicosanoids
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Roy J. Soberman, Harvard Medical School, USA

Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Endocannabinoid PG's and HETE's

Robert C. Murphy, University of Colorado Denver, USA
Covalent Binding of Leukotriene A4 to DNA and RNA

Giancarlo Folco, University of Milano, Italy
Transcellular Synthesis of Leukotrienes: The Dangerous Liaisons between Neutrophils and Endothelial Cells in Cardiac and Cerebral Vasculature

19:00—20:00
Dinner

Granhall
20:00—22:00
Workshop

Mountain/Lake Rooms
* Leslie J. Crofford, University of Kentucky, USA

Christine D. Harman, Michigan State University, USA
Crystal Structure of Aracidonic Acid Bound to a Mutant of Prostaglandin Endoperoxide Synthase-1 That Forms 11-HPETE instead of PGG2

Betty P. Stamatiou, Merck Frosst, Canada
5-Oxo-ETE is an Angiogenic Factor for Human Endothelial Cells

Sung-Hoon Cho, Korea University, South Korea
IgE-Dependent Leukotriene Synthesis via Rac-PKC-Delta-Linked Cascade in RBL-2H3 Mast Cells

Irving C. Allen, Virginia Tech, USA
The Thromboxane A2 Receptor Agonist U46619 Induces Airway Hyperresponsiveness by the Activation of Neural Pathways in Mice

Santosh K. Ramamurthy, University of Illinois at Chicago, USA
Role of the TXA2 Receptor in Oligodendrocyte Differentiation

Stacia Kargman, Merck Frosst Canada & Company, Canada
Rofecoxib Attenuates Tumors and Metastases and Increases Survival in a Mouse Model of Colorectal Cancer


SATURDAY, MARCH 15

07:00—08:00
Breakfast

Granhall
08:00—11:15
Leukotriene Receptors
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* Takao Shimizu, University of Tokyo, Japan

Takashi Izumi, Gunma University School of Medicine, Japan
Molecular Cloning and Regulation of Two Leukotriene B4 Receptors

Jilly F. Evans, PharmAkea Therapeutics, USA
Cysteinyl Leukotriene Receptors

Joseph Parello, Centre National de la Recherche Scientifique, France
Structure-Based Analysis of GPCR Function: The Leukotriene Receptors Expressed in Escherichia coli

Colin D. Funk, Queen's University, Canada
Transgenic Cysteinyl Leukotriene Receptor Mice

Jana Stankova, Université de Sherbrooke, Canada
Modulation of Expression and Function of Leukotriene Receptors

09:20—09:40
Coffee Break

Pre-Function
16:30—17:00
Coffee & Snacks Available

Pre-Function
17:00—19:30
Eicosanoids and Disease
Meeting has ended...abstracts no longer viewable online.

Mountain/Lake Rooms
* K. Frank Austen, Harvard Medical School, USA

Sally Wenzel-Morganroth, University of Pittsburgh, USA
The Role of Lipoxygenase Products in Asthma

Leslie J. Crofford, University of Kentucky, USA
Prostaglandins in Arthritis: Implications for Treatment

Andreas J. R. Habenicht, Institute for Prophylaxis of Cardiovascular Diseases, Germany
The 5-Lipoxygenase (5-LO) Pathway Constitutes Inflammatory Circuits in Diseased Arteries during Human Atherogenesis

Colin D. Funk, Queen's University, Canada

19:00—20:00
Social Hour

Granhall
20:00—21:00
Dinner

Mountain/Lake Rooms
21:00—12:00
Entertainment

Mountain/Lake Rooms

SUNDAY, MARCH 16

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI053151-01




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